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CONDENSED STATEMENTS OF CASH FLOWS - USD ($) $ in Thousands | 3 Months Ended
--- | ---
Mar. 31, 2022 | Mar. 31, 2021
Net Cash Provided by (Used in) Operating Activities [Abstract] |  |
Net loss | $ (28,071) | $ (33,155)
Adjustments to reconcile net loss to net cash used in operating activities: |  |
Depreciation expense | 232 | 422
Amortization of deferred financing costs | 169 | 157
Amortization of deferred compensation for services | 47 | 77
Amortization of (discount) premium on investment securities | 15 | 157
Non-cash lease expense | 842 | 607
Stock-based compensation | 3,722 | 3,087
Change in derivative liabilities | 15 | 36
Debt refinancing costs | 102 | 0
Gain on sale of equipment | (710) | 0
Non-cash interest associated with debt discount accretion | 109 | 70
Changes in operating assets and liabilities: |  |
Accounts receivable | (3,892) | (5,783)
Inventory | (3,487) | 0
Prepaid expenses and other assets | (307) | (13,662)
Accounts payable | 753 | (248)
Accrued compensation and benefits | 882 | (1,324)
Operating lease liabilities | (836) | (721)
Accrued and other liabilities | (1,041) | 7,517
Deferred revenue | 3,836 | (1,454)
Net cash used in operating activities | (27,620) | (44,217)
Investing activities |  |
Proceeds from maturities and redemptions of investments | 27,300 | 35,370
Purchases of investments | (25,763) | (32,107)
Proceeds from sale of equipment | 795 | 0
Purchases of property and equipment | 0 | (778)
Net cash provided by investing activities | 2,332 | 2,485
Financing activities |  |
Proceeds from 2022 Loan, net of issuance costs | 26,971 | 0
Repayment of 2018 Loan, net of settlement costs | (33,038) | 0
Proceeds from issuance of common stock in at the market offering, net of issuance costs | 5,921 | 34,272
Proceeds from issuance of common stock under equity incentive and stock purchase plans | 83 | 498
Net cash provided by (used in) financing activities | (63) | 34,770
Net decrease in cash and cash equivalents | (25,351) | (6,962)
Cash and cash equivalents at beginning of period | 72,428 | 91,032
Cash and cash equivalents at end of period | 47,077 | 84,070
Supplementary disclosure of cash flow information: |  |
Cash paid for interest | 741 | 963
Cash paid for income taxes | 1 | 0
Supplementary disclosure of non-cash activities: |  |
Right-of-use assets obtained in exchange for lease obligations | 0 | 450
Issuance of derivative in connection with issuance of loan payable | $ 375 | $ 0

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