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Organization and Basis of Presentation (Details) $ in Thousands	1 Months Ended	9 Months Ended
	Jun. 30, 2015 USD ($)	Sep. 30, 2022 USD ($) segment	Dec. 31, 2021 USD ($)
Organization, Consolidation and Presentation of Financial Statements [Abstract]
Number of segments | segment		1
Cash and investments		$ 90,623	$ 116,689
Accumulated deficit		790,832	712,930
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Accounts receivable		5,208	502
AstraZeneca | AZ Termination Agreement
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Percentage of royalty revenue	10.00%
Percentage of non-royalty revenue	20.00%
Maximum potential payment per agreement	$ 75,000
Aggregate cost of revenue recognized		$ 12,400
Minimum
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Payment terms		30 days
Maximum
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Payment terms		60 days
Collaborators
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Accounts receivable		$ 500	$ 500
Commercial customers
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Accounts receivable		$ 4,700

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