<SEC-DOCUMENT>0001628280-22-008924.txt : 20220411
<SEC-HEADER>0001628280-22-008924.hdr.sgml : 20220411
<ACCEPTANCE-DATETIME>20220411160618
ACCESSION NUMBER:		0001628280-22-008924
CONFORMED SUBMISSION TYPE:	8-K
PUBLIC DOCUMENT COUNT:		14
CONFORMED PERIOD OF REPORT:	20220411
ITEM INFORMATION:		Entry into a Material Definitive Agreement
ITEM INFORMATION:		Financial Statements and Exhibits
FILED AS OF DATE:		20220411
DATE AS OF CHANGE:		20220411

FILER:

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			ARDELYX, INC.
		CENTRAL INDEX KEY:			0001437402
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		IRS NUMBER:				000000000
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		8-K
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	001-36485
		FILM NUMBER:		22819742

	BUSINESS ADDRESS:	
		STREET 1:		34175 ARDENWOOD BLVD.
		CITY:			FREMONT
		STATE:			CA
		ZIP:			94555
		BUSINESS PHONE:		510-745-7047

	MAIL ADDRESS:	
		STREET 1:		34175 ARDENWOOD BLVD.
		CITY:			FREMONT
		STATE:			CA
		ZIP:			94555

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	NTERYX INC
		DATE OF NAME CHANGE:	20080611
</SEC-HEADER>
<DOCUMENT>
<TYPE>8-K
<SEQUENCE>1
<FILENAME>ardx-20220411.htm
<DESCRIPTION>8-K
<TEXT>
<XBRL>
<?xml version="1.0" ?><!--XBRL Document Created with Wdesk from Workiva--><!--Copyright 2022 Workiva--><!--r:ccbc2cf6-bdac-4e54-a5fb-ff8da01c5702,g:17174ae8-15b0-41fd-aa71-1c7a2f40728e,d:e432aad867704871848c26f9ca372077--><html xmlns:dei="http://xbrl.sec.gov/dei/2021" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:ixt="http://www.xbrl.org/inlineXBRL/transformation/2020-02-12" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:ix="http://www.xbrl.org/2013/inlineXBRL" xmlns="http://www.w3.org/1999/xhtml" xmlns:ixt-sec="http://www.sec.gov/inlineXBRL/transformation/2015-08-31" xmlns:xbrli="http://www.xbrl.org/2003/instance" xml:lang="en-US"><head><meta http-equiv="Content-Type" content="text/html"/>


<title>ardx-20220411</title></head><body><div style="display:none"><ix:header><ix:hidden><ix:nonNumeric contextRef="i99eb85ff74604dd8813b17eed2cb021d_D20220411-20220411" name="dei:EntityCentralIndexKey" id="id3VybDovL2RvY3MudjEvZG9jOmU0MzJhYWQ4Njc3MDQ4NzE4NDhjMjZmOWNhMzcyMDc3L3NlYzplNDMyYWFkODY3NzA0ODcxODQ4YzI2ZjljYTM3MjA3N180L2ZyYWc6MGYxOTk0MTIxMzcwNGZjZmJjYjk0Mjg4ZjRjMzVlN2MvdGFibGU6ZDc5ZmZhMjAzOWU1NDYwNjhiMjE4Y2Y4ZTZjYWM1OGEvdGFibGVyYW5nZTpkNzlmZmEyMDM5ZTU0NjA2OGIyMThjZjhlNmNhYzU4YV8yLTEtMS0xLTI3NzM5_f04dba25-02b7-4a6a-9c08-fcbcedf11aee">0001437402</ix:nonNumeric><ix:nonNumeric contextRef="i99eb85ff74604dd8813b17eed2cb021d_D20220411-20220411" name="dei:AmendmentFlag" id="id3VybDovL2RvY3MudjEvZG9jOmU0MzJhYWQ4Njc3MDQ4NzE4NDhjMjZmOWNhMzcyMDc3L3NlYzplNDMyYWFkODY3NzA0ODcxODQ4YzI2ZjljYTM3MjA3N180L2ZyYWc6MGYxOTk0MTIxMzcwNGZjZmJjYjk0Mjg4ZjRjMzVlN2MvdGFibGU6ZDc5ZmZhMjAzOWU1NDYwNjhiMjE4Y2Y4ZTZjYWM1OGEvdGFibGVyYW5nZTpkNzlmZmEyMDM5ZTU0NjA2OGIyMThjZjhlNmNhYzU4YV8zLTEtMS0xLTI3NzM5_1433a1bc-7e04-4644-90e3-3ce0656db101">false</ix:nonNumeric></ix:hidden><ix:references xml:lang="en-US"><link:schemaRef xlink:type="simple" xlink:href="ardx-20220411.xsd"></link:schemaRef></ix:references><ix:resources><xbrli:context id="i99eb85ff74604dd8813b17eed2cb021d_D20220411-20220411"><xbrli:entity><xbrli:identifier scheme="http://www.sec.gov/CIK">0001437402</xbrli:identifier></xbrli:entity><xbrli:period><xbrli:startDate>2022-04-11</xbrli:startDate><xbrli:endDate>2022-04-11</xbrli:endDate></xbrli:period></xbrli:context></ix:resources></ix:header></div><div id="ie432aad867704871848c26f9ca372077_1"></div><div style="min-height:45pt;width:100%"><div style="text-align:justify"><span><br/></span></div></div><div style="text-align:center"><span><br/></span></div><div style="text-align:center"><table style="border-collapse:collapse;display:inline-table;margin-bottom:5pt;vertical-align:text-bottom;width:100.000%"><tr><td style="width:1.0%"></td><td style="width:98.900%"></td><td style="width:0.1%"></td></tr><tr style="height:3pt"><td colspan="3" style="border-bottom:3pt double #000;padding:0 1pt"></td></tr></table></div><div style="margin-top:6pt;text-align:center"><table style="border-collapse:collapse;display:inline-table;margin-bottom:5pt;vertical-align:text-bottom;width:100.000%"><tr><td style="width:1.0%"></td><td style="width:98.900%"></td><td style="width:0.1%"></td></tr><tr style="height:3pt"><td colspan="3" style="border-bottom:1pt solid #000;padding:0 1pt"></td></tr></table></div><div style="margin-top:6pt;text-align:center"><span style="color:#000000;font-family:'Times New Roman',sans-serif;font-size:14pt;font-weight:700;line-height:120%">UNITED STATES</span></div><div style="text-align:center"><span style="color:#000000;font-family:'Times New Roman',sans-serif;font-size:14pt;font-weight:700;line-height:120%">SECURITIES AND EXCHANGE COMMISSION</span></div><div style="text-align:center"><span style="color:#000000;font-family:'Times New Roman',sans-serif;font-size:10pt;font-weight:700;line-height:120%">Washington, D.C. 20549</span></div><div style="margin-top:6pt;text-align:center"><table style="border-collapse:collapse;display:inline-table;margin-bottom:5pt;vertical-align:text-bottom;width:100.000%"><tr><td style="width:1.0%"></td><td style="width:98.900%"></td><td style="width:0.1%"></td></tr><tr style="height:3pt"><td colspan="3" style="border-bottom:1pt solid #000;padding:0 1pt"></td></tr></table></div><div style="margin-top:8pt;text-align:center"><span style="color:#000000;font-family:'Times New Roman',sans-serif;font-size:14pt;font-weight:700;line-height:120%">FORM&#160;<ix:nonNumeric contextRef="i99eb85ff74604dd8813b17eed2cb021d_D20220411-20220411" name="dei:DocumentType" id="id3VybDovL2RvY3MudjEvZG9jOmU0MzJhYWQ4Njc3MDQ4NzE4NDhjMjZmOWNhMzcyMDc3L3NlYzplNDMyYWFkODY3NzA0ODcxODQ4YzI2ZjljYTM3MjA3N18xL2ZyYWc6NmI4ZmNmNzQ4YTMxNGVlZDg1NzRjNGNkNjU2ZWQ3MzkvdGV4dHJlZ2lvbjo2YjhmY2Y3NDhhMzE0ZWVkODU3NGM0Y2Q2NTZlZDczOV8xMjU5_609cf7c5-d24a-4139-978c-c14d1489175a">8-K</ix:nonNumeric></span></div><div style="margin-top:6pt;text-align:center"><table style="border-collapse:collapse;display:inline-table;margin-bottom:5pt;vertical-align:text-bottom;width:100.000%"><tr><td style="width:1.0%"></td><td style="width:98.900%"></td><td style="width:0.1%"></td></tr><tr style="height:3pt"><td colspan="3" style="border-bottom:1pt solid #000;padding:0 1pt"></td></tr></table></div><div style="margin-top:8pt;text-align:center"><span style="color:#000000;font-family:'Times New Roman',sans-serif;font-size:10pt;font-weight:700;line-height:120%">CURRENT REPORT</span></div><div style="text-align:center"><span style="color:#000000;font-family:'Times New Roman',sans-serif;font-size:10pt;font-weight:700;line-height:120%">Pursuant to Section&#160;13 or 15(d)</span></div><div style="text-align:center"><span style="color:#000000;font-family:'Times New Roman',sans-serif;font-size:10pt;font-weight:700;line-height:120%">of the Securities Exchange Act of 1934</span></div><div style="margin-top:9pt;text-align:center"><span style="color:#000000;font-family:'Times New Roman',sans-serif;font-size:10pt;font-weight:700;line-height:120%">Date of Report (Date of earliest event reported):&#160;<ix:nonNumeric contextRef="i99eb85ff74604dd8813b17eed2cb021d_D20220411-20220411" name="dei:DocumentPeriodEndDate" format="ixt:date-monthname-day-year-en" id="id3VybDovL2RvY3MudjEvZG9jOmU0MzJhYWQ4Njc3MDQ4NzE4NDhjMjZmOWNhMzcyMDc3L3NlYzplNDMyYWFkODY3NzA0ODcxODQ4YzI2ZjljYTM3MjA3N18xL2ZyYWc6NmI4ZmNmNzQ4YTMxNGVlZDg1NzRjNGNkNjU2ZWQ3MzkvdGV4dHJlZ2lvbjo2YjhmY2Y3NDhhMzE0ZWVkODU3NGM0Y2Q2NTZlZDczOV8yMzE_8de56631-2530-4025-8727-1ecdc0939227">April 11, 2022</ix:nonNumeric></span></div><div style="margin-top:6pt;text-align:center"><table style="border-collapse:collapse;display:inline-table;margin-bottom:5pt;vertical-align:text-bottom;width:100.000%"><tr><td style="width:1.0%"></td><td style="width:98.900%"></td><td style="width:0.1%"></td></tr><tr style="height:3pt"><td colspan="3" style="border-bottom:1pt solid #000;padding:0 1pt"></td></tr></table></div><div style="margin-top:6pt;text-align:center"><img src="ardx-20220411_g1.jpg" alt="ardx-20220411_g1.jpg" style="height:75px;margin-bottom:5pt;vertical-align:text-bottom;width:75px"/></div><div style="text-align:center"><span style="color:#000000;font-family:'Times New Roman',sans-serif;font-size:16pt;font-weight:700;line-height:120%"><ix:nonNumeric contextRef="i99eb85ff74604dd8813b17eed2cb021d_D20220411-20220411" name="dei:EntityRegistrantName" id="id3VybDovL2RvY3MudjEvZG9jOmU0MzJhYWQ4Njc3MDQ4NzE4NDhjMjZmOWNhMzcyMDc3L3NlYzplNDMyYWFkODY3NzA0ODcxODQ4YzI2ZjljYTM3MjA3N18xL2ZyYWc6NmI4ZmNmNzQ4YTMxNGVlZDg1NzRjNGNkNjU2ZWQ3MzkvdGV4dHJlZ2lvbjo2YjhmY2Y3NDhhMzE0ZWVkODU3NGM0Y2Q2NTZlZDczOV8xMjYw_c62faaf1-99af-4d50-a5ad-560acb801150">ARDELYX, INC.</ix:nonNumeric></span></div><div style="text-align:center"><span style="color:#000000;font-family:'Times New Roman',sans-serif;font-size:9pt;font-weight:700;line-height:120%">(Exact name of registrant as specified in its charter)</span></div><div style="margin-top:6pt;text-align:center"><table style="border-collapse:collapse;display:inline-table;margin-bottom:5pt;vertical-align:text-bottom;width:100.000%"><tr><td style="width:1.0%"></td><td style="width:98.900%"></td><td style="width:0.1%"></td></tr><tr style="height:3pt"><td colspan="3" style="border-bottom:1pt solid #000;padding:0 1pt"></td></tr></table></div><div style="margin-top:7pt"><table style="border-collapse:collapse;display:inline-table;margin-bottom:5pt;vertical-align:text-bottom;width:100.000%"><tr><td style="width:1.0%"></td><td style="width:32.233%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:32.233%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:32.234%"></td><td style="width:0.1%"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:center;vertical-align:bottom"><span style="color:#000000;font-family:'Times New Roman',sans-serif;font-size:10pt;font-weight:700;line-height:100%"><ix:nonNumeric contextRef="i99eb85ff74604dd8813b17eed2cb021d_D20220411-20220411" name="dei:EntityIncorporationStateCountryCode" format="ixt-sec:stateprovnameen" id="id3VybDovL2RvY3MudjEvZG9jOmU0MzJhYWQ4Njc3MDQ4NzE4NDhjMjZmOWNhMzcyMDc3L3NlYzplNDMyYWFkODY3NzA0ODcxODQ4YzI2ZjljYTM3MjA3N18xL2ZyYWc6NmI4ZmNmNzQ4YTMxNGVlZDg1NzRjNGNkNjU2ZWQ3MzkvdGFibGU6Y2NlZTcyN2UyM2U0NDI2Zjg5YjI4NWVjMjNhZjA0OWMvdGFibGVyYW5nZTpjY2VlNzI3ZTIzZTQ0MjZmODliMjg1ZWMyM2FmMDQ5Y18wLTAtMS0xLTI3NzM5_1a2fb95e-4d48-40e4-94fb-c82cc9c4ab4e">Delaware</ix:nonNumeric></span></td><td colspan="3" style="padding:2px 1pt;text-align:center;vertical-align:top"><span style="color:#000000;font-family:'Times New Roman',sans-serif;font-size:10pt;font-weight:700;line-height:100%"><ix:nonNumeric contextRef="i99eb85ff74604dd8813b17eed2cb021d_D20220411-20220411" name="dei:EntityFileNumber" id="id3VybDovL2RvY3MudjEvZG9jOmU0MzJhYWQ4Njc3MDQ4NzE4NDhjMjZmOWNhMzcyMDc3L3NlYzplNDMyYWFkODY3NzA0ODcxODQ4YzI2ZjljYTM3MjA3N18xL2ZyYWc6NmI4ZmNmNzQ4YTMxNGVlZDg1NzRjNGNkNjU2ZWQ3MzkvdGFibGU6Y2NlZTcyN2UyM2U0NDI2Zjg5YjI4NWVjMjNhZjA0OWMvdGFibGVyYW5nZTpjY2VlNzI3ZTIzZTQ0MjZmODliMjg1ZWMyM2FmMDQ5Y18wLTEtMS0xLTI3NzM5_98f5a6ab-6551-4c82-9597-017731a1aa60">001-36485</ix:nonNumeric></span></td><td colspan="3" style="padding:2px 1pt;text-align:center;vertical-align:top"><span style="color:#000000;font-family:'Times New Roman',sans-serif;font-size:10pt;font-weight:700;line-height:100%"><ix:nonNumeric contextRef="i99eb85ff74604dd8813b17eed2cb021d_D20220411-20220411" name="dei:EntityTaxIdentificationNumber" id="id3VybDovL2RvY3MudjEvZG9jOmU0MzJhYWQ4Njc3MDQ4NzE4NDhjMjZmOWNhMzcyMDc3L3NlYzplNDMyYWFkODY3NzA0ODcxODQ4YzI2ZjljYTM3MjA3N18xL2ZyYWc6NmI4ZmNmNzQ4YTMxNGVlZDg1NzRjNGNkNjU2ZWQ3MzkvdGFibGU6Y2NlZTcyN2UyM2U0NDI2Zjg5YjI4NWVjMjNhZjA0OWMvdGFibGVyYW5nZTpjY2VlNzI3ZTIzZTQ0MjZmODliMjg1ZWMyM2FmMDQ5Y18wLTItMS0xLTI3NzM5_2bed332e-bbb4-44ee-b5bf-54f77172bc97">26-1303944</ix:nonNumeric></span></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:center;vertical-align:top"><span style="color:#000000;font-family:'Times New Roman',sans-serif;font-size:8pt;font-weight:700;line-height:100%">(State or other jurisdiction<br/>of incorporation)</span></td><td colspan="3" style="padding:2px 1pt;text-align:center;vertical-align:top"><span style="color:#000000;font-family:'Times New Roman',sans-serif;font-size:8pt;font-weight:700;line-height:100%">(Commission<br/>File Number)</span></td><td colspan="3" style="padding:2px 1pt;text-align:center;vertical-align:top"><span style="color:#000000;font-family:'Times New Roman',sans-serif;font-size:8pt;font-weight:700;line-height:100%">(IRS Employer<br/>Identification Number)</span></td></tr></table></div><div style="margin-top:6pt;text-align:center"><span style="color:#000000;font-family:'Times New Roman',sans-serif;font-size:10pt;font-weight:700;line-height:120%"><ix:nonNumeric contextRef="i99eb85ff74604dd8813b17eed2cb021d_D20220411-20220411" name="dei:EntityAddressAddressLine1" id="id3VybDovL2RvY3MudjEvZG9jOmU0MzJhYWQ4Njc3MDQ4NzE4NDhjMjZmOWNhMzcyMDc3L3NlYzplNDMyYWFkODY3NzA0ODcxODQ4YzI2ZjljYTM3MjA3N18xL2ZyYWc6NmI4ZmNmNzQ4YTMxNGVlZDg1NzRjNGNkNjU2ZWQ3MzkvdGV4dHJlZ2lvbjo2YjhmY2Y3NDhhMzE0ZWVkODU3NGM0Y2Q2NTZlZDczOV8xMjYy_c5a8904e-2aa6-4156-81ef-bcf705b8046a">400 FIFTH AVE.</ix:nonNumeric>,&#160;<ix:nonNumeric contextRef="i99eb85ff74604dd8813b17eed2cb021d_D20220411-20220411" name="dei:EntityAddressAddressLine2" id="id3VybDovL2RvY3MudjEvZG9jOmU0MzJhYWQ4Njc3MDQ4NzE4NDhjMjZmOWNhMzcyMDc3L3NlYzplNDMyYWFkODY3NzA0ODcxODQ4YzI2ZjljYTM3MjA3N18xL2ZyYWc6NmI4ZmNmNzQ4YTMxNGVlZDg1NzRjNGNkNjU2ZWQ3MzkvdGV4dHJlZ2lvbjo2YjhmY2Y3NDhhMzE0ZWVkODU3NGM0Y2Q2NTZlZDczOV8xMjU0_69d4a22b-3142-4f05-a0e9-7fd23bf28f6c">SUITE 210</ix:nonNumeric>,&#160;<ix:nonNumeric contextRef="i99eb85ff74604dd8813b17eed2cb021d_D20220411-20220411" name="dei:EntityAddressCityOrTown" id="id3VybDovL2RvY3MudjEvZG9jOmU0MzJhYWQ4Njc3MDQ4NzE4NDhjMjZmOWNhMzcyMDc3L3NlYzplNDMyYWFkODY3NzA0ODcxODQ4YzI2ZjljYTM3MjA3N18xL2ZyYWc6NmI4ZmNmNzQ4YTMxNGVlZDg1NzRjNGNkNjU2ZWQ3MzkvdGV4dHJlZ2lvbjo2YjhmY2Y3NDhhMzE0ZWVkODU3NGM0Y2Q2NTZlZDczOV8xMjYz_7daff03c-978d-467b-a7c3-94a39545c086">WALTHAM</ix:nonNumeric>,&#160;<ix:nonNumeric contextRef="i99eb85ff74604dd8813b17eed2cb021d_D20220411-20220411" name="dei:EntityAddressStateOrProvince" id="id3VybDovL2RvY3MudjEvZG9jOmU0MzJhYWQ4Njc3MDQ4NzE4NDhjMjZmOWNhMzcyMDc3L3NlYzplNDMyYWFkODY3NzA0ODcxODQ4YzI2ZjljYTM3MjA3N18xL2ZyYWc6NmI4ZmNmNzQ4YTMxNGVlZDg1NzRjNGNkNjU2ZWQ3MzkvdGV4dHJlZ2lvbjo2YjhmY2Y3NDhhMzE0ZWVkODU3NGM0Y2Q2NTZlZDczOV8xMjU2_3fbc340d-8192-4a40-94f5-23b18817c9dc">MA</ix:nonNumeric>SSACHUSETTS&#160;<ix:nonNumeric contextRef="i99eb85ff74604dd8813b17eed2cb021d_D20220411-20220411" name="dei:EntityAddressPostalZipCode" id="id3VybDovL2RvY3MudjEvZG9jOmU0MzJhYWQ4Njc3MDQ4NzE4NDhjMjZmOWNhMzcyMDc3L3NlYzplNDMyYWFkODY3NzA0ODcxODQ4YzI2ZjljYTM3MjA3N18xL2ZyYWc6NmI4ZmNmNzQ4YTMxNGVlZDg1NzRjNGNkNjU2ZWQ3MzkvdGV4dHJlZ2lvbjo2YjhmY2Y3NDhhMzE0ZWVkODU3NGM0Y2Q2NTZlZDczOV8xMjY0_9e2621a6-7a5f-4ccc-a3c4-a86497c7aee2">02451</ix:nonNumeric></span></div><div style="text-align:center"><span style="color:#000000;font-family:'Times New Roman',sans-serif;font-size:8pt;font-weight:700;line-height:120%">(Address of principal executive offices, including Zip Code)</span></div><div style="margin-top:8pt;text-align:center"><span style="color:#000000;font-family:'Times New Roman',sans-serif;font-size:10pt;font-weight:700;line-height:120%">Registrant&#8217;s telephone number, including area code: (<ix:nonNumeric contextRef="i99eb85ff74604dd8813b17eed2cb021d_D20220411-20220411" name="dei:CityAreaCode" id="id3VybDovL2RvY3MudjEvZG9jOmU0MzJhYWQ4Njc3MDQ4NzE4NDhjMjZmOWNhMzcyMDc3L3NlYzplNDMyYWFkODY3NzA0ODcxODQ4YzI2ZjljYTM3MjA3N18xL2ZyYWc6NmI4ZmNmNzQ4YTMxNGVlZDg1NzRjNGNkNjU2ZWQ3MzkvdGV4dHJlZ2lvbjo2YjhmY2Y3NDhhMzE0ZWVkODU3NGM0Y2Q2NTZlZDczOV8xMjY1_3770e60a-a9bf-4d94-9b32-0add723d80d9">510</ix:nonNumeric>)&#160;<ix:nonNumeric contextRef="i99eb85ff74604dd8813b17eed2cb021d_D20220411-20220411" name="dei:LocalPhoneNumber" id="id3VybDovL2RvY3MudjEvZG9jOmU0MzJhYWQ4Njc3MDQ4NzE4NDhjMjZmOWNhMzcyMDc3L3NlYzplNDMyYWFkODY3NzA0ODcxODQ4YzI2ZjljYTM3MjA3N18xL2ZyYWc6NmI4ZmNmNzQ4YTMxNGVlZDg1NzRjNGNkNjU2ZWQ3MzkvdGV4dHJlZ2lvbjo2YjhmY2Y3NDhhMzE0ZWVkODU3NGM0Y2Q2NTZlZDczOV8xMjU3_a04b6774-b964-4dda-b018-163ec9310a20">745-1700</ix:nonNumeric></span></div><div style="margin-top:6pt;text-align:center"><table style="border-collapse:collapse;display:inline-table;margin-bottom:5pt;vertical-align:text-bottom;width:100.000%"><tr><td style="width:1.0%"></td><td style="width:98.900%"></td><td style="width:0.1%"></td></tr><tr style="height:3pt"><td colspan="3" style="border-bottom:1pt solid #000;padding:0 1pt"></td></tr></table></div><div style="margin-top:8pt"><span style="color:#000000;font-family:'Times New Roman',sans-serif;font-size:9pt;font-weight:400;line-height:120%">Check the appropriate box below if the Form 8-K filing is intended to