<?xml version="1.0" encoding="us-ascii"?>
<!-- DFIN ActiveDisclosure(SM) XBRL Schema Document - http://www.dfinsolutions.com/ -->
<!-- Creation Date      : 2022-07-28T19:09:57.7733671+00:00 -->
<!-- Version            : 5.0.1.747 -->
<!-- Package ID         : ecbfb20b61f14226a4bd1792a78d4977 -->
<!-- Copyright (c) 2022 Donnelley Financial Solutions, Inc. All Rights Reserved. -->
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  <xsd:element id="tlry_IncomeTaxReconciliationEffectOfTransaction" name="IncomeTaxReconciliationEffectOfTransaction" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="tlry_PrincipalPortionIncludedInCurrentLiabilities" name="PrincipalPortionIncludedInCurrentLiabilities" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="tlry_ConvertibleNotesReceivableCurrent" name="ConvertibleNotesReceivableCurrent" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="tlry_InterestInEquityInvestees" name="InterestInEquityInvestees" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="tlry_ConvertibleNotesReceivableNoncurrent" name="ConvertibleNotesReceivableNoncurrent" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="tlry_WarrantLiabilityCurrent" name="WarrantLiabilityCurrent" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="tlry_OperatingAndFinanceLeaseLiabilityCurrent" name="OperatingAndFinanceLeaseLiabilityCurrent" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="tlry_OperatingAndFinanceLeaseLiabilityNoncurrent" name="OperatingAndFinanceLeaseLiabilityNoncurrent" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="tlry_ConvertibleDebenturesNoncurrent" name="ConvertibleDebenturesNoncurrent" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="tlry_TransactionCosts" name="TransactionCosts" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="tlry_ShareIssuanceSharesForDebtSettlement" name="ShareIssuanceSharesForDebtSettlement" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="tlry_ShareIssuanceValueForDebtSettlement" name="ShareIssuanceValueForDebtSettlement" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="tlry_ShareIssuanceSharesOfRSUsExercised" name="ShareIssuanceSharesOfRSUsExercised" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="tlry_ShareIssuanceValueOfRSUsExercised" name="ShareIssuanceValueOfRSUsExercised" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="tlry_ShareIssuanceSharesOfDSUsExercised" name="ShareIssuanceSharesOfDSUsExercised" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="tlry_ShareIssuanceValueOfDSUsExercised" name="ShareIssuanceValueOfDSUsExercised" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="tlry_SharesIssuedSharesForExerciseOfWarrants" name="SharesIssuedSharesForExerciseOfWarrants" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="tlry_SharesIssuedValueForExerciseOfWarrants" name="SharesIssuedValueForExerciseOfWarrants" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="tlry_AdjustmentsToAdditionalPaidInCapitalSharebasedCompensationOptionsExpired" name="AdjustmentsToAdditionalPaidInCapitalSharebasedCompensationOptionsExpired" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="tlry_AdjustmentsToAdditionalPaidInCapitalSharebasedCompensationWarrantsExpired" name="AdjustmentsToAdditionalPaidInCapitalSharebasedCompensationWarrantsExpired" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="tlry_StockIssuedDuringPeriodSharesLegalSettlement" name="StockIssuedDuringPeriodSharesLegalSettlement" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="tlry_StockIssuedDuringPeriodValueLegalSettlement" name="StockIssuedDuringPeriodValueLegalSettlement" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="tlry_StockIssuedDuringPeriodSharesEquityFinancing" name="StockIssuedDuringPeriodSharesEquityFinancing" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="tlry_StockIssuedDuringPeriodValueEquityFinancing" name="StockIssuedDuringPeriodValueEquityFinancing" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="tlry_StockIssuedDuringPeriodSharesContractSettlement" name="StockIssuedDuringPeriodSharesContractSettlement" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="tlry_StockIssuedDuringPeriodValuesContractSettlement" name="StockIssuedDuringPeriodValuesContractSettlement" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="tlry_StockIssuedDuringPeriodSharesArrangement" name="StockIssuedDuringPeriodSharesArrangement" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="tlry_StockIssuedDuringPeriodValueArrangement" name="StockIssuedDuringPeriodValueArrangement" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="tlry_SettlementOfConvertibleNotesReceivable" name="SettlementOfConvertibleNotesReceivable" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="tlry_StockIssuedDuringPeriodSharesDDHNote" name="StockIssuedDuringPeriodSharesDDHNote" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="tlry_StockIssuedDuringPeriodValueDDHNote" name="StockIssuedDuringPeriodValueDDHNote" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="tlry_StockIssuedDuringPeriodSharesPurchaseOfCapitalAndIntangibleAssets" name="StockIssuedDuringPeriodSharesPurchaseOfCapitalAndIntangibleAssets" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="tlry_StockIssuedDuringPeriodValuePurchaseOfCapitalAndIntangibleAssets" name="StockIssuedDuringPeriodValuePurchaseOfCapitalAndIntangibleAssets" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