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Equity Incentive Plans - Additional Information (Detail) - USD ($) |  |  |  | 1 Months Ended | 12 Months Ended |  |
--- | --- | --- | --- | --- | --- | --- | ---
Jan. 01, 2017 | Jan. 01, 2015 | Jun. 18, 2014 | Jun. 30, 2015 | Dec. 31, 2016 | Dec. 31, 2015 | Dec. 31, 2014 | Nov. 30, 2016 | Dec. 31, 2013
Share-based Compensation Arrangement by Share-based Payment Award [Line Items] |  |  |  |  |  |  |  |  |
Vesting period |  |  |  |  | 4 years |  |  |  |
Common stock reserved |  |  |  |  | 1,454,549 |  |  |  |
Increase in shares reserved for issuance, maximum shares to be issued up on exercise of stock options |  |  | 1,153,279 |  |  |  |  |  |
Number of shares granted during the period |  |  |  |  | 1,524,014 | 379,709 | 188,888 |  |
Weighted-average grant-date estimated fair value of options granted |  |  |  |  | $ 7.69 | $ 12.91 | $ 18.53 |  |
Estimated fair value of common stock |  |  |  |  | $ 14.20 |  |  |  |
Estimated fair value of options vested during period |  |  |  |  | $ 6,400,000 | $ 2,400,000 | $ 500,000 |  |
Estimated fair value of restricted stock vested during period |  |  |  |  | $ 500,000 |  |  |  |
Shares available for future grant |  |  |  |  | 2,206,626 | 1,644,420 | 1,265,282 |  | 3,914
Stock-based compensation charge |  |  |  |  |  |  | $ 800,000 |  |
Gross proceeds from issuance of common stock |  |  |  | $ 77,800,000 |  |  |  |  |
Proceeds from issuance of common stock, net of issuance costs |  |  |  | $ 74,300,000 | $ 190,573,000 | $ 74,323,000 | $ 61,241,000 |  |
Common stock sold and issued |  |  |  | 7,242,992 |  |  |  |  |
Purchase price of common shares |  |  |  | $ 10.70 |  |  |  |  |
Warrants issued to purchase common stock |  |  |  | 2,172,899 |  |  |  |  |
Purchase price for warrants |  |  |  | $ 0.125 |  |  |  |  |
Warrants exercise price per share |  |  |  | $ 13.91 |  |  |  |  |
Warrants expiration term |  |  |  | 5 years |  |  |  |  |
Warrants description |  |  |  |  | The warrants are exercisable for an exercise price of $13.91 per share at any time prior to the earlier of (i) 5 years from the date of issuance or (ii) certain changes in control of the Company. |  |  |  |
Maximum warrants ownership percentage by each holder of warrants |  |  |  | 9.99% |  |  |  |  |
Number of warrants exercised |  |  |  |  | 0 | 0 |  |  |
Expected dividend yield |  |  |  |  | $ 0 |  |  |  |
Issuance of common stock for services (Shares) |  |  |  |  | 20,118 | 13,285 | 10,000 |  |
Issuance of common stock for services, amount |  |  |  |  | $ 187,000 | $ 194,000 | $ 208,000 |  |
Subsequent Event [Member] |  |  |  |  |  |  |  |  |
Share-based Compensation Arrangement by Share-based Payment Award [Line Items] |  |  |  |  |  |  |  |  |
Increase in shares reserved for issuance, maximum shares to be issued up on exercise of stock options | 1,892,376 |  |  |  |  |  |  |  |
Employee Stock Purchase Plan [Member] |  |  |  |  |  |  |  |  |
Share-based Compensation Arrangement by Share-based Payment Award [Line Items] |  |  |  |  |  |  |  |  |
Unrecognized stock based compensation expense |  |  |  |  | $ 100,000 |  |  |  |
Unrecognized stock based compensation expense, weighted-average remaining recognition period |  |  |  |  | 2 months 12 days |  |  |  |
2014 Equity Incentive Award Plan [Member] |  |  |  |  |  |  |  |  |
Share-based Compensation Arrangement by Share-based Payment Award [Line Items] |  |  |  |  |  |  |  |  |
Common stock reserved |  |  |  |  | 1,419,328 |  |  |  |
