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Stock-Based Compensation (Tables)
 6 Months Ended
Jun. 30, 2022
Share-Based Payment Arrangement [Abstract]  
Schedule of Stock-Based Compensation Expense
The Company recorded all stock-based compensation expense in the consolidated statements of operations as follows (in thousands):
Three Months Ended
June 30,		Six Months Ended
June 30,
2022202120222021
Research and development$19,695 $24,779 $36,582 $48,569 
General and administrative18,353 28,344 34,399 57,614 
Total stock-based compensation expense$38,048 $53,123 $70,981 $106,183 
Schedule of Option and Appreciation Rights Activity
The following is a summary of stock options and SARs activity under the 2015 Plan and 2005 Plan for the six months ended June 30, 2022:
2015 Plan2005 Plan
Stock
Options		Weighted-Average
Exercise
Price		Stock
Options		Weighted-Average
Exercise
Price
Outstanding at December 31, 20213,635,837 $42.60 68,225 $109.52 
Granted506,821 73.94 — 
Exercised(59,727)15.61 (3,000)31.10 
Canceled(35,195)78.51 (1,500)121.00 
Outstanding at June 30, 20224,047,736 $46.61 63,725 $112.94 
Shares exercisable at June 30, 20221,463,037 $55.28 63,725 $112.94 
Shares available for grant at June 30, 20224,834,171 
Schedule of Assumptions Used in Estimation of Fair Value of Stock
The fair value of stock options granted under the 2015 Plan was estimated at the date of grant using the Black-Scholes option-pricing model with the following assumptions:
Three Months Ended
June 30,		Six Months Ended
June 30,
2022202120222021
Weighted average Black-Scholes fair value of stock options granted
$43.21
$166.66
$62.52
$131.66
Risk-free interest rate
2.7%-3.2%
0.6%-1.1%
1.4%-3.2%
0.5%-1.1%
Dividend yield—%—%—%—%
Volatility
120.5%-136.7%
126.2%-142.0%
120.5%-136.7%
124.7%-142.0%
Expected term (in years)
4.0-6.2
4.1-6.1
4.0-6.2
4.1-6.1
The ESPP is considered compensatory for financial reporting purposes. As such, the fair value of ESPP shares was estimated at the date of grant using the Black-Scholes option-pricing model with the following assumptions:
Six Months Ended
June 30,
20222021
Range of Black-Scholes fair values of ESPP shares granted
$44.67-$79.74
$128.70-$238.85
Risk-free interest rate
0.6%-1.4%
0.1%
Dividend yield—%—%
Volatility
116.2%-142.9%
120.4%-159.4%
Expected term (in years)
0.5-2
0.5-2.0
Schedule Of Share Based Compensation Restricted Stock Awards Activity
The following is a summary of RSU activity for the six months ended June 30, 2022:
Number of
Shares		Per Share
Weighted-
Average
Fair Value
Outstanding and unvested at December 31, 2021819,828 $116.70 
Granted882,828 74.34 
Vested(55,425)157.97 
Forfeited(71,989)110.57 
Outstanding and unvested at June 30, 20221,575,242 $91.79