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Selected Quarterly Financial Data (Unaudited) - Schedule of Selected Quarterly Financial Results from Operations (Detail) - USD ($) $ / shares in Units, $ in Thousands | 3 Months Ended | 12 Months Ended
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Dec. 31, 2016 | Sep. 30, 2016 | Jun. 30, 2016 | Mar. 31, 2016 | Dec. 31, 2015 | Sep. 30, 2015 | Jun. 30, 2015 | Mar. 31, 2015 | Dec. 31, 2016 | Dec. 31, 2015 | Dec. 31, 2014
Quarterly Financial Information Disclosure [Abstract] |  |  |  |  |  |  |  |  |  |  |
Total revenue |  |  |  |  |  |  | $ 18,143 | $ 5,883 |  | $ 24,026 | $ 31,623
Operating expenses | $ 31,476 | $ 29,200 | $ 28,690 | $ 23,529 | $ 16,876 | $ 18,079 | 9,087 | 9,373 | $ 112,895 | 53,415 | 33,187
Net (loss) income | $ (31,276) | $ (29,031) | $ (28,613) | $ (23,467) | $ (17,000) | $ (18,126) | $ 9,007 | $ (3,502) | $ (112,387) | $ (29,621) | $ (3,214)
Net (loss) income per share: |  |  |  |  |  |  |  |  |  |  |
Basic and Diluted | $ (0.66) | $ (0.65) | $ (0.83) | $ (0.70) |  |  |  |  | $ (2.80) | $ (1.29) | $ (0.31)
Basic |  |  |  |  | $ (0.65) | $ (0.70) | $ 0.43 | $ (0.19) |  |  |
Diluted |  |  |  |  | $ (0.65) | $ (0.70) | $ 0.42 | $ (0.19) |  |  |

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