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Restructuring
 9 Months Ended
Sep. 30, 2022
Restructuring and Related Activities [Abstract]  
Restructuring RESTRUCTURINGDuring 2021, we implemented restructuring plans in August 2021 and October 2021 following the receipt of a Complete Response Letter (“CRL”) from the U.S. FDA relating to our new drug application (“NDA”) for XPHOZAH® (tenapanor) and following the conclusion of an End of Review Type A meeting with the FDA, respectively. Both restructuring plans were substantially completed in December 2021 and most of the cash payments related to the reduction in workforce were disbursed prior to December 31, 2021.Impacted employees were eligible to receive severance benefits and additional Company funded COBRA premiums, contingent upon an impacted employee’s execution (and non-revocation) of a separation agreement, which included a general release of claims against us. In connection with restructuring, we incurred restructuring charges of $3.6 million during the three and nine months ended September 30, 2021 related to one-time termination notice and severance payments and other employee-related costs. We incurred no restructuring charges during the three and nine months ended September 30, 2022. We did not incur any significant contract termination costs pursuant to restructuring. Of the charges recognized as of September 30, 2021, $1.2 million was recorded in research and development expenses and $2.4 million was recorded in general and administrative expense in the accompanying statements of operations and comprehensive loss.