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Accrued and Other Liabilities - Schedule of Accrued Liabilities and Other Liabilities (Detail) - USD ($)
$ in Thousands
Mar. 31, 2018
Dec. 31, 2017
Payables and Accruals [Abstract]    
Accrued clinical and non-clinical expenses $ 3,912 $ 5,447
Accrued contract manufacturing 3,309 3,980
Accrued professional and consulting services 579 530
Other 984 752
Accrued liabilities and other liabilities $ 8,784 $ 10,709 [1]
[1] Derived from the audited consolidated financial statements included in the Company’s Annual Report on Form 10K for the year ended December 31, 2017.