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Equity Incentive Plans - Summary of Activity Under 2008 Plan, 2014 Plan and Inducement Plan Including Grants to Nonemployees Issued (Detail) - USD ($)
$ / shares in Units, $ in Thousands
 12 Months Ended
Dec. 31, 2016
Dec. 31, 2015
Dec. 31, 2014
Equity [Abstract]      
Shares Available for Grant, Beginning balance 1,644,420 1,265,282 3,914
Options Issued and Outstanding Average Exercise Price per Share, Additional shares reserved under the Inducement Plan $ 0    
Shares Available for Grant, Options authorized 1,038,595 743,569 1,452,661
Shares Available for Grant, Additional shares reserved under the Inducement Plan 1,000,000    
Shares Available for Grant, Options granted (1,524,014) (379,709) (188,888)
Shares Available for Grant, Options exercised 0 0 0
Shares Available for Grant, Options canceled 67,743 28,563 4,084
Shares Available for Grant, Options repurchased     3,511
Shares Available for Grant, Issuance of common stock for services (20,118) (13,285) (10,000)
Shares Available for Grant, Ending balance 2,206,626 1,644,420 1,265,282
Options Issued and Outstanding Number of Shares, Beginning balance 1,281,086 1,007,724 1,162,829
Options Issued and Outstanding Number of Shares, Options authorized 0 0 0
Options Issued and Outstanding Number of Shares, Additional shares reserved under the Inducement Plan 0    
Options Issued and Outstanding Number of Shares, Options granted 1,524,014 379,709 188,888
Options Issued and Outstanding Number of Shares, Options exercised (25,134) (77,784) (336,398)
Options Issued and Outstanding Number, Options cancelled (67,743) (28,563) (4,084)
Options Issued and Outstanding Number of Shares, Options repurchased     (3,511)
Options Issued and Outstanding Number of Shares, Issuance of common stock for services 0 0 0
Options Issued and Outstanding Number of Shares, Ending balance 2,712,223 1,281,086 1,007,724
Options Issued and Outstanding Average Exercise Price per Share, Beginning balance $ 9.78 $ 5.51 $ 1.03
Options Issued and Outstanding Number of Shares, Expected to vest 2,640,905    
Options Issued and Outstanding Number of Shares, Vested 1,263,430    
Options Issued and Outstanding Average Exercise Price per Share, Options granted $ 11.42 19.60 24.41
Options Issued and Outstanding Average Exercise Price per Share, Options exercised 2.19 1.42 0.71
Options Issued and Outstanding Average Exercise Price per Share, Options canceled 16.67 12.41 2.21
Options Issued and Outstanding Average Exercise Price per Share, Options repurchased     0.55
Options Issued and Outstanding Average Exercise Price per Share, Issuance of common stock for services 0 0 0
Options Issued and Outstanding Average Exercise Price per Share, Ending balance 10.60 $ 9.78 $ 5.51
Options Issued and Outstanding Average Exercise Price per Share, Expected to vest 10.54    
Options Issued and Outstanding Average Exercise Price per Share, Vested $ 7.58    
Aggregate Intrinsic Value, Ending balance $ 13,750    
Aggregate Intrinsic Value, Expected to Vest 13,574    
Aggregate Intrinsic Value, Vested $ 10,187