<SEC-DOCUMENT>0001628280-21-011446.txt : 20210601
<SEC-HEADER>0001628280-21-011446.hdr.sgml : 20210601
<ACCEPTANCE-DATETIME>20210601165845
ACCESSION NUMBER:		0001628280-21-011446
CONFORMED SUBMISSION TYPE:	8-K
PUBLIC DOCUMENT COUNT:		3
CONFORMED PERIOD OF REPORT:	20210525
ITEM INFORMATION:		Entry into a Material Definitive Agreement
ITEM INFORMATION:		Financial Statements and Exhibits
FILED AS OF DATE:		20210601
DATE AS OF CHANGE:		20210601

FILER:

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			ARDELYX, INC.
		CENTRAL INDEX KEY:			0001437402
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		IRS NUMBER:				000000000
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		8-K
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	001-36485
		FILM NUMBER:		21986144

	BUSINESS ADDRESS:	
		STREET 1:		34175 ARDENWOOD BLVD.
		CITY:			FREMONT
		STATE:			CA
		ZIP:			94555
		BUSINESS PHONE:		510-745-7047

	MAIL ADDRESS:	
		STREET 1:		34175 ARDENWOOD BLVD.
		CITY:			FREMONT
		STATE:			CA
		ZIP:			94555

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	NTERYX INC
		DATE OF NAME CHANGE:	20080611
</SEC-HEADER>
<DOCUMENT>
<TYPE>8-K
<SEQUENCE>1
<FILENAME>ardx-20210601x8k.htm
<DESCRIPTION>8-K
<TEXT>
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<title>Document</title></head><body><div id="i20006880be5148c8ad76051cc7aa1efe_1"></div><div style="min-height:45pt;width:100%"><div style="text-align:justify"><font><br></font></div></div><div style="text-align:center"><font><br></font></div><div style="text-align:center"><table style="border-collapse:collapse;display:inline-table;margin-bottom:5pt;vertical-align:text-bottom;width:100.000%"><tr><td style="width:1.0%"></td><td style="width:98.900%"></td><td style="width:0.1%"></td></tr><tr style="height:3pt"><td colspan="3" style="border-bottom:3pt double #000;padding:0 1pt"></td></tr></table></div><div style="margin-top:6pt;text-align:center"><table style="border-collapse:collapse;display:inline-table;margin-bottom:5pt;vertical-align:text-bottom;width:100.000%"><tr><td style="width:1.0%"></td><td style="width:98.900%"></td><td style="width:0.1%"></td></tr><tr style="height:3pt"><td colspan="3" style="border-bottom:1pt solid #000;padding:0 1pt"></td></tr></table></div><div style="margin-top:6pt;text-align:center"><font style="color:#000000;font-family:'Times New Roman',sans-serif;font-size:14pt;font-weight:700;line-height:120%">UNITED STATES</font></div><div style="text-align:center"><font style="color:#000000;font-family:'Times New Roman',sans-serif;font-size:14pt;font-weight:700;line-height:120%">SECURITIES AND EXCHANGE COMMISSION</font></div><div style="text-align:center"><font style="color:#000000;font-family:'Times New Roman',sans-serif;font-size:10pt;font-weight:700;line-height:120%">Washington, D.C. 20549</font></div><div style="margin-top:6pt;text-align:center"><table style="border-collapse:collapse;display:inline-table;margin-bottom:5pt;vertical-align:text-bottom;width:100.000%"><tr><td style="width:1.0%"></td><td style="width:98.900%"></td><td style="width:0.1%"></td></tr><tr style="height:3pt"><td colspan="3" style="border-bottom:1pt solid #000;padding:0 1pt"></td></tr></table></div><div style="margin-top:8pt;text-align:center"><font style="color:#000000;font-family:'Times New Roman',sans-serif;font-size:14pt;font-weight:700;line-height:120%">FORM&#160;8-K</font></div><div style="margin-top:6pt;text-align:center"><table style="border-collapse:collapse;display:inline-table;margin-bottom:5pt;vertical-align:text-bottom;width:100.000%"><tr><td style="width:1.0%"></td><td style="width:98.900%"></td><td style="width:0.1%"></td></tr><tr style="height:3pt"><td colspan="3" style="border-bottom:1pt solid #000;padding:0 1pt"></td></tr></table></div><div style="margin-top:8pt;text-align:center"><font style="color:#000000;font-family:'Times New Roman',sans-serif;font-size:10pt;font-weight:700;line-height:120%">CURRENT REPORT</font></div><div style="text-align:center"><font style="color:#000000;font-family:'Times New Roman',sans-serif;font-size:10pt;font-weight:700;line-height:120%">Pursuant to Section&#160;13 or 15(d)</font></div><div style="text-align:center"><font style="color:#000000;font-family:'Times New Roman',sans-serif;font-size:10pt;font-weight:700;line-height:120%">of the Securities Exchange Act of 1934</font></div><div style="margin-top:9pt;text-align:center"><font style="color:#000000;font-family:'Times New Roman',sans-serif;font-size:10pt;font-weight:700;line-height:120%">Date of Report (Date of earliest event reported)&#58;&#160;May 25, 2021</font></div><div style="margin-top:6pt;text-align:center"><table style="border-collapse:collapse;display:inline-table;margin-bottom:5pt;vertical-align:text-bottom;width:100.000%"><tr><td style="width:1.0%"></td><td style="width:98.900%"></td><td style="width:0.1%"></td></tr><tr style="height:3pt"><td colspan="3" style="border-bottom:1pt solid #000;padding:0 1pt"></td></tr></table></div><div style="margin-top:6pt;text-align:center"><img alt="image_0.jpg" src="image_0.jpg" style="height:75px;margin-bottom:5pt;vertical-align:text-bottom;width:75px"></div><div style="text-align:center"><font style="color:#000000;font-family:'Times New Roman',sans-serif;font-size:16pt;font-weight:700;line-height:120%">ARDELYX, INC.</font></div><div style="text-align:center"><font style="color:#000000;font-family:'Times New Roman',sans-serif;font-size:9pt;font-weight:700;line-height:120%">(Exact name of registrant as specified in its charter)</font></div><div style="margin-top:6pt;text-align:center"><table style="border-collapse:collapse;display:inline-table;margin-bottom:5pt;vertical-align:text-bottom;width:100.000%"><tr><td style="width:1.0%"></td><td style="width:98.900%"></td><td style="width:0.1%"></td></tr><tr style="height:3pt"><td colspan="3" style="border-bottom:1pt solid #000;padding:0 1pt"></td></tr></table></div><div style="margin-top:7pt"><table style="border-collapse:collapse;display:inline-table;margin-bottom:5pt;vertical-align:text-bottom;width:100.000%"><tr><td style="width:1.0%"></td><td style="width:32.233%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:32.233%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:32.234%"></td><td style="width:0.1%"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:center;vertical-align:bottom"><font style="color:#000000;font-family:'Times New Roman',sans-serif;font-size:10pt;font-weight:700;line-height:100%">Delaware</font></td><td colspan="3" style="padding:2px 1pt;text-align:center;vertical-align:top"><font style="color:#000000;font-family:'Times New Roman',sans-serif;font-size:10pt;font-weight:700;line-height:100%">001-36485</font></td><td colspan="3" style="padding:2px 1pt;text-align:center;vertical-align:top"><font style="color:#000000;font-family:'Times New Roman',sans-serif;font-size:10pt;font-weight:700;line-height:100%">26-1303944</font></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:center;vertical-align:top"><font style="color:#000000;font-family:'Times New Roman',sans-serif;font-size:8pt;font-weight:700;line-height:100%">(State or other jurisdiction<br>of incorporation)</font></td><td colspan="3" style="padding:2px 1pt;text-align:center;vertical-align:top"><font style="color:#000000;font-family:'Times New Roman',sans-serif;font-size:8pt;font-weight:700;line-height:100%">(Commission<br>File Number)</font></td><td colspan="3" style="padding:2px 1pt;text-align:center;vertical-align:top"><font style="color:#000000;font-family:'Times New Roman',sans-serif;font-size:8pt;font-weight:700;line-height:100%">(IRS Employer<br>Identification Number)</font></td></tr></table></div><div style="margin-top:6pt;text-align:center"><font style="color:#000000;font-family:'Times New Roman',sans-serif;font-size:10pt;font-weight:700;line-height:120%">34175 ARDENWOOD BLVD.,&#160;FREMONT,&#160;CALIFORNIA&#160;94555</font></div><div style="text-align:center"><font style="color:#000000;font-family:'Times New Roman',sans-serif;font-size:10pt;font-weight:700;line-height:120%">400 FIFTH AVE.,&#160;SUITE 210,&#160;WALTHAM,&#160;MASSACHUSETTS&#160;02451</font></div><div style="text-align:center"><font style="color:#000000;font-family:'Times New Roman',sans-serif;font-size:8pt;font-weight:700;line-height:120%">(Address of principal executive offices, including Zip Code)</font></div><div style="margin-top:8pt;text-align:center"><font style="color:#000000;font-family:'Times New Roman',sans-serif;font-size:10pt;font-weight:700;line-height:120%">Registrant&#8217;s telephone number, including area code&#58; (510)&#160;745-1700</font></div><div style="margin-top:6pt;text-align:center"><table style="border-collapse:collapse;display:inline-table;margin-bottom:5pt;vertical-align:text-bottom;width:100.000%"><tr><td style="width:1.0%"></td><td style="width:98.900%"></td><td style="width:0.1%"></td></tr><tr style="height:3pt"><td colspan="3" style="border-bottom:1pt solid #000;padding:0 1pt"></td></tr></table></div><div style="margin-top:8pt"><font style="color:#000000;font-family:'Times New Roman',sans-serif;font-size:9pt;font-weight:400;line-height:120%">Check the appropriate box below if the Form 8-K filing is intended to simultaneously satisfy the filing obligation of the registrant under any of the following provisions&#58;</font></div><div style="margin-top:8pt"><table style="border-collapse:collapse;display:inline-table;margin-bottom:5pt;vertical-align:text-bottom;width:99.561%"><tr><td style="width:1.0%"></td><td style="width:2.424%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:95.376%"></td><td style="width:0.1%"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:top"><font style="color:#000000;font-family:'Wingdings',sans-serif;font-size:9pt;font-weight:700;line-height:100%">&#9744;</font></td><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:top"><font style="color:#000000;font-family:'Times New Roman',sans-serif;font-size:9pt;font-weight:400;line-height:100%">Written communications pursuant to Rule 425 under the Securities Act (17 CFR 230.425)</font></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:top"><font style="color:#000000;font-family:'Wingdings',sans-serif;font-size:9pt;font-weight:700;line-height:100%">&#9744;</font></td><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:top"><font style="color:#000000;font-family:'Times New Roman',sans-serif;font-size:9pt;font-weight:400;line-height:100%">Soliciting material pursuant to Rule 14a-12 under the Exchange Act (17 CFR 240.14a-12)</font></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:top"><font style="color:#000000;font-family:'Wingdings',sans-serif;font-size:9pt;font-weight:700;line-height:100%">&#9744;</font></td><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:top"><font style="color:#000000;font-family:'Times New Roman',sans-serif;font-size:9pt;font-weight:400;line-height:100%">Pre-commencement communications pursuant to Rule 14d-2(b) under the Exchange Act (17 CFR 240.14d-2(b))</font></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:top"><font style="color:#000000;font-family:'Wingdings',sans-serif;font-size:9pt;font-weight:700;line-height:100%">&#9744;</font></td><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:top"><font style="color:#000000;font-family:'Times New Roman',sans-serif;font-size:9pt;font-weight:400;line-height:100%">Pre-commencement communications pursuant to Rule 13e-4(c) under the Exchange Act (17 CFR 240.13e-4(c))</font></td></tr></table></div><div style="margin-top:4pt"><font style="color:#000000;font-family:'Times New Roman',sans-serif;font-size:9pt;font-weight:400;line-height:120%">Securities registered pursuant to Section 12(b) of the Act&#58;</font></div><div style="margin-top:6pt"><table style="border-collapse:collapse;display:inline-table;margin-bottom:5pt;vertical-align:text-bottom;width:100.000%"><tr><td style="width:1.0%"></td><td style="width:33.695%"></td><td style="width:0.1%"></td><td style="width:0.1%"></td><td style="width:0.823%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:27.116%"></td><td style="width:0.1%"></td><td style="width:0.1%"></td><td style="width:0.823%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:33.843%"></td><td style="width:0.1%"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:center;vertical-align:top"><font style="color:#000000;font-family:'Times New Roman',sans-serif;font-size:9pt;font-weight:700;line-height:100%">Title of each class</font></td><td colspan="3" style="padding:0 1pt"></td><td colspan="3" style="padding:2px 1pt;text-align:center;vertical-align:top"><font style="color:#000000;font-family:'Times New Roman',sans-serif;font-size:9pt;font-weight:700;line-height:100%">Trading Symbol(s)</font></td><td colspan="3" style="padding:0 1pt"></td><td colspan="3" style="padding:2px 1pt;text-align:center;vertical-align:top"><font style="color:#000000;font-family:'Times New Roman',sans-serif;font-size:9pt;font-weight:700;line-height:100%">Name of each exchange on which registered</font></td></tr><tr><td colspan="3" style="border-top:1pt solid #000;padding:2px 1pt;text-align:center;vertical-align:top"><font style="color:#000000;font-family:'Times New Roman',sans-serif;font-size:9pt;font-weight:400;line-height:100%">Common Stock, par value $0.0001</font></td><td colspan="3" style="padding:0 1pt"></td><td colspan="3" style="border-top:1pt solid #000;padding:2px 1pt;text-align:center;vertical-align:top"><font style="color:#000000;font-family:'Times New Roman',sans-serif;font-size:9pt;font-weight:400;line-height:100%">ARDX</font></td><td colspan="3" style="padding:0 1pt"></td><td colspan="3" style="border-top:1pt solid #000;padding:2px 1pt;text-align:center;vertical-align:top"><font style="color:#000000;font-family:'Times New Roman',sans-serif;font-size:9pt;font-weight:400;line-height:100%">The Nasdaq Global Market</font></td></tr></table></div><div style="margin-top:6pt"><font style="color:#000000;font-family:'Times New Roman',sans-serif;font-size:9pt;font-weight:400;line-height:120%">Indicate by check mark whether the registrant is an emerging growth company as defined in Rule 405 of the Securities Act of 1933 (&#167;230.405 of this chapter) or Rule 12b-2 of the Securities Exchange Act of 1934 (&#167;240.12b-2 of this chapter).</font></div><div style="margin-top:8pt"><font style="color:#000000;font-family:'Times New Roman',sans-serif;font-size:9pt;font-weight:400;line-height:120%">Emerging growth company&#160;&#160;</font><font style="color:#000000;font-family:'Times New Roman',sans-serif;font-size:9pt;font-weight:700;line-height:120%">&#9744;</font></div><div style="margin-top:8pt"><font style="color:#000000;font-family:'Times New Roman',sans-serif;font-size:9pt;font-weight:400;line-height:120%">If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section&#160;13(a) of the Exchange Act.