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Other Financial Information | 12 Months Ended
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Dec. 31, 2022
Organization, Consolidation and Presentation of Financial Statements [Abstract] |
Other Financial Information | Other Financial Information Prepaid Expenses and Other Current Assets Prepaid expenses and other current assets consist of the following at December 31 (in thousands):
| December 31,
| 2022 |  | 2021
Prepaid expenses | $ | 160,773 |  |  | $ | 120,029 |
Other current assets | 76,374 |  |  | 44,619 |
Prepaid expenses and other current assets | $ | 237,147 |  |  | $ | 164,648 |
Property and Equipment, net Property and equipment is comprised of the following at December 31 (in thousands):
| December 31,
| 2022 |  | 2021
Land and buildings | $ | 101,342 |  |  | $ | 83,534 |
Machinery and equipment | 134,809 |  |  | 119,998 |
Leasehold improvements | 18,895 |  |  | 10,282 |
Computer hardware | 4,927 |  |  | 2,612 |
Construction in progress | 81,566 |  |  | 35,114 |
| 341,539 |  |  | 251,540 |
Less: accumulated depreciation | (47,292) |  |  | (25,799) |
Property and equipment, net | $ | 294,247 |  |  | $ | 225,741 |
As of December 31, 2022 and 2021, approximately $170.0 million and $164.0 million, respectively, of net assets used in operations were located in the Czech Republic. Depreciation expense was approximately $29.1 million, $12.5 million, and $4.3 million for the years ended December 31, 2022, 2021, and 2020, respectively. Accrued Expenses Accrued expenses consist of the following at December 31 (in thousands):
| December 31,
| 2022 |  | 2021
Employee benefits and compensation | $ | 52,569 |  |  | $ | 38,419 |
Research and development accruals | 468,214 |  |  | 577,100 |
Other accrued expenses | 70,375 |  |  | 58,212 |
Accrued expenses | $ | 591,158 |  |  | $ | 673,731 |
Other Current Liabilities Other current liabilities consist of the following at December 31 (in thousands):
| December 31,
| 2022 |  | 2021
Refunds to customers | $ | 210,362 |  |  | $ | — |
Other current liability related to Gavi (see Note 3 and Note 18) | 697,384 |  |  | — |
Other current liabilities | 22,309 |  |  | 36,061 |
Total other current liabilities | $ | 930,055 |  |  | $ | 36,061 |

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