simultaneously satisfy the filing obligation of the registrant under any of the following provisions:</span></div><div style="margin-top:8pt"><table style="border-collapse:collapse;display:inline-table;margin-bottom:5pt;vertical-align:text-bottom;width:99.561%"><tr><td style="width:1.0%"></td><td style="width:2.424%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:95.376%"></td><td style="width:0.1%"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:top"><span style="color:#000000;font-family:'Wingdings',sans-serif;font-size:9pt;font-weight:700;line-height:100%"><ix:nonNumeric contextRef="i99eb85ff74604dd8813b17eed2cb021d_D20220411-20220411" name="dei:WrittenCommunications" format="ixt-sec:boolballotbox" id="id3VybDovL2RvY3MudjEvZG9jOmU0MzJhYWQ4Njc3MDQ4NzE4NDhjMjZmOWNhMzcyMDc3L3NlYzplNDMyYWFkODY3NzA0ODcxODQ4YzI2ZjljYTM3MjA3N18xL2ZyYWc6NmI4ZmNmNzQ4YTMxNGVlZDg1NzRjNGNkNjU2ZWQ3MzkvdGFibGU6ODlhMDNmMzNmNzRjNGNmZDhmOGY5MmVkMDQ3ZDRkOTcvdGFibGVyYW5nZTo4OWEwM2YzM2Y3NGM0Y2ZkOGY4ZjkyZWQwNDdkNGQ5N18wLTAtMS0xLTI3NzM5_84f3ad4e-4af3-4098-9ec8-74e6a3651c84">&#9744;</ix:nonNumeric></span></td><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:top"><span style="color:#000000;font-family:'Times New Roman',sans-serif;font-size:9pt;font-weight:400;line-height:100%">Written communications pursuant to Rule 425 under the Securities Act (17 CFR 230.425)</span></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:top"><span style="color:#000000;font-family:'Wingdings',sans-serif;font-size:9pt;font-weight:700;line-height:100%"><ix:nonNumeric contextRef="i99eb85ff74604dd8813b17eed2cb021d_D20220411-20220411" name="dei:SolicitingMaterial" format="ixt-sec:boolballotbox" id="id3VybDovL2RvY3MudjEvZG9jOmU0MzJhYWQ4Njc3MDQ4NzE4NDhjMjZmOWNhMzcyMDc3L3NlYzplNDMyYWFkODY3NzA0ODcxODQ4YzI2ZjljYTM3MjA3N18xL2ZyYWc6NmI4ZmNmNzQ4YTMxNGVlZDg1NzRjNGNkNjU2ZWQ3MzkvdGFibGU6ODlhMDNmMzNmNzRjNGNmZDhmOGY5MmVkMDQ3ZDRkOTcvdGFibGVyYW5nZTo4OWEwM2YzM2Y3NGM0Y2ZkOGY4ZjkyZWQwNDdkNGQ5N18xLTAtMS0xLTI3NzM5_d56fc725-d009-442d-9364-26c6ae58d1fa">&#9744;</ix:nonNumeric></span></td><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:top"><span style="color:#000000;font-family:'Times New Roman',sans-serif;font-size:9pt;font-weight:400;line-height:100%">Soliciting material pursuant to Rule 14a-12 under the Exchange Act (17 CFR 240.14a-12)</span></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:top"><span style="color:#000000;font-family:'Wingdings',sans-serif;font-size:9pt;font-weight:700;line-height:100%"><ix:nonNumeric contextRef="i99eb85ff74604dd8813b17eed2cb021d_D20220411-20220411" name="dei:PreCommencementTenderOffer" format="ixt-sec:boolballotbox" id="id3VybDovL2RvY3MudjEvZG9jOmU0MzJhYWQ4Njc3MDQ4NzE4NDhjMjZmOWNhMzcyMDc3L3NlYzplNDMyYWFkODY3NzA0ODcxODQ4YzI2ZjljYTM3MjA3N18xL2ZyYWc6NmI4ZmNmNzQ4YTMxNGVlZDg1NzRjNGNkNjU2ZWQ3MzkvdGFibGU6ODlhMDNmMzNmNzRjNGNmZDhmOGY5MmVkMDQ3ZDRkOTcvdGFibGVyYW5nZTo4OWEwM2YzM2Y3NGM0Y2ZkOGY4ZjkyZWQwNDdkNGQ5N18yLTAtMS0xLTI3NzM5_05e17cc0-0920-4d8d-b396-e7f87b40e9c2">&#9744;</ix:nonNumeric></span></td><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:top"><span style="color:#000000;font-family:'Times New Roman',sans-serif;font-size:9pt;font-weight:400;line-height:100%">Pre-commencement communications pursuant to Rule 14d-2(b) under the Exchange Act (17 CFR 240.14d-2(b))</span></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:top"><span style="color:#000000;font-family:'Wingdings',sans-serif;font-size:9pt;font-weight:700;line-height:100%"><ix:nonNumeric contextRef="i99eb85ff74604dd8813b17eed2cb021d_D20220411-20220411" name="dei:PreCommencementIssuerTenderOffer" format="ixt-sec:boolballotbox" id="id3VybDovL2RvY3MudjEvZG9jOmU0MzJhYWQ4Njc3MDQ4NzE4NDhjMjZmOWNhMzcyMDc3L3NlYzplNDMyYWFkODY3NzA0ODcxODQ4YzI2ZjljYTM3MjA3N18xL2ZyYWc6NmI4ZmNmNzQ4YTMxNGVlZDg1NzRjNGNkNjU2ZWQ3MzkvdGFibGU6ODlhMDNmMzNmNzRjNGNmZDhmOGY5MmVkMDQ3ZDRkOTcvdGFibGVyYW5nZTo4OWEwM2YzM2Y3NGM0Y2ZkOGY4ZjkyZWQwNDdkNGQ5N18zLTAtMS0xLTI3NzM5_69a40725-1fef-4d68-9fca-34fdb394da89">&#9744;</ix:nonNumeric></span></td><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:top"><span style="color:#000000;font-family:'Times New Roman',sans-serif;font-size:9pt;font-weight:400;line-height:100%">Pre-commencement communications pursuant to Rule 13e-4(c) under the Exchange Act (17 CFR 240.13e-4(c))</span></td></tr></table></div><div style="margin-top:4pt"><span style="color:#000000;font-family:'Times New Roman',sans-serif;font-size:9pt;font-weight:400;line-height:120%">Securities registered pursuant to Section 12(b) of the Act:</span></div><div style="margin-top:6pt"><table style="border-collapse:collapse;display:inline-table;margin-bottom:5pt;vertical-align:text-bottom;width:100.000%"><tr><td style="width:1.0%"></td><td style="width:33.695%"></td><td style="width:0.1%"></td><td style="width:0.1%"></td><td style="width:0.823%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:27.116%"></td><td style="width:0.1%"></td><td style="width:0.1%"></td><td style="width:0.823%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:33.843%"></td><td style="width:0.1%"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:center;vertical-align:top"><span style="color:#000000;font-family:'Times New Roman',sans-serif;font-size:9pt;font-weight:700;line-height:100%">Title of each class</span></td><td colspan="3" style="padding:0 1pt"></td><td colspan="3" style="padding:2px 1pt;text-align:center;vertical-align:top"><span style="color:#000000;font-family:'Times New Roman',sans-serif;font-size:9pt;font-weight:700;line-height:100%">Trading Symbol(s)</span></td><td colspan="3" style="padding:0 1pt"></td><td colspan="3" style="padding:2px 1pt;text-align:center;vertical-align:top"><span style="color:#000000;font-family:'Times New Roman',sans-serif;font-size:9pt;font-weight:700;line-height:100%">Name of each exchange on which registered</span></td></tr><tr><td colspan="3" style="border-top:1pt solid #000;padding:2px 1pt;text-align:center;vertical-align:top"><span style="color:#000000;font-family:'Times New Roman',sans-serif;font-size:9pt;font-weight:400;line-height:100%"><ix:nonNumeric contextRef="i99eb85ff74604dd8813b17eed2cb021d_D20220411-20220411" name="dei:Security12bTitle" id="id3VybDovL2RvY3MudjEvZG9jOmU0MzJhYWQ4Njc3MDQ4NzE4NDhjMjZmOWNhMzcyMDc3L3NlYzplNDMyYWFkODY3NzA0ODcxODQ4YzI2ZjljYTM3MjA3N18xL2ZyYWc6NmI4ZmNmNzQ4YTMxNGVlZDg1NzRjNGNkNjU2ZWQ3MzkvdGFibGU6ODBkMjFhODY4ODkyNDRmY2E3ZDliNjNmYzI0YzRjMTEvdGFibGVyYW5nZTo4MGQyMWE4Njg4OTI0NGZjYTdkOWI2M2ZjMjRjNGMxMV8xLTAtMS0xLTI3NzM5_ab895881-1517-47ab-9fd8-846a48eb42ac">Common Stock, par value $0.0001</ix:nonNumeric></span></td><td colspan="3" style="padding:0 1pt"></td><td colspan="3" style="border-top:1pt solid #000;padding:2px 1pt;text-align:center;vertical-align:top"><span style="color:#000000;font-family:'Times New Roman',sans-serif;font-size:9pt;font-weight:400;line-height:100%"><ix:nonNumeric contextRef="i99eb85ff74604dd8813b17eed2cb021d_D20220411-20220411" name="dei:TradingSymbol" id="id3VybDovL2RvY3MudjEvZG9jOmU0MzJhYWQ4Njc3MDQ4NzE4NDhjMjZmOWNhMzcyMDc3L3NlYzplNDMyYWFkODY3NzA0ODcxODQ4YzI2ZjljYTM3MjA3N18xL2ZyYWc6NmI4ZmNmNzQ4YTMxNGVlZDg1NzRjNGNkNjU2ZWQ3MzkvdGFibGU6ODBkMjFhODY4ODkyNDRmY2E3ZDliNjNmYzI0YzRjMTEvdGFibGVyYW5nZTo4MGQyMWE4Njg4OTI0NGZjYTdkOWI2M2ZjMjRjNGMxMV8xLTItMS0xLTI3NzM5_5bdc741c-aee9-4320-b45b-c0b8764992fc">ARDX</ix:nonNumeric></span></td><td colspan="3" style="padding:0 1pt"></td><td colspan="3" style="border-top:1pt solid #000;padding:2px 1pt;text-align:center;vertical-align:top"><span style="color:#000000;font-family:'Times New Roman',sans-serif;font-size:9pt;font-weight:400;line-height:100%"><ix:nonNumeric contextRef="i99eb85ff74604dd8813b17eed2cb021d_D20220411-20220411" name="dei:SecurityExchangeName" format="ixt-sec:exchnameen" id="id3VybDovL2RvY3MudjEvZG9jOmU0MzJhYWQ4Njc3MDQ4NzE4NDhjMjZmOWNhMzcyMDc3L3NlYzplNDMyYWFkODY3NzA0ODcxODQ4YzI2ZjljYTM3MjA3N18xL2ZyYWc6NmI4ZmNmNzQ4YTMxNGVlZDg1NzRjNGNkNjU2ZWQ3MzkvdGFibGU6ODBkMjFhODY4ODkyNDRmY2E3ZDliNjNmYzI0YzRjMTEvdGFibGVyYW5nZTo4MGQyMWE4Njg4OTI0NGZjYTdkOWI2M2ZjMjRjNGMxMV8xLTQtMS0xLTI3NzM5_4067516a-2c3c-46f8-b080-f764ec23501c">The Nasdaq Global Market</ix:nonNumeric></span></td></tr></table></div><div style="margin-top:6pt"><span style="color:#000000;font-family:'Times New Roman',sans-serif;font-size:9pt;font-weight:400;line-height:120%">Indicate by check mark whether the registrant is an emerging growth company as defined in Rule 405 of the Securities Act of 1933 (&#167;230.405 of this chapter) or Rule 12b-2 of the Securities Exchange Act of 1934 (&#167;240.12b-2 of this chapter).</span></div><div style="margin-top:8pt"><span style="color:#000000;font-family:'Times New Roman',sans-serif;font-size:9pt;font-weight:400;line-height:120%">Emerging growth company&#160;&#160;</span><span style="color:#000000;font-family:'Times New Roman',sans-serif;font-size:9pt;font-weight:700;line-height:120%"><ix:nonNumeric contextRef="i99eb85ff74604dd8813b17eed2cb021d_D20220411-20220411" name="dei:EntityEmergingGrowthCompany" format="ixt:fixed-false" id="id3VybDovL2RvY3MudjEvZG9jOmU0MzJhYWQ4Njc3MDQ4NzE4NDhjMjZmOWNhMzcyMDc3L3NlYzplNDMyYWFkODY3NzA0ODcxODQ4YzI2ZjljYTM3MjA3N18xL2ZyYWc6NmI4ZmNmNzQ4YTMxNGVlZDg1NzRjNGNkNjU2ZWQ3MzkvdGV4dHJlZ2lvbjo2YjhmY2Y3NDhhMzE0ZWVkODU3NGM0Y2Q2NTZlZDczOV8xMjU4_5237859f-621c-4622-b3ee-2a30dd17d76d">&#9744;</ix:nonNumeric></span></div><div style="margin-top:8pt"><span style="color:#000000;font-family:'Times New Roman',sans-serif;font-size:9pt;font-weight:400;line-height:120%">If an emerging growth company, indicate by check mark if the registrant has elected not to use the extended transition period for complying with any new or revised financial accounting standards provided pursuant to Section&#160;13(a) of the Exchange Act.&#160;&#160;</span><span style="color:#000000;font-family:'Wingdings',sans-serif;font-size:9pt;font-weight:400;line-height:120%">o</span></div><div style="margin-top:5pt;text-align:center"><span><br/></span></div><div style="text-align:center"><table style="border-collapse:collapse;display:inline-table;margin-bottom:5pt;vertical-align:text-bottom;width:100.000%"><tr><td style="width:1.0%"></td><td style="width:98.900%"></td><td style="width:0.1%"></td></tr><tr style="height:3pt"><td colspan="3" style="border-bottom:3pt double #000;padding:0 1pt"></td></tr></table></div><div style="height:45pt;position:relative;width:100%"><div style="bottom:0;position:absolute;width:100%"><div><span><br/></span></div></div></div><div id="ie432aad867704871848c26f9ca372077_7"></div><hr style="page-break-after:always"/><div style="min-height:45pt;width:100%"><div style="text-align:justify"><span><br/></span></div></div><div style="padding-left:58.5pt;text-indent:-58.5pt"><span style="color:#000000;font-family:'Times New Roman',sans-serif;font-size:10pt;font-weight:700;line-height:115%">Item&#160;1.01&#160;&#160;&#160;&#160;Entry into a Material Definitive Agreement. </span><span style="color:#000000;font-family:'Times New Roman',sans-serif;font-size:10pt;font-weight:400;line-height:115%"> </span></div><div><span><br/></span></div><div><span style="color:#000000;font-family:'Times New Roman',sans-serif;font-size:10pt;font-weight:400;line-height:120%">On April 11, 2022, Ardelyx, Inc. (the &#8220;Company&#8221;) entered into that certain Amendment Number 2 to License Agreement (the &#8220;Amendment&#8221;), which amended that certain License Agreement (the &#8220;Agreement&#8221;) dated as of November 27, 2017, by and between Kyowa Kirin Co., Ltd. (&#8220;Kyowa Kirin&#8221;, f/k/a Kyowa Hakko Kirin Co., Ltd.).  Under the terms of the Amendment, the parties have agreed to a reduction in the royalty rate payable to the Company by Kyowa Kirin upon net sales of tenapanor in Japan.   The royalty rate will be reduced from the high teens to low double digits for a two-year period of time following the first commercial sale in Japan, and then to mid-single digits for the remainder of the royalty term.   As consideration for the reduction in the royalty rate, Kyowa Kirin has agreed to pay the Company up to additional U.S. $40 million payable in two tranches, with the first payment due following Kyowa Kirin&#8217;s filing with the Japanese Ministry Health, Labour and Welfare (MHLW) of its application for marketing approval for tenapanor and the second payment due following Kyowa Kirin&#8217;s receipt of regulatory approval to market tenapanor for hyperphosphatemia in Japan.  </span></div><div><span><br/></span></div><div><span style="color:#000000;font-family:'Times New Roman',sans-serif;font-size:10pt;font-weight:400;line-height:120%">The above summary of the material terms of the Amendment do not purport to be complete and are qualified in their entirety by reference to the Amendment, a copy of which is filed as Exhibit 10.1, respectively, to this Current Report on Form 8-K and incorporated by reference herein.</span></div><div><span><br/></span></div><div><span style="color:#000000;font-family:'Times New Roman',sans-serif;font-size:10pt;font-weight:400;line-height:120%">The above summary of the material terms of the Amendment do not purport to be complete and are qualified in their entirety by reference to the Amendment, a copy of which is filed as Exhibit 10.1, respectively, to this Current Report on Form 8-K and incorporated by reference herein.</span></div><div><span><br/></span></div><div id="ie432aad867704871848c26f9ca372077_71"></div><div style="-sec-extract:summary;margin-top:12pt;padding-left:58.5pt;text-indent:-58.5pt"><span style="color:#000000;font-family:'Times New Roman',sans-serif;font-size:10pt;font-weight:700;line-height:120%">Item&#160;9.01&#160;&#160;&#160;&#160;Financial Statements and Exhibits.</span></div><div style="margin-top:6pt"><span style="color:#000000;font-family:'Times New Roman',sans-serif;font-size:10pt;font-weight:700;line-height:120%">(d) Exhibits.</span></div><div style="margin-top:6pt"><table style="border-collapse:collapse;display:inline-table;margin-bottom:5pt;vertical-align:text-bottom;width:99.415%"><tr><td style="width:1.0%"></td><td style="width:7.723%"></td><td style="width:0.1%"></td><td style="width:0.1%"></td><td style="width:1.711%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:88.166%"></td><td style="width:0.1%"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:center;vertical-align:bottom"><span style="color:#000000;font-family:'Times New Roman',sans-serif;font-size:8pt;font-weight:400;line-height:100%">Exhibit<br/>No.</span></td><td colspan="3" style="padding:0 1pt"></td><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Times New Roman',sans-serif;font-size:8pt;font-weight:400;line-height:100%">Description</span></td></tr><tr><td colspan="3" style="border-top:1pt solid #000;padding:2px 1pt;text-align:left;vertical-align:top"><span style="color:#000000;font-family:'Times New Roman',sans-serif;font-size:10pt;font-weight:400;line-height:100%">99.1</span></td><td colspan="3" style="padding:0 1pt"></td><td colspan="3" style="border-top:1pt solid #000;padding:2px 1pt;text-align:left;vertical-align:top"><div><span style="color:#0000ff;font-family:'Times New Roman',sans-serif;font-size:10pt;font-weight:400;line-height:120%;text-decoration:underline"><a style="-sec-extract:exhibit;color:#0000ff;font-family:'Times New Roman',sans-serif;font-size:10pt;font-weight:400;line-height:120%;text-decoration:underline" href="a2ndamendmenttokkc-ardxlic.htm">Amendment Number 2 to License Agreement, dated as of April 11, 2022, by and among Ardelyx, Inc. and Kyowa Kirin Co., Ltd.</a></span></div></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:top"><span style="color:#000000;font-family:'Times New Roman',sans-serif;font-size:10pt;font-weight:400;line-height:100%">104</span></td><td colspan="3" style="padding:0 1pt"></td><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:top"><span style="color:#000000;font-family:'Times New Roman',sans-serif;font-size:10pt;font-weight:400;line-height:100%">Cover Page Interactive Data File (embedded within the Inline XBRL document).</span></td></tr></table></div><div><span><br/></span></div><div><span style="color:#000000;font-family:'Times New Roman',sans-serif;font-size:10pt;font-weight:400;line-height:112%">* Certain portions of this exhibit have been redacted pursuant to Item 601(b)(10) of Regulation S-K. A copy of the omitted portions will be furnished supplementally to the Securities and Exchange Commission upon request.