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Collaboration and Licensing Agreements - Additional Information (Detail) $ in Millions, ¥ in Billions | 1 Months Ended | 3 Months Ended | 6 Months Ended | 12 Months Ended |
--- | --- | --- | --- | --- | ---
Dec. 31, 2017 USD ($) | Nov. 30, 2017 USD ($) | Jun. 30, 2015 USD ($) | Jun. 30, 2018 USD ($) | Jun. 30, 2018 CAD ($) | Jun. 30, 2018 JPY (¥) | Jun. 30, 2018 USD ($) | Dec. 31, 2017 USD ($) | Jan. 02, 2018 USD ($)
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |  |  |  |  |
Current assets | $ 149,712,000 | [1] |  |  | $ 221,688,000 |  |  | $ 221,688,000 | $ 149,712,000 | [1] | $ 5,000,000
Current liabilities | 17,871,000 | [1] |  |  | 15,609,000 |  |  | 15,609,000 | 17,871,000 | [1] | 1,000,000
Revenue |  |  |  |  | 30,000 |  |  | 2,350,000 |  |  |
Cost of revenue |  |  |  |  |  |  |  | 464,000 |  |  |
Other |  |  |  |  |  |  |  |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |  |  |  |  |
Revenue |  |  |  |  | 30,000 |  |  | 30,000 |  |  |
Adjustments | ASU 2014-09 |  |  |  |  |  |  |  |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |  |  |  |  |
Current assets |  |  |  |  | 5,000,000 |  |  | 5,000,000 |  |  | 5,000,000
Current liabilities |  |  |  |  | 1,000,000 |  |  | 1,000,000 |  |  | 1,000,000
Kyowa Hakko Kirin [Member] |  |  |  |  |  |  |  |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |  |  |  |  |
Upfront payment received |  |  | $ 30,000,000 |  |  |  |  |  |  |  |
Kyowa Hakko Kirin [Member] | Product supply |  |  |  |  |  |  |  |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |  |  |  |  |
Revenue |  |  |  |  | 30,000 |  |  | 30,000 |  |  |
Kyowa Hakko Kirin [Member] | Adjustments | ASU 2014-09 |  |  |  |  |  |  |  |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |  |  |  |  |
Current assets |  |  |  |  |  |  |  |  |  |  | 5,000,000
Current liabilities |  |  |  |  |  |  |  |  |  |  | $ 1,000,000
Shanghai Fosun Pharmaceutical Industrial Development [Member] |  |  |  |  |  |  |  |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |  |  |  |  |
Upfront payment received | 12,000,000 |  |  |  |  |  |  |  |  |  |
Revenue |  |  |  |  | 0 |  |  | 0 |  |  |
Future development milestones | $ 113,000,000 |  |  |  |  |  |  |  |  |  |
Threshold percentage of net sales for tiered royalties | 20.00% |  |  |  |  |  |  |  |  |  |
Astra Zeneca [Member] |  |  |  |  |  |  |  |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |  |  |  |  |
Upfront payment received |  |  |  | $ 75,000,000 |  |  |  |  |  |  |
Development And Commercialization [Member] | Kyowa Hakko Kirin [Member] |  |  |  |  |  |  |  |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |  |  |  |  |
Development milestones |  |  |  |  |  |  |  | 55,000,000 |  |  |
Commercialization milestones | ¥ |  |  |  |  |  |  | ¥ 8.5 |  |  |  |
Development And Commercialization [Member] | Shanghai Fosun Pharmaceutical Industrial Development [Member] |  |  |  |  |  |  |  |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |  |  |  |  |
Cost of revenue |  |  |  |  |  |  |  |  | 2,400,000 |  |
Development And Commercialization [Member] | Astra Zeneca [Member] |  |  |  |  |  |  |  |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |  |  |  |  |
Cost of revenue |  |  |  |  |  |  |  | 1,000,000 |  |  |
Development And Commercialization [Member] | Knight Therapeutics Inc [Member] |  |  |  |  |  |  |  |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |  |  |  |  |
Revenue |  |  |  |  | $ 0 |  |  | 2,300,000 |  |  |
Total payments, including an up-front payment and development and sales milestones to be received |  |  |  |  |  | $ 25 |  |  |  |  |
Cost of revenue |  |  |  |  |  |  |  | 500,000 | $ 6,000,000 |  |
Termination Agreement [Member] | Astra Zeneca [Member] |  |  |  |  |  |  |  |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |  |  |  |  |
Cost of revenue |  |  |  |  |  |  |  | $ 500,000 |  |  |
Termination Agreement [Member] | Knight Therapeutics Inc [Member] |  |  |  |  |  |  |  |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |  |  |  |  |
Cost of revenue |  |  |  | $ 9,900,000 |  |  |  |  |  |  |
[1] | Derived from the audited consolidated financial statements included in the Company’s Annual Report on Form 10K for the year ended December 31, 2017.

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