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Income Taxes Income Tax (Tables) | 12 Months Ended
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Dec. 31, 2019
Income Tax Disclosure [Abstract] |
Schedule of Income before Income Tax, Domestic and Foreign [Table Text Block] | The domestic and international components of loss before income taxes are presented as follows:
| Years Ended December 31,
| 2019 |  | 2018 |  | 2017
| (in thousands)
Domestic | $ | (61,893 | ) |  | $ | 16,405 |  |  | $ | 42,580 |
Foreign | 29,409 |  |  | (49,257 | ) |  | (76,578 | )
Loss before income taxes | $ | (32,484 | ) |  | $ | (32,852 | ) |  | $ | (33,998 | )
Schedule of Components of Income Tax Expense (Benefit) [Table Text Block] | The income tax provision (benefit) consists of the following:
| Years Ended December 31,
| 2019 |  | 2018 |  | 2017
| (in thousands)
Current: |  |  |  |  |
Federal | $ | 1,604 |  |  | $ | 3,292 |  |  | $ | 13,470 |
State | 16 |  |  | 37 |  |  | 26 |
Foreign | 1,560 |  |  | 1,640 |  |  | 1,784 |
Total current | 3,180 |  |  | 4,969 |  |  | 15,280 |
Deferred: |  |  |  |  |
Federal | (13,793 | ) |  | 788 |  |  | 19,451 |
State | (1,829 | ) |  | (2,799 | ) |  | (4,668 | )
Foreign | 1,095 |  |  | (3,884 | ) |  | (3,697 | )
Change in valuation allowance | (1,239 | ) |  | (5,727 | ) |  | (51,177 | )
Total deferred | (15,766 | ) |  | (11,622 | ) |  | (40,091 | )
Total income tax benefit | $ | (12,586 | ) |  | $ | (6,653 | ) |  | $ | (24,811 | )
Schedule of Effective Income Tax Rate Reconciliation [Table Text Block] | The actual income tax provision (benefit) differs from the amount computed using the federal statutory rate as follows:
| Years Ended December 31,
| 2019 |  | 2018 |  | 2017
| (in thousands)
Provision (benefit) at statutory rate | $ | (6,821 | ) |  | $ | (6,814 | ) |  | $ | (11,899 | )
State income taxes (net of federal benefit) | 11 |  |  | 20 |  |  | 17 |
Research and development credits | (7,815 | ) |  | (8,849 | ) |  | (8,153 | )
Foreign rate differential | (4,489 | ) |  | 8,640 |  |  | 23,666 |
Stock compensation | (2,750 | ) |  | 74 |  |  | (5,713 | )
Foreign income inclusion | 3,936 |  |  | 1,103 |  |  | — |
Transaction costs | — |  |  | — |  |  | 553 |
Provision to return | 1,887 |  |  | (27 | ) |  | (917 | )
Uncertain tax positions | 1,244 |  |  | 1,463 |  |  | 1,993 |
Foreign tax credits | — |  |  | — |  |  | (5 | )
Permanent and other | 716 |  |  | 1,319 |  |  | 1,730 |
Foreign unremitted earnings | (103 | ) |  | 1,960 |  |  | (1,368 | )
Tax Act | — |  |  | 185 |  |  | 25,205 |
Other tax rate changes | — |  |  | — |  |  | 1,257 |
Attribute expirations | 2,837 |  |  | — |  |  | — |
Valuation allowance | (1,239 | ) |  | (5,727 | ) |  | (51,177 | )
Total income tax benefit | $ | (12,586 | ) |  | $ | (6,653 | ) |  | $ | (24,811 | )
Schedule of Deferred Tax Assets and Liabilities [Table Text Block] | The components of the deferred income tax assets are as follows:
| December 31,
| 2019 |  | 2018
| (in thousands)
Deferred tax assets: |  |  |
Net operating loss carryforwards | $ | 65,477 |  |  | $ | 64,887 |
Research and development credits | 80,404 |  |  | 75,032 |
Accrued expenses and other | 7,768 |  |  | 7,965 |
Lease obligation | 2,047 |  |  | — |
Accrued compensation | 1,441 |  |  | 2,504 |
Stock-based compensation | 3,460 |  |  | 2,550 |
| 160,597 |  |  | 152,938 |
Less valuation allowance | (77,957 | ) |  | (79,196 | )
| 82,640 |  |  | 73,742 |
Deferred tax liabilities: |  |  |
Fixed assets | (246 | ) |  | (1,391 | )
Leased right-of-use assets | (1,483 | ) |  | — |
Intangible assets | (13,627 | ) |  | (20,833 | )
Net deferred tax assets | $ | 67,284 |  |  | $ | 51,518 |
Schedule of Unrecognized Tax Benefits Roll Forward [Table Text Block] | The following table summarizes the changes to the unrecognized tax benefits during 2019, 2018 and 2017:
| (in thousands)
Balance as of December 31, 2016 | $ | 23,417 |
Additions based on tax positions related to the current year | 3,037 |
Additions related to acquisitions | 37,090 |
Decreases based on tax positions of prior year | (458 | )
Balance as of December 31, 2017 | $ | 63,086 |
Additions based on tax positions related to the current year | 3,080 |
Decreases based on tax positions of prior year | (4,696 | )
Balance as of December 31, 2018 | $ | 61,470 |
Additions based on tax positions related to the current year | 1,678 |
Decreases based on tax positions of prior year | (1,121 | )
Balance as of December 31, 2019 | $ | 62,027 |

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