&#160;&#160;</font><font style="color:#000000;font-family:'Wingdings',sans-serif;font-size:9pt;font-weight:400;line-height:120%">o</font></div><div style="margin-top:5pt;text-align:center"><table style="border-collapse:collapse;display:inline-table;margin-bottom:5pt;vertical-align:text-bottom;width:100.000%"><tr><td style="width:1.0%"></td><td style="width:98.900%"></td><td style="width:0.1%"></td></tr><tr style="height:3pt"><td colspan="3" style="border-bottom:3pt double #000;padding:0 1pt"></td></tr></table></div><div style="height:45pt;position:relative;width:100%"><div style="bottom:0;position:absolute;width:100%"><div><font><br></font></div></div></div><div id="i20006880be5148c8ad76051cc7aa1efe_7"></div><hr style="page-break-after:always"><div style="min-height:45pt;width:100%"><div style="text-align:justify"><font><br></font></div></div><div style="margin-top:12pt;padding-left:58.5pt;text-indent:-58.5pt"><font style="color:#000000;font-family:'Times New Roman',sans-serif;font-size:10pt;font-weight:700;line-height:120%">Item 1.01 Entry into a Material Definitive Agreement.</font></div><div><font><br></font></div><div style="text-align:justify"><font style="color:#000000;font-family:'Times New Roman',sans-serif;font-size:10pt;font-weight:400;line-height:120%">On May 25, 2021, Ardelyx, Inc. (the &#8220;Company&#8221;) and Ardenwood Venture, LLC (the &#8220;Landlord&#8221;) entered into a Fifth Amendment to Lease (the &#8220;Lease Amendment&#8221;), which amended certain terms of the Lease, dated August 8, 2008, as previously amended (the &#8220;Original Lease&#8221;), between the Company and the Landlord with respect to the Company&#8217;s office space and laboratory facilities located at 34175 Ardenwood Boulevard in Fremont, California. Among other things, the Lease Amendment extends the term of the Original Lease for an additional period of forty-two (42) months, with a new expiration date of March 10, 2025. Commencing September 11, 2021, the monthly base rent shall equal three and 75&#47;100 dollars ($3.75) per square foot of rentable area of the premises and shall be subject to an annual upward adjustment of three point five percent (3.5%) of the then-current base rent.</font></div><div style="text-align:justify"><font><br></font></div><div style="text-align:justify"><font style="color:#000000;font-family:'Times New Roman',sans-serif;font-size:10pt;font-weight:400;line-height:120%">The foregoing description of the Lease Amendment is qualified in its entirety by reference to the full text of the Lease Amendment, which is filed herewith as Exhibit 10.1.</font></div><div style="text-align:justify"><font><br></font></div><div id="i20006880be5148c8ad76051cc7aa1efe_10"></div><div style="-sec-extract:summary;margin-top:12pt;padding-left:58.5pt;text-indent:-58.5pt"><font style="color:#000000;font-family:'Times New Roman',sans-serif;font-size:10pt;font-weight:700;line-height:120%">Item 9.01 Financial Statements and Exhibits.</font></div><div><font><br></font></div><div><font style="color:#000000;font-family:'Times New Roman',sans-serif;font-size:10pt;font-weight:700;line-height:120%">(d) Exhibits.</font></div><div style="margin-top:6pt"><table style="border-collapse:collapse;display:inline-table;margin-bottom:5pt;vertical-align:text-bottom;width:99.415%"><tr><td style="width:1.0%"></td><td style="width:7.723%"></td><td style="width:0.1%"></td><td style="width:0.1%"></td><td style="width:1.711%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:88.166%"></td><td style="width:0.1%"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:center;vertical-align:bottom"><font style="color:#000000;font-family:'Times New Roman',sans-serif;font-size:8pt;font-weight:400;line-height:100%">Exhibit<br>No.</font></td><td colspan="3" style="padding:0 1pt"></td><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><font style="color:#000000;font-family:'Times New Roman',sans-serif;font-size:8pt;font-weight:400;line-height:100%">Description</font></td></tr><tr><td colspan="3" style="border-top:1pt solid #000;padding:2px 1pt;text-align:left;vertical-align:top"><font style="color:#000000;font-family:'Times New Roman',sans-serif;font-size:10pt;font-weight:400;line-height:100%">10.1</font></td><td colspan="3" style="padding:0 1pt"></td><td colspan="3" style="border-top:1pt solid #000;padding:2px 1pt;text-align:left;vertical-align:top"><div><font style="color:#0000ff;font-family:'Times New Roman',sans-serif;font-size:10pt;font-weight:400;line-height:120%;text-decoration:underline"><a href="ardenwoodleasefifthamendme.htm" style="-sec-extract:exhibit;color:#0000ff;font-family:'Times New Roman',sans-serif;font-size:10pt;font-weight:400;line-height:120%;text-decoration:underline">Fifth</a><a href="ardenwoodleasefifthamendme.htm" style="-sec-extract:exhibit;color:#0000ff;font-family:'Times New Roman',sans-serif;font-size:10pt;font-weight:400;line-height:120%;text-decoration:underline"> Amendment to Lease, dated </a><a href="ardenwoodleasefifthamendme.htm" style="-sec-extract:exhibit;color:#0000ff;font-family:'Times New Roman',sans-serif;font-size:10pt;font-weight:400;line-height:120%;text-decoration:underline">May 25, 2021</a><a href="ardenwoodleasefifthamendme.htm" style="-sec-extract:exhibit;color:#0000ff;font-family:'Times New Roman',sans-serif;font-size:10pt;font-weight:400;line-height:120%;text-decoration:underline">, by and between Ardelyx, Inc. and 34175 Ardenwood Venture, LLC</a></font></div></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:top"><font style="color:#000000;font-family:'Times New Roman',sans-serif;font-size:10pt;font-weight:400;line-height:100%">104</font></td><td colspan="3" style="padding:0 1pt"></td><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:top"><font style="color:#000000;font-family:'Times New Roman',sans-serif;font-size:10pt;font-weight:400;line-height:120%">Cover Page Interactive Data File (embedded within the Inline XBRL document).</font></td></tr></table></div><div style="height:45pt;position:relative;width:100%"><div style="bottom:0;position:absolute;width:100%"><div><font><br></font></div></div></div><div id="i20006880be5148c8ad76051cc7aa1efe_13"></div><hr style="page-break-after:always"><div style="min-height:45pt;width:100%"><div style="text-align:justify"><font><br></font></div></div><div style="margin-top:12pt;text-align:center"><font style="color:#000000;font-family:'Times New Roman',sans-serif;font-size:10pt;font-weight:700;line-height:120%">SIGNATURES</font></div><div style="margin-top:6pt"><font style="color:#000000;font-family:'Times New Roman',sans-serif;font-size:10pt;font-weight:400;line-height:120%">Pursuant to the requirements of the Securities Exchange Act of 1934, as amended, the registrant has duly caused this report to be signed on its behalf by the undersigned hereunto duly authorized.</font></div><div style="margin-top:6pt"><table style="border-collapse:collapse;display:inline-table;margin-bottom:5pt;vertical-align:text-bottom;width:99.561%"><tr><td style="width:1.0%"></td><td style="width:41.924%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:3.158%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:51.618%"></td><td style="width:0.1%"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:top"><font style="color:#000000;font-family:'Times New Roman',sans-serif;font-size:10pt;font-weight:400;line-height:100%">Date&#58; June 1, 2021</font></td><td colspan="6" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><font style="color:#000000;font-family:'Times New Roman',sans-serif;font-size:10pt;font-weight:400;line-height:100%">ARDELYX, INC.