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Subsequent Events (Details) - USD ($) $ in Thousands | Feb. 23, 2022 | May 16, 2018 | Dec. 31, 2021 | Oct. 09, 2020
--- | --- | --- | --- | ---
Subsequent Event [Line Items] |  |  |  |
Principal outstanding |  |  | $ 33,031 |
2018 Term Loan | Term loan |  |  |  |
Subsequent Event [Line Items] |  |  |  |
Proceeds from loan payable, net of issuance costs |  | $ 49,300 |  |
Final fee due upon maturity, acceleration, prepayment, or termination (percent) |  | 3.95% |  | 4.95%
Additional default interest rate |  | 4.00% |  |
2018 Term Loan | Term loan | Prior to first anniversary of closing date |  |  |  |
Subsequent Event [Line Items] |  |  |  |
Prepayment premium (as a percent) |  | 3.00% |  |
2018 Term Loan | Term loan | After first anniversary through second anniversary of closing date |  |  |  |
Subsequent Event [Line Items] |  |  |  |
Prepayment premium (as a percent) |  | 2.00% |  |
2018 Term Loan | Term loan | After second anniversary to maturity date |  |  |  |
Subsequent Event [Line Items] |  |  |  |
Prepayment premium (as a percent) |  | 1.00% |  |
2018 Term Loan | Term loan | LIBOR |  |  |  |
Subsequent Event [Line Items] |  |  |  |
Floating per annum rate (percent) |  | 7.45% |  |
Subsequent event | 2022 Term Loan | Term loan |  |  |  |
Subsequent Event [Line Items] |  |  |  |
Final fee due upon maturity, acceleration, prepayment, or termination (percent) | 4.95% |  |  |
Loan agreement covenant, cash and cash equivalents as percentage of outstanding loan balance, minimum | 80.00% |  |  |
Loan agreement covenant, net product revenue as percentage of outstanding loan balance, minimum | 60.00% |  |  |
Additional default interest rate | 4.00% |  |  |
Subsequent event | 2022 Term Loan | Term loan | Prior to first anniversary of closing date |  |  |  |
Subsequent Event [Line Items] |  |  |  |
Prepayment premium (as a percent) | 3.00% |  |  |
Subsequent event | 2022 Term Loan | Term loan | After first anniversary through second anniversary of closing date |  |  |  |
Subsequent Event [Line Items] |  |  |  |
Prepayment premium (as a percent) | 2.00% |  |  |
Subsequent event | 2022 Term Loan | Term loan | After second anniversary to maturity date |  |  |  |
Subsequent Event [Line Items] |  |  |  |
Prepayment premium (as a percent) | 1.00% |  |  |
Subsequent event | 2022 Term Loan | Term loan | LIBOR |  |  |  |
Subsequent Event [Line Items] |  |  |  |
Floating per annum rate (percent) | 7.95% |  |  |
Addition to floating per annum rate (percent) | 0.10% |  |  |
Subsequent event | Term Loan A | Term loan |  |  |  |
Subsequent Event [Line Items] |  |  |  |
Proceeds from loan payable, net of issuance costs | $ 27,500 |  |  |
Closing fee | 200 |  |  |
Subsequent event | Term Loan B | Term loan |  |  |  |
Subsequent Event [Line Items] |  |  |  |
Remaining funding based on milestone achievement | 22,500 |  |  |
Future obligation upon loan funding or other events | 100 |  |  |
Subsequent event | 2018 Term Loan | Term loan |  |  |  |
Subsequent Event [Line Items] |  |  |  |
Principal outstanding | $ 25,000 |  |  |
Subsequent event | 2022 Exit Fee | Term loan |  |  |  |
Subsequent Event [Line Items] |  |  |  |
Exit fee (percent) | 2.00% |  |  |
Exit fee, net product revenue threshold | $ 100,000 |  |  |
Exit fee, term (in years) | 10 years |  |  |

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