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Income Taxes - Significant Components of the Company's Deferred Tax Assets (Detail) - USD ($) $ in Thousands	Dec. 31, 2016	Dec. 31, 2015
Deferred Tax Assets, Net [Abstract]
Net operating loss carryforwards	$ 68,639	$ 30,572
Research credits	2,643	1,919
Stock awards	2,583	1,011
Other	1,558	571
Gross deferred tax assets	75,423	34,073
Valuation allowance	(74,520)	(33,845)
Total deferred tax assets	903	228
Deferred tax liabilities	(903)	(228)
Net deferred tax assets	$ 0	$ 0

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Amount before allocation of valuation allowances of deferred tax asset attributable to deductible temporary differences and carryforwards.

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