</span></div><div style="height:45pt;position:relative;width:100%"><div style="bottom:0;position:absolute;width:100%"><div><span><br/></span></div></div></div><div id="ie432aad867704871848c26f9ca372077_10"></div><hr style="page-break-after:always"/><div style="min-height:45pt;width:100%"><div style="text-align:justify"><span><br/></span></div></div><div style="margin-top:12pt;text-align:center"><span style="color:#000000;font-family:'Times New Roman',sans-serif;font-size:10pt;font-weight:700;line-height:120%">SIGNATURES</span></div><div style="margin-top:6pt"><span style="color:#000000;font-family:'Times New Roman',sans-serif;font-size:10pt;font-weight:400;line-height:120%">Pursuant to the requirements of the Securities Exchange Act of 1934, as amended, the registrant has duly caused this report to be signed on its behalf by the undersigned hereunto duly authorized.</span></div><div style="margin-top:6pt"><table style="border-collapse:collapse;display:inline-table;margin-bottom:5pt;vertical-align:text-bottom;width:99.561%"><tr><td style="width:1.0%"></td><td style="width:41.924%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:3.158%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:51.618%"></td><td style="width:0.1%"></td></tr><tr><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:top"><span style="color:#000000;font-family:'Times New Roman',sans-serif;font-size:10pt;font-weight:400;line-height:100%">Date: April 11, 2022</span></td><td colspan="6" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Times New Roman',sans-serif;font-size:10pt;font-weight:400;line-height:100%">ARDELYX, INC.</span></td></tr><tr style="height:12pt"><td colspan="3" style="padding:0 1pt"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="3" style="padding:0 1pt"></td></tr><tr><td colspan="3" style="padding:0 1pt"></td><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Times New Roman',sans-serif;font-size:10pt;font-weight:400;line-height:100%">By:</span></td><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Times New Roman',sans-serif;font-size:10pt;font-weight:400;line-height:100%">/s/ Justin Renz</span></td></tr><tr><td colspan="3" style="padding:0 1pt"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="3" style="border-top:1pt solid #000000;padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Times New Roman',sans-serif;font-size:10pt;font-weight:400;line-height:100%">Justin Renz</span></td></tr><tr><td colspan="3" style="padding:0 1pt"></td><td colspan="3" style="padding:0 1pt"></td><td colspan="3" style="padding:2px 1pt;text-align:left;vertical-align:bottom"><span style="color:#000000;font-family:'Times New Roman',sans-serif;font-size:10pt;font-weight:400;line-height:100%">Chief Financial Officer</span></td></tr></table></div><div style="height:45pt;position:relative;width:100%"><div style="bottom:0;position:absolute;width:100%"><div><span><br/></span></div></div></div></body></html>
</XBRL>
</TEXT>
</DOCUMENT>
<DOCUMENT>
<TYPE>EX-99.1
<SEQUENCE>2
<FILENAME>a2ndamendmenttokkc-ardxlic.htm
<DESCRIPTION>EX-99.1
<TEXT>
<!DOCTYPE html PUBLIC "-//W3C//DTD HTML 4.01 Transitional//EN" "http://www.w3.org/TR/html4/loose.dtd"><html><head>
<!-- Document created using Wdesk -->
<!-- Copyright 2022 Workiva -->
<title>Document</title></head><body><div id="i058e874210e447d18815669444da5ed6_1"></div><div style="min-height:79.92pt;width:100%"><div style="margin-bottom:8pt;text-align:right"><table style="border-collapse:collapse;display:inline-table;margin-bottom:5pt;vertical-align:text-bottom;width:99.679%"><tr><td style="width:1.0%"></td><td style="width:98.900%"></td><td style="width:0.1%"></td></tr><tr><td colspan="3" style="background-color:#ffffff;border-bottom:0.75pt solid #000000;border-left:0.75pt solid #000000;border-right:0.75pt solid #000000;border-top:0.75pt solid #000000;padding:2px 1pt;text-align:left;vertical-align:bottom"><div style="margin-bottom:8pt;text-align:justify"><font style="color:#000000;font-family:'Calibri',sans-serif;font-size:10.5pt;font-weight:700;line-height:125%">Certain confidential information contained in this document, marked by &#91;***&#93;, has been omitted because it is both (i) not material and (ii) is the type that the registrant treats as private or confidential.</font></div></td></tr></table><font style="color:#000000;font-family:'Calibri',sans-serif;font-size:11pt;font-weight:700;line-height:125%">Exhibit 99.1</font></div></div><div style="margin-bottom:12pt;text-align:center"><font style="color:#000000;font-family:'Calibri',sans-serif;font-size:11pt;font-weight:700;line-height:100%">AMENDMENT NO.2 to <br>LICENSE AGREEMENT</font></div><div style="margin-bottom:12pt;text-align:justify;text-indent:36pt"><font style="color:#000000;font-family:'Calibri',sans-serif;font-size:11pt;font-weight:400;line-height:100%">This</font><font style="color:#000000;font-family:'Calibri',sans-serif;font-size:11pt;font-weight:700;line-height:100%"> SECOND AMENDMENT </font><font style="color:#000000;font-family:'Calibri',sans-serif;font-size:11pt;font-weight:400;line-height:100%">(the &#8220;Amendment&#8221;), effective as of the date last signed below (the &#8220;</font><font style="color:#000000;font-family:'Calibri',sans-serif;font-size:11pt;font-weight:400;line-height:100%;text-decoration:underline">Effective Date</font><font style="color:#000000;font-family:'Calibri',sans-serif;font-size:11pt;font-weight:400;line-height:100%">&#8221;), amends that certain License Agreement dated November 27, 2017 (together with all exhibits, amendments and attachments thereto, the &#8220;</font><font style="color:#000000;font-family:'Calibri',sans-serif;font-size:11pt;font-weight:400;line-height:100%;text-decoration:underline">Original Agreement</font><font style="color:#000000;font-family:'Calibri',sans-serif;font-size:11pt;font-weight:400;line-height:100%">&#8221;) by and between Kyowa Kirin Co., Ltd. (f&#47;k&#47;a Kyowa Hakko Kirin Co., Ltd.), a Japanese corporation with a place of business at 1-9-2 Otemachi, Chiyoda-ku, Tokyo 100-0004, Japan (&#8220;</font><font style="color:#000000;font-family:'Calibri',sans-serif;font-size:11pt;font-weight:400;line-height:100%;text-decoration:underline">KKC</font><font style="color:#000000;font-family:'Calibri',sans-serif;font-size:11pt;font-weight:400;line-height:100%">&#8221;), and Ardelyx, Inc., a Delaware corporation having its principal place of business at 400 Fifth Avenue, Suite 210 Waltham, MA 02451, United States of America (&#8220;</font><font style="color:#000000;font-family:'Calibri',sans-serif;font-size:11pt;font-weight:400;line-height:100%;text-decoration:underline">Ardelyx</font><font style="color:#000000;font-family:'Calibri',sans-serif;font-size:11pt;font-weight:400;line-height:100%">&#8221;). KKC and Ardelyx shall each be hereinafter referred to as a &#8220;</font><font style="color:#000000;font-family:'Calibri',sans-serif;font-size:11pt;font-weight:400;line-height:100%;text-decoration:underline">Party</font><font style="color:#000000;font-family:'Calibri',sans-serif;font-size:11pt;font-weight:400;line-height:100%">&#8221; and collectively as the &#8220;</font><font style="color:#000000;font-family:'Calibri',sans-serif;font-size:11pt;font-weight:400;line-height:100%;text-decoration:underline">Parties</font><font style="color:#000000;font-family:'Calibri',sans-serif;font-size:11pt;font-weight:400;line-height:100%">&#8221;.  Capitalized terms used but not otherwise defined herein shall have the meanings ascribed to them in the Original Agreement.</font></div><div style="margin-bottom:12pt;text-align:justify"><font style="color:#000000;font-family:'Calibri',sans-serif;font-size:11pt;font-weight:400;line-height:100%">&#160;&#160;&#160;&#160;</font><font style="color:#000000;font-family:'Calibri',sans-serif;font-size:11pt;font-weight:700;line-height:100%">WHEREAS, </font><font style="color:#000000;font-family:'Calibri',sans-serif;font-size:11pt;font-weight:400;line-height:100%">the Parties desire to amend the milestone payments and the royalties under Sections 6.02, 6.04 and 11.04 of the Original Agreement. </font></div><div style="margin-bottom:12pt;text-align:justify;text-indent:36pt"><font style="color:#000000;font-family:'Calibri',sans-serif;font-size:11pt;font-weight:700;line-height:100%">Now Therefore, </font><font style="color:#000000;font-family:'Calibri',sans-serif;font-size:11pt;font-weight:400;line-height:100%">in consideration of the premises and the terms and conditions contained herein, the Parties hereby agree as follows&#58;</font></div><div style="margin-bottom:12pt;padding-left:18pt;text-align:justify;text-indent:-18pt"><font style="color:#000000;font-family:'Calibri',sans-serif;font-size:11pt;font-weight:700;line-height:100%">1)</font><font style="color:#000000;font-family:'Calibri',sans-serif;font-size:11pt;font-weight:700;line-height:100%;padding-left:9.01pt">Amendment to the Milestone Payments.  </font><font style="color:#000000;font-family:'Calibri',sans-serif;font-size:11pt;font-weight:400;line-height:100%">As of the Effective Date, the table of the milestone events for a Licensed Product set forth in Section 6.02 (a) of the Original Agreement shall be deleted and replaced in its entirety as follows&#58;</font></div><div style="margin-bottom:12pt;padding-left:44.45pt;text-align:justify"><font><br></font></div><div style="margin-bottom:0.08pt"><table style="border-collapse:collapse;display:inline-table;margin-bottom:5pt;vertical-align:text-bottom;width:100.000%"><tr><td style="width:1.0%"></td><td style="width:57.460%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:16.180%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:23.060%"></td><td style="width:0.1%"></td></tr><tr><td colspan="3" style="border-left:0.5pt solid #000000;border-top:0.5pt solid #000000;padding:2px 1pt 2px 12.77pt;text-align:left;vertical-align:top"><font style="color:#000000;font-family:'Calibri',sans-serif;font-size:11pt;font-weight:700;line-height:125%">Milestone Event for a Licensed Product</font></td><td colspan="3" style="border-left:0.5pt solid #000000;border-top:0.5pt solid #000000;padding:2px 1pt 2px 12.77pt;text-align:left;vertical-align:top"><font style="color:#000000;font-family:'Calibri',sans-serif;font-size:11pt;font-weight:700;line-height:125%">Milestone Number</font></td><td colspan="3" style="border-left:0.5pt solid #000000;border-right:0.5pt solid #000000;border-top:0.5pt solid #000000;padding:2px 1pt 2px 12.77pt;text-align:left;vertical-align:top"><font style="color:#000000;font-family:'Calibri',sans-serif;font-size:11pt;font-weight:700;line-height:125%">Milestone Payment</font></td></tr><tr><td colspan="3" style="border-left:0.5pt solid #000000;border-top:0.5pt solid #000000;padding:2px 1pt 2px 12.77pt;text-align:left;vertical-align:top"><font style="color:#000000;font-family:'Calibri',sans-serif;font-size:11pt;font-weight:400;line-height:125%">&#91;***&#93;</font></td><td colspan="3" style="border-left:0.5pt solid #000000;border-top:0.5pt solid #000000;padding:2px 1pt 2px 12.77pt;text-align:left;vertical-align:top"><font style="color:#000000;font-family:'Calibri',sans-serif;font-size:11pt;font-weight:400;line-height:125%">01</font></td><td colspan="3" style="border-left:0.5pt solid #000000;border-right:0.5pt solid #000000;border-top:0.5pt solid #000000;padding:2px 1pt 2px 12.77pt;text-align:left;vertical-align:top"><font style="color:#000000;font-family:'Calibri',sans-serif;font-size:11pt;font-weight:400;line-height:125%">USD &#91;***&#93;</font></td></tr><tr><td colspan="3" style="border-left:0.5pt solid #000000;border-top:0.5pt solid #000000;padding:2px 1pt 2px 12.77pt;text-align:left;vertical-align:top"><font style="color:#000000;font-family:'Calibri',sans-serif;font-size:11pt;font-weight:400;line-height:125%">&#91;***&#93;</font></td><td colspan="3" style="border-left:0.5pt solid #000000;border-top:0.5pt solid #000000;padding:2px 1pt 2px 12.77pt;text-align:left;vertical-align:top"><font style="color:#000000;font-family:'Calibri',sans-serif;font-size:11pt;font-weight:400;line-height:125%">02</font></td><td colspan="3" style="border-left:0.5pt solid #000000;border-right:0.5pt solid #000000;border-top:0.5pt solid #000000;padding:2px 1pt 2px 12.77pt;text-align:left;vertical-align:top"><font style="color:#000000;font-family:'Calibri',sans-serif;font-size:11pt;font-weight:400;line-height:125%">USD &#91;***&#93;</font></td></tr><tr><td colspan="3" style="border-left:0.5pt solid #000000;border-top:0.5pt solid #000000;padding:2px 1pt 2px 12.77pt;text-align:left;vertical-align:top"><font style="color:#000000;font-family:'Calibri',sans-serif;font-size:11pt;font-weight:400;line-height:125%">&#91;***&#93;</font></td><td colspan="3" style="border-left:0.5pt solid #000000;border-top:0.5pt solid #000000;padding:2px 1pt 2px 12.77pt;text-align:left;vertical-align:top"><font style="color:#000000;font-family:'Calibri',sans-serif;font-size:11pt;font-weight:400;line-height:125%">03</font></td><td colspan="3" style="border-left:0.5pt solid #000000;border-right:0.5pt solid #000000;border-top:0.5pt solid #000000;padding:2px 1pt 2px 12.77pt;text-align:left;vertical-align:top"><font style="color:#000000;font-family:'Calibri',sans-serif;font-size:11pt;font-weight:400;line-height:125%">USD &#91;***&#93;</font></td></tr><tr><td colspan="3" style="border-left:0.5pt solid #000000;border-top:0.5pt solid #000000;padding:2px 1pt 2px 12.77pt;text-align:left;vertical-align:top"><font style="color:#000000;font-family:'Calibri',sans-serif;font-size:11pt;font-weight:400;line-height:125%">&#91;***&#93;</font></td><td colspan="3" style="border-left:0.5pt solid #000000;border-top:0.5pt solid #000000;padding:2px 1pt 2px 12.77pt;text-align:left;vertical-align:top"><font style="color:#000000;font-family:'Calibri',sans-serif;font-size:11pt;font-weight:400;line-height:125%">04</font></td><td colspan="3" style="border-left:0.5pt solid #000000;border-right:0.5pt solid #000000;border-top:0.5pt solid #000000;padding:2px 1pt 2px 12.77pt;text-align:left;vertical-align:top"><font style="color:#000000;font-family:'Calibri',sans-serif;font-size:11pt;font-weight:400;line-height:125%">USD &#91;***&#93;</font></td></tr><tr><td colspan="3" style="border-left:0.5pt solid #000000;border-top:0.5pt solid #000000;padding:2px 1pt 2px 12.77pt;text-align:left;vertical-align:top"><font style="color:#000000;font-family:'Calibri',sans-serif;font-size:11pt;font-weight:400;line-height:125%">&#91;***&#93;</font></td><td colspan="3" style="border-left:0.5pt solid #000000;border-top:0.5pt solid #000000;padding:2px 1pt 2px 12.77pt;text-align:left;vertical-align:top"><font style="color:#000000;font-family:'Calibri',sans-serif;font-size:11pt;font-weight:400;line-height:125%">05</font></td><td colspan="3" style="border-left:0.5pt solid #000000;border-right:0.5pt solid #000000;border-top:0.5pt solid #000000;padding:2px 1pt 2px 12.77pt;text-align:left;vertical-align:top"><font style="color:#000000;font-family:'Calibri',sans-serif;font-size:11pt;font-weight:400;line-height:125%">USD &#91;***&#93;</font></td></tr><tr><td colspan="3" style="border-left:0.5pt solid #000000;border-top:0.5pt solid #000000;padding:2px 1pt 2px 12.77pt;text-align:left;vertical-align:top"><font style="color:#000000;font-family:'Calibri',sans-serif;font-size:11pt;font-weight:400;line-height:125%">&#91;***&#93;</font></td><td colspan="3" style="border-left:0.5pt solid #000000;border-top:0.5pt solid #000000;padding:2px 1pt 2px 12.77pt;text-align:left;vertical-align:top"><font style="color:#000000;font-family:'Calibri',sans-serif;font-size:11pt;font-weight:400;line-height:125%">06</font></td><td colspan="3" style="border-left:0.5pt solid #000000;border-right:0.5pt solid #000000;border-top:0.5pt solid #000000;padding:2px 1pt 2px 12.77pt;text-align:left;vertical-align:top"><font style="color:#000000;font-family:'Calibri',sans-serif;font-size:11pt;font-weight:400;line-height:125%">USD &#91;***&#93;</font></td></tr><tr><td colspan="3" style="border-bottom:0.5pt solid #000000;border-left:0.5pt solid #000000;border-top:0.5pt solid #000000;padding:2px 1pt 2px 12.77pt;text-align:left;vertical-align:top"><font style="color:#000000;font-family:'Calibri',sans-serif;font-size:11pt;font-weight:400;line-height:125%">&#91;***&#93;</font></td><td colspan="3" style="border-bottom:0.5pt solid #000000;border-left:0.5pt solid #000000;border-top:0.5pt solid #000000;padding:2px 1pt 2px 12.77pt;text-align:left;vertical-align:top"><font style="color:#000000;font-family:'Calibri',sans-serif;font-size:11pt;font-weight:400;line-height:125%">07</font></td><td colspan="3" style="border-bottom:0.5pt solid #000000;border-left:0.5pt solid #000000;border-right:0.5pt solid #000000;border-top:0.5pt solid #000000;padding:2px 1pt 2px 12.77pt;text-align:left;vertical-align:top"><font style="color:#000000;font-family:'Calibri',sans-serif;font-size:11pt;font-weight:400;line-height:125%">USD &#91;***&#93;</font></td></tr></table></div><div style="margin-bottom:12pt;padding-left:26.95pt;text-align:justify"><font><br></font></div><div style="margin-bottom:12pt;padding-left:18pt;text-align:justify;text-indent:-18pt"><font style="color:#000000;font-family:'Calibri',sans-serif;font-size:11pt;font-weight:700;line-height:100%">2)</font><font style="color:#000000;font-family:'Calibri',sans-serif;font-size:11pt;font-weight:700;line-height:100%;padding-left:9.01pt">Amendment to the Royalties.  </font><font style="color:#000000;font-family:'Calibri',sans-serif;font-size:11pt;font-weight:400;line-height:100%">As of the Effective Date, Section 6.04 and Section 11.04 of the Original Agreement shall be deleted and replaced in its entirety as set forth on </font><font style="color:#000000;font-family:'Calibri',sans-serif;font-size:11pt;font-weight:400;line-height:100%;text-decoration:underline">Exhibit A</font><font style="color:#000000;font-family:'Calibri',sans-serif;font-size:11pt;font-weight:400;line-height:100%"> to this Amendment.  </font></div><div style="height:123.84pt;position:relative;width:100%"><div style="bottom:0;position:absolute;width:100%"><div style="margin-bottom:0.08pt"><font><br></font></div></div></div><hr style="page-break-after:always"><div style="min-height:79.92pt;width:100%"><div style="margin-bottom:8pt;text-align:right"><font style="color:#000000;font-family:'Calibri',sans-serif;font-size:11pt;font-style:italic;font-weight:400;line-height:125%">Execution Copy</font></div><div style="margin-bottom:8pt;text-align:right"><font><br></font></div></div><div style="margin-bottom:0.08pt;padding-left:18pt;text-align:justify"><font style="color:#000000;font-family:'Calibri',sans-serif;font-size:11pt;font-weight:400;line-height:125%">As full and complete consideration for the amendments to the royalty provisions of the Original Agreement KKC shall make the following payments to Ardelyx, when and if earned&#58;  </font></div><div style="margin-bottom:0.08pt;padding-left:0.36pt;text-align:justify"><font><br></font></div><div style="margin-bottom:12pt;padding-left:36pt;text-align:justify;text-indent:-18pt"><font style="color:#000000;font-family:'Calibri',sans-serif;font-size:11pt;font-weight:400;line-height:100%">(a)</font><font style="color:#000000;font-family:'Calibri',sans-serif;font-size:11pt;font-weight:400;line-height:100%;padding-left:6.08pt">&#91;***&#93; U.S. dollars (U.S. &#91;***&#93;) shall be paid to Ardelyx within &#91;***&#93;days following the first filing of a Drug Approval Application in the Territory for the first indication of a Licensed Product&#59; and </font></div><div style="margin-bottom:12pt;padding-left:36pt;text-align:justify;text-indent:-18pt"><font style="color:#000000;font-family:'Calibri',sans-serif;font-size:11pt;font-weight:400;line-height:100%">(b)</font><font style="color:#000000;font-family:'Calibri',sans-serif;font-size:11pt;font-weight:400;line-height:100%;padding-left:5.57pt"> &#91;***&#93; U.S. dollars (U.S. &#91;***&#93;) shall be paid to Ardelyx within &#91;***&#93; days following KKC&#8217;s first receipt of Regulatory Approval in the Territory for the first indication of a Licensed Product.</font></div><div style="margin-bottom:12pt;padding-left:18pt;text-align:justify;text-indent:-18pt"><font style="color:#000000;font-family:'Calibri',sans-serif;font-size:11pt;font-weight:700;line-height:100%">3)</font><font style="color:#000000;font-family:'Calibri',sans-serif;font-size:11pt;font-weight:700;line-height:100%;padding-left:9.01pt">Publicity.  </font><font style="color:#000000;font-family:'Calibri',sans-serif;font-size:11pt;font-weight:400;line-height:100%">Notwithstanding the provisions of Section 10.02 of the Original Agreement, the Parties agree that Ardelyx and KKC may issue a press release set forth on Exhibit B regarding this Amendment.</font></div><div style="margin-bottom:12pt;padding-left:18pt;text-align:justify;text-indent:-18pt"><font style="color:#000000;font-family:'Calibri',sans-serif;font-size:11pt;font-weight:700;line-height:100%">4)</font><font style="color:#000000;font-family:'Calibri',sans-serif;font-size:11pt;font-weight:700;line-height:100%;padding-left:9.01pt">Miscellaneous.  </font><font style="color:#000000;font-family:'Calibri',sans-serif;font-size:11pt;font-weight:400;line-height:100%">This Amendment shall be governed and construed in accordance with the laws of the State of New York, without giving effect to the conflict of law rules thereof that would require application of the laws of any other jurisdiction.</font><font style="color:#000000;font-family:'Calibri',sans-serif;font-size:11pt;font-weight:700;line-height:100%">  </font><font style="color:#000000;font-family:'Calibri',sans-serif;font-size:11pt;font-weight:400;line-height:100%">Except for those amendments expressly described in this Amendment, the Original Agreement remains unchanged and in full force and effect.  This Amendment may be executed in any number of counterparts, each of which shall be deemed an original and all of which taken together shall be deemed to constitute one and the same instrument.</font></div><div style="margin-bottom:12pt;text-align:center"><font style="color:#000000;font-family:'Calibri',sans-serif;font-size:11pt;font-weight:700;line-height:100%">*   *   *</font></div><div style="margin-bottom:12pt;text-indent:36pt"><font style="color:#000000;font-family:'Calibri',sans-serif;font-size:11pt;font-weight:700;line-height:100%">IN WITNESS WHEREOF, </font><font style="color:#000000;font-family:'Calibri',sans-serif;font-size:11pt;font-weight:400;line-height:100%">the Parties have caused this Amendment to be executed by their duly authorized representatives as of the Effective Date.</font></div><div style="text-indent:36pt"><font style="color:#000000;font-family:'Calibri',sans-serif;font-size:11pt;font-weight:700;line-height:100%">Kyowa Kirin Co., Ltd.&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;Ardelyx, Inc.</font></div><div style="margin-bottom:4pt;text-indent:36pt"><font><br></font></div><div style="margin-bottom:4pt;text-indent:36pt"><font><br></font></div><div style="margin-bottom:4pt;text-indent:36pt"><font style="color:#000000;font-family:'Calibri',sans-serif;font-size:11pt;font-weight:400;line-height:100%;text-decoration:underline">&#47;s&#47; Yasuo Fujii&#160;&#160;&#160;&#160;</font><font style="color:#000000;font-family:'Calibri',sans-serif;font-size:11pt;font-weight:400;line-height:100%">&#160;&#160;&#160;&#160;</font><font style="color:#000000;font-family:'Calibri',sans-serif;font-size:11pt;font-weight:400;line-height:100%;text-decoration:underline">&#47;s&#47; Michael Raab&#160;&#160;&#160;&#160;</font></div><div style="margin-bottom:4pt;text-indent:36pt"><font style="color:#000000;font-family:'Calibri',sans-serif;font-size:11pt;font-weight:400;line-height:100%">Name&#58;  Yasuo Fujii&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;Name&#58; Michael Raab</font></div><div style="margin-bottom:4pt;text-indent:36pt"><font><br></font></div><div style="margin-bottom:4pt;text-indent:36pt"><font style="color:#000000;font-family:'Calibri',sans-serif;font-size:11pt;font-weight:400;line-height:100%">Title&#58;  Executive Officer, Director,  &#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;Title&#58; President and Chief Executive Officer</font></div><div style="margin-bottom:4pt"><font style="color:#000000;font-family:'Calibri',sans-serif;font-size:11pt;font-weight:400;line-height:100%">&#160;&#160;&#160;&#160;Business Development Department&#160;&#160;&#160;&#160;</font></div><div style="margin-bottom:4pt;text-indent:36pt"><font style="color:#000000;font-family:'Calibri',sans-serif;font-size:11pt;font-weight:400;line-height:100%">&#160;&#160;&#160;&#160;</font></div><div style="margin-bottom:4pt;text-indent:36pt"><font style="color:#000000;font-family:'Calibri',sans-serif;font-size:11pt;font-weight:400;line-height:100%">Date&#58; April 11th, 2022&#160;&#160;&#160;&#160;&#160;&#160;&#160;&#160;Date&#58; April 10th, 2022</font></div><div style="margin-bottom:8pt;text-align:center"><font><br></font></div><div style="height:123.84pt;position:relative;width:100%"><div style="bottom:0;position:absolute;width:100%"><div style="margin-bottom:8pt"><font style="color:#000000;font-family:'Calibri',sans-serif;font-size:11pt;font-weight:400;line-height:125%">2</font></div><div style="margin-bottom:8pt"><font><br></font></div><div style="margin-bottom:8pt"><font style="color:#000000;font-family:'Calibri',sans-serif;font-size:10pt;font-weight:400;line-height:125%">&#91;***&#93; &#61; Certain confidential information contained in this document, marked by &#91;***&#93;, has been omitted because it is both (i) not material and (ii) is the type that the registrant treats as private or confidential.</font></div><div style="margin-bottom:8pt"><font><br></font></div></div></div><hr style="page-break-after:always"><div style="min-height:79.92pt;width:100%"><div style="margin-bottom:8pt;text-align:right"><font style="color:#000000;font-family:'Calibri',sans-serif;font-size:11pt;font-style:italic;font-weight:400;line-height:125%">Execution Copy</font></div><div style="margin-bottom:8pt;text-align:right"><font><br></font></div></div><div style="margin-bottom:8pt;text-align:center"><font style="color:#000000;font-family:'Calibri',sans-serif;font-size:11pt;font-weight:700;line-height:100%">EXHIBIT A</font></div><div style="margin-bottom:12pt"><font style="color:#000000;font-family:'Calibri',sans-serif;font-size:11pt;font-weight:700;line-height:100%">Section 6.04   </font><font style="color:#000000;font-family:'Calibri',sans-serif;font-size:11pt;font-weight:700;line-height:100%;text-decoration:underline">Royalties</font><font style="color:#000000;font-family:'Calibri',sans-serif;font-size:11pt;font-weight:700;line-height:100%">.</font></div><div style="margin-bottom:12pt;text-indent:27.35pt"><font style="color:#000000;font-family:'Calibri',sans-serif;font-size:11pt;font-weight:400;line-height:100%">(a)</font><font style="color:#000000;font-family:'Calibri',sans-serif;font-size:11pt;font-weight:400;line-height:100%;padding-left:32.73pt">Subject to the provisions set forth below in Section 6.04(b) through Section 6.04(e) and Section 6.05, KKC shall pay to Ardelyx a royalty on aggregate Annual Net Sales of the Licensed Products made by KKC, its Affiliates, or its Sublicensees as follows&#58;</font></div><div style="margin-bottom:0.08pt;padding-left:27.35pt"><table style="border-collapse:collapse;display:inline-table;margin-bottom:5pt;vertical-align:text-bottom;width:85.576%"><tr><td style="width:1.0%"></td><td style="width:79.798%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:18.002%"></td><td style="width:0.1%"></td></tr><tr><td colspan="3" style="background-color:#fafafa;border-left:0.5pt solid #000000;border-top:0.5pt solid #000000;padding:2px 1pt 2px 3.77pt;text-align:left;vertical-align:top"><font style="color:#000000;font-family:'Calibri',sans-serif;font-size:11pt;font-weight:700;line-height:125%">Period</font></td><td colspan="3" style="background-color:#fafafa;border-left:0.5pt solid #000000;border-right:0.5pt solid #000000;border-top:0.5pt solid #000000;padding:2px 1pt;text-align:center;vertical-align:top"><font style="color:#000000;font-family:'Calibri',sans-serif;font-size:11pt;font-weight:700;line-height:125%">Royalty Rate</font></td></tr><tr><td colspan="3" style="border-left:0.5pt solid #000000;border-top:0.5pt solid #000000;padding:2px 1pt;text-align:left;vertical-align:top"><div style="padding-left:2.75pt;padding-right:2.75pt"><font style="color:#000000;font-family:'Calibri',sans-serif;font-size:11pt;font-weight:400;line-height:100%">The first twenty-four (24) months after First Commercial Sale  (&#8220;Royalty Period 1&#8221;) </font></div></td><td colspan="3" style="border-left:0.5pt solid #000000;border-right:0.5pt solid #000000;border-top:0.5pt solid #000000;padding:2px 1pt;text-align:center;vertical-align:top"><font style="color:#000000;font-family:'Calibri',sans-serif;font-size:11pt;font-weight:400;line-height:125%">&#91;***&#93;</font></td></tr><tr><td colspan="3" style="border-bottom:0.5pt solid #000000;border-left:0.5pt solid #000000;border-top:0.5pt solid #000000;padding:2px 1pt;text-align:left;vertical-align:top"><div style="padding-left:2.75pt;padding-right:2.75pt"><font style="color:#000000;font-family:'Calibri',sans-serif;font-size:11pt;font-weight:400;line-height:100%">&#91;***&#93; after the end of the Royalty Period 1 (&#8220;Royalty Period 2&#8221;)</font></div></td><td colspan="3" style="border-bottom:0.5pt solid #000000;border-left:0.5pt solid #000000;border-right:0.5pt solid #000000;border-top:0.5pt solid #000000;padding:2px 1pt;text-align:center;vertical-align:top"><font style="color:#000000;font-family:'Calibri',sans-serif;font-size:11pt;font-weight:400;line-height:125%">&#91;***&#93;</font></td></tr></table></div><div style="padding-left:27.35pt"><font><br></font></div><div style="margin-bottom:12pt;text-indent:27.35pt"><font style="color:#000000;font-family:'Calibri',sans-serif;font-size:11pt;font-weight:400;line-height:100%">(b)</font><font style="color:#000000;font-family:'Calibri',sans-serif;font-size:11pt;font-weight:400;line-height:100%;padding-left:32.22pt">Sales between KKC, its Affiliates and Sublicensees shall not be subject to royalties hereunder.  Royalties shall be calculated on KKC&#8217;s, its Affiliates&#8217; and Sublicensees&#8217; sales of the Licensed Products to a Third Party, including Distributors (but excluding for the avoidance of doubt Sublicensees).</font></div><div style="margin-bottom:12pt;text-indent:27.35pt"><font style="color:#000000;font-family:'Calibri',sans-serif;font-size:11pt;font-weight:400;line-height:100%">(c)</font><font style="color:#000000;font-family:'Calibri',sans-serif;font-size:11pt;font-weight:400;line-height:100%;padding-left:33.34pt">If, at any time, a Generic Product receives Regulatory Approval then the royalties that would otherwise have been payable on Net Sales of such Licensed Product in the Territory under this Agreement shall be reduced as follows&#58;</font></div><div style="margin-bottom:12pt;text-indent:54pt"><font style="color:#1f1f1f;font-family:'Calibri',sans-serif;font-size:11pt;font-weight:400;line-height:100%">(i)</font><font style="color:#000000;font-family:'Calibri',sans-serif;font-size:11pt;font-weight:400;line-height:100%;padding-left:8.82pt">Effective as of the first day of the first Calendar Quarter following the Calendar Quarter in which the NHI Price of the Licensed Product is reduced to a NHI Price being less than &#91;***&#93; of the NHI Price in effect immediately prior to the launch of the Generic Product&#58;</font></div><div style="margin-bottom:0.08pt;padding-left:27.35pt"><table style="border-collapse:collapse;display:inline-table;margin-bottom:5pt;vertical-align:text-bottom;width:85.576%"><tr><td style="width:1.0%"></td><td style="width:79.798%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:18.002%"></td><td style="width:0.1%"></td></tr><tr><td colspan="3" style="background-color:#fafafa;border-left:0.5pt solid #000000;border-top:0.5pt solid #000000;padding:2px 1pt 2px 3.77pt;text-align:left;vertical-align:top"><font style="color:#000000;font-family:'Calibri',sans-serif;font-size:11pt;font-weight:700;line-height:125%">Period</font></td><td colspan="3" style="background-color:#fafafa;border-left:0.5pt solid #000000;border-right:0.5pt solid #000000;border-top:0.5pt solid #000000;padding:2px 1pt;text-align:center;vertical-align:top"><font style="color:#000000;font-family:'Calibri',sans-serif;font-size:11pt;font-weight:700;line-height:125%">Royalty Rate</font></td></tr><tr><td colspan="3" style="border-left:0.5pt solid #000000;border-top:0.5pt solid #000000;padding:2px 1pt 2px 3.77pt;text-align:left;vertical-align:top"><font style="color:#000000;font-family:'Calibri',sans-serif;font-size:11pt;font-weight:400;line-height:125%">Royalty Period 1</font></td><td colspan="3" style="border-left:0.5pt solid #000000;border-right:0.5pt solid #000000;border-top:0.5pt solid #000000;padding:2px 1pt;text-align:center;vertical-align:top"><font style="color:#000000;font-family:'Calibri',sans-serif;font-size:11pt;font-weight:400;line-height:125%">&#91;***&#93;</font></td></tr><tr><td colspan="3" style="border-bottom:0.5pt solid #000000;border-left:0.5pt solid #000000;border-top:0.5pt solid #000000;padding:2px 1pt 2px 3.77pt;text-align:left;vertical-align:top"><font style="color:#000000;font-family:'Calibri',sans-serif;font-size:11pt;font-weight:400;line-height:125%">Royalty Period 2</font></td><td colspan="3" style="border-bottom:0.5pt solid #000000;border-left:0.5pt solid #000000;border-right:0.5pt solid #000000;border-top:0.5pt solid #000000;padding:2px 1pt;text-align:center;vertical-align:top"><font style="color:#000000;font-family:'Calibri',sans-serif;font-size:11pt;font-weight:400;line-height:125%">&#91;***&#93;</font></td></tr></table></div><div