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Collaboration and License Agreements (Details) $ in Thousands | 12 Months Ended |  |
--- | --- | --- | ---
Dec. 31, 2022 USD ($) installment | Dec. 31, 2021 USD ($) | Dec. 31, 2020 USD ($) | Sep. 30, 2021 dose | Feb. 28, 2021 dose
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |  |
Research and development | $ 1,235,278 | $ 2,534,508 | $ 747,027 |  |
Takeda Arrangement |  |  |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |  |
Number of doses to be distributed | dose |  |  |  | 150,000,000 |
Milestone payment recognized | 20,000 |  | $ 20,000 |  |
SK Bioscience Agreement |  |  |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |  |
Number of doses to be distributed | dose |  |  |  |  | 40,000,000
Settlement Agreement |  |  |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |  |
Settlement payment | 185,000 |  |  |  |
Initial reservation fee | $ 47,800 |  |  |  |
Number of quarterly installment payments | installment | 4 |  |  |  |
Settlement agreement, quarterly installment amount | $ 34,300 |  |  |  |
Research and development | 98,300 |  |  |  |
Settlement Agreement | Accrued Liabilities |  |  |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |  |
Settlement payment | $ 137,200 |  |  |  |

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- Definition The aggregate costs incurred (1) in a planned search or critical investigation aimed at discovery of new knowledge with the hope that such knowledge will be useful in developing a new product or service, a new process or technique, or in bringing about a significant improvement to an existing product or process; or (2) to translate research findings or other knowledge into a plan or design for a new product or process or for a significant improvement to an existing product or process whether intended for sale or the entity's use, during the reporting period charged to research and development projects, including the costs of developing computer software up to the point in time of achieving technological feasibility, and costs allocated in accounting for a business combination to in-process projects deemed to have no alternative future use. + References Reference 1: http://www.xbrl.org/2009/role/commonPracticeRef -Publisher FASB -Name Accounting Standards Codification -Topic 912 -SubTopic 730 -Section 25 -Paragraph 1 -URI https://asc.fasb.org/extlink&oid=6472174&loc=d3e58812-109433 Reference 2: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 985 -SubTopic 20 -Section 50 -Paragraph 1 -URI https://asc.fasb.org/extlink&oid=6501960&loc=d3e128462-111756 Reference 3: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 730 -SubTopic 10 -Section 50 -Paragraph 1 -URI https://asc.fasb.org/extlink&oid=6420194&loc=d3e21568-108373 + Details
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