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Summary of Significant Accounting Policies - Narrative (Details) - USD ($)	12 Months Ended
	Dec. 31, 2021	Dec. 31, 2020	Dec. 31, 2019	Feb. 28, 2019	Jan. 01, 2018
Summary of significant accounting policies
Impairment loss of long-lived assets	$ 0	$ 0	$ 0
Accumulated deficit	$ (712,930,000)	$ (554,765,000)
Minimum
Summary of significant accounting policies
Estimated useful lives	3 years
Maximum
Summary of significant accounting policies
Estimated useful lives	5 years
Kyowa Kirin Co. Ltd | 2017 KKC Agreement
Summary of significant accounting policies
Unbilled revenue				$ 0
ASU 2014-09 | Adjustments | 2017 KKC Agreement
Summary of significant accounting policies
Accumulated deficit					$ 4,000,000
ASU 2014-09 | Adjustments | Kyowa Kirin Co. Ltd | 2017 KKC Agreement
Summary of significant accounting policies
Unbilled revenue					5,000,000
ASU 2014-09 | Adjustments | AstraZeneca | 2017 KKC Agreement
Summary of significant accounting policies
Uncharged license fee					$ 1,000,000

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