style="padding-left:27.35pt"><font><br></font></div><div style="margin-bottom:12pt;text-indent:54pt"><font style="color:#1f1f1f;font-family:'Calibri',sans-serif;font-size:11pt;font-weight:400;line-height:100%">(ii)</font><font style="color:#000000;font-family:'Calibri',sans-serif;font-size:11pt;font-weight:400;line-height:100%;padding-left:6.3pt">Effective as of the first day of the first Calendar Quarter following the Calendar Quarter in which the NHI Price of the Licensed Product is reduced to a NHI Price being less than &#91;***&#93; of the NHI Price in effect immediately prior to the launch of the Generic Product&#58;</font></div><div style="margin-bottom:0.08pt;padding-left:27.35pt"><table style="border-collapse:collapse;display:inline-table;margin-bottom:5pt;vertical-align:text-bottom;width:85.576%"><tr><td style="width:1.0%"></td><td style="width:79.798%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:18.002%"></td><td style="width:0.1%"></td></tr><tr><td colspan="3" style="background-color:#fafafa;border-left:0.5pt solid #000000;border-top:0.5pt solid #000000;padding:2px 1pt 2px 3.77pt;text-align:left;vertical-align:top"><font style="color:#000000;font-family:'Calibri',sans-serif;font-size:11pt;font-weight:700;line-height:125%">Period</font></td><td colspan="3" style="background-color:#fafafa;border-left:0.5pt solid #000000;border-right:0.5pt solid #000000;border-top:0.5pt solid #000000;padding:2px 1pt;text-align:center;vertical-align:top"><font style="color:#000000;font-family:'Calibri',sans-serif;font-size:11pt;font-weight:700;line-height:125%">Royalty Rate</font></td></tr><tr><td colspan="3" style="border-left:0.5pt solid #000000;border-top:0.5pt solid #000000;padding:2px 1pt 2px 3.77pt;text-align:left;vertical-align:top"><font style="color:#000000;font-family:'Calibri',sans-serif;font-size:11pt;font-weight:400;line-height:125%">Royalty Period 1</font></td><td colspan="3" style="border-left:0.5pt solid #000000;border-right:0.5pt solid #000000;border-top:0.5pt solid #000000;padding:2px 1pt;text-align:center;vertical-align:top"><font style="color:#000000;font-family:'Calibri',sans-serif;font-size:11pt;font-weight:400;line-height:125%">&#91;***&#93;</font></td></tr><tr><td colspan="3" style="border-bottom:0.5pt solid #000000;border-left:0.5pt solid #000000;border-top:0.5pt solid #000000;padding:2px 1pt 2px 3.77pt;text-align:left;vertical-align:top"><font style="color:#000000;font-family:'Calibri',sans-serif;font-size:11pt;font-weight:400;line-height:125%">Royalty Period 2</font></td><td colspan="3" style="border-bottom:0.5pt solid #000000;border-left:0.5pt solid #000000;border-right:0.5pt solid #000000;border-top:0.5pt solid #000000;padding:2px 1pt;text-align:center;vertical-align:top"><font style="color:#000000;font-family:'Calibri',sans-serif;font-size:11pt;font-weight:400;line-height:125%">&#91;***&#93;</font></td></tr></table></div><div style="margin-bottom:12pt;padding-left:27.35pt"><font><br></font></div><div style="margin-bottom:12pt;text-indent:27.35pt"><font style="color:#000000;font-family:'Calibri',sans-serif;font-size:11pt;font-weight:400;line-height:100%">(d)</font><font style="color:#000000;font-family:'Calibri',sans-serif;font-size:11pt;font-weight:400;line-height:100%;padding-left:32.22pt">KKC&#8217;s obligation to pay royalties due under this Section 6.04 shall commence with respect to each separate Licensed Product, on the date of the First Commercial Sale of such Licensed Product in the Territory and shall expire with respect to such Licensed Product, at the latest of&#58; (i) the &#91;***&#93; (&#91;***&#93;) anniversary of the First Commercial Sale of such Licensed Product in the Territory, (ii) the date on which there is no longer a Valid Claim that covers the Exploitation of the Licensed Product or the Licensed Compound contained within such Licensed Product in the Territory, and (iii) the expiration of all Regulatory Exclusivities associated with the indication of &#91;***&#93; for such Licensed Product in the Territory&#59; provided that (i) under no circumstances shall KKC have an obligation to pay royalties to Ardelyx after the end of the Royalty Period 2 and (ii) in the event that the only Valid Claim that claims </font></div><div style="height:123.84pt;position:relative;width:100%"><div style="bottom:0;position:absolute;width:100%"><div style="margin-bottom:8pt"><font style="color:#000000;font-family:'Calibri',sans-serif;font-size:11pt;font-weight:400;line-height:125%">3</font></div><div style="margin-bottom:8pt"><font><br></font></div><div style="margin-bottom:8pt"><font style="color:#000000;font-family:'Calibri',sans-serif;font-size:10pt;font-weight:400;line-height:125%">&#91;***&#93; &#61; Certain confidential information contained in this document, marked by &#91;***&#93;, has been omitted because it is both (i) not material and (ii) is the type that the registrant treats as private or confidential.</font></div><div style="margin-bottom:8pt"><font><br></font></div></div></div><hr style="page-break-after:always"><div style="min-height:79.92pt;width:100%"><div style="margin-bottom:8pt;text-align:right"><font style="color:#000000;font-family:'Calibri',sans-serif;font-size:11pt;font-style:italic;font-weight:400;line-height:125%">Execution Copy</font></div><div style="margin-bottom:8pt;text-align:right"><font><br></font></div></div><div style="margin-bottom:12pt"><font style="color:#000000;font-family:'Calibri',sans-serif;font-size:11pt;font-weight:400;line-height:100%">the Licensed Product is a &#91;***&#93;, the royalty that would otherwise have been payable on Net Sales of such Licensed Product shall be reduced as follows, subject to the reduction of the Third Party Compensation set out in Section 6.04(e). </font></div><div style="margin-bottom:0.08pt;padding-left:27.35pt"><table style="border-collapse:collapse;display:inline-table;margin-bottom:5pt;vertical-align:text-bottom;width:85.576%"><tr><td style="width:1.0%"></td><td style="width:79.798%"></td><td style="width:0.1%"></td><td style="width:1.0%"></td><td style="width:18.002%"></td><td style="width:0.1%"></td></tr><tr><td colspan="3" style="background-color:#fafafa;border-left:0.5pt solid #000000;border-top:0.5pt solid #000000;padding:2px 1pt 2px 3.77pt;text-align:left;vertical-align:top"><font style="color:#000000;font-family:'Calibri',sans-serif;font-size:11pt;font-weight:700;line-height:125%">Period</font></td><td colspan="3" style="background-color:#fafafa;border-left:0.5pt solid #000000;border-right:0.5pt solid #000000;border-top:0.5pt solid #000000;padding:2px 1pt;text-align:center;vertical-align:top"><font style="color:#000000;font-family:'Calibri',sans-serif;font-size:11pt;font-weight:700;line-height:125%">Royalty Rate</font></td></tr><tr><td colspan="3" style="border-left:0.5pt solid #000000;border-top:0.5pt solid #000000;padding:2px 1pt 2px 3.77pt;text-align:left;vertical-align:top"><font style="color:#000000;font-family:'Calibri',sans-serif;font-size:11pt;font-weight:400;line-height:125%">Royalty Period 1</font></td><td colspan="3" style="border-left:0.5pt solid #000000;border-right:0.5pt solid #000000;border-top:0.5pt solid #000000;padding:2px 1pt;text-align:center;vertical-align:top"><font style="color:#000000;font-family:'Calibri',sans-serif;font-size:11pt;font-weight:400;line-height:125%">&#91;***&#93;</font></td></tr><tr><td colspan="3" style="border-bottom:0.5pt solid #000000;border-left:0.5pt solid #000000;border-top:0.5pt solid #000000;padding:2px 1pt 2px 3.77pt;text-align:left;vertical-align:top"><font style="color:#000000;font-family:'Calibri',sans-serif;font-size:11pt;font-weight:400;line-height:125%">Royalty Period 2</font></td><td colspan="3" style="border-bottom:0.5pt solid #000000;border-left:0.5pt solid #000000;border-right:0.5pt solid #000000;border-top:0.5pt solid #000000;padding:2px 1pt;text-align:center;vertical-align:top"><font style="color:#000000;font-family:'Calibri',sans-serif;font-size:11pt;font-weight:400;line-height:125%">&#91;***&#93;</font></td></tr></table></div><div style="padding-left:27.35pt"><font><br></font></div><div style="margin-bottom:12pt"><font style="color:#000000;font-family:'Calibri',sans-serif;font-size:11pt;font-weight:400;line-height:100%">At such time as KKC&#8217;s obligation to pay royalties under this Section 6.04 has expired with respect to a Licensed Product, the license granted to KKC under Section 2.01 shall automatically, and without further action on the part of Ardelyx or KKC, become non-exclusive, fully-paid, irrevocable and perpetual with respect to such Licensed Product and the Net Sales of such Licensed Product shall be excluded from royalty calculations under this Section 6.04 (including for purposes of applying thresholds and ceilings) and shall be excluded from the sales milestones set forth in Section 6.03.</font></div><div style="margin-bottom:12pt;text-indent:27pt"><font style="color:#000000;font-family:'Calibri',sans-serif;font-size:11pt;font-weight:400;line-height:100%">(e)</font><font style="color:#000000;font-family:'Calibri',sans-serif;font-size:11pt;font-weight:400;line-height:100%;padding-left:32.87pt">If, during the Term, (i) KKC obtains a license to Exploit any Third Party Patent in the Territory that (i) &#91;***&#93; required for KKC to Develop, Manufacture and Commercialize the Lead Licensed Compound or the Lead Licensed Product (as Manufactured and formulated by Ardelyx prior to the transfer of the responsibility to KKC for the Manufacture of Lead Licensed Product and with regard to the Lead Licensed Compound prior to the exercise of the Manufacturing Option, if such exercise occurred) in accordance with the terms of this Agreement &#91;***&#93;, and (ii) which &#91;***&#93; would, in the absence of such license, be infringed by the Development, Manufacture or Commercialization of the Licensed Compound or the Licensed Product (as Manufactured and formulated by Ardelyx prior to the transfer of the responsibility to KKC for the Manufacture of the Lead Licensed Product and with regard to the Lead Licensed Compound prior to the exercise of the Manufacturing Option, if such exercise occurred) in the Territory &#91;***&#93;, (iii) KKC does not have any other &#91;***&#93; available to avoid such infringement, and (iv) KKC is required to pay to such Third Party a royalty, milestone payments or other monetary compensation in consideration for the grant of such license (&#8220;</font><font style="color:#000000;font-family:'Calibri',sans-serif;font-size:11pt;font-weight:700;line-height:100%">Third Party Compensation</font><font style="color:#000000;font-family:'Calibri',sans-serif;font-size:11pt;font-weight:400;line-height:100%">&#34;), then for the period during which KKC owes royalties to Ardelyx hereunder, the amounts that would otherwise have been payable as royalties to Ardelyx under this Agreement shall be reduced by &#91;***&#93; Third Party Compensation payable by or on behalf of KKC to such Third Party&#59; provided, however, that in no event shall the amount of the royalties payable by KKC to Ardelyx be reduced by more than &#91;***&#93; percent (&#91;***&#93;).  </font></div><div style="margin-bottom:8pt"><font><br></font></div><div style="height:123.84pt;position:relative;width:100%"><div style="bottom:0;position:absolute;width:100%"><div style="margin-bottom:8pt"><font style="color:#000000;font-family:'Calibri',sans-serif;font-size:11pt;font-weight:400;line-height:125%">4</font></div><div style="margin-bottom:8pt"><font><br></font></div><div style="margin-bottom:8pt"><font style="color:#000000;font-family:'Calibri',sans-serif;font-size:10pt;font-weight:400;line-height:125%">&#91;***&#93; &#61; Certain confidential information contained in this document, marked by &#91;***&#93;, has been omitted because it is both (i) not material and (ii) is the type that the registrant treats as private or confidential.</font></div><div style="margin-bottom:8pt"><font><br></font></div></div></div><hr style="page-break-after:always"><div style="min-height:79.92pt;width:100%"><div style="margin-bottom:8pt;text-align:right"><font style="color:#000000;font-family:'Calibri',sans-serif;font-size:11pt;font-style:italic;font-weight:400;line-height:125%">Execution Copy</font></div><div style="margin-bottom:8pt;text-align:right"><font><br></font></div></div><div style="margin-bottom:12pt"><font style="color:#000000;font-family:'Calibri',sans-serif;font-size:11pt;font-weight:700;line-height:100%">Section 11.04 Consequences of Ardelyx Triggered Termination (or Right to Terminate) .</font></div><div style="margin-bottom:12pt"><font style="color:#000000;font-family:'Calibri',sans-serif;font-size:11pt;font-weight:400;line-height:100%">If KKC is entitled to terminate this Agreement pursuant to Section 11.02 (a) as a result of a material breach by Ardelyx or Section 11.02 (e) for an insolvency or other transaction described therein affecting Ardelyx, KKC may elect to terminate this Agreement subject to the provisions set forth in Section 11.04 (a), or to continue the Agreement subject to the provisions set forth in Section 11.04 (b).</font></div><div style="padding-left:36pt;text-indent:-18pt"><font style="color:#000000;font-family:'Calibri',sans-serif;font-size:11pt;font-weight:400;line-height:125%">(a)</font><font style="color:#000000;font-family:'Calibri',sans-serif;font-size:11pt;font-weight:400;line-height:125%;padding-left:6.08pt">If KKC terminates the Agreement under Section 11.02 (a) or under Section 11.02 (e), Section 11.03 shall apply as if such termination were an KKC Triggered Termination, except that (i) &#91;***&#93; and (ii) in consideration of the &#91;***&#93; and any other rights granted under the above provisions in Section 11.03, if this Agreement is terminated pursuant to Section 11.02 (a) by KKC after the First Commercial Sale of the Licensed Product in the Territory, Ardelyx shall &#91;***&#93;&#59; provided however that the &#91;***&#93;. The foregoing shall be &#91;***&#93;in connection with its termination pursuant to Section 11.02(a).</font></div><div style="padding-left:108pt;text-indent:-18pt"><font style="color:#000000;font-family:'Calibri',sans-serif;font-size:11pt;font-weight:400;line-height:125%">(i)</font><font style="color:#000000;font-family:'Calibri',sans-serif;font-size:11pt;font-weight:400;line-height:125%;padding-left:8.82pt">&#91;***&#93;&#59; and</font></div><div style="padding-left:108pt;text-indent:-18pt"><font style="color:#000000;font-family:'Calibri',sans-serif;font-size:11pt;font-weight:400;line-height:125%">(ii)</font><font style="color:#000000;font-family:'Calibri',sans-serif;font-size:11pt;font-weight:400;line-height:125%;padding-left:6.3pt"> &#91;***&#93;</font><font style="color:#000000;font-family:'Calibri',sans-serif;font-size:11pt;font-weight:400;line-height:125%;text-decoration:underline">.</font><font style="color:#000000;font-family:'Calibri',sans-serif;font-size:11pt;font-weight:400;line-height:125%"> </font></div><div style="padding-left:108pt"><font><br></font></div><div style="padding-left:36pt;text-indent:-18pt"><font style="color:#000000;font-family:'Calibri',sans-serif;font-size:11pt;font-weight:400;line-height:125%">(b)</font><font style="color:#000000;font-family:'Calibri',sans-serif;font-size:11pt;font-weight:400;line-height:125%;padding-left:5.57pt">If KKC has the right to terminate this Agreement under Section 11.02 (a) or Section 11.02 (e), but elects to continue this Agreement, this Agreement shall continue in full force and effect except that if KKC is entitled to terminate this Agreement under Section 11.02 (a) due to Ardelyx breach (but not if KKC&#8217;s right to terminate is based solely on Ardelyx&#8217;s insolvency pursuant to Section 11.02 (e)), the royalties that Ardelyx shall be entitled to receive on Net Sales of Licensed Products by KKC, its Affiliates, or its Sublicensees as set forth in Section 6.04 shall each be reduced to &#91;***&#93;percent (&#91;***&#93;) in Royalty Period 1 and &#91;***&#93; percent (&#91;***&#93;) in Royalty Period 2, provided that when a Generic Product is launched in the Territory, the royalty rate shall be further reduced to &#91;***&#93; percent (&#91;***&#93;) in Royalty Period 1 and &#91;***&#93; percent (&#91;***&#93;) in Royalty Period 2, subject to the reduction of the Third Party Compensation as set out in Section 6.04 (e).</font></div><div style="padding-left:36pt"><font><br></font></div><div style="padding-left:90pt"><font><br></font></div><div style="margin-bottom:8pt;padding-left:36pt;text-indent:-18pt"><font style="color:#000000;font-family:'Calibri',sans-serif;font-size:11pt;font-weight:400;line-height:125%">(c)</font><font style="color:#000000;font-family:'Calibri',sans-serif;font-size:11pt;font-weight:400;line-height:125%;padding-left:6.69pt">Except where expressly provided for otherwise in this Agreement, termination of this Agreement by either Party shall not relieve the Parties of any liability, including without limitation any obligation to make payments hereunder, which accrued hereunder prior to the effective date of such termination, nor preclude any Party from pursuing all rights and remedies it may have hereunder or at law or in equity with respect to any breach of this Agreement, nor prejudice any Party&#8217;s right to obtain performance of any obligation.  In the event of such termination, this Section 11.04 (c) shall survive in addition to others specified in this Agreement to survive in such event.</font></div><div style="margin-bottom:12pt"><font><br></font></div><div style="height:123.84pt;position:relative;width:100%"><div style="bottom:0;position:absolute;width:100%"><div style="margin-bottom:8pt"><font style="color:#000000;font-family:'Calibri',sans-serif;font-size:11pt;font-weight:400;line-height:125%">5</font></div><div style="margin-bottom:8pt"><font><br></font></div><div style="margin-bottom:8pt"><font style="color:#000000;font-family:'Calibri',sans-serif;font-size:10pt;font-weight:400;line-height:125%">&#91;***&#93; &#61; Certain confidential information contained in this document, marked by &#91;***&#93;, has been omitted because it is both (i) not material and (ii) is the type that the registrant treats as private or confidential.</font></div><div style="margin-bottom:8pt"><font><br></font></div></div></div></body></html>
