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CONDENSED STATEMENTS OF CASH FLOWS - USD ($) $ in Thousands | 6 Months Ended
--- | ---
Jun. 30, 2022 | Jun. 30, 2021
Operating activities |  |
Net loss | $ (55,009) | $ (78,344)
Adjustments to reconcile net loss to net cash used in operating activities: |  |
Depreciation expense | 407 | 787
Amortization of deferred financing costs | 226 | 316
Amortization of deferred compensation for services | 105 | 145
Amortization of premium on investment securities | 16 | 274
Non-cash lease expense | 1,698 | 1,318
Stock-based compensation | 6,976 | 6,306
Change in derivative liabilities | 18 | (713)
Debt refinancing costs | 102 | 0
Gain on sale of equipment | (853) | 0
Non-cash interest associated with debt discount accretion | 151 | 141
Changes in operating assets and liabilities: |  |
Accounts receivable | (5,121) | 0
Inventory | (4,529) | 0
Prepaid commercial manufacturing | (12,197) | (8,481)
Prepaid expenses and other assets | 1,848 | 1,102
Accounts payable | 17 | (3,039)
Accrued compensation and benefits | 983 | 267
Operating lease liabilities | (1,692) | (1,361)
Accrued and other liabilities | 259 | 2,607
Deferred revenue | 7,694 | 182
Net cash used in operating activities | (58,901) | (78,493)
Investing activities |  |
Proceeds from maturities and redemptions of investments | 42,300 | 60,550
Purchases of investments | (25,762) | (48,314)
Proceeds from sale of property and equipment | 1,268 | 0
Purchases of property and equipment | 0 | (1,517)
Net cash provided by investing activities | 17,806 | 10,719
Financing activities |  |
Proceeds from 2022 Loan, net of issuance costs | 26,971 | 0
Repayment of 2018 Loan, net of settlement costs | (33,038) | 0
Proceeds from the sale of future royalties, net of issuance costs | 9,581 | 0
Proceeds from issuance of common stock in at the market offering, net of issuance costs | 18,478 | 62,446
Proceeds from issuance of common stock under equity incentive and stock purchase plans | 83 | 1,041
Net cash provided by financing activities | 22,075 | 63,487
Net decrease in cash and cash equivalents | (19,020) | (4,287)
Cash and cash equivalents at beginning of period | 72,428 | 91,032
Cash and cash equivalents at end of period | 53,408 | 86,745
Supplementary disclosure of cash flow information: |  |
Cash paid for interest | 1,360 | 1,936
Cash paid for income taxes | 6 | 3
Supplementary disclosure of non-cash activities: |  |
Right-of-use assets obtained in exchange for lease obligations | 0 | 14,379
Issuance of derivative in connection with issuance of loan payable | $ 375 | $ 0

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