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Collaboration, License, and Supply Agreements (Details)
$ / shares in Units, $ in Thousands, shares in Millions, dose in Millions
 1 Months Ended 12 Months Ended
Aug. 31, 2023
USD ($)
$ / shares
shares
Dec. 31, 2023
USD ($)
installment
$ / shares
Dec. 31, 2022
USD ($)
$ / shares
Dec. 31, 2021
USD ($)
Sep. 30, 2022
USD ($)
installment
Sep. 30, 2021
dose
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]            
Royalty period   15 years        
Revenues   $ 983,705 $ 1,981,872 $ 1,146,290    
Deferred revenue   $ 863,521 $ 549,551 1,595,472    
Common stock, par value per share (in usd per share) | $ / shares   $ 0.01 $ 0.01      
Net proceeds from sales of common stock   $ 360,243 $ 249,230 $ 564,859    
Takeda Arrangement            
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]            
Number of doses to be distributed | dose           150
Revenues   $ 6,000        
Milestone payment recognized     $ 20,000      
Settlement Agreement            
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]            
Settlement payment $ 149,800       $ 185,000  
Initial reservation fee 130,400       $ 47,800  
Deferred revenue 4,000          
Number of quarterly installment payments | installment   2     4  
Settlement agreement, quarterly installment amount   $ 34,300        
Settlement Agreement | Accrued Liabilities            
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]            
Settlement payment   68,600        
Securities Subscription Arrangement            
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]            
Settlement agreement, benefit   79,200        
Securities Subscription Arrangement | Research and development            
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]            
Settlement agreement, benefit   $ 57,700        
Securities Subscription Arrangement | Cost of sales            
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]            
Settlement agreement, benefit $ 21,500          
Securities Subscription Arrangement | Private Placement            
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]            
Shares sell and issue | shares 6.5          
Common stock, par value per share (in usd per share) | $ / shares $ 0.01          
Sale of stock (in usd per share) | $ / shares $ 13.00          
Net proceeds from sales of common stock $ 84,500          
Common stock, quoted market price 46,500          
Common stock, premium paid $ 38,000