</TEXT>
</DOCUMENT>
<DOCUMENT>
<TYPE>EX-101.SCH
<SEQUENCE>3
<FILENAME>ardx-20220411.xsd
<DESCRIPTION>XBRL TAXONOMY EXTENSION SCHEMA DOCUMENT
<TEXT>
<XBRL>
<?xml version="1.0" encoding="UTF-8"?>

<!--XBRL Document Created with Wdesk from Workiva-->
<!--Copyright 2022 Workiva-->
<!--r:ccbc2cf6-bdac-4e54-a5fb-ff8da01c5702,g:17174ae8-15b0-41fd-aa71-1c7a2f40728e-->
<xs:schema xmlns:xs="http://www.w3.org/2001/XMLSchema" xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:ardx="http://www.ardelyx.com/20220411" attributeFormDefault="unqualified" elementFormDefault="qualified" targetNamespace="http://www.ardelyx.com/20220411">
  <xs:import namespace="http://www.w3.org/1999/xlink" schemaLocation="http://www.xbrl.org/2003/xlink-2003-12-31.xsd"/>
  <xs:import namespace="http://www.xbrl.org/2003/instance" schemaLocation="http://www.xbrl.org/2003/xbrl-instance-2003-12-31.xsd"/>
  <xs:import namespace="http://www.xbrl.org/2003/linkbase" schemaLocation="http://www.xbrl.org/2003/xbrl-linkbase-2003-12-31.xsd"/>
  <xs:import namespace="http://xbrl.sec.gov/dei/2021" schemaLocation="https://xbrl.sec.gov/dei/2021/dei-2021.xsd"/>
  <xs:annotation>
    <xs:appinfo>
      <link:linkbaseRef xmlns:xlink="http://www.w3.org/1999/xlink" xlink:arcrole="http://www.w3.org/1999/xlink/properties/linkbase" xlink:href="ardx-20220411_lab.xml" xlink:role="http://www.xbrl.org/2003/role/labelLinkbaseRef" xlink:type="simple"/>
      <link:linkbaseRef xmlns:xlink="http://www.w3.org/1999/xlink" xlink:arcrole="http://www.w3.org/1999/xlink/properties/linkbase" xlink:href="ardx-20220411_pre.xml" xlink:role="http://www.xbrl.org/2003/role/presentationLinkbaseRef" xlink:type="simple"/>
      <link:roleType id="Cover" roleURI="http://www.ardelyx.com/role/Cover">
        <link:definition>0001001 - Document - Cover</link:definition>
        <link:usedOn>link:presentationLink</link:usedOn>
        <link:usedOn>link:calculationLink</link:usedOn>
        <link:usedOn>link:definitionLink</link:usedOn>
      </link:roleType>
    </xs:appinfo>
  </xs:annotation>
</xs:schema>
</XBRL>
</TEXT>
</DOCUMENT>
<DOCUMENT>
<TYPE>EX-101.LAB
<SEQUENCE>4
<FILENAME>ardx-20220411_lab.xml
<DESCRIPTION>XBRL TAXONOMY EXTENSION LABEL LINKBASE DOCUMENT
<TEXT>
<XBRL>
<?xml version="1.0" encoding="UTF-8"?>

<!--XBRL Document Created with Wdesk from Workiva-->
<!--Copyright 2022 Workiva-->
<!--r:ccbc2cf6-bdac-4e54-a5fb-ff8da01c5702,g:17174ae8-15b0-41fd-aa71-1c7a2f40728e-->
<link:linkbase xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.xbrl.org/2003/linkbase http://www.xbrl.org/2003/xbrl-linkbase-2003-12-31.xsd">
  <link:roleRef roleURI="http://www.xbrl.org/2009/role/negatedPeriodStartLabel" xlink:type="simple" xlink:href="http://www.xbrl.org/lrr/role/negated-2009-12-16.xsd#negatedPeriodStartLabel"/>
  <link:roleRef roleURI="http://www.xbrl.org/2009/role/netLabel" xlink:type="simple" xlink:href="http://www.xbrl.org/lrr/role/net-2009-12-16.xsd#netLabel"/>
  <link:roleRef roleURI="http://www.xbrl.org/2009/role/negatedNetLabel" xlink:type="simple" xlink:href="http://www.xbrl.org/lrr/role/negated-2009-12-16.xsd#negatedNetLabel"/>
  <link:roleRef roleURI="http://www.xbrl.org/2009/role/negatedTerseLabel" xlink:type="simple" xlink:href="http://www.xbrl.org/lrr/role/negated-2009-12-16.xsd#negatedTerseLabel"/>
  <link:roleRef roleURI="http://www.xbrl.org/2009/role/negatedPeriodEndLabel" xlink:type="simple" xlink:href="http://www.xbrl.org/lrr/role/negated-2009-12-16.xsd#negatedPeriodEndLabel"/>
  <link:roleRef roleURI="http://www.xbrl.org/2009/role/negatedLabel" xlink:type="simple" xlink:href="http://www.xbrl.org/lrr/role/negated-2009-12-16.xsd#negatedLabel"/>
  <link:roleRef roleURI="http://www.xbrl.org/2009/role/negatedTotalLabel" xlink:type="simple" xlink:href="http://www.xbrl.org/lrr/role/negated-2009-12-16.xsd#negatedTotalLabel"/>
  <link:labelLink xlink:role="http://www.xbrl.org/2003/role/link" xlink:type="extended">
    <link:label id="lab_dei_PreCommencementTenderOffer_b1290c8a-b974-4640-a21d-a2a187bb6565_terseLabel_en-US" xlink:label="lab_dei_PreCommencementTenderOffer" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Pre-commencement Tender Offer</link:label>
    <link:label id="lab_dei_PreCommencementTenderOffer_label_en-US" xlink:label="lab_dei_PreCommencementTenderOffer" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Pre-commencement Tender Offer</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_dei_PreCommencementTenderOffer" xlink:href="https://xbrl.sec.gov/dei/2021/dei-2021.xsd#dei_PreCommencementTenderOffer"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_dei_PreCommencementTenderOffer" xlink:to="lab_dei_PreCommencementTenderOffer" xlink:type="arc" order="1"/>
    <link:label id="lab_dei_AmendmentFlag_fe4edd2d-4c47-4387-8891-3595e2ef578b_terseLabel_en-US" xlink:label="lab_dei_AmendmentFlag" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Amendment Flag</link:label>
    <link:label id="lab_dei_AmendmentFlag_label_en-US" xlink:label="lab_dei_AmendmentFlag" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Amendment Flag</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_dei_AmendmentFlag" xlink:href="https://xbrl.sec.gov/dei/2021/dei-2021.xsd#dei_AmendmentFlag"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_dei_AmendmentFlag" xlink:to="lab_dei_AmendmentFlag" xlink:type="arc" order="1"/>
    <link:label id="lab_dei_EntityAddressStateOrProvince_01e5d86b-b54d-4178-a7d0-d088b60bbf70_terseLabel_en-US" xlink:label="lab_dei_EntityAddressStateOrProvince" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Entity Address, State or Province</link:label>
    <link:label id="lab_dei_EntityAddressStateOrProvince_label_en-US" xlink:label="lab_dei_EntityAddressStateOrProvince" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Entity Address, State or Province</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressStateOrProvince" xlink:href="https://xbrl.sec.gov/dei/2021/dei-2021.xsd#dei_EntityAddressStateOrProvince"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_dei_EntityAddressStateOrProvince" xlink:to="lab_dei_EntityAddressStateOrProvince" xlink:type="arc" order="1"/>
    <link:label id="lab_dei_EntityTaxIdentificationNumber_f3786e29-1666-4b2d-ab77-ee249f8b1161_terseLabel_en-US" xlink:label="lab_dei_EntityTaxIdentificationNumber" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Entity Tax Identification Number</link:label>
    <link:label id="lab_dei_EntityTaxIdentificationNumber_label_en-US" xlink:label="lab_dei_EntityTaxIdentificationNumber" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Entity Tax Identification Number</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityTaxIdentificationNumber" xlink:href="https://xbrl.sec.gov/dei/2021/dei-2021.xsd#dei_EntityTaxIdentificationNumber"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_dei_EntityTaxIdentificationNumber" xlink:to="lab_dei_EntityTaxIdentificationNumber" xlink:type="arc" order="1"/>
    <link:label id="lab_dei_Security12bTitle_e91fd8ac-0f2f-4358-8b59-ce95c2916fa8_terseLabel_en-US" xlink:label="lab_dei_Security12bTitle" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Title of 12(b) Security</link:label>
    <link:label id="lab_dei_Security12bTitle_label_en-US" xlink:label="lab_dei_Security12bTitle" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Title of 12(b) Security</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_dei_Security12bTitle" xlink:href="https://xbrl.sec.gov/dei/2021/dei-2021.xsd#dei_Security12bTitle"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_dei_Security12bTitle" xlink:to="lab_dei_Security12bTitle" xlink:type="arc" order="1"/>
    <link:label id="lab_dei_EntityFileNumber_b57bdc19-070a-4192-a2d4-83fd648856d8_terseLabel_en-US" xlink:label="lab_dei_EntityFileNumber" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Entity File Number</link:label>
    <link:label id="lab_dei_EntityFileNumber_label_en-US" xlink:label="lab_dei_EntityFileNumber" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Entity File Number</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityFileNumber" xlink:href="https://xbrl.sec.gov/dei/2021/dei-2021.xsd#dei_EntityFileNumber"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_dei_EntityFileNumber" xlink:to="lab_dei_EntityFileNumber" xlink:type="arc" order="1"/>
    <link:label id="lab_dei_WrittenCommunications_979d2a22-52cf-49fc-a5ac-8aed3b2a7706_terseLabel_en-US" xlink:label="lab_dei_WrittenCommunications" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Written Communications</link:label>
    <link:label id="lab_dei_WrittenCommunications_label_en-US" xlink:label="lab_dei_WrittenCommunications" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Written Communications</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_dei_WrittenCommunications" xlink:href="https://xbrl.sec.gov/dei/2021/dei-2021.xsd#dei_WrittenCommunications"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_dei_WrittenCommunications" xlink:to="lab_dei_WrittenCommunications" xlink:type="arc" order="1"/>
    <link:label id="lab_dei_PreCommencementIssuerTenderOffer_8bf5d9fa-09f5-4b29-80fb-e31f862b5f4f_terseLabel_en-US" xlink:label="lab_dei_PreCommencementIssuerTenderOffer" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Pre-commencement Issuer Tender Offer</link:label>
    <link:label id="lab_dei_PreCommencementIssuerTenderOffer_label_en-US" xlink:label="lab_dei_PreCommencementIssuerTenderOffer" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Pre-commencement Issuer Tender Offer</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_dei_PreCommencementIssuerTenderOffer" xlink:href="https://xbrl.sec.gov/dei/2021/dei-2021.xsd#dei_PreCommencementIssuerTenderOffer"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_dei_PreCommencementIssuerTenderOffer" xlink:to="lab_dei_PreCommencementIssuerTenderOffer" xlink:type="arc" order="1"/>
    <link:label id="lab_dei_EntityEmergingGrowthCompany_823969ea-06f6-42dc-b064-0fdf454798ce_terseLabel_en-US" xlink:label="lab_dei_EntityEmergingGrowthCompany" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Entity Emerging Growth Company</link:label>
    <link:label id="lab_dei_EntityEmergingGrowthCompany_label_en-US" xlink:label="lab_dei_EntityEmergingGrowthCompany" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Entity Emerging Growth Company</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityEmergingGrowthCompany" xlink:href="https://xbrl.sec.gov/dei/2021/dei-2021.xsd#dei_EntityEmergingGrowthCompany"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_dei_EntityEmergingGrowthCompany" xlink:to="lab_dei_EntityEmergingGrowthCompany" xlink:type="arc" order="1"/>
    <link:label id="lab_dei_TradingSymbol_1a821fb7-234b-4d5c-8d64-a1c9abe79897_terseLabel_en-US" xlink:label="lab_dei_TradingSymbol" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Trading Symbol</link:label>
    <link:label id="lab_dei_TradingSymbol_label_en-US" xlink:label="lab_dei_TradingSymbol" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Trading Symbol</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_dei_TradingSymbol" xlink:href="https://xbrl.sec.gov/dei/2021/dei-2021.xsd#dei_TradingSymbol"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_dei_TradingSymbol" xlink:to="lab_dei_TradingSymbol" xlink:type="arc" order="1"/>
    <link:label id="lab_dei_DocumentPeriodEndDate_cf939ffd-1f69-4025-b1bb-375e0dd252ae_terseLabel_en-US" xlink:label="lab_dei_DocumentPeriodEndDate" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Document Period End Date</link:label>
    <link:label id="lab_dei_DocumentPeriodEndDate_label_en-US" xlink:label="lab_dei_DocumentPeriodEndDate" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Document Period End Date</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_dei_DocumentPeriodEndDate" xlink:href="https://xbrl.sec.gov/dei/2021/dei-2021.xsd#dei_DocumentPeriodEndDate"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_dei_DocumentPeriodEndDate" xlink:to="lab_dei_DocumentPeriodEndDate" xlink:type="arc" order="1"/>
    <link:label id="lab_dei_SolicitingMaterial_b5693b81-6730-4df4-ab7b-d724efa187d6_terseLabel_en-US" xlink:label="lab_dei_SolicitingMaterial" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Soliciting Material</link:label>
    <link:label id="lab_dei_SolicitingMaterial_label_en-US" xlink:label="lab_dei_SolicitingMaterial" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Soliciting Material</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_dei_SolicitingMaterial" xlink:href="https://xbrl.sec.gov/dei/2021/dei-2021.xsd#dei_SolicitingMaterial"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_dei_SolicitingMaterial" xlink:to="lab_dei_SolicitingMaterial" xlink:type="arc" order="1"/>
    <link:label id="lab_dei_DocumentType_628df019-e0be-4af7-88ce-44a30326717c_terseLabel_en-US" xlink:label="lab_dei_DocumentType" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Document Type</link:label>
    <link:label id="lab_dei_DocumentType_label_en-US" xlink:label="lab_dei_DocumentType" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Document Type</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_dei_DocumentType" xlink:href="https://xbrl.sec.gov/dei/2021/dei-2021.xsd#dei_DocumentType"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_dei_DocumentType" xlink:to="lab_dei_DocumentType" xlink:type="arc" order="1"/>
    <link:label id="lab_dei_CityAreaCode_ec91ff92-511d-4b9b-892b-5d1eca3b6519_terseLabel_en-US" xlink:label="lab_dei_CityAreaCode" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">City Area Code</link:label>
    <link:label id="lab_dei_CityAreaCode_label_en-US" xlink:label="lab_dei_CityAreaCode" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">City Area Code</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_dei_CityAreaCode" xlink:href="https://xbrl.sec.gov/dei/2021/dei-2021.xsd#dei_CityAreaCode"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_dei_CityAreaCode" xlink:to="lab_dei_CityAreaCode" xlink:type="arc" order="1"/>
    <link:label id="lab_dei_EntityIncorporationStateCountryCode_e8e27a21-893a-41b2-aa58-0a9d022bab2e_terseLabel_en-US" xlink:label="lab_dei_EntityIncorporationStateCountryCode" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Entity Incorporation, State or Country Code</link:label>
    <link:label id="lab_dei_EntityIncorporationStateCountryCode_label_en-US" xlink:label="lab_dei_EntityIncorporationStateCountryCode" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Entity Incorporation, State or Country Code</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityIncorporationStateCountryCode" xlink:href="https://xbrl.sec.gov/dei/2021/dei-2021.xsd#dei_EntityIncorporationStateCountryCode"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_dei_EntityIncorporationStateCountryCode" xlink:to="lab_dei_EntityIncorporationStateCountryCode" xlink:type="arc" order="1"/>
    <link:label id="lab_dei_EntityAddressAddressLine1_0b792484-4bee-4410-9e09-4b112fd3c4ce_terseLabel_en-US" xlink:label="lab_dei_EntityAddressAddressLine1" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Entity Address, Address Line One</link:label>
