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Stock-Based Compensation (Tables) | 12 Months Ended
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Dec. 31, 2023
Share-Based Payment Arrangement [Abstract] |
Schedule of Stock-Based Compensation Expense | The Company recorded stock-based compensation expense in the consolidated statements of operations as follows (in thousands):
| Year Ended December 31,
| 2023 |  | 2022 |  | 2021
Cost of sales | $ | 3,417 |  |  | $ | 1,032 |  |  | $ | — |
Research and development | 41,211 |  |  | 66,565 |  |  | 86,928 |
Selling, general, and administrative | 40,729 |  |  | 62,703 |  |  | 96,698 |
Total stock-based compensation expense | $ | 85,357 |  |  | $ | 130,300 |  |  | $ | 183,626 |
Schedule of Option and Appreciation Rights Activity | The following is a summary of stock options and SARs activity under the 2023 Inducement Plan, 2015 Plan and the 2005 Plan for the year ended December 31, 2023:
| 2023 Inducement Plan |  | 2015 Plan |  | 2005 Plan
| Stock Options |  | Weighted- Average Exercise Price |  | Stock Options & SARs |  | Weighted- Average Exercise Price |  | Stock Options |  | Weighted- Average Exercise Price
Outstanding at January 1, 2023 | — |  |  | $ | — |  |  | 4,053,290 |  |  | $ | 46.07 |  |  | 63,725 |  |  | $ | 112.94 |
Granted | 422,800 |  |  | $ | 10.67 |  |  | 1,021,596 |  |  | $ | 7.04 |  |  | — |  |  | $ | — |
Exercised | — |  |  | $ | — |  |  | (9,483) |  |  | $ | 6.07 |  |  | — |  |  | $ | — |
Canceled | — |  |  | $ | — |  |  | (278,361) |  |  | $ | 41.38 |  |  | (5,450) |  |  | $ | 39.70 |
Outstanding at December 31, 2023 | 422,800 |  |  | $ | 10.67 |  |  | 4,787,042 |  |  | $ | 38.10 |  |  | 58,275 |  |  | $ | 119.79 |
Shares exercisable at December 31, 2023 | — |  |  | $ | — |  |  | 3,436,339 |  |  | $ | 41.51 |  |  | 58,275 |  |  | $ | 119.79 |
Schedule of Assumptions Used in Estimation of Fair Value of Stock | The fair value of stock options granted under the 2023 Inducement Plan and the 2015 Plan was estimated at the date of grant using the Black-Scholes option-pricing model with the following assumptions:
| Year Ended December 31,
| 2023 |  | 2022 |  | 2021
Weighted average Black-Scholes fair value of stock options and SARs granted | $7.00 |  | $55.32 |  | $158.02
Risk-free interest rate | 3.5%-4.8% |  | 1.4%-4.3% |  | 0.5%-1.3%
Dividend yield | —% |  | —% |  | —%
Volatility | 120.4%-140.3% |  | 120.5%-140.1% |  | 124.7%-142.0%
Expected term (in years) | 3.9-6.4 |  | 4.0-6.3 |  | 4.1-6.1
Schedule of Restricted Stock Units Activity | The following is a summary of RSU activity for the year ended December 31, 2023:
| 2023 Inducement Plan |  | 2015 Plan
| Number of Shares |  | Per Share Weighted- Average Fair Value |  | Number of Shares |  | Per Share Weighted- Average Fair Value
Outstanding and unvested at January 1, 2022 | — |  |  | $ | — |  |  | 2,034,574 |  |  | $ | 61.65 |
Restricted stock units granted | 363,990 |  |  | $ | 10.66 |  |  | 3,314,452 |  |  | $ | 7.06 |
Restricted stock units vested | — |  |  | $ | — |  |  | (696,553) |  |  | $ | 73.73 |
Restricted stock units forfeited | — |  |  | $ | — |  |  | (937,603) |  |  | $ | 27.04 |
Outstanding and unvested at December 31, 2023 | 363,990 |  |  | $ | 10.66 |  |  | 3,714,870 |  |  | $ | 19.43 |

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- Definition Tabular disclosure of allocation of amount expensed and capitalized for award under share-based payment arrangement to statement of income or comprehensive income and statement of financial position. Includes, but is not limited to, corresponding line item in financial statement. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (h)(1) -Publisher FASB -URI https://asc.fasb.org//1943274/2147480429/718-10-50-2 + Details
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- Definition Tabular disclosure for stock option plans. Includes, but is not limited to, outstanding awards at beginning and end of year, grants, exercises, forfeitures, and weighted-average grant date fair value. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (c)(1) -Publisher FASB -URI https://asc.fasb.org//1943274/2147480429/718-10-50-2 Reference 2: http://fasb.org/us-gaap/role/ref/legacyRef -Name Accounting Standards Codification -Section 50 -Paragraph 2 -Subparagraph (d) -SubTopic 10 -Topic 718 -Publisher FASB -URI https://asc.fasb.org//1943274/2147480429/718-10-50-2 Reference 3: http://fasb.org/us-gaap/role/ref/legacyRef -Name Accounting Standards Codification -Section 50 -Paragraph 2 -Subparagraph (e) -SubTopic 10 -Topic 718 -Publisher FASB -URI https://asc.fasb.org//1943274/2147480429/718-10-50-2 + Details
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- Definition Tabular disclosure of the significant assumptions used during the year to estimate the fair value of stock options, including, but not limited to: (a) expected term of share options and similar instruments, (b) expected volatility of the entity's shares, (c) expected dividends, (d) risk-free rate(s), and (e) discount for post-vesting restrictions. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Topic 718 -SubTopic 10 -Subparagraph (f)(2) -Name Accounting Standards Codification -Paragraph 2 -Section 50 -Publisher FASB -URI https://asc.fasb.org//1943274/2147480429/718-10-50-2 + Details
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