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Income Taxes (Tables) | 12 Months Ended
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Dec. 31, 2021
Income Tax Disclosure [Abstract] |
Schedule of Components of Provision for Income Taxes | The components of our provision for income taxes for the year ended December 31, 2021, 2020 and 2019, are as follows (in thousands):
| Year Ended December 31,
| 2021 |  | 2020 |  | 2019
Current: |  |  |  |  |
State | $ | 4 |  |  | $ | 2 |  |  | $ | 2 |
Foreign | — |  |  | — |  |  | 301 |
Total current | 4 |  |  | 2 |  |  | 303 |
Deferred: |  |  |  |  |
Federal | — |  |  | — |  |  | — |
Total deferred | — |  |  | — |  |  | — |
Provision for income taxes | $ | 4 |  |  | $ | 2 |  |  | $ | 303 |
Schedule of Reconciliation of Effective Tax Rate | The following is a reconciliation of the statutory federal income tax rate to our effective tax rate:
| Year Ended December 31,
| 2021 |  | 2020 |  | 2019
Change in valuation allowance | (20.0) | % |  | (22.3) | % |  | (21.9) | %
Income tax at the federal statutory rate | 21.0 |  |  | 21.0 |  |  | 21.0 |
Tax credits | 1.0 |  |  | 1.3 |  |  | 1.6 |
State taxes, net of federal benefit | 0.4 |  |  | 0.7 |  |  | 0.3 |
Stock based compensation | (1.3) |  |  | (0.1) |  |  | (0.4) |
Executive compensation disallowed under IRC Sec 162(m) | (1.1) |  |  | (0.5) |  |  | (0.5) |
Other | — |  |  | (0.1) |  |  | (0.4) |
Income tax provision | — | % |  | — | % |  | (0.3) | %
Schedule of Components of Deferred Tax Assets | Significant components of our deferred tax assets are as follows as of December 31, 2021 and 2020 (in thousands):
| December 31,
| 2021 |  | 2020
Deferred tax assets: |  |  |
Amortization and depreciation | $ | 61,098 |  |  | $ | 51,370 |
Net operating loss carryforwards | 74,989 |  |  | 53,436 |
Tax credits | 13,827 |  |  | 11,777 |
Stock-based compensation | 4,054 |  |  | 5,524 |
Other | 3,867 |  |  | 1,804 |
Gross deferred tax assets | 157,835 |  |  | 123,911 |
Valuation allowance | (155,141) |  |  | (123,402) |
Deferred tax assets net of valuation allowance | 2,694 |  |  | 509 |
Deferred tax liabilities: |  |  |
Right-of-use asset | (2,689) |  |  | (479) |
Other | (5) |  |  | (30) |
Net deferred tax assets | $ | — |  |  | $ | — |
Schedule of Reconciliation of Unrecognized Tax Benefits | A reconciliation of the beginning and ending amount of unrecognized tax benefits is as follows (in thousands):
| December 31,
| 2021 |  | 2020 |  | 2019
Balance at beginning of year | $ | 23,624 |  |  | $ | 24,538 |  |  | $ | 23,052 |
Additions (subtractions) based on tax positions related to prior year | (811) |  |  | (1,388) |  |  | 755 |
Additions based on tax positions related to current year | 1,613 |  |  | 474 |  |  | 731 |
Balance at end of year | $ | 24,426 |  |  | $ | 23,624 |  |  | $ | 24,538 |

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