    <link:label id="lab_dei_EntityAddressAddressLine1_label_en-US" xlink:label="lab_dei_EntityAddressAddressLine1" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Entity Address, Address Line One</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressAddressLine1" xlink:href="https://xbrl.sec.gov/dei/2021/dei-2021.xsd#dei_EntityAddressAddressLine1"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_dei_EntityAddressAddressLine1" xlink:to="lab_dei_EntityAddressAddressLine1" xlink:type="arc" order="1"/>
    <link:label id="lab_dei_EntityRegistrantName_0452f578-1643-4e02-8307-db70444714b5_terseLabel_en-US" xlink:label="lab_dei_EntityRegistrantName" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Entity Registrant Name</link:label>
    <link:label id="lab_dei_EntityRegistrantName_label_en-US" xlink:label="lab_dei_EntityRegistrantName" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Entity Registrant Name</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityRegistrantName" xlink:href="https://xbrl.sec.gov/dei/2021/dei-2021.xsd#dei_EntityRegistrantName"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_dei_EntityRegistrantName" xlink:to="lab_dei_EntityRegistrantName" xlink:type="arc" order="1"/>
    <link:label id="lab_dei_EntityAddressAddressLine2_7b2254e2-0ab9-4e3d-a7f6-684bd9b92ec1_terseLabel_en-US" xlink:label="lab_dei_EntityAddressAddressLine2" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Entity Address, Address Line Two</link:label>
    <link:label id="lab_dei_EntityAddressAddressLine2_label_en-US" xlink:label="lab_dei_EntityAddressAddressLine2" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Entity Address, Address Line Two</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressAddressLine2" xlink:href="https://xbrl.sec.gov/dei/2021/dei-2021.xsd#dei_EntityAddressAddressLine2"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_dei_EntityAddressAddressLine2" xlink:to="lab_dei_EntityAddressAddressLine2" xlink:type="arc" order="1"/>
    <link:label id="lab_dei_LocalPhoneNumber_145b767b-928a-421c-8d05-652c28436cda_terseLabel_en-US" xlink:label="lab_dei_LocalPhoneNumber" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Local Phone Number</link:label>
    <link:label id="lab_dei_LocalPhoneNumber_label_en-US" xlink:label="lab_dei_LocalPhoneNumber" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Local Phone Number</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_dei_LocalPhoneNumber" xlink:href="https://xbrl.sec.gov/dei/2021/dei-2021.xsd#dei_LocalPhoneNumber"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_dei_LocalPhoneNumber" xlink:to="lab_dei_LocalPhoneNumber" xlink:type="arc" order="1"/>
    <link:label id="lab_dei_EntityAddressCityOrTown_39627c71-a2cc-4d3c-aba0-428891b225c8_terseLabel_en-US" xlink:label="lab_dei_EntityAddressCityOrTown" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Entity Address, City or Town</link:label>
    <link:label id="lab_dei_EntityAddressCityOrTown_label_en-US" xlink:label="lab_dei_EntityAddressCityOrTown" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Entity Address, City or Town</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressCityOrTown" xlink:href="https://xbrl.sec.gov/dei/2021/dei-2021.xsd#dei_EntityAddressCityOrTown"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_dei_EntityAddressCityOrTown" xlink:to="lab_dei_EntityAddressCityOrTown" xlink:type="arc" order="1"/>
    <link:label id="lab_dei_CoverAbstract_label_en-US" xlink:label="lab_dei_CoverAbstract" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Cover [Abstract]</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_dei_CoverAbstract" xlink:href="https://xbrl.sec.gov/dei/2021/dei-2021.xsd#dei_CoverAbstract"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_dei_CoverAbstract" xlink:to="lab_dei_CoverAbstract" xlink:type="arc" order="1"/>
    <link:label id="lab_dei_EntityAddressPostalZipCode_cbb19e49-0c23-4af6-ad81-1fbabec20244_terseLabel_en-US" xlink:label="lab_dei_EntityAddressPostalZipCode" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Entity Address, Postal Zip Code</link:label>
    <link:label id="lab_dei_EntityAddressPostalZipCode_label_en-US" xlink:label="lab_dei_EntityAddressPostalZipCode" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Entity Address, Postal Zip Code</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressPostalZipCode" xlink:href="https://xbrl.sec.gov/dei/2021/dei-2021.xsd#dei_EntityAddressPostalZipCode"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_dei_EntityAddressPostalZipCode" xlink:to="lab_dei_EntityAddressPostalZipCode" xlink:type="arc" order="1"/>
    <link:label id="lab_dei_EntityCentralIndexKey_0c24bd75-e66f-4cd4-8bbc-0e9cbd0ee696_terseLabel_en-US" xlink:label="lab_dei_EntityCentralIndexKey" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Entity Central Index Key</link:label>
    <link:label id="lab_dei_EntityCentralIndexKey_label_en-US" xlink:label="lab_dei_EntityCentralIndexKey" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Entity Central Index Key</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityCentralIndexKey" xlink:href="https://xbrl.sec.gov/dei/2021/dei-2021.xsd#dei_EntityCentralIndexKey"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_dei_EntityCentralIndexKey" xlink:to="lab_dei_EntityCentralIndexKey" xlink:type="arc" order="1"/>
    <link:label id="lab_dei_SecurityExchangeName_9af91ca2-0ba1-477d-9d72-e4fcd5b0fbd4_terseLabel_en-US" xlink:label="lab_dei_SecurityExchangeName" xlink:role="http://www.xbrl.org/2003/role/terseLabel" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Security Exchange Name</link:label>
    <link:label id="lab_dei_SecurityExchangeName_label_en-US" xlink:label="lab_dei_SecurityExchangeName" xlink:role="http://www.xbrl.org/2003/role/label" xlink:type="resource" xmlns:xml="http://www.w3.org/XML/1998/namespace" xml:lang="en-US">Security Exchange Name</link:label>
    <link:loc xlink:type="locator" xlink:label="loc_dei_SecurityExchangeName" xlink:href="https://xbrl.sec.gov/dei/2021/dei-2021.xsd#dei_SecurityExchangeName"/>
    <link:labelArc xlink:arcrole="http://www.xbrl.org/2003/arcrole/concept-label" xlink:from="loc_dei_SecurityExchangeName" xlink:to="lab_dei_SecurityExchangeName" xlink:type="arc" order="1"/>
  </link:labelLink>
</link:linkbase>
</XBRL>
</TEXT>
</DOCUMENT>
<DOCUMENT>
<TYPE>EX-101.PRE
<SEQUENCE>5
<FILENAME>ardx-20220411_pre.xml
<DESCRIPTION>XBRL TAXONOMY EXTENSION PRESENTATION LINKBASE DOCUMENT
<TEXT>
<XBRL>
<?xml version="1.0" encoding="UTF-8"?>

<!--XBRL Document Created with Wdesk from Workiva-->
<!--Copyright 2022 Workiva-->
<!--r:ccbc2cf6-bdac-4e54-a5fb-ff8da01c5702,g:17174ae8-15b0-41fd-aa71-1c7a2f40728e-->
<link:linkbase xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.xbrl.org/2003/linkbase http://www.xbrl.org/2003/xbrl-linkbase-2003-12-31.xsd">
  <link:roleRef roleURI="http://www.ardelyx.com/role/Cover" xlink:type="simple" xlink:href="ardx-20220411.xsd#Cover"/>
  <link:presentationLink xlink:role="http://www.ardelyx.com/role/Cover" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_dei_CoverAbstract_6486856e-2f2c-4fd2-9a76-2745c8d6f233" xlink:href="https://xbrl.sec.gov/dei/2021/dei-2021.xsd#dei_CoverAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_DocumentType_8b8cfaea-c04c-49db-a64f-afb2975b2379" xlink:href="https://xbrl.sec.gov/dei/2021/dei-2021.xsd#dei_DocumentType"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_6486856e-2f2c-4fd2-9a76-2745c8d6f233" xlink:to="loc_dei_DocumentType_8b8cfaea-c04c-49db-a64f-afb2975b2379" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_DocumentPeriodEndDate_12e17aba-926a-4095-9904-f9df7b59de8d" xlink:href="https://xbrl.sec.gov/dei/2021/dei-2021.xsd#dei_DocumentPeriodEndDate"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_6486856e-2f2c-4fd2-9a76-2745c8d6f233" xlink:to="loc_dei_DocumentPeriodEndDate_12e17aba-926a-4095-9904-f9df7b59de8d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityRegistrantName_f17557a4-b78d-49f4-97c9-f0e3505debe3" xlink:href="https://xbrl.sec.gov/dei/2021/dei-2021.xsd#dei_EntityRegistrantName"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_6486856e-2f2c-4fd2-9a76-2745c8d6f233" xlink:to="loc_dei_EntityRegistrantName_f17557a4-b78d-49f4-97c9-f0e3505debe3" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityIncorporationStateCountryCode_853af637-2535-428b-9c22-c0c7cf04f3ec" xlink:href="https://xbrl.sec.gov/dei/2021/dei-2021.xsd#dei_EntityIncorporationStateCountryCode"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_6486856e-2f2c-4fd2-9a76-2745c8d6f233" xlink:to="loc_dei_EntityIncorporationStateCountryCode_853af637-2535-428b-9c22-c0c7cf04f3ec" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityFileNumber_6244e56e-2494-4867-8bbc-a0cf230cb63f" xlink:href="https://xbrl.sec.gov/dei/2021/dei-2021.xsd#dei_EntityFileNumber"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_6486856e-2f2c-4fd2-9a76-2745c8d6f233" xlink:to="loc_dei_EntityFileNumber_6244e56e-2494-4867-8bbc-a0cf230cb63f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityTaxIdentificationNumber_f58b1f4b-3c35-4863-973c-49b32429c756" xlink:href="https://xbrl.sec.gov/dei/2021/dei-2021.xsd#dei_EntityTaxIdentificationNumber"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_6486856e-2f2c-4fd2-9a76-2745c8d6f233" xlink:to="loc_dei_EntityTaxIdentificationNumber_f58b1f4b-3c35-4863-973c-49b32429c756" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressAddressLine1_f06a125a-293f-44cc-afad-66ab652e92d8" xlink:href="https://xbrl.sec.gov/dei/2021/dei-2021.xsd#dei_EntityAddressAddressLine1"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_6486856e-2f2c-4fd2-9a76-2745c8d6f233" xlink:to="loc_dei_EntityAddressAddressLine1_f06a125a-293f-44cc-afad-66ab652e92d8" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressAddressLine2_e13421e9-d786-409c-a4c5-a8040dd0bb3f" xlink:href="https://xbrl.sec.gov/dei/2021/dei-2021.xsd#dei_EntityAddressAddressLine2"/>
    <link:presentationArc order="8" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_6486856e-2f2c-4fd2-9a76-2745c8d6f233" xlink:to="loc_dei_EntityAddressAddressLine2_e13421e9-d786-409c-a4c5-a8040dd0bb3f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressCityOrTown_4b8d8736-7b77-4b98-958b-3e26bc93528d" xlink:href="https://xbrl.sec.gov/dei/2021/dei-2021.xsd#dei_EntityAddressCityOrTown"/>
    <link:presentationArc order="9" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_6486856e-2f2c-4fd2-9a76-2745c8d6f233" xlink:to="loc_dei_EntityAddressCityOrTown_4b8d8736-7b77-4b98-958b-3e26bc93528d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressStateOrProvince_e8f8fa13-6fe7-4b19-8926-87884041ebaf" xlink:href="https://xbrl.sec.gov/dei/2021/dei-2021.xsd#dei_EntityAddressStateOrProvince"/>
    <link:presentationArc order="10" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_6486856e-2f2c-4fd2-9a76-2745c8d6f233" xlink:to="loc_dei_EntityAddressStateOrProvince_e8f8fa13-6fe7-4b19-8926-87884041ebaf" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressPostalZipCode_caa726a0-9c28-4e39-9c2f-a881d6f17677" xlink:href="https://xbrl.sec.gov/dei/2021/dei-2021.xsd#dei_EntityAddressPostalZipCode"/>
    <link:presentationArc order="11" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_6486856e-2f2c-4fd2-9a76-2745c8d6f233" xlink:to="loc_dei_EntityAddressPostalZipCode_caa726a0-9c28-4e39-9c2f-a881d6f17677" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_CityAreaCode_917640d1-8557-4df4-ae09-9af7c4d985b5" xlink:href="https://xbrl.sec.gov/dei/2021/dei-2021.xsd#dei_CityAreaCode"/>
    <link:presentationArc order="12" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_6486856e-2f2c-4fd2-9a76-2745c8d6f233" xlink:to="loc_dei_CityAreaCode_917640d1-8557-4df4-ae09-9af7c4d985b5" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_LocalPhoneNumber_a0bd55a3-f4e2-4f01-a873-9c9cc4a28878" xlink:href="https://xbrl.sec.gov/dei/2021/dei-2021.xsd#dei_LocalPhoneNumber"/>
    <link:presentationArc order="13" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_6486856e-2f2c-4fd2-9a76-2745c8d6f233" xlink:to="loc_dei_LocalPhoneNumber_a0bd55a3-f4e2-4f01-a873-9c9cc4a28878" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_WrittenCommunications_2efa2a38-89b7-45bb-b04e-ea60df4d6eeb" xlink:href="https://xbrl.sec.gov/dei/2021/dei-2021.xsd#dei_WrittenCommunications"/>
    <link:presentationArc order="14" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_6486856e-2f2c-4fd2-9a76-2745c8d6f233" xlink:to="loc_dei_WrittenCommunications_2efa2a38-89b7-45bb-b04e-ea60df4d6eeb" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_SolicitingMaterial_3c4f3e6a-5fc6-4b65-a0f5-43719d0b4749" xlink:href="https://xbrl.sec.gov/dei/2021/dei-2021.xsd#dei_SolicitingMaterial"/>
    <link:presentationArc order="15" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_6486856e-2f2c-4fd2-9a76-2745c8d6f233" xlink:to="loc_dei_SolicitingMaterial_3c4f3e6a-5fc6-4b65-a0f5-43719d0b4749" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_PreCommencementTenderOffer_a9892fa1-7fa7-4121-9ac9-e69334266e35" xlink:href="https://xbrl.sec.gov/dei/2021/dei-2021.xsd#dei_PreCommencementTenderOffer"/>
    <link:presentationArc order="16" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_6486856e-2f2c-4fd2-9a76-2745c8d6f233" xlink:to="loc_dei_PreCommencementTenderOffer_a9892fa1-7fa7-4121-9ac9-e69334266e35" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_PreCommencementIssuerTenderOffer_aac336d9-b301-41a5-8e16-4c6f6f603372" xlink:href="https://xbrl.sec.gov/dei/2021/dei-2021.xsd#dei_PreCommencementIssuerTenderOffer"/>
    <link:presentationArc order="17" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_6486856e-2f2c-4fd2-9a76-2745c8d6f233" xlink:to="loc_dei_PreCommencementIssuerTenderOffer_aac336d9-b301-41a5-8e16-4c6f6f603372" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_Security12bTitle_14c5058c-c3ca-4483-854d-2adabefee9c5" xlink:href="https://xbrl.sec.gov/dei/2021/dei-2021.xsd#dei_Security12bTitle"/>
    <link:presentationArc order="18" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_6486856e-2f2c-4fd2-9a76-2745c8d6f233" xlink:to="loc_dei_Security12bTitle_14c5058c-c3ca-4483-854d-2adabefee9c5" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_TradingSymbol_395a6cf1-d83f-43c2-88a6-a046c43614e5" xlink:href="https://xbrl.sec.gov/dei/2021/dei-2021.xsd#dei_TradingSymbol"/>
    <link:presentationArc order="19" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_6486856e-2f2c-4fd2-9a76-2745c8d6f233" xlink:to="loc_dei_TradingSymbol_395a6cf1-d83f-43c2-88a6-a046c43614e5" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_SecurityExchangeName_c90acc0d-55d0-4275-8617-6349059b59b4" xlink:href="https://xbrl.sec.gov/dei/2021/dei-2021.xsd#dei_SecurityExchangeName"/>
    <link:presentationArc order="20" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_6486856e-2f2c-4fd2-9a76-2745c8d6f233" xlink:to="loc_dei_SecurityExchangeName_c90acc0d-55d0-4275-8617-6349059b59b4" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityEmergingGrowthCompany_c7417c2e-91e0-4ef3-aaaf-52284ab7be14" xlink:href="https://xbrl.sec.gov/dei/2021/dei-2021.xsd#dei_EntityEmergingGrowthCompany"/>
    <link:presentationArc order="21" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_6486856e-2f2c-4fd2-9a76-2745c8d6f233" xlink:to="loc_dei_EntityEmergingGrowthCompany_c7417c2e-91e0-4ef3-aaaf-52284ab7be14" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityCentralIndexKey_875d5d3e-962d-4f78-aa9e-8a90db8a224b" xlink:href="https://xbrl.sec.gov/dei/2021/dei-2021.xsd#dei_EntityCentralIndexKey"/>
    <link:presentationArc order="22" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_6486856e-2f2c-4fd2-9a76-2745c8d6f233" xlink:to="loc_dei_EntityCentralIndexKey_875d5d3e-962d-4f78-aa9e-8a90db8a224b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_AmendmentFlag_e4539b7d-b0bf-404e-a5c6-719228a0537a" xlink:href="https://xbrl.sec.gov/dei/2021/dei-2021.xsd#dei_AmendmentFlag"/>
    <link:presentationArc order="23" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_6486856e-2f2c-4fd2-9a76-2745c8d6f233" xlink:to="loc_dei_AmendmentFlag_e4539b7d-b0bf-404e-a5c6-719228a0537a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
</link:linkbase>
</XBRL>
</TEXT>
</DOCUMENT>
<DOCUMENT>
<TYPE>GRAPHIC
<SEQUENCE>6
<FILENAME>ardx-20220411_g1.jpg
<TEXT>
begin 644 ardx-20220411_g1.jpg
M_]C_X  02D9)1@ ! @   0 !  #_VP!#  @&!@<&!0@'!P<)"0@*#!0-# L+
M#!D2$P\4'1H?'AT:'!P@)"XG("(L(QP<*#<I+# Q-#0T'R<Y/3@R/"XS-#+_
MVP!# 0D)"0P+#!@-#1@R(1PA,C(R,C(R,C(R,C(R,C(R,C(R,C(R,C(R,C(R
M,C(R,C(R,C(R,C(R,C(R,C(R,C(R,C+_P  1" !K &L# 2(  A$! Q$!_\0
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%BB@#_]D!

