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Condensed Consolidated Statements of Operations and Comprehensive Loss - USD ($) $ in Thousands	3 Months Ended
	Mar. 31, 2018	Mar. 31, 2017
Revenue:
Cost of revenue	$ 464
Gross profit	1,856
Operating expenses:
Research and development	13,350	$ 22,387
General and administrative	6,191	6,047
Total operating expenses	19,541	28,434
Loss from operations	(17,685)	(28,434)
Other income, net	670	426
Loss before provision for income taxes	(17,015)	(28,008)
Provision for income taxes	4
Net loss	$ (17,019)	$ (28,008)
Net loss per common share, basic and diluted	$ (0.36)	$ (0.59)
Shares used in computing net loss per share - basic and diluted	47,559,366	47,343,234
Comprehensive loss:
Net loss	$ (17,019)	$ (28,008)
Unrealized (loss) gain on available-for-sale securities, net of tax	(44)	23
Comprehensive loss	(17,063)	$ (27,985)
License
Revenue:
Licensing revenue	$ 2,320

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