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STATEMENTS OF STOCKHOLDERS' EQUITY - USD ($)
$ in Thousands
Total
Underwritten public offering
Private placement
Common Stock
Common Stock
Underwritten public offering
Common Stock
Private placement
Additional Paid-In Capital
Additional Paid-In Capital
Underwritten public offering
Additional Paid-In Capital
Private placement
Accumulated Deficit
Accumulated Other Comprehensive (Loss) Income
Balance at Dec. 31, 2018 $ 115,813     $ 6     $ 481,357     $ (365,512) $ (38)
Balance (in shares) at Dec. 31, 2018       62,516,627              
Issuance of common stock under employee stock purchase plan 396           396        
Issuance of common stock under employee stock purchase plan (in shares)       160,744              
Issuance of common stock for services 312           312        
Issuance of common stock for services (in shares)       113,136              
Issuance of common stock upon exercise of options 178           178        
Issuance of common stock upon exercise of options (in shares)       68,062              
Issuance of common stock upon vesting of restricted stock units (in shares)       85,609              
Stock-based compensation 9,936           9,936        
Unrealized (losses) gains on available-for-sale securities 58                   58
Issuance of common stock   $ 134,927 $ 19,975   $ 3     $ 134,924 $ 19,975    
Issuance of common stock (in shares)         23,000,000 2,873,563          
Net loss (94,940)                 (94,940)  
Balance at Dec. 31, 2019 186,655     $ 9     647,078     (460,452) 20
Balance (in shares) at Dec. 31, 2019       88,817,741              
Issuance of common stock under employee stock purchase plan 834           834        
Issuance of common stock under employee stock purchase plan (in shares)       169,931              
Issuance of common stock for services 310           310        
Issuance of common stock for services (in shares)       42,403              
Issuance of common stock upon exercise of options 1,020           1,020        
Issuance of common stock upon exercise of options (in shares)       445,942              
Issuance of common stock upon vesting of restricted stock units (in shares)       866,528              
Stock-based compensation 10,583           10,583        
Unrealized (losses) gains on available-for-sale securities (24)                   (24)
Issuance of common stock 21,047     $ 0     21,047        
Issuance of common stock (in shares)       3,257,430              
Net loss (94,313)                 (94,313)  
Balance at Dec. 31, 2020 126,112     $ 9     680,872     (554,765) (4)
Balance (in shares) at Dec. 31, 2020       93,599,975              
Issuance of common stock under employee stock purchase plan 819           819        
Issuance of common stock under employee stock purchase plan (in shares)       386,664              
Issuance of common stock for services 190           190        
Issuance of common stock for services (in shares)       25,989              
Issuance of common stock upon exercise of options $ 584           584        
Issuance of common stock upon exercise of options (in shares) 331,310     331,310              
Issuance of common stock upon vesting of restricted stock units (in shares)       167,158              
Taxes paid for net share settlement of equity awards $ (106)           (106)        
Stock-based compensation 12,039           12,039        
Unrealized (losses) gains on available-for-sale securities (2)                   (2)
Issuance of common stock 101,146     $ 4     101,142        
Issuance of common stock (in shares)       35,671,439              
Net loss (158,165)                 (158,165)  
Balance at Dec. 31, 2021 $ 82,617     $ 13     $ 795,540     $ (712,930) $ (6)
Balance (in shares) at Dec. 31, 2021       130,182,535