="tlry_CashPaidToNetSettleEmployeeWithholdingTaxesEffectivelyBuyingBackShares" name="CashPaidToNetSettleEmployeeWithholdingTaxesEffectivelyBuyingBackShares" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="tlry_AdjustmentsToAdditionalPaidInCapitalShareBasedCompensation" name="AdjustmentsToAdditionalPaidInCapitalShareBasedCompensation" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="tlry_ReverseAcquisition" name="ReverseAcquisition" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="tlry_SuperheroLPMember" name="SuperheroLPMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="tlry_JanuaryTwoThousandTwentyBoughtDealMember" name="JanuaryTwoThousandTwentyBoughtDealMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="tlry_BreckenridgeAcquisitionMember" name="BreckenridgeAcquisitionMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="tlry_SweetWaterMember" name="SweetWaterMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="tlry_NuuveraMaltaMember" name="NuuveraMaltaMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="tlry_ReverseAcquisitionShares" name="ReverseAcquisitionShares" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="tlry_Impairment" name="Impairment" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="tlry_ProceedsFromPaymentForWarrantsAndOptionsExercised" name="ProceedsFromPaymentForWarrantsAndOptionsExercised" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="tlry_IncreaseInBankIndebtedness" name="IncreaseInBankIndebtedness" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="tlry_BasisOfPreparationAbstract" name="BasisOfPreparationAbstract" type="xbrli:stringItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="tlry_LeasesDisclosureTextBlock" name="LeasesDisclosureTextBlock" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="tlry_GoodwillDisclosureAbstract" name="GoodwillDisclosureAbstract" type="xbrli:stringItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="tlry_ConvertibleNotesReceivableAbstract" name="ConvertibleNotesReceivableAbstract" type="xbrli:stringItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="tlry_BankIndebtednessAbstract" name="BankIndebtednessAbstract" type="xbrli:stringItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="tlry_ConvertibleDebenturesTextBlock" name="ConvertibleDebenturesTextBlock" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="tlry_WarrantsTextBlock" name="WarrantsTextBlock" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="tlry_CostOfGoodSoldTextBlock" name="CostOfGoodSoldTextBlock" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="tlry_GeneralAndAdministrativeExpenseTextBlock" name="GeneralAndAdministrativeExpenseTextBlock" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="tlry_InterestExpenseNetTextBlock" name="InterestExpenseNetTextBlock" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="tlry_ChangeInNonCashWorkingCapitalTextBlock" name="ChangeInNonCashWorkingCapitalTextBlock" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="tlry_ChangeInNonCashWorkingCapitalAbstract" name="ChangeInNonCashWorkingCapitalAbstract" type="xbrli:stringItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="tlry_FinancialRiskManagementAndFinancialInstrumentsAbstract" name="FinancialRiskManagementAndFinancialInstrumentsAbstract" type="xbrli:stringItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="tlry_LongTermInvestmentsPolicyTextBlock" name="LongTermInvestmentsPolicyTextBlock" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="tlry_ConvertibleDebenturesPolicyTextBlock" name="ConvertibleDebenturesPolicyTextBlock" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="tlry_WarrantsPolicyTextBlock" name="WarrantsPolicyTextBlock" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="tlry_GeneralAndAdministrativeExpensesPolicyTextBlock" name="GeneralAndAdministrativeExpensesPolicyTextBlock" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="tlry_SellingPolicyTextBlock" name="SellingPolicyTextBlock" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="tlry_MarketingAndPromotionsPolicyTextBlock" name="MarketingAndPromotionsPolicyTextBlock" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="tlry_CriticalAccountingEstimatesAndJudgmentsPolicyTextBlock" name="CriticalAccountingEstimatesAndJudgmentsPolicyTextBlock" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="tlry_LeaseRelatedAssetsAndLiabilitiesRecordedOnBalanceSheetTableTextBlock" name="LeaseRelatedAssetsAndLiabilitiesRecordedOnBalanceSheetTableTextBlock" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="tlry_SummaryOfSupplementalCashFlowInformationRelatedToLeaseTableTextBlock" name="SummaryOfSupplementalCashFlowInformationRelatedToLeaseTableTextBlock" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="tlry_LesseeOperatingAndFinancingLeasesLiabilityMaturityTableTextBlock" name="LesseeOperatingAndFinancingLeasesLiabilityMaturityTableTextBlock" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="tlry_AphriaIncMember" name="AphriaIncMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="tlry_ConvertibleDebenturesMember" name="ConvertibleDebenturesMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="tlry_FivePointTwoFivePercentageConvertibleNotesAPHA24Member" name="FivePointTwoFivePercentageConvertibleNotesAPHA24Member" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="tlry_FivePointZeroZeroPercentageConvertibleNotesTLRY23Member" name="FivePointZeroZeroPercentageConvertibleNotesTLRY23Member" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="tlry_TilrayTwoThousandAndEighteenEquityIncentivePlanAndOriginalPlanMember" name="TilrayTwoThousandAndEighteenEquityIncentivePlanAndOriginalPlanMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="tlry_EIPOriginalPlanAndTimeBasedRSUMember" name="EIPOriginalPlanAndTimeBasedRSUMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="tlry_PredecessorPlanMember" name="PredecessorPlanMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="tlry_AphriaMember" name="AphriaMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="tlry_TimeBasedStockOptionsMember" name="TimeBasedStockOptionsMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="tlry_TimeBasedAndPerformanceBasedRSUMember" name="TimeBasedAndPerformanceBasedRSUMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="tlry_CostOfGoodSoldTableTextBlock" name="CostOfGoodSoldTableTextBlock" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="tlry_ScheduleOfGeneralAndAdministrativeExpensesTableTextBlock" name="ScheduleOfGeneralAndAdministrativeExpensesTableTextBlock" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="tlry_InterestExpenseNetTableTextBlock" name="InterestExpenseNetTableTextBlock" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="tlry_ScheduleOfSegmentGrossProfitFromExternalCustomersTableTextBlock" name="ScheduleOfSegmentGrossProfitFromExternalCustomersTableTextBlock" type="dtr-types:textBlockItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="tlry_WorkingCapital" name="WorkingCapital" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="tlry_CashAndCashEquivalentsMaturityPeriod" name="CashAndCashEquivalentsMaturityPeriod" type="xbrli:durationItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="tlry_SummaryOfSignificantAccountingPoliciesLineItems" name="SummaryOfSignificantAccountingPoliciesLineItems" type="xbrli:stringItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="tlry_SummaryOfSignificantAccountingPoliciesTable" name="SummaryOfSignificantAccountingPoliciesTable" type="xbrli:stringItemType" substitutionGroup="xbrldt:hypercubeItem" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="tlry_ProductionFacilityMember" name="ProductionFacilityMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="tlry_FinanceLeaseRightOfUseAssetsMember" name="FinanceLeaseRightOfUseAssetsMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="tlry_FiniteLivedIntangibleAssetUsefulLifeDescription" name="FiniteLivedIntangibleAssetUsefulLifeDescription" type="xbrli:stringItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="tlry_CustomerRelationshipsAndDistributionChannelMember" name="CustomerRelationshipsAndDistributionChannelMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="tlry_LicencesPermitsAndApplicationsMember" name="LicencesPermitsAndApplicationsMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="tlry_KnowHowMember" name="KnowHowMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="tlry_WorkforceMember" name="WorkforceMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="tlry_PlantsMember" name="PlantsMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="tlry_DriedCannabisMember" name="DriedCannabisMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="tlry_CannabisTrimMember" name="CannabisTrimMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="tlry_CannabisDerivativesMember" name="CannabisDerivativesMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="tlry_CannabisVapesMember" name="CannabisVapesMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="tlry_CannabisPackagingAndOtherInventoryItemsMember" name="CannabisPackagingAndOtherInventoryItemsMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="tlry_WellnessInventoryMember" name="WellnessInventoryMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="tlry_BeverageAlcoholInventoryMember" name="BeverageAlcoholInventoryMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="tlry_DistributionInventoryMember" name="DistributionInventoryMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="tlry_PurchasePriceAccountingStepUpForInventorySold" name="PurchasePriceAccountingStepUpForInventorySold" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="tlry_CannabisMember" name="CannabisMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="tlry_DistributionProductsMember" name="DistributionProductsMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="tlry_SellingExpensesMember" name="SellingExpensesMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="tlry_DocklightLLCMember" name="DocklightLLCMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="tlry_FluentAndCannfectionsMember" name="FluentAndCannfectionsMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="tlry_EdibleCannabisProductsMember" name="EdibleCannabisProductsMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="tlry_CapitalAndIntangibleAssets" name="CapitalAndIntangibleAssets" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="tlry_ROUAssetsUnderFinanceLeaseMember" name="ROUAssetsUnderFinanceLeaseMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="tlry_OperatingAndFinanceLeaseRightOfUseAssets" name="OperatingAndFinanceLeaseRightOfUseAssets" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="tlry_OperatingAndFinancingLeaseLiability" name="OperatingAndFinancingLeaseLiability" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="tlry_LeaseAssetsAbstract" name="LeaseAssetsAbstract" type="xbrli:stringItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="tlry_LeaseLiabilitiesAbstract" name="LeaseLiabilitiesAbstract" type="xbrli:stringItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="tlry_FinanceLeaseCostAmortizationOfRightOfUseAssets" name="FinanceLeaseCostAmortizationOfRightOfUseAssets" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="tlry_FinanceLeaseCostsAbstract" name="FinanceLeaseCostsAbstract" type="xbrli:stringItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="tlry_FinancingCashFlowsFromFinanceLeases" name="FinancingCashFlowsFromFinanceLeases" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="tlry_CashPaidForAmountsIncludedInMeasurementOfLeaseLiabilitiesAbstract" name="CashPaidForAmountsIncludedInMeasurementOfLeaseLiabilitiesAbstract" type="xbrli:stringItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="tlry_LicensesPermitsAndApplicationsMember" name="LicensesPermitsAndApplicationsMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="tlry_IntellectualPropertyTrademarksKnowHowAndBrandsMember" name="IntellectualPropertyTrademarksKnowHowAndBrandsMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="tlry_IntangibleAssetsNetExcludingGoodwillLineItems" name="IntangibleAssetsNetExcludingGoodwillLineItems" type="xbrli:stringItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="tlry_IntangibleAssetsNetExcludingGoodwillTable" name="IntangibleAssetsNetExcludingGoodwillTable" type="xbrli:stringItemType" substitutionGroup="xbrldt:hypercubeItem" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="tlry_FiniteLivedIntangibleAssetsAmortizationExpenseNet" name="FiniteLivedIntangibleAssetsAmortizationExpenseNet" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="tlry_BusinessAcquisitionConversionRatio" name="BusinessAcquisitionConversionRatio" type="xbrli:pureItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="tlry_BusinessAcquisitionEquityInterestIssuedAtClosingDate" name="BusinessAcquisitionEquityInterestIssuedAtClosingDate" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" />
  <xsd:element id="tlry_BusinessAcquisitionMarketSharePriceOfConvertedStockUnits" name="BusinessAcquisitionMarketSharePriceOfConvertedStockUnits" type="dtr-types:perShareItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" />
  <xsd:element id="tlry_BusinessAcquisitionFairValueOfCommonStockTransferredToShareholders" name="BusinessAcquisitionFairValueOfCommonStockTransferredToShareholders" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="tlry_BusinessCombinationNetFairValueOfConsiderationTransferred" name="BusinessCombinationNetFairValueOfConsiderationTransferred" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="tlry_BusinessAcquisitionPreCombinationFairValue" name="BusinessAcquisitionPreCombinationFairValue" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="tlry_IncreaseDecreaseInNonCashWorkingCapital" name="IncreaseDecreaseInNonCashWorkingCapital" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="tlry_BusinessAcquisitionAndGoodwillAbstract" name="BusinessAcquisitionAndGoodwillAbstract" type="xbrli:stringItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="tlry_BusinessAcquisitionAndGoodwillLineItems" name="BusinessAcquisitionAndGoodwillLineItems" type="xbrli:stringItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="tlry_BusinessAcquisitionAndGoodwillTable" name="BusinessAcquisitionAndGoodwillTable" type="xbrli:stringItemType" substitutionGroup="xbrldt:hypercubeItem" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="tlry_CommonClassTwoMember" name="CommonClassTwoMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="tlry_SWBrewingCompanyLLCMember" name="SWBrewingCompanyLLCMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="tlry_BusinessCombinationFairValueOfShares" name="BusinessCombinationFairValueOfShares" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="tlry_BrandsMember" name="BrandsMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="tlry_ContingentConsiderationExpectedPaymentDate" name="ContingentConsiderationExpectedPaymentDate" type="xbrli:gYearMonthItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="tlry_BusinessCombinationFairValueOfContingentConsideration" name="BusinessCombinationFairValueOfContingentConsideration" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="tlry_DistributionMember" name="DistributionMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="tlry_BeverageAlcoholMember" name="BeverageAlcoholMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="tlry_WellnessMember" name="WellnessMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="tlry_GoodwillImpairmentDiscountRate" name="GoodwillImpairmentDiscountRate" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="tlry_GoodwillImpairmentTerminalGrowthRate" name="GoodwillImpairmentTerminalGrowthRate" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="tlry_GoodwillImpairmentAverageRevenueGrowthRate" name="GoodwillImpairmentAverageRevenueGrowthRate" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="tlry_AdditionalImpairmentFromOnePercentageIncreaseInDiscountRate" name="AdditionalImpairmentFromOnePercentageIncreaseInDiscountRate" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="tlry_AdditionalImpairmentFromOnePercentageDecreaseInTerminalGrowthRate" name="AdditionalImpairmentFromOnePercentageDecreaseInTerminalGrowthRate" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="tlry_AdditionalImpairmentFromFivePercentageDecreaseInAverageRevenueGrowthRate" name="AdditionalImpairmentFromFivePercentageDecreaseInAverageRevenueGrowthRate" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="tlry_ImpairmentChargesRecordedInCapitalAssets" name="ImpairmentChargesRecordedInCapitalAssets" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="tlry_ImpairmentChargesOffsetInNetLiabilities" name="ImpairmentChargesOffsetInNetLiabilities" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="tlry_ImpairmentChargesOffsetInNCIPortion" name="ImpairmentChargesOffsetInNCIPortion" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="tlry_ConvertibleNotesReceivableLineItems" name="ConvertibleNotesReceivableLineItems" type="xbrli:stringItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="tlry_ConvertibleNotesReceivableTable" name="ConvertibleNotesReceivableTable" type="xbrli:stringItemType" substitutionGroup="xbrldt:hypercubeItem" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="tlry_MedMenEnterprisesIncMember" name="MedMenEnterprisesIncMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="tlry_ConvertibleNotesReceivableMember" name="ConvertibleNotesReceivableMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="tlry_MeasurementInputForfeitureRateMember" name="MeasurementInputForfeitureRateMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="tlry_MeasurementInputProbabilityOfLegalizationMember" name="MeasurementInputProbabilityOfLegalizationMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="tlry_CanadaLtdMember" name="CanadaLtdMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="tlry_HighTideIncMember" name="HighTideIncMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="tlry_EquityInvestmentsUnderMeasurementAlternative" name="EquityInvestmentsUnderMeasurementAlternative" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="tlry_UnrealizedLossesOnChangeInFairValueOfInvestments" name="UnrealizedLossesOnChangeInFairValueOfInvestments" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="tlry_OthersCountriesMember" name="OthersCountriesMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="tlry_CurrentOtherCountriesForeignTaxExpenseBenefit" name="CurrentOtherCountriesForeignTaxExpenseBenefit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="tlry_DeferredOtherCountriesForeignTaxExpenseBenefit" name="DeferredOtherCountriesForeignTaxExpenseBenefit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="tlry_OtherCountriesMember" name="OtherCountriesMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="tlry_NetOperatingLossCarryforwardsOffsetPercentageOfTaxableIncome" name="NetOperatingLossCarryforwardsOffsetPercentageOfTaxableIncome" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="tlry_AdjustableTaxableIncomeDeductibleNetInterestPercentage" name="AdjustableTaxableIncomeDeductibleNetInterestPercentage" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="tlry_OperatingLossCarryForwardsExpirationYear" name="OperatingLossCarryForwardsExpirationYear" type="xbrli:gYearItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="tlry_OperatingLossCarryforwardExpirationPeriod" name="OperatingLossCarryforwardExpirationPeriod" type="xbrli:durationItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="tlry_OperatingLineOfCredit" name="OperatingLineOfCredit" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="tlry_EuroOverNightIndexAveragePlusMember" name="EuroOverNightIndexAveragePlusMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="tlry_EuroInterbankOfferedRatePlusMember" name="EuroInterbankOfferedRatePlusMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="tlry_OperatingLinesOfCreditOneMember" name="OperatingLinesOfCreditOneMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="tlry_OperatingLinesOfCreditTwoMember" name="OperatingLinesOfCreditTwoMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="tlry_CCPharmaMember" name="CCPharmaMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="tlry_FourTwentyCorporationMember" name="FourTwentyCorporationMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="tlry_EUROBIRRateMember" name="EUROBIRRateMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="tlry_NumberOfOperatingLinesOfCredit" name="NumberOfOperatingLinesOfCredit" type="xbrli:integerItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="tlry_CreditFacilityDueInNovemberTwoThousandTwentyTwoMember" name="CreditFacilityDueInNovemberTwoThousandTwentyTwoMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="tlry_TermLoanDueInJulyTwoThousandTwentyThreeMember" name="TermLoanDueInJulyTwoThousandTwentyThreeMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="tlry_TermLoanDueInAprilTwoThousandTwentyTwoMember" name="TermLoanDueInAprilTwoThousandTwentyTwoMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="tlry_TermLoanDueInAugustTwoThousandTwentySixMember" name="TermLoanDueInAugustTwoThousandTwentySixMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="tlry_MortgagePayableDueInAugustTwoThousandTwentySixMember" name="MortgagePayableDueInAugustTwoThousandTwentySixMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="tlry_VendorTakeBackMortgageDueInJuneTwoThousandTwentyOneMember" name="VendorTakeBackMortgageDueInJuneTwoThousandTwentyOneMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="tlry_TermLoanDueInDecemberTwoThousandTwentyThreeMember" name="TermLoanDueInDecemberTwoThousandTwentyThreeMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="tlry_TermLoanDueInAprilTwoThousandTwentyFiveMember" name="TermLoanDueInAprilTwoThousandTwentyFiveMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="tlry_TermLoanDueInJuneTwoThousandTwentyFiveMember" name="TermLoanDueInJuneTwoThousandTwentyFiveMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="tlry_MortgagePayableDueInOctoberTwoThousandThirtyMember" name="MortgagePayableDueInOctoberTwoThousandThirtyMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="tlry_TermLoanPrincipalDueInDecemberTwoThousandTwentyThreeMember" name="TermLoanPrincipalDueInDecemberTwoThousandTwentyThreeMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="tlry_EuroInterbankOfferedRatePlusOnePointSevenNinePercentageMember" name="EuroInterbankOfferedRatePlusOnePointSevenNinePercentageMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="tlry_EuroInterbankOfferedRatePlusTwoPointSixEightPercentageMember" name="EuroInterbankOfferedRatePlusTwoPointSixEightPercentageMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="tlry_EuroInterbankOfferedRatePlusTwoPointZeroZeroPercentageMember" name="EuroInterbankOfferedRatePlusTwoPointZeroZeroPercentageMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="tlry_EUROBIRRatePlusOnePointFivePercentageMember" name="EUROBIRRatePlusOnePointFivePercentageMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="tlry_EUROBIRRatePlusApplicableMarginMember" name="EUROBIRRatePlusApplicableMarginMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="tlry_DebtInstrumentAmortizationPeriod" name="DebtInstrumentAmortizationPeriod" type="xbrli:durationItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="tlry_CanadianPrimeInterestRateMember" name="CanadianPrimeInterestRateMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="tlry_CanadianFiveYearBondInterestRatePlusTwoPointSevenThreeMember" name="CanadianFiveYearBondInterestRatePlusTwoPointSevenThreeMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="tlry_AphriaDiamondMember" name="AphriaDiamondMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="tlry_TermLoanDueInMarchTwoThousandTwentyFourMember" name="TermLoanDueInMarchTwoThousandTwentyFourMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="tlry_MinimumBalanceMaintainedInCashOperatingAccounts" name="MinimumBalanceMaintainedInCashOperatingAccounts" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="tlry_MinimumBalanceMaintainedToRemoveFinancialCovenants" name="MinimumBalanceMaintainedToRemoveFinancialCovenants" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="tlry_TilrayMember" name="TilrayMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="tlry_ConvertibleDebtGross" name="ConvertibleDebtGross" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="tlry_DebtSettlements" name="DebtSettlements" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="tlry_DebtInstrumentConvertibleDescription" name="DebtInstrumentConvertibleDescription" type="xbrli:stringItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="tlry_DebtInstrumentConvertibleMinimumThresholdPercentageDuringMeasurementPeriod" name="DebtInstrumentConvertibleMinimumThresholdPercentageDuringMeasurementPeriod" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="tlry_PercentageOfRedemptionValueOnPrincipalPlusAccruedAndUnpaidInterest" name="PercentageOfRedemptionValueOnPrincipalPlusAccruedAndUnpaidInterest" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="tlry_DebtInstrumentPrincipalOutstanding" name="DebtInstrumentPrincipalOutstanding" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="tlry_ForeignExchangeImpact" name="ForeignExchangeImpact" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="tlry_ConvertibleDebtIssued" name="ConvertibleDebtIssued" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="tlry_ConvertibleDebenturePrincipalAmountIssued" name="ConvertibleDebenturePrincipalAmountIssued" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="tlry_ConvertibleDebentureUnamortizedDiscount" name="ConvertibleDebentureUnamortizedDiscount" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="tlry_ClassOfWarrantOrRightExpirationDate" name="ClassOfWarrantOrRightExpirationDate" type="xbrli:dateItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="tlry_ClassOfWarrantExpired" name="ClassOfWarrantExpired" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="tlry_ClassOfWarrantsExpiredExercisePrice" name="ClassOfWarrantsExpiredExercisePrice" type="dtr-types:perShareItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="tlry_MeasurementInputStrikePriceMember" name="MeasurementInputStrikePriceMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="tlry_MeasurementInputFairValueOfCommonStockMember" name="MeasurementInputFairValueOfCommonStockMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="tlry_PercentageOfDailyCashPenalty" name="PercentageOfDailyCashPenalty" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="tlry_ReductionInExercisePriceOfWarrants" name="ReductionInExercisePriceOfWarrants" type="dtr-types:perShareItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" />
