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Other Financial Information | 12 Months Ended
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Dec. 31, 2023
Organization, Consolidation and Presentation of Financial Statements [Abstract] |
Other Financial Information | Other Financial Information Prepaid Expenses and Other Current Assets Prepaid expenses and other current assets consist of the following as of (in thousands):
| December 31,
| 2023 |  | 2022
Prepaid expenses | $ | 70,297 |  |  | $ | 160,773 |
Other current assets | 155,726 |  |  | 76,374 |
Prepaid expenses and other current assets | $ | 226,023 |  |  | $ | 237,147 |
Property and Equipment, net Property and equipment is comprised of the following as of (in thousands):
| December 31,
| 2023 |  | 2022
Land and buildings | $ | 102,916 |  |  | $ | 101,342 |
Machinery and equipment | 148,243 |  |  | 134,809 |
Leasehold improvements | 48,310 |  |  | 18,895 |
Computer hardware | 5,114 |  |  | 4,927 |
Construction in progress | 76,156 |  |  | 81,566 |
| 380,739 |  |  | 341,539 |
Less: accumulated depreciation | (74,968) |  |  | (47,292) |
Property and equipment, net | $ | 305,771 |  |  | $ | 294,247 |
As of December 31, 2023 and 2022, approximately $155 million and $170 million, respectively, of net assets used in operations were located in the Czech Republic. Depreciation expense was approximately $41 million, $29 million, and $13 million for the years ended December 31, 2023, 2022, and 2021, respectively. Accrued Expenses Accrued expenses consist of the following as of (in thousands):
| December 31,
| 2023 |  | 2022
Employee benefits and compensation | $ | 55,952 |  |  | $ | 52,569 |
Gross-to-net deductions | 20,616 |  |  | — |
U.S. product sales returns accrual | 82,506 |  |  | — |
Research and development accruals | 131,027 |  |  | 468,214 |
Other accrued expenses | 104,567 |  |  | 70,375 |
Accrued expenses | $ | 394,668 |  |  | $ | 591,158 |
Other Current Liabilities Other current liabilities consist of the following as of (in thousands):
| December 31,
| 2023 |  | 2022
Refunds due to APA customers | $ | 142,165 |  |  | $ | 210,362 |
Other current liability related to Gavi (see Note 3) | 696,390 |  |  | 697,384 |
Other current liabilities | 22,853 |  |  | 22,309 |
Total other current liabilities | $ | 861,408 |  |  | $ | 930,055 |

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