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Stock-Based Compensation (Tables)

12 Months Ended

Dec. 31, 2023

Share-Based Payment Arrangement [Abstract]

Schedule of Stock-Based Compensation Expense

The Company recorded stock-based compensation expense in the consolidated statements of operations as follows (in thousands):

			Year Ended December 31,
			2023						2022						2021
Cost of sales			$	3,417					$	1,032					$	—
Research and development			41,211						66,565						86,928
Selling, general, and administrative			40,729						62,703						96,698
Total stock-based compensation expense			$	85,357					$	130,300					$	183,626

Schedule of Option and Appreciation Rights Activity

The following is a summary of stock options and SARs activity under the 2023 Inducement Plan, 2015 Plan and the 2005 Plan for the year ended December 31, 2023:

			2023 Inducement Plan												2015 Plan												2005 Plan
			Stock Options						Weighted- Average Exercise Price						Stock Options & SARs						Weighted- Average Exercise Price						Stock Options						Weighted- Average Exercise Price
Outstanding at January 1, 2023			—						$	—					4,053,290						$	46.07					63,725						$	112.94
Granted			422,800						$	10.67					1,021,596						$	7.04					—						$	—
Exercised			—						$	—					(9,483)						$	6.07					—						$	—
Canceled			—						$	—					(278,361)						$	41.38					(5,450)						$	39.70
Outstanding at December 31, 2023			422,800						$	10.67					4,787,042						$	38.10					58,275						$	119.79
Shares exercisable at December 31, 2023			—						$	—					3,436,339						$	41.51					58,275						$	119.79

Schedule of Assumptions Used in Estimation of Fair Value of Stock

The fair value of stock options granted under the 2023 Inducement Plan and the 2015 Plan was estimated at the date of grant using the Black-Scholes option-pricing model with the following assumptions:

			Year Ended December 31,
			2023						2022						2021
Weighted average Black-Scholes fair value of stock options and SARs granted			$7.00						$55.32						$158.02
Risk-free interest rate			3.5%-4.8%						1.4%-4.3%						0.5%-1.3%
Dividend yield			—%						—%						—%
Volatility			120.4%-140.3%						120.5%-140.1%						124.7%-142.0%
Expected term (in years)			3.9-6.4						4.0-6.3						4.1-6.1

Schedule of Restricted Stock Units Activity

The following is a summary of RSU activity for the year ended December 31, 2023:

			2023 Inducement Plan												2015 Plan
			Number of Shares						Per Share Weighted- Average Fair Value						Number of Shares						Per Share Weighted- Average Fair Value
Outstanding and unvested at January 1, 2022			—						$	—					2,034,574						$	61.65
Restricted stock units granted			363,990						$	10.66					3,314,452						$	7.06
Restricted stock units vested			—						$	—					(696,553)						$	73.73
Restricted stock units forfeited			—						$	—					(937,603)						$	27.04
Outstanding and unvested at December 31, 2023			363,990						$	10.66					3,714,870						$	19.43

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Schedule Of Share Based Compensation, Restricted Stock Awards, Activity

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Tabular disclosure of allocation of amount expensed and capitalized for award under share-based payment arrangement to statement of income or comprehensive income and statement of financial position. Includes, but is not limited to, corresponding line item in financial statement.

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Tabular disclosure for stock option plans. Includes, but is not limited to, outstanding awards at beginning and end of year, grants, exercises, forfeitures, and weighted-average grant date fair value.

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Tabular disclosure of the significant assumptions used during the year to estimate the fair value of stock options, including, but not limited to: (a) expected term of share options and similar instruments, (b) expected volatility of the entity's shares, (c) expected dividends, (d) risk-free rate(s), and (e) discount for post-vesting restrictions.

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