</font></td></tr><tr style="height:12pt"><td colspan="3" style="padding:0 1pt"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="3" style="padding:0 1pt"></td></tr><tr><td colspan="3" style="padding:0 1pt"></td><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><font style="color:#000000;font-family:'Times New Roman',sans-serif;font-size:10pt;font-weight:400;line-height:100%">By&#58;</font></td><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><font style="color:#000000;font-family:'Times New Roman',sans-serif;font-size:10pt;font-weight:400;line-height:100%">&#47;s&#47; Justin Renz</font></td></tr><tr><td colspan="3" style="padding:0 1pt"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="3" style="border-top:1pt solid #000000;padding:2px 1pt;text-align:left;vertical-align:bottom"><font style="color:#000000;font-family:'Times New Roman',sans-serif;font-size:10pt;font-weight:400;line-height:100%">Justin Renz</font></td></tr><tr><td colspan="3" style="padding:0 1pt"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><font style="color:#000000;font-family:'Times New Roman',sans-serif;font-size:10pt;font-weight:400;line-height:100%">Chief Financial Officer</font></td></tr></table></div><div style="height:45pt;position:relative;width:100%"><div style="bottom:0;position:absolute;width:100%"><div><font><br></font></div></div></div></body></html>
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</DOCUMENT>
<DOCUMENT>
<TYPE>EX-10.1
<SEQUENCE>2
<FILENAME>ardenwoodleasefifthamendme.htm
<DESCRIPTION>EX-10.1
<TEXT>
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<title>Document</title></head><body><div id="id97e5f187a344abaa79635b1aa2e0f38_1"></div><div style="min-height:64pt;width:100%"><div style="text-align:right"><font style="color:#000000;font-family:'Times New Roman',sans-serif;font-size:11pt;font-weight:700;line-height:120%">Exhibit 10.1</font></div></div><div style="margin-top:5.65pt;padding-left:11.8pt;padding-right:11.8pt;text-align:center"><font style="color:#1f2224;font-family:'Times New Roman',sans-serif;font-size:12pt;font-weight:700;line-height:120%">FIFTH AMENDMENT TO LEASE</font></div><div style="margin-top:13.55pt;padding-left:30.7pt;padding-right:6.5pt;text-align:justify;text-indent:35.8pt"><font style="color:#1b1e1f;font-family:'Times New Roman',sans-serif;font-size:12pt;font-weight:400;line-height:95%">THIS FIFTH AMENDMENT TO LEASE (this </font><font style="color:#1b1e1f;font-family:'Times New Roman',sans-serif;font-size:12pt;font-weight:400;line-height:95%;text-decoration:underline">&#34;Amendment&#34;)</font><font style="color:#1b1e1f;font-family:'Times New Roman',sans-serif;font-size:12pt;font-weight:400;line-height:95%"> is entered into as of this 25th day of May 2021, by and between 34175 ARDENWOOD VENTURE, LLC, a Delaware limited liability company </font><font style="color:#1b1e1f;font-family:'Times New Roman',sans-serif;font-size:12pt;font-weight:400;line-height:95%;text-decoration:underline">(&#34;Landlord&#34;),</font><font style="color:#1b1e1f;font-family:'Times New Roman',sans-serif;font-size:12pt;font-weight:400;line-height:95%"> and ARDELYX, INC., a Delaware corporation </font><font style="color:#2c2d2e;font-family:'Times New Roman',sans-serif;font-size:12pt;font-weight:400;line-height:95%;text-decoration:underline">('Tenant&#34;)</font><font style="color:#2c2d2e;font-family:'Times New Roman',sans-serif;font-size:12pt;font-weight:400;line-height:95%">.</font></div><div style="margin-top:0.05pt"><font><br></font></div><div style="margin-top:6.35pt;padding-left:12.07pt;padding-right:12.07pt;text-align:center"><font style="color:#1e2022;font-family:'Times New Roman',sans-serif;font-size:12pt;font-weight:700;line-height:120%;text-decoration:underline">RECITALS</font></div><div style="margin-top:12.25pt;padding-left:30.3pt;padding-right:5.75pt;text-align:justify;text-indent:36.4pt"><font style="color:#1e2021;font-family:'Times New Roman',sans-serif;font-size:12pt;font-weight:400;line-height:110%">A. WHEREAS, Landlord and Tenant are parties to that certain Lease dated as of </font><font style="color:#1a1c1e;font-family:'Times New Roman',sans-serif;font-size:12pt;font-weight:400;line-height:110%">August 8, 2008 (the </font><font style="color:#1a1c1e;font-family:'Times New Roman',sans-serif;font-size:12pt;font-weight:400;line-height:110%;text-decoration:underline">&#34;Original Lease&#34;),</font><font style="color:#1a1c1e;font-family:'Times New Roman',sans-serif;font-size:12pt;font-weight:400;line-height:110%"> as amended by that certain First Amendment to Lease dated as of December 20, 2012, that certain Second Amendment to Lease dated as of September 5, 2014, that certain Third Amendment to Lease dated as of April 28, 2016 (the </font><font style="color:#1a1c1e;font-family:'Times New Roman',sans-serif;font-size:12pt;font-weight:400;line-height:110%;text-decoration:underline">&#34;Third Amendment&#34;)</font><font style="color:#1a1c1e;font-family:'Times New Roman',sans-serif;font-size:12pt;font-weight:400;line-height:110%">, and that certain Fourth Amendment to Lease dated as of May 11, 2018 (collectively, and as the same may have been further amended, amended and restated, supplemented or modified from time to time, the </font><font style="color:#1a1c1e;font-family:'Times New Roman',sans-serif;font-size:12pt;font-weight:400;line-height:110%;text-decoration:underline">&#34;Existing Lease&#34;),</font><font style="color:#1a1c1e;font-family:'Times New Roman',sans-serif;font-size:12pt;font-weight:400;line-height:110%"> whereby Tenant leases certain premises (the </font><font style="color:#1a1c1e;font-family:'Times New Roman',sans-serif;font-size:12pt;font-weight:400;line-height:110%;text-decoration:underline">&#34;Premises&#34;)</font><font style="color:#1a1c1e;font-family:'Times New Roman',sans-serif;font-size:12pt;font-weight:400;line-height:110%"> from Landlord at 34175 Ardenwood Boulevard in Fremont, California (the </font><font style="color:#1a1c1e;font-family:'Times New Roman',sans-serif;font-size:12pt;font-weight:400;line-height:110%;text-decoration:underline">&#34;Building&#34;)&#59;</font></div><div style="margin-top:11.8pt;padding-left:11.22pt;padding-right:11.22pt;text-align:center"><font style="color:#161a1b;font-family:'Times New Roman',sans-serif;font-size:12pt;font-weight:400;line-height:120%">&#160;&#160;&#160;&#160;   </font><font style="color:#1e2021;font-family:'Times New Roman',sans-serif;font-size:12pt;font-weight:400;line-height:120%">B.&#160;&#160;&#160;&#160;WHEREAS, Landlord and Tenant desire to extend the Term of the Existing Lease&#59;</font></div><div style="padding-left:31.5pt"><font style="color:#000000;font-family:'Times New Roman',sans-serif;font-size:11pt;font-weight:400;line-height:120%">and</font></div><div style="margin-top:12.95pt;padding-left:30.4pt;padding-right:7.05pt;text-align:justify;text-indent:35.8pt"><font style="color:#1f2123;font-family:'Times New Roman',sans-serif;font-size:12pt;font-weight:400;line-height:109%">C.  WHEREAS, Landlord and Tenant desire to modify and amend the Existing Lease </font><font style="color:#1f2122;font-family:'Times New Roman',sans-serif;font-size:12pt;font-weight:400;line-height:109%">only in the respects and on the conditions hereinafter stated.