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STATEMENTS OF CASH FLOWS - USD ($)
$ in Thousands
 12 Months Ended
Dec. 31, 2021
Dec. 31, 2020
Dec. 31, 2019
Operating activities      
Net loss $ (158,165) $ (94,313) $ (94,940)
Adjustments to reconcile net loss to net cash used in operating activities:      
Depreciation expense 1,441 1,824 2,501
Amortization of deferred financing costs 638 496 670
Amortization of deferred compensation for services 240 313 309
Amortization of (discount) premium on investment securities 488 (92) (698)
Non-cash lease expense 3,085 2,147 1,839
Stock-based compensation 12,039 10,583 9,936
Change in derivative liabilities (678) 407 436
Non-cash interest associated with debt discount accretion 283 413 478
Changes in operating assets and liabilities:      
Unbilled revenue 0 750 4,250
Accounts receivable (502) 0 85
Prepaid expenses and other assets (8,904) (4,653) 93
Accounts payable (1,349) 3,439 39
Accrued compensation and benefits (250) 1,219 1,730
Operating Lease liabilities (2,853) (2,604) (1,892)
Accrued and other liabilities 1,386 (1,000) (5,861)
Deferred revenue 550 (364) 4,541
Net cash used in operating activities (152,551) (81,435) (76,484)
Investing activities      
Proceeds from maturities and redemptions of investments 125,550 119,734 126,369
Purchases of investments (72,735) (150,852) (102,671)
Purchases of property and equipment (1,867) (324) (325)
Net cash provided by (used in) investing activities 50,948 (31,442) 23,373
Financing activities      
Proceeds from underwritten public offering, net of issuance costs 0 0 134,927
Proceeds from issuance of common stock upon private placement, net of issuance costs 0 0 19,975
Proceeds from issuance of common stock in At-the-market offering, net of issuance costs 101,146 21,047 0
Proceeds from issuance of common stock under equity incentive and stock purchase plans 1,403 1,854 574
Principal repayments for loan payable (19,444) 0 0
Payments for loan payable, net of issuance costs 0 (125) 0
Payments for taxes related to net share settlement of equity awards (106) 0 0
Net cash provided by financing activities 82,999 22,776 155,476
Net (decrease) increase in cash and cash equivalents (18,604) (90,101) 102,365
Cash and cash equivalents at beginning of period 91,032 181,133 78,768
Cash and cash equivalents at end of period 72,428 91,032 181,133
Supplementary disclosure of cash flow information:      
Cash paid for interest 3,469 4,200 4,920
Cash paid for income taxes 4 1 2
Supplementary disclosure of non-cash activities:      
Right-of-use assets obtained in exchange for lease obligations 1,604 450 5,810
Issuance of common stock for services $ 190 $ 310 $ 312