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Subsequent Events (Details) - USD ($) $ in Thousands	Feb. 23, 2022	May 16, 2018	Dec. 31, 2021	Oct. 09, 2020
Subsequent Event [Line Items]
Principal outstanding			$ 33,031
2018 Term Loan | Term loan
Subsequent Event [Line Items]
Proceeds from loan payable, net of issuance costs		$ 49,300
Final fee due upon maturity, acceleration, prepayment, or termination (percent)		3.95%		4.95%
Additional default interest rate		4.00%
2018 Term Loan | Term loan | Prior to first anniversary of closing date
Subsequent Event [Line Items]
Prepayment premium (as a percent)		3.00%
2018 Term Loan | Term loan | After first anniversary through second anniversary of closing date
Subsequent Event [Line Items]
Prepayment premium (as a percent)		2.00%
2018 Term Loan | Term loan | After second anniversary to maturity date
Subsequent Event [Line Items]
Prepayment premium (as a percent)		1.00%
2018 Term Loan | Term loan | LIBOR
Subsequent Event [Line Items]
Floating per annum rate (percent)		7.45%
Subsequent event | 2022 Term Loan | Term loan
Subsequent Event [Line Items]
Final fee due upon maturity, acceleration, prepayment, or termination (percent)	4.95%
Loan agreement covenant, cash and cash equivalents as percentage of outstanding loan balance, minimum	80.00%
Loan agreement covenant, net product revenue as percentage of outstanding loan balance, minimum	60.00%
Additional default interest rate	4.00%
Subsequent event | 2022 Term Loan | Term loan | Prior to first anniversary of closing date
Subsequent Event [Line Items]
Prepayment premium (as a percent)	3.00%
Subsequent event | 2022 Term Loan | Term loan | After first anniversary through second anniversary of closing date
Subsequent Event [Line Items]
Prepayment premium (as a percent)	2.00%
Subsequent event | 2022 Term Loan | Term loan | After second anniversary to maturity date
Subsequent Event [Line Items]
Prepayment premium (as a percent)	1.00%
Subsequent event | 2022 Term Loan | Term loan | LIBOR
Subsequent Event [Line Items]
Floating per annum rate (percent)	7.95%
Addition to floating per annum rate (percent)	0.10%
Subsequent event | Term Loan A | Term loan
Subsequent Event [Line Items]
Proceeds from loan payable, net of issuance costs	$ 27,500
Closing fee	200
Subsequent event | Term Loan B | Term loan
Subsequent Event [Line Items]
Remaining funding based on milestone achievement	22,500
Future obligation upon loan funding or other events	100
Subsequent event | 2018 Term Loan | Term loan
Subsequent Event [Line Items]
Principal outstanding	$ 25,000
Subsequent event | 2022 Exit Fee | Term loan
Subsequent Event [Line Items]
Exit fee (percent)	2.00%
Exit fee, net product revenue threshold	$ 100,000
Exit fee, term (in years)	10 years

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- Definition

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- Definition

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- Definition

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Amount, before unamortized (discount) premium and debt issuance costs, of long-term debt. Includes, but is not limited to, notes payable, bonds payable, commercial loans, mortgage loans, convertible debt, subordinated debt and other types of debt.

+ References

Reference 1: http://www.xbrl.org/2003/role/disclosureRef
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- Definition

The cash inflow from additional borrowings, net of cash paid to third parties in connection with debt origination.

+ References

Reference 1: http://www.xbrl.org/2003/role/disclosureRef
-Publisher FASB
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Detail information of subsequent event by type. User is expected to use existing line items from elsewhere in the taxonomy as the primary line items for this disclosure, which is further associated with dimension and member elements pertaining to a subsequent event.

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