</font></div><div style="margin-top:11.9pt;padding-left:11.4pt;padding-right:11.4pt;text-align:center"><font style="color:#202428;font-family:'Times New Roman',sans-serif;font-size:12pt;font-weight:700;line-height:120%;text-decoration:underline">AGREEMENT</font></div><div style="margin-top:12.2pt;padding-left:29.7pt;padding-right:5.5pt;text-align:justify;text-indent:36.15pt"><font style="color:#202325;font-family:'Times New Roman',sans-serif;font-size:12pt;font-weight:400;line-height:109%">NOW, THEREFORE, Landlord and Tenant, in consideration of the mutual promises contained herein and for other good and valuable consideration, the receipt and sufficiency of which are hereby acknowledged, and intending to be legally bound, agree as follows&#58;</font></div><div style="margin-top:12.25pt;padding-left:29.85pt;padding-right:7.25pt;text-align:justify;text-indent:36.05pt"><font style="color:#202325;font-family:'Times New Roman',sans-serif;font-size:12pt;font-weight:400;line-height:111%">1.</font><font style="color:#202325;font-family:'Times New Roman',sans-serif;font-size:12pt;font-weight:400;line-height:111%;padding-left:33.1pt;text-decoration:underline">Definitions.</font><font style="color:#202325;font-family:'Times New Roman',sans-serif;font-size:12pt;font-weight:400;line-height:111%"> For purposes of this Amendment, capitalized terms shall have the </font><font style="color:#202123;font-family:'Times New Roman',sans-serif;font-size:12pt;font-weight:400;line-height:111%">meanings ascribed to them in the Existing Lease unless otherwise defined herein. The Existing Lease, as amended by this Amendment, is referred to collectively herein as the </font><font style="color:#202123;font-family:'Times New Roman',sans-serif;font-size:12pt;font-weight:400;line-height:111%;text-decoration:underline">&#34;Lease.&#34;</font><font style="color:#202123;font-family:'Times New Roman',sans-serif;font-size:12pt;font-weight:400;line-height:111%"> From and after the date hereof, the term &#34;Lease,&#34; as used in the Existing Lease, shall mean the Existing Lease, as amended by this Amendment.</font></div><div style="margin-top:12pt;padding-left:29.5pt;padding-right:7.1pt;text-align:justify;text-indent:36.4pt"><font style="color:#1a1d1f;font-family:'Times New Roman',sans-serif;font-size:12pt;font-weight:400;line-height:110%">2.</font><font style="color:#1a1d1f;font-family:'Times New Roman',sans-serif;font-size:12pt;font-weight:400;line-height:110%;padding-left:33.1pt;text-decoration:underline">Fifth Amendment Extension Term.</font><font style="color:#1a1d1f;font-family:'Times New Roman',sans-serif;font-size:12pt;font-weight:400;line-height:110%"> The Term of the Lease is hereby extended for forty-two (42) months and, therefore, the Term Expiration Date is hereby amended to mean March 10, 2025. The period commencing on September 11, 2021 (the </font><font style="color:#1a1d1f;font-family:'Times New Roman',sans-serif;font-size:12pt;font-weight:400;line-height:110%;text-decoration:underline">&#34;Fifth Amendment Extension</font><font style="color:#1a1d1f;font-family:'Times New Roman',sans-serif;font-size:12pt;font-weight:400;line-height:110%"> </font><font style="color:#1a1d1f;font-family:'Times New Roman',sans-serif;font-size:12pt;font-weight:400;line-height:110%;text-decoration:underline">Term Commencement Date&#34;)</font><font style="color:#1a1d1f;font-family:'Times New Roman',sans-serif;font-size:12pt;font-weight:400;line-height:110%"> and ending on the Term Expiration Date shall be referred to herein as the </font><font style="color:#1a1d1f;font-family:'Times New Roman',sans-serif;font-size:12pt;font-weight:400;line-height:110%;text-decoration:underline">&#34;Fifth Amendment Extension Term.&#34;</font></div><div style="margin-top:12.5pt;padding-left:29.95pt;padding-right:7.25pt;text-align:justify;text-indent:35.6pt"><font style="color:#1b1d1e;font-family:'Times New Roman',sans-serif;font-size:12pt;font-weight:400;line-height:109%">3.</font><font style="color:#1b1d1e;font-family:'Times New Roman',sans-serif;font-size:12pt;font-weight:400;line-height:109%;padding-left:33.45pt;text-decoration:underline">Base Rent.</font><font style="color:#1b1d1e;font-family:'Times New Roman',sans-serif;font-size:12pt;font-weight:400;line-height:109%"> Commencing as of the Fifth Amendment Extension Term </font><font style="color:#181b1d;font-family:'Times New Roman',sans-serif;font-size:12pt;font-weight:400;line-height:109%">Commencement Date, monthly Base Rent shall equal Three and 75&#47;100 Dollars ($3.75) per square foot of Rentable Area of the Premises. Thereafter, Base Rent shall be subject to an annual upward adjustment of three point five percent (3.5%) of the then-current Base Rent. The first such adjustment shall become effective on the first (1</font><font style="color:#181b1d;font-family:'Times New Roman',sans-serif;font-size:8pt;font-weight:400;line-height:109%">st</font><font style="color:#181b1d;font-family:'Times New Roman',sans-serif;font-size:9pt;font-weight:400;line-height:109%">) </font><font style="color:#181b1d;font-family:'Times New Roman',sans-serif;font-size:12pt;font-weight:400;line-height:109%">annual anniversary of the Fifth Amendment </font><font style="color:#171b1c;font-family:'Times New Roman',sans-serif;font-size:12pt;font-weight:400;line-height:109%">Extension Term Commencement Date, and subsequent adjustments shall become effective on every successive annual anniversary of the Fifth Amendment Extension Term Commencement Date for so long as the Lease continues in effect.</font></div><div style="padding-right:7.25pt;text-align:justify;text-indent:53.6pt"><font><br></font></div><div style="height:14pt;position:relative;width:100%"><div style="bottom:0;position:absolute;width:100%"><div><font><br></font></div></div></div><hr style="page-break-after:always"><div style="min-height:64pt;width:100%"><div style="text-align:right"><font><br></font></div><div style="text-align:right"><font><br></font></div></div><div style="padding-right:7.25pt;text-align:justify;text-indent:53.6pt"><font><br></font></div><div style="margin-top:0.11pt;padding-left:29.95pt;padding-right:7.25pt;text-align:justify;text-indent:35.6pt"><font style="color:#000000;font-family:'Times New Roman',sans-serif;font-size:11pt;font-weight:400;line-height:120%">4.</font><font style="color:#181c1d;font-family:'Times New Roman',sans-serif;font-size:12pt;font-weight:400;line-height:120%;padding-left:34.2pt;text-decoration:underline">Condition of Premises.</font><font style="color:#181c1d;font-family:'Times New Roman',sans-serif;font-size:12pt;font-weight:400;line-height:120%"> Tenant acknowledges that (a) it is in possession of and is </font><font style="color:#1c1f20;font-family:'Times New Roman',sans-serif;font-size:12pt;font-weight:400;line-height:120%">fully familiar with the condition of the Premises and, notwithstanding anything contained in the Lease to the contrary, agrees to take the same in its condition &#34;as is&#34; as of the first day of the Fifth Amendment Extension Term, and (b) Landlord shall have no obligation to alter, repair or otherwise prepare the Premises for Tenant's continued occupancy for the Fifth Amendment Extension Term or to pay for any improvements to the Premises. </font></div><div style="padding-right:7.25pt;text-align:justify;text-indent:53.6pt"><font><br></font></div><div style="margin-top:0.11pt;padding-left:29.95pt;padding-right:7.25pt;text-align:justify;text-indent:35.6pt"><font style="color:#000000;font-family:'Times New Roman',sans-serif;font-size:11pt;font-weight:400;line-height:120%">5.