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CONDENSED STATEMENTS OF CASH FLOWS - USD ($)
$ in Thousands
 9 Months Ended
Sep. 30, 2020
Sep. 30, 2019
Operating activities    
Net loss $ (65,437) $ (75,150)
Adjustments to reconcile net loss to net cash used in operating activities:    
Depreciation expense 1,399 1,993
Amortization of deferred financing costs 416 550
Amortization of deferred compensation for services 235 231
Amortization of premium on investment securities (241) (666)
Non-cash lease expense 1,568 1,356
Stock-based compensation 8,149 7,724
Change in derivative liabilities 290 246
Non-cash interest associated with debt discount accretion 393 353
Changes in operating assets and liabilities:    
Unbilled revenue   5,000
Prepaid expenses and other assets (3,748) (3,068)
Accounts payable 303 541
Accrued compensation and benefits (731) 81
Lease liabilities (1,914) (1,301)
Accrued and other liabilities (871) (3,237)
Deferred revenue (3,656)  
Net cash used in operating activities (63,845) (65,347)
Investing activities    
Proceeds from maturities of investments 79,402 115,484
Purchases of investments (107,200) (36,325)
Purchases of property and equipment (74) (325)
Net cash (used in) provided by investing activities (27,872) 78,834
Financing activities    
Proceeds from issuance of common stock under equity incentive and stock purchase plans 1,593 418
Net cash provided by financing activities 1,593 418
Net (decrease) increase in cash and cash equivalents (90,124) 13,905
Cash and cash equivalents at beginning of period 181,133 78,768
Cash and cash equivalents at end of period 91,009 92,673
Supplementary disclosure of cash flow information:    
Income taxes paid $ 1 2
Supplementary disclosure of non-cash activities:    
Right-of-use assets obtained in exchange for lease obligations   $ 5,810