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v3.22.2.2

CONDENSED STATEMENTS OF CASH FLOWS - USD ($) $ in Thousands | 3 Months Ended | 9 Months Ended | 12 Months Ended
--- | --- | --- | ---
Sep. 30, 2022 | Sep. 30, 2021 | Sep. 30, 2022 | Sep. 30, 2021 | Dec. 31, 2021
Operating activities |  |  |  |  |
Net loss | $ (22,893) | $ (43,587) | $ (77,902) | $ (121,931) |
Adjustments to reconcile net loss to net cash used in operating activities: |  |  |  |  |
Depreciation and amortization expense |  |  | 1,035 | 2,312 |
Non-cash lease expense |  |  | 2,570 | 2,257 |
Stock-based compensation |  |  | 8,824 | 8,568 |
Change in derivative liabilities |  |  | 54 | (696) |
Debt refinancing costs |  |  | 102 | 0 |
Gain on sale of equipment |  |  | (1,260) | 0 |
Non-cash interest expense |  |  | 1,055 | 212 |
Changes in operating assets and liabilities: |  |  |  |  |
Accounts receivable |  |  | (4,706) | (287) |
Inventory |  |  | (9,774) | 0 |
Prepaid commercial manufacturing |  |  | (10,549) | (4,954) |
Prepaid expenses and other assets |  |  | 754 | 1,027 |
Accounts payable |  |  | (1,164) | (1,363) |
Accrued compensation and benefits |  |  | 1,743 | (902) |
Operating lease liabilities |  |  | (2,571) | (2,033) |
Accrued and other liabilities |  |  | (375) | 5,411 |
Deferred revenue |  |  | 7,836 | (703) |
Net cash used in operating activities |  |  | (84,328) | (113,082) |
Investing activities |  |  |  |  |
Proceeds from maturities and redemptions of investments |  |  | 59,000 | 103,550 |
Purchases of investments |  |  | (43,824) | (72,736) |
Proceeds from sale of property and equipment |  |  | 1,798 | 0 |
Purchases of property and equipment |  |  | 0 | (1,962) |
Net cash provided by investing activities |  |  | 16,974 | 28,852 |
Financing activities |  |  |  |  |
Proceeds from 2022 Loan, net of issuance costs |  |  | 26,971 | 0 |
Repayment of 2018 Loan, net of settlement costs |  |  | (33,038) | 0 |
Proceeds from the sale of future royalties, net of issuance costs |  |  | 9,581 | 0 |
Proceeds from issuance of common stock in at the market offering, net of issuance costs |  |  | 52,845 | 67,189 |
Proceeds from issuance of common stock under equity incentive and stock purchase plans |  |  | 195 | 1,403 |
Payments for taxes related to net share settlement of equity awards |  |  | 0 | (106) |
Net cash provided by financing activities |  |  | 56,554 | 68,486 |
Net decrease in cash and cash equivalents |  |  | (10,800) | (15,744) |
Cash and cash equivalents at beginning of period |  |  | 72,428 | 91,032 | $ 91,032
Cash and cash equivalents at end of period | $ 61,628 | $ 75,288 | 61,628 | 75,288 | $ 72,428
Supplementary disclosure of cash flow information: |  |  |  |  |
Cash paid for interest |  |  | 2,079 | 2,920 |
Cash paid for income taxes |  |  | 6 | 4 |
Supplementary disclosure of non-cash activities: |  |  |  |  |
Right-of-use assets obtained in exchange for lease obligations |  |  | 0 | 14,379 |
Issuance of common stock for services |  |  | 390 | 190 |
Issuance of derivative in connection with issuance of loan payable |  |  | $ 375 | $ 0 |

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