</font><font style="color:#1c1e20;font-family:'Times New Roman',sans-serif;font-size:12pt;font-weight:400;line-height:120%;padding-left:34.2pt;text-decoration:underline">Option to Extend.</font><font style="color:#1c1e20;font-family:'Times New Roman',sans-serif;font-size:12pt;font-weight:400;line-height:120%"> Landlord and Tenant acknowledge and agree that </font><font style="color:#1c1e20;font-family:'Times New Roman',sans-serif;font-size:12pt;font-weight:400;line-height:120%;text-decoration:underline">Article 42</font><font style="color:#1c1e20;font-family:'Times New Roman',sans-serif;font-size:12pt;font-weight:400;line-height:120%"> of </font><font style="color:#1f2122;font-family:'Times New Roman',sans-serif;font-size:12pt;font-weight:400;line-height:120%">the Original Lease (as amended by </font><font style="color:#1f2122;font-family:'Times New Roman',sans-serif;font-size:12pt;font-weight:400;line-height:120%;text-decoration:underline">Article 13</font><font style="color:#1f2122;font-family:'Times New Roman',sans-serif;font-size:12pt;font-weight:400;line-height:120%"> of the Third Amendment), shall continue to apply&#59; </font><font style="color:#1f2122;font-family:'Times New Roman',sans-serif;font-size:12pt;font-weight:400;line-height:120%;text-decoration:underline">provided,</font><font style="color:#1f2122;font-family:'Times New Roman',sans-serif;font-size:12pt;font-weight:400;line-height:120%"> however, that the first grammatical sentence of </font><font style="color:#1f2122;font-family:'Times New Roman',sans-serif;font-size:12pt;font-weight:400;line-height:120%;text-decoration:underline">Section 42.1</font><font style="color:#1f2122;font-family:'Times New Roman',sans-serif;font-size:12pt;font-weight:400;line-height:120%"> of the Original Lease (as amended by </font><font style="color:#1f2122;font-family:'Times New Roman',sans-serif;font-size:12pt;font-weight:400;line-height:120%;text-decoration:underline">Section 13.2</font><font style="color:#1f2122;font-family:'Times New Roman',sans-serif;font-size:12pt;font-weight:400;line-height:120%"> of the Third Amendment) is hereby deleted in its entirety and replaced with the following&#58;</font></div><div style="margin-top:12.35pt;padding-left:102.1pt;padding-right:78.75pt;text-align:justify;text-indent:0.25pt"><font style="color:#202325;font-family:'Times New Roman',sans-serif;font-size:12pt;font-weight:400;line-height:120%">&#34;Base Rent during the Option term shall equal the then-current fair market value for comparable office, research and development and laboratory space in the Fremont&#47;Newark market of comparable age, quality, level of finish and proximity to amenities and public transit, and containing the systems and improvements present in the Premises as of the date that Tenant gives Tenant's election to exercise the Option </font><font style="color:#202325;font-family:'Times New Roman',sans-serif;font-size:12pt;font-weight:400;line-height:120%;text-decoration:underline">(&#34;FMV&#34;).&#34;</font></div><div style="padding-right:7.25pt;text-align:justify;text-indent:53.6pt"><font><br></font></div><div style="margin-top:0.11pt;padding-left:29.95pt;padding-right:7.25pt;text-align:justify;text-indent:35.6pt"><font style="color:#000000;font-family:'Times New Roman',sans-serif;font-size:11pt;font-weight:400;line-height:120%">6.</font><font style="color:#202123;font-family:'Times New Roman',sans-serif;font-size:12pt;font-weight:400;line-height:120%;padding-left:34.2pt;text-decoration:underline">CASp.</font><font style="color:#202123;font-family:'Times New Roman',sans-serif;font-size:12pt;font-weight:400;line-height:120%"> The Premises have not undergone inspection by a Certified Access Specialist </font><font style="color:#202123;font-family:'Times New Roman',sans-serif;font-size:12pt;font-weight:400;line-height:120%;text-decoration:underline">(&#34;CASp.&#34;</font><font style="color:#202123;font-family:'Times New Roman',sans-serif;font-size:12pt;font-weight:400;line-height:120%"> as defined in California Civil Code Section 55.52). Even if not required by California law, the Premises may be inspected by a CASp to determine whether the Premises comply with the ADA, and Landlord may not prohibit a CASp performing such an inspection. If Tenant requests that such an inspection take place, Landlord and Tenant shall agree on the time and manner of the inspection, as well as which party will pay the cost of the inspection and the cost to remedy any defects identified by the CASp. A Certified Access Specialist can inspect the Premises and determine whether the Premises comply with all of the applicable construction related accessibility standards under State law. Although State law does not require a Certified Access Specialist inspection of the Premises, Landlord may not prohibit Tenant from obtaining a Certified Access Specialist inspection of the Premises for the occupancy or potential occupancy of Tenant, if requested by Tenant. Landlord and Tenant shall agree on the arrangements for the time and manner of the Certified Access Specialist inspection, the payment of the fee for the Certified Access Specialist inspection, and the cost of making any repairs necessary to correct violations of construction-related accessibility standards within the Premises.</font></div><div style="padding-right:7.25pt;text-align:justify;text-indent:53.6pt"><font><br></font></div><div style="margin-top:0.11pt;padding-left:29.95pt;padding-right:7.25pt;text-align:justify;text-indent:35.6pt"><font style="color:#000000;font-family:'Times New Roman',sans-serif;font-size:10pt;font-weight:400;line-height:120%">7.</font><font style="color:#171b1c;font-family:'Times New Roman',sans-serif;font-size:12pt;font-weight:400;line-height:120%;padding-left:34.95pt;text-decoration:underline">Broker.</font><font style="color:#171b1c;font-family:'Times New Roman',sans-serif;font-size:12pt;font-weight:400;line-height:120%"> Tenant represents and warrants that it has not dealt with any broker or agent </font><font style="color:#161a1b;font-family:'Times New Roman',sans-serif;font-size:12pt;font-weight:400;line-height:120%">in the negotiation for or the obtaining of this Amendment, other than Savills </font><font style="color:#161a1b;font-family:'Times New Roman',sans-serif;font-size:12pt;font-weight:400;line-height:120%;text-decoration:underline">(&#34;Broker&#34;),</font><font style="color:#161a1b;font-family:'Times New Roman',sans-serif;font-size:12pt;font-weight:400;line-height:120%"> and agrees to reimburse, indemnify, save, defend (at Landlord's option and with counsel reasonably acceptable to Landlord, at Tenant's sole cost and expense) and hold harmless Landlord for, from and against any and all cost or liability for compensation claimed by any such broker or agent, </font></div><div style="height:14pt;position:relative;width:100%"><div style="bottom:0;position:absolute;width:100%"><div><font><br></font></div></div></div><hr style="page-break-after:always"><div style="min-height:64pt;width:100%"><div style="text-align:right"><font><br></font></div><div style="text-align:right"><font><br></font></div></div><div style="margin-top:0.11pt;padding-left:29.95pt;padding-right:7.25pt;text-align:justify;text-indent:-0.4pt"><font style="color:#16181a;font-family:'Times New Roman',sans-serif;font-size:12pt;font-weight:400;line-height:120%">other than Broker, employed or engaged by it or claiming to have been employed or engaged by it. Broker is entitled to a leasing commission in connection with the making of this Amendment, and Landlord shall pay such commission to Broker pursuant to a separate agreement between Landlord and Broker. </font></div><div style="padding-right:7.25pt;text-align:justify;text-indent:53.6pt"><font><br></font></div><div style="margin-top:0.11pt;padding-left:29.95pt;padding-right:7.25pt;text-align:justify;text-indent:35.6pt"><font style="color:#000000;font-family:'Times New Roman',sans-serif;font-size:11pt;font-weight:400;line-height:120%">8.