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STATEMENTS OF CASH FLOWS - USD ($) $ in Thousands | 12 Months Ended
--- | ---
Dec. 31, 2021 | Dec. 31, 2020 | Dec. 31, 2019
Operating activities |  |  |
Net loss | $ (158,165) | $ (94,313) | $ (94,940)
Adjustments to reconcile net loss to net cash used in operating activities: |  |  |
Depreciation expense | 1,441 | 1,824 | 2,501
Amortization of deferred financing costs | 638 | 496 | 670
Amortization of deferred compensation for services | 240 | 313 | 309
Amortization of (discount) premium on investment securities | 488 | (92) | (698)
Non-cash lease expense | 3,085 | 2,147 | 1,839
Stock-based compensation | 12,039 | 10,583 | 9,936
Change in derivative liabilities | (678) | 407 | 436
Non-cash interest associated with debt discount accretion | 283 | 413 | 478
Changes in operating assets and liabilities: |  |  |
Unbilled revenue | 0 | 750 | 4,250
Accounts receivable | (502) | 0 | 85
Prepaid expenses and other assets | (8,904) | (4,653) | 93
Accounts payable | (1,349) | 3,439 | 39
Accrued compensation and benefits | (250) | 1,219 | 1,730
Operating Lease liabilities | (2,853) | (2,604) | (1,892)
Accrued and other liabilities | 1,386 | (1,000) | (5,861)
Deferred revenue | 550 | (364) | 4,541
Net cash used in operating activities | (152,551) | (81,435) | (76,484)
Investing activities |  |  |
Proceeds from maturities and redemptions of investments | 125,550 | 119,734 | 126,369
Purchases of investments | (72,735) | (150,852) | (102,671)
Purchases of property and equipment | (1,867) | (324) | (325)
Net cash provided by (used in) investing activities | 50,948 | (31,442) | 23,373
Financing activities |  |  |
Proceeds from underwritten public offering, net of issuance costs | 0 | 0 | 134,927
Proceeds from issuance of common stock upon private placement, net of issuance costs | 0 | 0 | 19,975
Proceeds from issuance of common stock in At-the-market offering, net of issuance costs | 101,146 | 21,047 | 0
Proceeds from issuance of common stock under equity incentive and stock purchase plans | 1,403 | 1,854 | 574
Principal repayments for loan payable | (19,444) | 0 | 0
Payments for loan payable, net of issuance costs | 0 | (125) | 0
Payments for taxes related to net share settlement of equity awards | (106) | 0 | 0
Net cash provided by financing activities | 82,999 | 22,776 | 155,476
Net (decrease) increase in cash and cash equivalents | (18,604) | (90,101) | 102,365
Cash and cash equivalents at beginning of period | 91,032 | 181,133 | 78,768
Cash and cash equivalents at end of period | 72,428 | 91,032 | 181,133
Supplementary disclosure of cash flow information: |  |  |
Cash paid for interest | 3,469 | 4,200 | 4,920
Cash paid for income taxes | 4 | 1 | 2
Supplementary disclosure of non-cash activities: |  |  |
Right-of-use assets obtained in exchange for lease obligations | 1,604 | 450 | 5,810
Issuance of common stock for services | $ 190 | $ 310 | $ 312

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