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v3.24.0.1

Collaboration, License, and Supply Agreements (Details) $ / shares in Units, $ in Thousands, shares in Millions, dose in Millions | 1 Months Ended | 12 Months Ended |  |
--- | --- | --- | --- | ---
Aug. 31, 2023 USD ($) $ / shares shares | Dec. 31, 2023 USD ($) installment $ / shares | Dec. 31, 2022 USD ($) $ / shares | Dec. 31, 2021 USD ($) | Sep. 30, 2022 USD ($) installment | Sep. 30, 2021 dose
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |  |  |
Royalty period |  | 15 years |  |  |  |
Revenues |  | $ 983,705 | $ 1,981,872 | $ 1,146,290 |  |
Deferred revenue |  | $ 863,521 | $ 549,551 | 1,595,472 |  |
Common stock, par value per share (in usd per share) | $ / shares |  | $ 0.01 | $ 0.01 |  |  |
Net proceeds from sales of common stock |  | $ 360,243 | $ 249,230 | $ 564,859 |  |
Takeda Arrangement |  |  |  |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |  |  |
Number of doses to be distributed | dose |  |  |  |  |  | 150
Revenues |  | $ 6,000 |  |  |  |
Milestone payment recognized |  |  | $ 20,000 |  |  |
Settlement Agreement |  |  |  |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |  |  |
Settlement payment | $ 149,800 |  |  |  | $ 185,000 |
Initial reservation fee | 130,400 |  |  |  | $ 47,800 |
Deferred revenue | 4,000 |  |  |  |  |
Number of quarterly installment payments | installment |  | 2 |  |  | 4 |
Settlement agreement, quarterly installment amount |  | $ 34,300 |  |  |  |
Settlement Agreement | Accrued Liabilities |  |  |  |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |  |  |
Settlement payment |  | 68,600 |  |  |  |
Securities Subscription Arrangement |  |  |  |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |  |  |
Settlement agreement, benefit |  | 79,200 |  |  |  |
Securities Subscription Arrangement | Research and development |  |  |  |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |  |  |
Settlement agreement, benefit |  | $ 57,700 |  |  |  |
Securities Subscription Arrangement | Cost of sales |  |  |  |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |  |  |
Settlement agreement, benefit | $ 21,500 |  |  |  |  |
Securities Subscription Arrangement | Private Placement |  |  |  |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |  |  |
Shares sell and issue | shares | 6.5 |  |  |  |  |
Common stock, par value per share (in usd per share) | $ / shares | $ 0.01 |  |  |  |  |
Sale of stock (in usd per share) | $ / shares | $ 13.00 |  |  |  |  |
Net proceeds from sales of common stock | $ 84,500 |  |  |  |  |
Common stock, quoted market price | 46,500 |  |  |  |  |
Common stock, premium paid | $ 38,000 |  |  |  |  |

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