</font><font style="color:#1a1c1e;font-family:'Times New Roman',sans-serif;font-size:12pt;font-weight:400;line-height:120%;padding-left:34.2pt;text-decoration:underline">No Default.</font><font style="color:#1a1c1e;font-family:'Times New Roman',sans-serif;font-size:12pt;font-weight:400;line-height:120%"> Tenant represents, warrants and covenants that, to the best of Tenant's </font><font style="color:#181b1d;font-family:'Times New Roman',sans-serif;font-size:12pt;font-weight:400;line-height:120%">knowledge, Landlord and Tenant are not in default of any of their respective obligations under the Existing Lease and no event has occurred that, with the passage of time or the giving of notice (or both) would constitute a default by either Landlord or Tenant thereunder. </font></div><div style="padding-right:7.25pt;text-align:justify;text-indent:53.6pt"><font><br></font></div><div style="margin-top:0.11pt;padding-left:29.95pt;padding-right:7.25pt;text-align:justify;text-indent:35.6pt"><font style="color:#000000;font-family:'Times New Roman',sans-serif;font-size:11pt;font-weight:400;line-height:120%">9.</font><font style="color:#202223;font-family:'Times New Roman',sans-serif;font-size:12pt;font-weight:400;line-height:120%;padding-left:34.2pt;text-decoration:underline">Notices.</font><font style="color:#202223;font-family:'Times New Roman',sans-serif;font-size:12pt;font-weight:400;line-height:120%"> Tenant confirms that, notwithstanding anything in the Lease to the </font><font style="color:#212425;font-family:'Times New Roman',sans-serif;font-size:12pt;font-weight:400;line-height:120%">contrary, notices delivered to Tenant pursuant to the Lease should be sent to&#58;</font></div><div style="margin-top:12.05pt;padding-left:141.4pt"><font style="color:#2a2c2d;font-family:'Times New Roman',sans-serif;font-size:12pt;font-weight:400;line-height:120%">Ardelyx, Inc.</font></div><div style="margin-top:0.2pt;padding-left:141.15pt"><font style="color:#232729;font-family:'Times New Roman',sans-serif;font-size:12pt;font-weight:400;line-height:120%">34175 Ardenwood Blvd.</font></div><div style="margin-top:0.15pt;padding-left:141.4pt;padding-right:238.05pt"><font style="color:#232729;font-family:'Times New Roman',sans-serif;font-size:12pt;font-weight:400;line-height:120%">Fremont, California 94555 Attn&#58; Director of Facilities</font></div><div style="padding-right:238.05pt"><font><br></font></div><div style="margin-top:1.55pt;padding-left:141pt;padding-right:303.8pt;text-indent:-17.6pt"><font style="color:#1f2021;font-family:'Times New Roman',sans-serif;font-size:12pt;font-weight:400;line-height:217%">with a copy to&#58; </font></div><div style="margin-top:0.15pt;padding-left:141.4pt"><font style="color:#2c2f30;font-family:'Times New Roman',sans-serif;font-size:12pt;font-weight:400;line-height:115%">Ardelyx, Inc.</font></div><div style="padding-left:74.95pt;text-indent:36pt"><font style="color:#2c2f30;font-family:'Times New Roman',sans-serif;font-size:12pt;font-weight:400;line-height:120%">          34175 Ardenwood Blvd.</font></div><div style="padding-left:141.2pt;padding-right:237.45pt;text-indent:0.4pt"><font style="color:#2c2f30;font-family:'Times New Roman',sans-serif;font-size:12pt;font-weight:400;line-height:120%">Fremont, California 94555 Attn&#58; General Counsel</font></div><div style="padding-right:237.45pt"><font><br></font></div><div style="margin-top:0.11pt;padding-left:29.95pt;padding-right:7.25pt;text-align:justify;text-indent:35.6pt"><font style="color:#000000;font-family:'Times New Roman',sans-serif;font-size:11pt;font-weight:400;line-height:120%">10.</font><font style="color:#25282a;font-family:'Times New Roman',sans-serif;font-size:12pt;font-weight:400;line-height:120%;padding-left:28.7pt;text-decoration:underline">Effect of Amendment.</font><font style="color:#25282a;font-family:'Times New Roman',sans-serif;font-size:12pt;font-weight:400;line-height:120%"> Except as modified by this Amendment, the Existing Lease </font><font style="color:#222427;font-family:'Times New Roman',sans-serif;font-size:12pt;font-weight:400;line-height:120%">and all the covenants, agreements, terms, provisions and conditions thereof shall remain in full force and effect and are hereby ratified and affirmed. In the event of any conflict between the terms contained in this Amendment and the Existing Lease, the terms herein contained shall supersede and control the obligations and liabilities of the parties. </font></div><div style="padding-right:7.25pt;text-align:justify;text-indent:53.6pt"><font><br></font></div><div style="margin-top:0.11pt;padding-left:29.95pt;padding-right:7.25pt;text-align:justify;text-indent:35.6pt"><font style="color:#000000;font-family:'Times New Roman',sans-serif;font-size:11pt;font-weight:400;line-height:120%">11.</font><font style="color:#1d2020;font-family:'Times New Roman',sans-serif;font-size:12pt;font-weight:400;line-height:120%;padding-left:28.7pt;text-decoration:underline">Successors and Assigns.</font><font style="color:#1d2020;font-family:'Times New Roman',sans-serif;font-size:12pt;font-weight:400;line-height:120%"> Each of the covenants, conditions and agreements </font><font style="color:#1c1f20;font-family:'Times New Roman',sans-serif;font-size:12pt;font-weight:400;line-height:120%">contained in this Amendment shall inure to the benefit of and shall apply to and be binding upon the parties hereto and their respective heirs, legatees, devisees, executors, administrators and permitted successors and assigns and sublessees. Nothing in this section shall in any way alter the provisions of the Lease restricting assignment or subletting.</font></div><div style="padding-right:7.25pt;text-align:justify;text-indent:53.6pt"><font><br></font></div><div style="margin-top:0.11pt;padding-left:29.95pt;padding-right:7.25pt;text-align:justify;text-indent:35.6pt"><font style="color:#000000;font-family:'Times New Roman',sans-serif;font-size:11pt;font-weight:400;line-height:120%">12.</font><font style="color:#1e2022;font-family:'Times New Roman',sans-serif;font-size:12pt;font-weight:400;line-height:120%;padding-left:28.7pt;text-decoration:underline">Miscellaneous.</font><font style="color:#1e2022;font-family:'Times New Roman',sans-serif;font-size:12pt;font-weight:400;line-height:120%"> This Amendment becomes effective only upon execution and </font><font style="color:#171b1c;font-family:'Times New Roman',sans-serif;font-size:12pt;font-weight:400;line-height:120%">delivery hereof by Landlord and Tenant. The captions of the paragraphs and subparagraphs in this Amendment are inserted and included solely for convenience and shall not be considered or given any effect in construing the provisions hereof. All exhibits hereto are incorporated herein by reference. Submission of this instrument for examination or signature by Tenant does not constitute a reservation of or option for a lease, and shall not be effective as a lease, lease amendment or otherwise until execution by and delivery to both Landlord and Tenant. </font></div><div style="padding-right:7.25pt;text-align:justify;text-indent:53.6pt"><font><br></font></div><div style="margin-top:0.11pt;padding-left:29.95pt;padding-right:7.25pt;text-align:justify;text-indent:35.6pt"><font style="color:#000000;font-family:'Times New Roman',sans-serif;font-size:11pt;font-weight:400;line-height:120%">13.