Increase in shares reserved for issuance, maximum shares to be issued up on exercise of stock options |  |  |  |  | 10,683,053 |  |  |  |
Possible increase in shares reserved for issuance as percentage of outstanding stock |  |  |  |  | 4.00% |  |  |  |
2008 Stock Incentive Plan [Member] |  |  |  |  |  |  |  |  |
Share-based Compensation Arrangement by Share-based Payment Award [Line Items] |  |  |  |  |  |  |  |  |
Common stock reserved |  |  |  |  | 35,221 |  |  |  |
2014 Employee Stock Purchase Plan [Member] |  |  |  |  |  |  |  |  |
Share-based Compensation Arrangement by Share-based Payment Award [Line Items] |  |  |  |  |  |  |  |  |
Common stock reserved |  |  |  |  | 202,762 |  |  |  |
Increase in shares reserved for issuance, maximum shares to be issued up on exercise of stock options |  | 185,892 |  |  | 2,230,374 |  |  |  |
Possible increase in shares reserved for issuance as percentage of outstanding stock |  |  |  |  | 1.00% |  |  |  |
Employee stock purchase plan initial offering commenced period |  |  |  |  | Sep. 01, 2014 |  |  |  |
Employee stock purchase plan initial offering ending period |  |  |  |  | Feb. 27, 2015 |  |  |  |
Shares available for future grant |  |  |  |  | 278,020 |  |  |  |
Number of shares sold under the plan |  |  |  |  | 69,054 | 41,580 | 0 |  |
Weighted-average purchase price |  |  |  |  | $ 8.34 | $ 13.25 |  |  |
Proceeds from issuance of shares |  |  |  |  | $ 600,000 | $ 600,000 |  |  |
2016 Employment Commencement Incentive Plan [Member] |  |  |  |  |  |  |  |  |
Share-based Compensation Arrangement by Share-based Payment Award [Line Items] |  |  |  |  |  |  |  |  |
Number of shares granted during the period |  |  |  |  | 0 |  |  |  |
2016 Employment Commencement Incentive Plan [Member] | Board of Directors [Member] |  |  |  |  |  |  |  |  |
Share-based Compensation Arrangement by Share-based Payment Award [Line Items] |  |  |  |  |  |  |  |  |
Common stock reserved |  |  |  |  |  |  |  | 1,000,000 |
Restricted Stock [Member] |  |  |  |  |  |  |  |  |
Share-based Compensation Arrangement by Share-based Payment Award [Line Items] |  |  |  |  |  |  |  |  |
Share-based award accelerated vesting number of shares |  |  |  |  |  |  | 58,969 |  |
Options to Purchase Common Stock [Member] |  |  |  |  |  |  |  |  |
Share-based Compensation Arrangement by Share-based Payment Award [Line Items] |  |  |  |  |  |  |  |  |
Unrecognized stock based compensation expense |  |  |  |  | $ 11,500,000 |  |  |  |
Unrecognized stock based compensation expense, weighted-average remaining recognition period |  |  |  |  | 2 years 10 months 24 days |  |  |  |
Non Employee Stock Option [Member] |  |  |  |  |  |  |  |  |
Share-based Compensation Arrangement by Share-based Payment Award [Line Items] |  |  |  |  |  |  |  |  |
Number of shares granted during the period |  |  |  |  | 12,500 | 5,000 | 10,000 |  |
Weighted-average grant-date estimated fair value of options granted |  |  |  |  | $ 13.71 | $ 18.58 | $ 20.77 |  |
Stock-based compensation charge |  |  |  |  | $ 100,000 | $ 200,000 | $ 100,000 |  |
Restricted Stock Units (RSUs) [Member] |  |  |  |  |  |  |  |  |
Share-based Compensation Arrangement by Share-based Payment Award [Line Items] |  |  |  |  |  |  |  |  |
Unrecognized stock based compensation expense |  |  |  |  | $ 2,100,000 |  |  |  |
Unrecognized stock based compensation expense, weighted-average remaining recognition period |  |  |  |  | 3 years 6 months |  |  |  |

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