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Summary of Significant Accounting Policies - Additional Information (Details) |  |  |  |  | 1 Months Ended | 12 Months Ended |  |
--- | --- | --- | --- | --- | --- | --- | --- | ---
Feb. 01, 2023 USD ($) | Jan. 31, 2023 USD ($) | Oct. 01, 2022 USD ($) | Oct. 01, 2021 USD ($) | Dec. 31, 2022 USD ($) $ / shares | Dec. 31, 2022 USD ($) reporting_unit segment $ / shares shares | Dec. 31, 2021 USD ($) | Dec. 31, 2020 USD ($) | Dec. 31, 2016 shares | Dec. 31, 2019 USD ($) | Jan. 25, 2016 $ / shares
Summary of Significant Accounting Policies [Line Items] |  |  |  |  |  |  |  |  |  |  |
Cash and cash equivalents and restricted cash |  |  |  |  | $ 1,348,845,000 | $ 1,348,845,000 | $ 1,528,259,000 | $ 648,738,000 |  | $ 82,180,000 |
Net loss |  |  |  |  |  | (657,939,000) | (1,743,751,000) | (418,259,000) |  |  |
Net cash provided by (used in) operating activities |  |  |  |  |  | (415,937,000) | 322,946,000 | (42,541,000) |  |  |
Collaboration agreement upfront payment amount |  |  |  |  | 819,000,000 | 819,000,000 |  |  |  |  |
Advertising costs |  |  |  |  |  | $ 84,000,000 | 8,900,000 |  |  |  |
Number of reporting units | reporting_unit |  |  |  |  |  | 1 |  |  |  |  |
Impairment to goodwill |  |  | $ 0 | $ 0 |  |  |  |  |  |  |
Income tax expense |  |  |  |  |  | $ 4,292,000 | 29,215,000 | 0 |  |  |
Foreign currency translation adjustment |  |  |  |  | (6,400,000) | (6,400,000) | (1,400,000) |  |  |  |
Foreign currency transaction (losses) gain |  |  |  |  |  | $ (2,500,000) | $ (5,300,000) | $ 9,600,000 |  |  |
Number of operating segments | segment |  |  |  |  |  | 1 |  |  |  |  |
Gavi Advance Purchase Agreement- COVAX Facility |  |  |  |  |  |  |  |  |  |  |
Summary of Significant Accounting Policies [Line Items] |  |  |  |  |  |  |  |  |  |  |
Collaboration agreement upfront payment amount |  |  |  |  | 697,400,000 | $ 697,400,000 |  |  |  |  |
Government Contract | USG Agreement |  |  |  |  |  |  |  |  |  |  |
Summary of Significant Accounting Policies [Line Items] |  |  |  |  |  |  |  |  |  |  |
Research and development arrangement, contract to perform for others, contract remaining |  |  |  |  | 416,000,000 | $ 416,000,000 |  |  |  |  |
5.00% Convertible notes due 2027 | Unsecured Debt |  |  |  |  |  |  |  |  |  |  |
Summary of Significant Accounting Policies [Line Items] |  |  |  |  |  |  |  |  |  |  |
Sale of common stock and issuance debt |  |  |  |  | $ 236,200,000 |  |  |  |  |  |
Number of shares issued for debt converted (in shares) | shares |  |  |  |  |  | 16,400,000 |  |  |  |  |
Debt instrument, convertible, conversion price (in usd per share) | $ / shares |  |  |  |  | $ 12.50 | $ 12.50 |  |  |  |  |
3.75% Convertible notes due 2023 | Unsecured Debt |  |  |  |  |  |  |  |  |  |  |
Summary of Significant Accounting Policies [Line Items] |  |  |  |  |  |  |  |  |  |  |
Number of shares issued for debt converted (in shares) | shares |  |  |  |  |  | 16,400,000 |  |  | 2,385,800 |  |
Debt instrument, convertible, conversion price (in usd per share) | $ / shares |  |  |  |  | $ 136.20 | $ 136.20 |  |  |  |  | $ 136.20
3.75% Convertible notes due 2023 | Unsecured Debt | Subsequent Event |  |  |  |  |  |  |  |  |  |  |
Summary of Significant Accounting Policies [Line Items] |  |  |  |  |  |  |  |  |  |  |
Repayments of debt | $ 325,000,000 | $ 325,000,000 |  |  |  |  |  |  |  |  |
Minimum |  |  |  |  |  |  |  |  |  |  |
Summary of Significant Accounting Policies [Line Items] |  |  |  |  |  |  |  |  |  |  |
Requisite service period |  |  |  |  |  | 1 year |  |  |  |  |
Maximum |  |  |  |  |  |  |  |  |  |  |
Summary of Significant Accounting Policies [Line Items] |  |  |  |  |  |  |  |  |  |  |
Requisite service period |  |  |  |  |  | 4 years |  |  |  |  |

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