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CONDENSED STATEMENTS OF CASH FLOWS - USD ($)
$ in Thousands
 3 Months Ended 9 Months Ended 12 Months Ended
Sep. 30, 2022
Sep. 30, 2021
Sep. 30, 2022
Sep. 30, 2021
Dec. 31, 2021
Operating activities          
Net loss $ (22,893) $ (43,587) $ (77,902) $ (121,931)  
Adjustments to reconcile net loss to net cash used in operating activities:          
Depreciation and amortization expense     1,035 2,312  
Non-cash lease expense     2,570 2,257  
Stock-based compensation     8,824 8,568  
Change in derivative liabilities     54 (696)  
Debt refinancing costs     102 0  
Gain on sale of equipment     (1,260) 0  
Non-cash interest expense     1,055 212  
Changes in operating assets and liabilities:          
Accounts receivable     (4,706) (287)  
Inventory     (9,774) 0  
Prepaid commercial manufacturing     (10,549) (4,954)  
Prepaid expenses and other assets     754 1,027  
Accounts payable     (1,164) (1,363)  
Accrued compensation and benefits     1,743 (902)  
Operating lease liabilities     (2,571) (2,033)  
Accrued and other liabilities     (375) 5,411  
Deferred revenue     7,836 (703)  
Net cash used in operating activities     (84,328) (113,082)  
Investing activities          
Proceeds from maturities and redemptions of investments     59,000 103,550  
Purchases of investments     (43,824) (72,736)  
Proceeds from sale of property and equipment     1,798 0  
Purchases of property and equipment     0 (1,962)  
Net cash provided by investing activities     16,974 28,852  
Financing activities          
Proceeds from 2022 Loan, net of issuance costs     26,971 0  
Repayment of 2018 Loan, net of settlement costs     (33,038) 0  
Proceeds from the sale of future royalties, net of issuance costs     9,581 0  
Proceeds from issuance of common stock in at the market offering, net of issuance costs     52,845 67,189  
Proceeds from issuance of common stock under equity incentive and stock purchase plans     195 1,403  
Payments for taxes related to net share settlement of equity awards     0 (106)  
Net cash provided by financing activities     56,554 68,486  
Net decrease in cash and cash equivalents     (10,800) (15,744)  
Cash and cash equivalents at beginning of period     72,428 91,032 $ 91,032
Cash and cash equivalents at end of period $ 61,628 $ 75,288 61,628 75,288 $ 72,428
Supplementary disclosure of cash flow information:          
Cash paid for interest     2,079 2,920  
Cash paid for income taxes     6 4  
Supplementary disclosure of non-cash activities:          
Right-of-use assets obtained in exchange for lease obligations     0 14,379  
Issuance of common stock for services     390 190  
Issuance of derivative in connection with issuance of loan payable     $ 375 $ 0