</font><font style="color:#171b1b;font-family:'Times New Roman',sans-serif;font-size:12pt;font-weight:400;line-height:120%;padding-left:28.7pt;text-decoration:underline">Authority.</font><font style="color:#171b1b;font-family:'Times New Roman',sans-serif;font-size:12pt;font-weight:400;line-height:120%">&#160;&#160;&#160;&#160;Tenant guarantees, warrants and represents that the individual or </font><font style="color:#1e1f21;font-family:'Times New Roman',sans-serif;font-size:12pt;font-weight:400;line-height:120%">individuals signing this </font></div><div style="padding-right:7.25pt;text-align:justify"><font><br></font></div><div style="height:14pt;position:relative;width:100%"><div style="bottom:0;position:absolute;width:100%"><div><font><br></font></div></div></div><hr style="page-break-after:always"><div style="min-height:64pt;width:100%"><div style="text-align:right"><font><br></font></div><div style="text-align:right"><font><br></font></div></div><div style="margin-top:0.11pt;padding-left:29.95pt;padding-right:7.25pt;text-align:justify;text-indent:0.36pt"><font style="color:#181b1d;font-family:'Times New Roman',sans-serif;font-size:12pt;font-weight:400;line-height:120%">Amendment have the power, authority and legal capacity to sign this Amendment on behalf of and to bind all entities, corporations, partnerships, limited liability companies, joint venturers or other organizations and entities on whose behalf such individual or individuals have signed. </font></div><div style="padding-right:7.25pt;text-align:justify;text-indent:53.6pt"><font><br></font></div><div style="margin-top:0.11pt;padding-left:29.95pt;padding-right:7.25pt;text-align:justify;text-indent:35.6pt"><font style="color:#000000;font-family:'Times New Roman',sans-serif;font-size:11pt;font-weight:400;line-height:120%">14.</font><font style="color:#181b1d;font-family:'Times New Roman',sans-serif;font-size:12pt;font-weight:400;line-height:120%;padding-left:28.7pt;text-decoration:underline">Counterparts&#59; Facsimile and PDF Signatures.</font><font style="color:#181b1d;font-family:'Times New Roman',sans-serif;font-size:12pt;font-weight:400;line-height:120%"> This Amendment may be executed </font><font style="color:#1b1e20;font-family:'Times New Roman',sans-serif;font-size:12pt;font-weight:400;line-height:120%">in one or more counterparts, each of which, when taken together, shall constitute one and the same document. A facsimile or portable document format (PDF) signature on this Amendment shall be equivalent to, and have the same force and effect as, an original signature.</font></div><div style="margin-top:10.5pt;padding-left:12.17pt;padding-right:12.17pt;text-align:center"><font style="color:#222425;font-family:'Times New Roman',sans-serif;font-size:13pt;font-weight:400;line-height:120%">&#91;REMAINDER OF THIS PAGE INTENTIONALLY LEFT BLANK&#93;</font></div><div><font><br></font></div><div style="padding-right:7.25pt;text-align:justify;text-indent:53.6pt"><font><br></font></div><div style="height:14pt;position:relative;width:100%"><div style="bottom:0;position:absolute;width:100%"><div><font><br></font></div></div></div><hr style="page-break-after:always"><div style="min-height:64pt;width:100%"><div style="text-align:right"><font><br></font></div><div style="text-align:right"><font><br></font></div></div><div style="margin-top:5.35pt;padding-left:30.75pt;text-indent:35.65pt"><font style="color:#1b1e1f;font-family:'Times New Roman',sans-serif;font-size:12pt;font-weight:400;line-height:111%">IN WITNESS WHEREOF, Landlord and Tenant have executed this Amendment as of the date and year first above written.</font></div><div style="margin-top:14.15pt;padding-left:30.65pt"><font style="color:#202224;font-family:'Times New Roman',sans-serif;font-size:12pt;font-weight:700;line-height:120%;text-decoration:underline">LANDLORD&#58;</font></div><div style="margin-top:5.35pt;padding-left:30.75pt;text-align:justify;text-indent:0.36pt"><font style="color:#1b1e1f;font-family:'Times New Roman',sans-serif;font-size:12pt;font-weight:400;line-height:111%">34175 ARDENWOOD VENTURE' LLC'</font></div><div style="margin-top:5.35pt;padding-left:30.75pt;text-align:justify;text-indent:0.36pt"><font style="color:#1b1e1f;font-family:'Times New Roman',sans-serif;font-size:12pt;font-weight:400;line-height:111%">a Delaware limited liability company</font></div><div><font><br></font></div><div><font><br></font></div><div style="padding-left:31.5pt"><font style="color:#000000;font-family:'Times New Roman',sans-serif;font-size:11pt;font-weight:400;line-height:120%">By&#58;       &#47;s&#47; Kevin Simonson</font></div><div style="padding-left:31.5pt"><font style="color:#000000;font-family:'Times New Roman',sans-serif;font-size:11pt;font-weight:400;line-height:120%">Name&#58;  Kevin Simonson</font></div><div style="padding-left:31.5pt"><font style="color:#000000;font-family:'Times New Roman',sans-serif;font-size:11pt;font-weight:400;line-height:120%">Title&#58;    EVP, General Counsel &#38; Secretary</font></div><div><font><br></font></div><div style="margin-top:13.6pt;padding-left:31.2pt"><font><br></font></div><div style="margin-top:14.15pt;padding-left:30.65pt"><font style="color:#202224;font-family:'Times New Roman',sans-serif;font-size:12pt;font-weight:700;line-height:120%;text-decoration:underline">TENANT</font><font style="color:#2c2f34;font-family:'Times New Roman',sans-serif;font-size:12pt;font-weight:700;line-height:120%;text-decoration:underline">&#58;</font></div><div style="margin-top:5.35pt;padding-left:30.75pt;text-align:justify;text-indent:0.36pt"><font style="color:#1b1e1f;font-family:'Times New Roman',sans-serif;font-size:12pt;font-weight:400;line-height:111%">ARDELYX, INC.,</font></div><div style="margin-top:5.35pt;padding-left:30.75pt;text-align:justify;text-indent:0.36pt"><font style="color:#1b1e1f;font-family:'Times New Roman',sans-serif;font-size:12pt;font-weight:400;line-height:111%">a Delaware corporation</font></div><div style="margin-top:0.25pt"><font><br></font></div><div><font><br></font></div><div style="padding-left:31.5pt"><font style="color:#000000;font-family:'Times New Roman',sans-serif;font-size:11pt;font-weight:400;line-height:120%">By&#58;       &#47;s&#47; Justin Renz</font></div><div style="padding-left:31.5pt"><font style="color:#000000;font-family:'Times New Roman',sans-serif;font-size:11pt;font-weight:400;line-height:120%">Name&#58;  Justin Renz</font></div><div style="padding-left:31.5pt"><font style="color:#000000;font-family:'Times New Roman',sans-serif;font-size:11pt;font-weight:400;line-height:120%">Title&#58;    CFO</font></div><div style="height:14pt;position:relative;width:100%"><div style="bottom:0;position:absolute;width:100%"><div><font><br></font></div></div></div></body></html>
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end
</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