  <xsd:element id="tlry_EstimatedFairValueOfWarrantLiabilityPerWarrant" name="EstimatedFairValueOfWarrantLiabilityPerWarrant" type="dtr-types:perShareItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" />
  <xsd:element id="tlry_AgentsCommissionsAndFees" name="AgentsCommissionsAndFees" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="tlry_SharebasedCompensationArrangementBySharebasedPaymentAwardStockOptionsSharesOutstandingWeightedAverageExercisePriceAndAdditionalDisclosuresAbstract" name="SharebasedCompensationArrangementBySharebasedPaymentAwardStockOptionsSharesOutstandingWeightedAverageExercisePriceAndAdditionalDisclosuresAbstract" type="xbrli:stringItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="tlry_StockGrantedFairValueShareBasedCompensation" name="StockGrantedFairValueShareBasedCompensation" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="tlry_NumberOfCommonStockReservedForIssuanceTerm" name="NumberOfCommonStockReservedForIssuanceTerm" type="xbrli:durationItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="tlry_CommonStockCapitalSharesReservedForFutureIssuanceAnnualAutomaticIncreasePercentage" name="CommonStockCapitalSharesReservedForFutureIssuanceAnnualAutomaticIncreasePercentage" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" />
  <xsd:element id="tlry_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsCancelledInPeriod" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsCancelledInPeriod" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="tlry_EIPTimeBasedStockOptionsMember" name="EIPTimeBasedStockOptionsMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="tlry_OriginalPlanTimeBasedStockOptionMember" name="OriginalPlanTimeBasedStockOptionMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="tlry_EIPTimeBasedRSUMember" name="EIPTimeBasedRSUMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="tlry_ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionsCancelledInPeriodWeightedAverageExercisePrice" name="ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionsCancelledInPeriodWeightedAverageExercisePrice" type="dtr-types:perShareItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="tlry_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsForfeitureRate" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsForfeitureRate" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="tlry_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExercisedInPeriodWeightedAverageGrantDateFairValue" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExercisedInPeriodWeightedAverageGrantDateFairValue" type="dtr-types:perShareItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="tlry_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExpirationsInPeriodWeightedAverageGrantDateFairValue" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExpirationsInPeriodWeightedAverageGrantDateFairValue" type="dtr-types:perShareItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="tlry_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsVestedAndExpectedToVestExercisableWeightedAverageGrantDateFairValue" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsVestedAndExpectedToVestExercisableWeightedAverageGrantDateFairValue" type="dtr-types:perShareItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" />
  <xsd:element id="tlry_TimeBasedRSUMember" name="TimeBasedRSUMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="tlry_CCPharmaNordicApSMember" name="CCPharmaNordicApSMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="tlry_ColCannaSASMember" name="ColCannaSASMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="tlry_AssetsLaibilittyNet" name="AssetsLaibilittyNet" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="tlry_MarigoldMember" name="MarigoldMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="tlry_CannabisRevenueMember" name="CannabisRevenueMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="tlry_CannabisExciseTaxesMember" name="CannabisExciseTaxesMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="tlry_CannabisRevenueNetMember" name="CannabisRevenueNetMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="tlry_BeverageAlcoholRevenueMember" name="BeverageAlcoholRevenueMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="tlry_BeverageAlcoholExciseTaxesMember" name="BeverageAlcoholExciseTaxesMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="tlry_BeverageAlcoholRevenueNetMember" name="BeverageAlcoholRevenueNetMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="tlry_DistributionRevenueMember" name="DistributionRevenueMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="tlry_WellnessRevenueMember" name="WellnessRevenueMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="tlry_CannabiCosts" name="CannabiCosts" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="tlry_BeverageAlcoholCost" name="BeverageAlcoholCost" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="tlry_DistributionCost" name="DistributionCost" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="tlry_WellnessCost" name="WellnessCost" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="tlry_OfficeAndGeneralExpenses" name="OfficeAndGeneralExpenses" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="tlry_FairValueAdjustmentOfConvertibleDebenture" name="FairValueAdjustmentOfConvertibleDebenture" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