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Collaboration and Licensing Agreements - Additional Information (Detail) $ in Thousands, $ in Millions, ¥ in Billions |  | 1 Months Ended | 3 Months Ended | 9 Months Ended | 12 Months Ended |
--- | --- | --- | --- | --- | --- | ---
Nov. 02, 2018 USD ($) | Dec. 31, 2017 USD ($) | Nov. 30, 2017 USD ($) | Jun. 30, 2015 USD ($) | Sep. 30, 2018 USD ($) | Sep. 30, 2018 CAD ($) | Sep. 30, 2018 JPY (¥) | Sep. 30, 2018 USD ($) | Dec. 31, 2017 USD ($) | Jan. 02, 2018 USD ($)
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |  |  |  |  |  |
Current assets |  | $ 149,712 | [1] |  |  | $ 199,322 |  |  | $ 199,322 | $ 149,712 | [1] | $ 5,000
Current liabilities |  | 17,871 | [1] |  |  | 15,549 |  |  | 15,549 | 17,871 | [1] | 1,000
Revenues |  |  |  |  |  | 172 |  |  | 2,522 |  |  |
Cost of revenue |  |  |  |  |  | 2 |  |  | 466 |  |  |
Other |  |  |  |  |  |  |  |  |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |  |  |  |  |  |
Revenues |  |  |  |  |  | 172 |  |  | 202 |  |  |
Adjustments | ASU 2014-09 |  |  |  |  |  |  |  |  |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |  |  |  |  |  |
Current assets |  |  |  |  |  | 5,000 |  |  | 5,000 |  |  | 5,000
Current liabilities |  |  |  |  |  | 1,000 |  |  | 1,000 |  |  | 1,000
Kyowa Hakko Kirin [Member] |  |  |  |  |  |  |  |  |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |  |  |  |  |  |
Upfront payment received |  |  |  | $ 30,000 |  |  |  |  |  |  |  |
Kyowa Hakko Kirin [Member] | Product supply |  |  |  |  |  |  |  |  |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |  |  |  |  |  |
Revenues |  |  |  |  |  | 200 |  |  | 200 |  |  |
Kyowa Hakko Kirin [Member] | Adjustments | ASU 2014-09 |  |  |  |  |  |  |  |  |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |  |  |  |  |  |
Current assets |  |  |  |  |  |  |  |  |  |  |  | 5,000
Current liabilities |  |  |  |  |  |  |  |  |  |  |  | $ 1,000
Kyowa Hakko Kirin [Member] | Development and Commercialization [Member] |  |  |  |  |  |  |  |  |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |  |  |  |  |  |
Development milestones |  |  |  |  |  |  |  |  | 55,000 |  |  |
Commercialization milestones | ¥ |  |  |  |  |  |  |  | ¥ 8.5 |  |  |  |
Shanghai Fosun Pharmaceutical Industrial Development [Member] |  |  |  |  |  |  |  |  |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |  |  |  |  |  |
Upfront payment received |  | $ 12,000 |  |  |  |  |  |  |  |  |  |
Revenues |  |  |  |  |  | 0 |  |  | 0 |  |  |
Future development milestones | $ 113,000 |  |  |  |  |  |  |  |  |  |  |
Threshold percentage of net sales for tiered royalties |  | 20.00% |  |  |  |  |  |  |  |  |  |
Shanghai Fosun Pharmaceutical Industrial Development [Member] | Development and Commercialization [Member] |  |  |  |  |  |  |  |  |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |  |  |  |  |  |
Cost of revenue |  |  |  |  |  |  |  |  |  | 2,400 |  |
AstraZeneca [Member] |  |  |  |  |  |  |  |  |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |  |  |  |  |  |
Upfront payment received |  |  |  |  | $ 75,000 |  |  |  |  |  |  |
AstraZeneca [Member] | Development and Commercialization [Member] |  |  |  |  |  |  |  |  |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |  |  |  |  |  |
Cost of revenue |  |  |  |  |  |  |  |  | 1,000 |  |  |
AstraZeneca [Member] | Termination Agreement [Member] |  |  |  |  |  |  |  |  |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |  |  |  |  |  |
Cost of revenue |  |  |  |  |  |  |  |  | 500 |  |  |
Knight Therapeutics Inc [Member] | Development and Commercialization [Member] |  |  |  |  |  |  |  |  |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |  |  |  |  |  |
Revenues |  |  |  |  |  | 0 |  |  | 2,300 |  |  |
Total payments, including an up-front payment and development and sales milestones to be received |  |  |  |  |  |  | $ 25 |  |  |  |  |
Cost of revenue |  |  |  |  |  |  |  |  |  | $ 6,000 |  |
Knight Therapeutics Inc [Member] | Termination Agreement [Member] |  |  |  |  |  |  |  |  |  |  |  |
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |  |  |  |  |  |
Cost of revenue |  |  |  |  | $ 9,900 | $ 0 |  |  | $ 500 |  |  |
[1] | Derived from the audited consolidated financial statements included in the Company’s Annual Report on Form 10K for the year ended December 31, 2017.

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