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Equity Incentive Plans - Summary of Activity Under 2008 Plan, 2014 Plan and Inducement Plan Including Grants to Nonemployees Issued (Detail) - USD ($) $ / shares in Units, $ in Thousands | 12 Months Ended
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Dec. 31, 2016 | Dec. 31, 2015 | Dec. 31, 2014
Equity [Abstract] |  |  |
Shares Available for Grant, Beginning balance | 1,644,420 | 1,265,282 | 3,914
Options Issued and Outstanding Average Exercise Price per Share, Additional shares reserved under the Inducement Plan | $ 0 |  |
Shares Available for Grant, Options authorized | 1,038,595 | 743,569 | 1,452,661
Shares Available for Grant, Additional shares reserved under the Inducement Plan | 1,000,000 |  |
Shares Available for Grant, Options granted | (1,524,014) | (379,709) | (188,888)
Shares Available for Grant, Options exercised | 0 | 0 | 0
Shares Available for Grant, Options canceled | 67,743 | 28,563 | 4,084
Shares Available for Grant, Options repurchased |  |  | 3,511
Shares Available for Grant, Issuance of common stock for services | (20,118) | (13,285) | (10,000)
Shares Available for Grant, Ending balance | 2,206,626 | 1,644,420 | 1,265,282
Options Issued and Outstanding Number of Shares, Beginning balance | 1,281,086 | 1,007,724 | 1,162,829
Options Issued and Outstanding Number of Shares, Options authorized | 0 | 0 | 0
Options Issued and Outstanding Number of Shares, Additional shares reserved under the Inducement Plan | 0 |  |
Options Issued and Outstanding Number of Shares, Options granted | 1,524,014 | 379,709 | 188,888
Options Issued and Outstanding Number of Shares, Options exercised | (25,134) | (77,784) | (336,398)
Options Issued and Outstanding Number, Options cancelled | (67,743) | (28,563) | (4,084)
Options Issued and Outstanding Number of Shares, Options repurchased |  |  | (3,511)
Options Issued and Outstanding Number of Shares, Issuance of common stock for services | 0 | 0 | 0
Options Issued and Outstanding Number of Shares, Ending balance | 2,712,223 | 1,281,086 | 1,007,724
Options Issued and Outstanding Average Exercise Price per Share, Beginning balance | $ 9.78 | $ 5.51 | $ 1.03
Options Issued and Outstanding Number of Shares, Expected to vest | 2,640,905 |  |
Options Issued and Outstanding Number of Shares, Vested | 1,263,430 |  |
Options Issued and Outstanding Average Exercise Price per Share, Options granted | $ 11.42 | 19.60 | 24.41
Options Issued and Outstanding Average Exercise Price per Share, Options exercised | 2.19 | 1.42 | 0.71
Options Issued and Outstanding Average Exercise Price per Share, Options canceled | 16.67 | 12.41 | 2.21
Options Issued and Outstanding Average Exercise Price per Share, Options repurchased |  |  | 0.55
Options Issued and Outstanding Average Exercise Price per Share, Issuance of common stock for services | 0 | 0 | 0
Options Issued and Outstanding Average Exercise Price per Share, Ending balance | 10.60 | $ 9.78 | $ 5.51
Options Issued and Outstanding Average Exercise Price per Share, Expected to vest | 10.54 |  |
Options Issued and Outstanding Average Exercise Price per Share, Vested | $ 7.58 |  |
Aggregate Intrinsic Value, Ending balance | $ 13,750 |  |
Aggregate Intrinsic Value, Expected to Vest | 13,574 |  |
Aggregate Intrinsic Value, Vested | $ 10,187 |  |

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- Definition The difference between the maximum number of shares (or other type of equity) authorized for issuance under the plan (including the effects of amendments and adjustments), and the sum of: 1) the number of shares (or other type of equity) already issued upon exercise of options or other equity-based awards under the plan; and 2) shares (or other type of equity) reserved for issuance on granting of outstanding awards, net of cancellations and forfeitures, if applicable. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -URI http://asc.fasb.org/extlink&oid=6415400&loc=d3e5070-113901 + Details
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