="tlry_GainLossOnLongTermInvestments" name="GainLossOnLongTermInvestments" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="tlry_LongTermDebtRepaymentMember" name="LongTermDebtRepaymentMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="tlry_ConvertibleNotesPrincipalAndInterestMember" name="ConvertibleNotesPrincipalAndInterestMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="tlry_MaterialPurchaseObligationsMember" name="MaterialPurchaseObligationsMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="tlry_ConstructionCommitmentMember" name="ConstructionCommitmentMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="tlry_FinancialRiskManagementAndFinancialInstrumentLineItems" name="FinancialRiskManagementAndFinancialInstrumentLineItems" type="xbrli:stringItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="tlry_FinancialRiskManagementAndFinancialInstrumentTable" name="FinancialRiskManagementAndFinancialInstrumentTable" type="xbrli:stringItemType" substitutionGroup="xbrldt:hypercubeItem" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="tlry_APHATwentyFourConvertibleDebentureMember" name="APHATwentyFourConvertibleDebentureMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="tlry_BusinessCombinationContingentConsiderationLiabilityProbabilityAchievement" name="BusinessCombinationContingentConsiderationLiabilityProbabilityAchievement" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="tlry_WarrantLiabilityMember" name="WarrantLiabilityMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="tlry_ContingentConsiderationsMember" name="ContingentConsiderationsMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="tlry_DebtInstrumentValuationTechniquesExtensibleList" name="DebtInstrumentValuationTechniquesExtensibleList" type="xbrli:tokenItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="tlry_WarrantsAndRightsOutstandingValuationsTechniqueExtensibleList" name="WarrantsAndRightsOutstandingValuationsTechniqueExtensibleList" type="xbrli:tokenItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="tlry_DebtSecuritiesAvailableForSaleValuationTechniquesExtensibleList" name="DebtSecuritiesAvailableForSaleValuationTechniquesExtensibleList" type="xbrli:tokenItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="tlry_MeasurementInputAchievementRateMember" name="MeasurementInputAchievementRateMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="tlry_MeasurementInputInterestRateMember" name="MeasurementInputInterestRateMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="tlry_HypotheticalDecreaseInFairValueOfInvestments" name="HypotheticalDecreaseInFairValueOfInvestments" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="tlry_EstimatedDecreaseInFairValuesOfInvestmentsUponHypotheticalDecreaseInPrices" name="EstimatedDecreaseInFairValuesOfInvestmentsUponHypotheticalDecreaseInPrices" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="tlry_HypotheticalIncreaseInCommonStock" name="HypotheticalIncreaseInCommonStock" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="tlry_EstimatedIncreaseInFairValuesOfWarrantLiabilityOnHypotheticalIncreaseInPrices" name="EstimatedIncreaseInFairValuesOfWarrantLiabilityOnHypotheticalIncreaseInPrices" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="tlry_MajorCustomersMember" name="MajorCustomersMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="tlry_CanadianMedicalProductsMember" name="CanadianMedicalProductsMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="tlry_CanadianAdultUseProductsMember" name="CanadianAdultUseProductsMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="tlry_WholesaleProductsMember" name="WholesaleProductsMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="tlry_InternationalProductsMember" name="InternationalProductsMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="tlry_RestOfWorldMember" name="RestOfWorldMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="tlry_CapitalAssets" name="CapitalAssets" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="tlry_NumberOfMajorCustomers" name="NumberOfMajorCustomers" type="xbrli:integerItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="tlry_SaleOfStockConsiderationReceivableOnTransaction" name="SaleOfStockConsiderationReceivableOnTransaction" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="debit" />
  <xsd:element id="tlry_SaleOfStockCommissionPercentage" name="SaleOfStockCommissionPercentage" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" />
  <xsd:element id="tlry_SalesAgreementMember" name="SalesAgreementMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="tlry_ClassTwoCommonSharesMember" name="ClassTwoCommonSharesMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="tlry_HEXONoteMember" name="HEXONoteMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="tlry_HTInvestmentsMALLCMember" name="HTInvestmentsMALLCMember" type="dtr-types:domainItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="true" />
  <xsd:element id="tlry_RemainingAvailability" name="RemainingAvailability" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" nillable="true" abstract="false" xbrli:balance="credit" />
  <xsd:element id="tlry_PurchasePriceDiscountedRate" name="PurchasePriceDiscountedRate" type="dtr-types:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" nillable="true" abstract="false" />
</xsd:schema>