end
</TEXT>
</DOCUMENT>
<DOCUMENT>
<TYPE>XML
<SEQUENCE>7
<FILENAME>R1.htm
<DESCRIPTION>IDEA: XBRL DOCUMENT
<TEXT>
<html>
<head>
<title></title>
<link rel="stylesheet" type="text/css" href="report.css">
<script type="text/javascript" src="Show.js">/* Do Not Remove This Comment */</script><script type="text/javascript">
							function toggleNextSibling (e) {
							if (e.nextSibling.style.display=='none') {
							e.nextSibling.style.display='block';
							} else { e.nextSibling.style.display='none'; }
							}</script>
</head>
<body>
<span style="display: none;">v3.22.1</span><table class="report" border="0" cellspacing="2" id="idm139934625455464">
<tr>
<th class="tl" colspan="1" rowspan="1"><div style="width: 200px;"><strong>Cover<br></strong></div></th>
<th class="th"><div>Apr. 11, 2022</div></th>
</tr>
<tr class="re">
<td class="pl " style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_dei_CoverAbstract', window );"><strong>Cover [Abstract]</strong></a></td>
<td class="text">&#160;<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl custom" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_dei_DocumentType', window );">Document Type</a></td>
<td class="text">8-K<span></span>
</td>
</tr>
<tr class="re">
<td class="pl custom" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_dei_DocumentPeriodEndDate', window );">Document Period End Date</a></td>
<td class="text">Apr. 11,  2022<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl custom" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_dei_EntityRegistrantName', window );">Entity Registrant Name</a></td>
<td class="text">ARDELYX, INC.<span></span>
</td>
</tr>
<tr class="re">
<td class="pl custom" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_dei_EntityIncorporationStateCountryCode', window );">Entity Incorporation, State or Country Code</a></td>
<td class="text">DE<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl custom" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_dei_EntityFileNumber', window );">Entity File Number</a></td>
<td class="text">001-36485<span></span>
</td>
</tr>
<tr class="re">
<td class="pl custom" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_dei_EntityTaxIdentificationNumber', window );">Entity Tax Identification Number</a></td>
<td class="text">26-1303944<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl custom" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_dei_EntityAddressAddressLine1', window );">Entity Address, Address Line One</a></td>
<td class="text">400 FIFTH AVE.<span></span>
</td>
</tr>
<tr class="re">
<td class="pl custom" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_dei_EntityAddressAddressLine2', window );">Entity Address, Address Line Two</a></td>
<td class="text">SUITE 210<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl custom" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_dei_EntityAddressCityOrTown', window );">Entity Address, City or Town</a></td>
<td class="text">WALTHAM<span></span>
</td>
</tr>
<tr class="re">
<td class="pl custom" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_dei_EntityAddressStateOrProvince', window );">Entity Address, State or Province</a></td>
<td class="text">MA<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl custom" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_dei_EntityAddressPostalZipCode', window );">Entity Address, Postal Zip Code</a></td>
<td class="text">02451<span></span>
</td>
</tr>
<tr class="re">
<td class="pl custom" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_dei_CityAreaCode', window );">City Area Code</a></td>
<td class="text">510<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl custom" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_dei_LocalPhoneNumber', window );">Local Phone Number</a></td>
<td class="text">745-1700<span></span>
</td>
</tr>
<tr class="re">
<td class="pl custom" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_dei_WrittenCommunications', window );">Written Communications</a></td>
<td class="text">false<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl custom" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_dei_SolicitingMaterial', window );">Soliciting Material</a></td>
<td class="text">false<span></span>
</td>
</tr>
<tr class="re">
<td class="pl custom" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_dei_PreCommencementTenderOffer', window );">Pre-commencement Tender Offer</a></td>
<td class="text">false<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl custom" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_dei_PreCommencementIssuerTenderOffer', window );">Pre-commencement Issuer Tender Offer</a></td>
<td class="text">false<span></span>
</td>
</tr>
<tr class="re">
<td class="pl custom" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_dei_Security12bTitle', window );">Title of 12(b) Security</a></td>
<td class="text">Common Stock, par value $0.0001<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl custom" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_dei_TradingSymbol', window );">Trading Symbol</a></td>
<td class="text">ARDX<span></span>
</td>
</tr>
<tr class="re">
<td class="pl custom" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_dei_SecurityExchangeName', window );">Security Exchange Name</a></td>
<td class="text">NASDAQ<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl custom" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_dei_EntityEmergingGrowthCompany', window );">Entity Emerging Growth Company</a></td>
<td class="text">false<span></span>
</td>
</tr>
<tr class="re">
<td class="pl custom" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_dei_EntityCentralIndexKey', window );">Entity Central Index Key</a></td>
<td class="text">0001437402<span></span>
</td>
</tr>
<tr class="ro">
<td class="pl custom" style="border-bottom: 0px;" valign="top"><a class="a" href="javascript:void(0);" onclick="top.Show.showAR( this, 'defref_dei_AmendmentFlag', window );">Amendment Flag</a></td>
<td class="text">false<span></span>
</td>
</tr>
</table>
<div style="display: none;">
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_dei_AmendmentFlag">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Boolean flag that is true when the XBRL content amends previously-filed or accepted submission.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">dei_AmendmentFlag</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>dei_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:booleanItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_dei_CityAreaCode">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Area code of city</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">dei_CityAreaCode</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>dei_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:normalizedStringItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_dei_CoverAbstract">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Cover page.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">dei_CoverAbstract</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>dei_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:stringItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_dei_DocumentPeriodEndDate">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>For the EDGAR submission types of Form 8-K: the date of the report, the date of the earliest event reported; for the EDGAR submission types of Form N-1A: the filing date; for all other submission types: the end of the reporting or transition period.  The format of the date is YYYY-MM-DD.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">dei_DocumentPeriodEndDate</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>dei_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:dateItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_dei_DocumentType">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>The type of document being provided (such as 10-K, 10-Q, 485BPOS, etc). The document type is limited to the same value as the supporting SEC submission type, or the word 'Other'.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">dei_DocumentType</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>dei_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>dei:submissionTypeItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_dei_EntityAddressAddressLine1">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Address Line 1 such as Attn, Building Name, Street Name</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">dei_EntityAddressAddressLine1</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>dei_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:normalizedStringItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_dei_EntityAddressAddressLine2">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Address Line 2 such as Street or Suite number</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">dei_EntityAddressAddressLine2</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>dei_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:normalizedStringItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_dei_EntityAddressCityOrTown">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Name of the City or Town</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">dei_EntityAddressCityOrTown</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>dei_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:normalizedStringItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_dei_EntityAddressPostalZipCode">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Code for the postal or zip code</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">dei_EntityAddressPostalZipCode</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>dei_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:normalizedStringItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_dei_EntityAddressStateOrProvince">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Name of the state or province.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">dei_EntityAddressStateOrProvince</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>dei_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>dei:stateOrProvinceItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_dei_EntityCentralIndexKey">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>A unique 10-digit SEC-issued value to identify entities that have filed disclosures with the SEC. It is commonly abbreviated as CIK.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://www.xbrl.org/2003/role/presentationRef<br> -Publisher SEC<br> -Name Regulation 12B<br> -Number 240<br> -Section 12<br> -Subsection b-2<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">dei_EntityCentralIndexKey</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>dei_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>dei:centralIndexKeyItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_dei_EntityEmergingGrowthCompany">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Indicate if registrant meets the emerging growth company criteria.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://www.xbrl.org/2003/role/presentationRef<br> -Publisher SEC<br> -Name Regulation 12B<br> -Number 240<br> -Section 12<br> -Subsection b-2<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">dei_EntityEmergingGrowthCompany</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>dei_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:booleanItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_dei_EntityFileNumber">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Commission file number. The field allows up to 17 characters. The prefix may contain 1-3 digits, the sequence number may contain 1-8 digits, the optional suffix may contain 1-4 characters, and the fields are separated with a hyphen.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">dei_EntityFileNumber</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>dei_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>dei:fileNumberItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_dei_EntityIncorporationStateCountryCode">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Two-character EDGAR code representing the state or country of incorporation.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">dei_EntityIncorporationStateCountryCode</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>dei_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>dei:edgarStateCountryItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_dei_EntityRegistrantName">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>The exact name of the entity filing the report as specified in its charter, which is required by forms filed with the SEC.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://www.xbrl.org/2003/role/presentationRef<br> -Publisher SEC<br> -Name Regulation 12B<br> -Number 240<br> -Section 12<br> -Subsection b-2<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">dei_EntityRegistrantName</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>dei_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:normalizedStringItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_dei_EntityTaxIdentificationNumber">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>The Tax Identification Number (TIN), also known as an Employer Identification Number (EIN), is a unique 9-digit value assigned by the IRS.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://www.xbrl.org/2003/role/presentationRef<br> -Publisher SEC<br> -Name Regulation 12B<br> -Number 240<br> -Section 12<br> -Subsection b-2<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">dei_EntityTaxIdentificationNumber</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>dei_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>dei:employerIdItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_dei_LocalPhoneNumber">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Local phone number for entity.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">dei_LocalPhoneNumber</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>dei_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:normalizedStringItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_dei_PreCommencementIssuerTenderOffer">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Boolean flag that is true when the Form 8-K filing is intended to satisfy the filing obligation of the registrant as pre-commencement communications pursuant to Rule 13e-4(c) under the Exchange Act.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://www.xbrl.org/2003/role/presentationRef<br> -Publisher SEC<br> -Name Exchange Act<br> -Number 240<br> -Section 13e<br> -Subsection 4c<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">dei_PreCommencementIssuerTenderOffer</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>dei_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:booleanItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_dei_PreCommencementTenderOffer">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Boolean flag that is true when the Form 8-K filing is intended to satisfy the filing obligation of the registrant as pre-commencement communications pursuant to Rule 14d-2(b) under the Exchange Act.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://www.xbrl.org/2003/role/presentationRef<br> -Publisher SEC<br> -Name Exchange Act<br> -Number 240<br> -Section 14d<br> -Subsection 2b<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">dei_PreCommencementTenderOffer</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>dei_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:booleanItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_dei_Security12bTitle">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Title of a 12(b) registered security.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://www.xbrl.org/2003/role/presentationRef<br> -Publisher SEC<br> -Name Exchange Act<br> -Number 240<br> -Section 12<br> -Subsection b<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">dei_Security12bTitle</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>dei_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>dei:securityTitleItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_dei_SecurityExchangeName">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Name of the Exchange on which a security is registered.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://www.xbrl.org/2003/role/presentationRef<br> -Publisher SEC<br> -Name Exchange Act<br> -Number 240<br> -Section 12<br> -Subsection d1-1<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">dei_SecurityExchangeName</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>dei_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>dei:edgarExchangeCodeItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_dei_SolicitingMaterial">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Boolean flag that is true when the Form 8-K filing is intended to satisfy the filing obligation of the registrant as soliciting material pursuant to Rule 14a-12 under the Exchange Act.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://www.xbrl.org/2003/role/presentationRef<br> -Publisher SEC<br> -Name Exchange Act<br> -Section 14a<br> -Number 240<br> -Subsection 12<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">dei_SolicitingMaterial</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>dei_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:booleanItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_dei_TradingSymbol">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Trading symbol of an instrument as listed on an exchange.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>No definition available.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">dei_TradingSymbol</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>dei_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>dei:tradingSymbolItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
<table border="0" cellpadding="0" cellspacing="0" class="authRefData" style="display: none;" id="defref_dei_WrittenCommunications">
<tr><td class="hide"><a style="color: white;" href="javascript:void(0);" onclick="top.Show.hideAR();">X</a></td></tr>
<tr><td><div class="body" style="padding: 2px;">
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">- Definition</a><div><p>Boolean flag that is true when the Form 8-K filing is intended to satisfy the filing obligation of the registrant as written communications pursuant to Rule 425 under the Securities Act.</p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ References</a><div style="display: none;"><p>Reference 1: http://www.xbrl.org/2003/role/presentationRef<br> -Publisher SEC<br> -Name Securities Act<br> -Number 230<br> -Section 425<br></p></div>
<a href="javascript:void(0);" onclick="top.Show.toggleNext( this );">+ Details</a><div style="display: none;"><table border="0" cellpadding="0" cellspacing="0">
<tr>
<td><strong> Name:</strong></td>
<td style="white-space:nowrap;">dei_WrittenCommunications</td>
</tr>
<tr>
<td style="padding-right: 4px;white-space:nowrap;"><strong> Namespace Prefix:</strong></td>
<td>dei_</td>
</tr>
<tr>
<td><strong> Data Type:</strong></td>
<td>xbrli:booleanItemType</td>
</tr>
<tr>
<td><strong> Balance Type:</strong></td>
<td>na</td>
</tr>
<tr>
<td><strong> Period Type:</strong></td>
<td>duration</td>
</tr>
</table></div>
</div></td></tr>
</table>
</div>
</body>
</html>
</TEXT>
</DOCUMENT>
<DOCUMENT>
<TYPE>XML
<SEQUENCE>8
<FILENAME>ardx-20220411_htm.xml
<DESCRIPTION>IDEA: XBRL DOCUMENT
<TEXT>
<XML>
<?xml version="1.0" encoding="utf-8"?>
<xbrl
  xml:lang="en-US"
  xmlns="http://www.xbrl.org/2003/instance"
  xmlns:dei="http://xbrl.sec.gov/dei/2021"
  xmlns:link="http://www.xbrl.org/2003/linkbase"
  xmlns:xlink="http://www.w3.org/1999/xlink">
    <link:schemaRef xlink:href="ardx-20220411.xsd" xlink:type="simple"/>
    <context id="i99eb85ff74604dd8813b17eed2cb021d_D20220411-20220411">
        <entity>
            <identifier scheme="http://www.sec.gov/CIK">0001437402</identifier>
        </entity>
        <period>
            <startDate>2022-04-11</startDate>
            <endDate>2022-04-11</endDate>
        </period>
    </context>
    <dei:EntityCentralIndexKey
      contextRef="i99eb85ff74604dd8813b17eed2cb021d_D20220411-20220411"
      id="id3VybDovL2RvY3MudjEvZG9jOmU0MzJhYWQ4Njc3MDQ4NzE4NDhjMjZmOWNhMzcyMDc3L3NlYzplNDMyYWFkODY3NzA0ODcxODQ4YzI2ZjljYTM3MjA3N180L2ZyYWc6MGYxOTk0MTIxMzcwNGZjZmJjYjk0Mjg4ZjRjMzVlN2MvdGFibGU6ZDc5ZmZhMjAzOWU1NDYwNjhiMjE4Y2Y4ZTZjYWM1OGEvdGFibGVyYW5nZTpkNzlmZmEyMDM5ZTU0NjA2OGIyMThjZjhlNmNhYzU4YV8yLTEtMS0xLTI3NzM5_f04dba25-02b7-4a6a-9c08-fcbcedf11aee">0001437402</dei:EntityCentralIndexKey>
    <dei:AmendmentFlag
      contextRef="i99eb85ff74604dd8813b17eed2cb021d_D20220411-20220411"
      id="id3VybDovL2RvY3MudjEvZG9jOmU0MzJhYWQ4Njc3MDQ4NzE4NDhjMjZmOWNhMzcyMDc3L3NlYzplNDMyYWFkODY3NzA0ODcxODQ4YzI2ZjljYTM3MjA3N180L2ZyYWc6MGYxOTk0MTIxMzcwNGZjZmJjYjk0Mjg4ZjRjMzVlN2MvdGFibGU6ZDc5ZmZhMjAzOWU1NDYwNjhiMjE4Y2Y4ZTZjYWM1OGEvdGFibGVyYW5nZTpkNzlmZmEyMDM5ZTU0NjA2OGIyMThjZjhlNmNhYzU4YV8zLTEtMS0xLTI3NzM5_1433a1bc-7e04-4644-90e3-3ce0656db101">false</dei:AmendmentFlag>
    <dei:DocumentType
      contextRef="i99eb85ff74604dd8813b17eed2cb021d_D20220411-20220411"
      id="id3VybDovL2RvY3MudjEvZG9jOmU0MzJhYWQ4Njc3MDQ4NzE4NDhjMjZmOWNhMzcyMDc3L3NlYzplNDMyYWFkODY3NzA0ODcxODQ4YzI2ZjljYTM3MjA3N18xL2ZyYWc6NmI4ZmNmNzQ4YTMxNGVlZDg1NzRjNGNkNjU2ZWQ3MzkvdGV4dHJlZ2lvbjo2YjhmY2Y3NDhhMzE0ZWVkODU3NGM0Y2Q2NTZlZDczOV8xMjU5_609cf7c5-d24a-4139-978c-c14d1489175a">8-K</dei:DocumentType>
    <dei:DocumentPeriodEndDate
      contextRef="i99eb85ff74604dd8813b17eed2cb021d_D20220411-20220411"
      id="id3VybDovL2RvY3MudjEvZG9jOmU0MzJhYWQ4Njc3MDQ4NzE4NDhjMjZmOWNhMzcyMDc3L3NlYzplNDMyYWFkODY3NzA0ODcxODQ4YzI2ZjljYTM3MjA3N18xL2ZyYWc6NmI4ZmNmNzQ4YTMxNGVlZDg1NzRjNGNkNjU2ZWQ3MzkvdGV4dHJlZ2lvbjo2YjhmY2Y3NDhhMzE0ZWVkODU3NGM0Y2Q2NTZlZDczOV8yMzE_8de56631-2530-4025-8727-1ecdc0939227">2022-04-11</dei:DocumentPeriodEndDate>
    <dei:EntityRegistrantName
      contextRef="i99eb85ff74604dd8813b17eed2cb021d_D20220411-20220411"
      id="id3VybDovL2RvY3MudjEvZG9jOmU0MzJhYWQ4Njc3MDQ4NzE4NDhjMjZmOWNhMzcyMDc3L3NlYzplNDMyYWFkODY3NzA0ODcxODQ4YzI2ZjljYTM3MjA3N18xL2ZyYWc6NmI4ZmNmNzQ4YTMxNGVlZDg1NzRjNGNkNjU2ZWQ3MzkvdGV4dHJlZ2lvbjo2YjhmY2Y3NDhhMzE0ZWVkODU3NGM0Y2Q2NTZlZDczOV8xMjYw_c62faaf1-99af-4d50-a5ad-560acb801150">ARDELYX, INC.</dei:EntityRegistrantName>
    <dei:EntityIncorporationStateCountryCode
      contextRef="i99eb85ff74604dd8813b17eed2cb021d_D20220411-20220411"
      id="id3VybDovL2RvY3MudjEvZG9jOmU0MzJhYWQ4Njc3MDQ4NzE4NDhjMjZmOWNhMzcyMDc3L3NlYzplNDMyYWFkODY3NzA0ODcxODQ4YzI2ZjljYTM3MjA3N18xL2ZyYWc6NmI4ZmNmNzQ4YTMxNGVlZDg1NzRjNGNkNjU2ZWQ3MzkvdGFibGU6Y2NlZTcyN2UyM2U0NDI2Zjg5YjI4NWVjMjNhZjA0OWMvdGFibGVyYW5nZTpjY2VlNzI3ZTIzZTQ0MjZmODliMjg1ZWMyM2FmMDQ5Y18wLTAtMS0xLTI3NzM5_1a2fb95e-4d48-40e4-94fb-c82cc9c4ab4e">DE</dei:EntityIncorporationStateCountryCode>
    <dei:EntityFileNumber
      contextRef="i99eb85ff74604dd8813b17eed2cb021d_D20220411-20220411"
      id="id3VybDovL2RvY3MudjEvZG9jOmU0MzJhYWQ4Njc3MDQ4NzE4NDhjMjZmOWNhMzcyMDc3L3NlYzplNDMyYWFkODY3NzA0ODcxODQ4YzI2ZjljYTM3MjA3N18xL2ZyYWc6NmI4ZmNmNzQ4YTMxNGVlZDg1NzRjNGNkNjU2ZWQ3MzkvdGFibGU6Y2NlZTcyN2UyM2U0NDI2Zjg5YjI4NWVjMjNhZjA0OWMvdGFibGVyYW5nZTpjY2VlNzI3ZTIzZTQ0MjZmODliMjg1ZWMyM2FmMDQ5Y18wLTEtMS0xLTI3NzM5_98f5a6ab-6551-4c82-9597-017731a1aa60">001-36485</dei:EntityFileNumber>
    <dei:EntityTaxIdentificationNumber
      contextRef="i99eb85ff74604dd8813b17eed2cb021d_D20220411-20220411"
      id="id3VybDovL2RvY3MudjEvZG9jOmU0MzJhYWQ4Njc3MDQ4NzE4NDhjMjZmOWNhMzcyMDc3L3NlYzplNDMyYWFkODY3NzA0ODcxODQ4YzI2ZjljYTM3MjA3N18xL2ZyYWc6NmI4ZmNmNzQ4YTMxNGVlZDg1NzRjNGNkNjU2ZWQ3MzkvdGFibGU6Y2NlZTcyN2UyM2U0NDI2Zjg5YjI4NWVjMjNhZjA0OWMvdGFibGVyYW5nZTpjY2VlNzI3ZTIzZTQ0MjZmODliMjg1ZWMyM2FmMDQ5Y18wLTItMS0xLTI3NzM5_2bed332e-bbb4-44ee-b5bf-54f77172bc97">26-1303944</dei:EntityTaxIdentificationNumber>
    <dei:EntityAddressAddressLine1
      contextRef="i99eb85ff74604dd8813b17eed2cb021d_D20220411-20220411"
      id="id3VybDovL2RvY3MudjEvZG9jOmU0MzJhYWQ4Njc3MDQ4NzE4NDhjMjZmOWNhMzcyMDc3L3NlYzplNDMyYWFkODY3NzA0ODcxODQ4YzI2ZjljYTM3MjA3N18xL2ZyYWc6NmI4ZmNmNzQ4YTMxNGVlZDg1NzRjNGNkNjU2ZWQ3MzkvdGV4dHJlZ2lvbjo2YjhmY2Y3NDhhMzE0ZWVkODU3NGM0Y2Q2NTZlZDczOV8xMjYy_c5a8904e-2aa6-4156-81ef-bcf705b8046a">400 FIFTH AVE.</dei:EntityAddressAddressLine1>
    <dei:EntityAddressAddressLine2
      contextRef="i99eb85ff74604dd8813b17eed2cb021d_D20220411-20220411"
      id="id3VybDovL2RvY3MudjEvZG9jOmU0MzJhYWQ4Njc3MDQ4NzE4NDhjMjZmOWNhMzcyMDc3L3NlYzplNDMyYWFkODY3NzA0ODcxODQ4YzI2ZjljYTM3MjA3N18xL2ZyYWc6NmI4ZmNmNzQ4YTMxNGVlZDg1NzRjNGNkNjU2ZWQ3MzkvdGV4dHJlZ2lvbjo2YjhmY2Y3NDhhMzE0ZWVkODU3NGM0Y2Q2NTZlZDczOV8xMjU0_69d4a22b-3142-4f05-a0e9-7fd23bf28f6c">SUITE 210</dei:EntityAddressAddressLine2>
    <dei:EntityAddressCityOrTown
      contextRef="i99eb85ff74604dd8813b17eed2cb021d_D20220411-20220411"
      id="id3VybDovL2RvY3MudjEvZG9jOmU0MzJhYWQ4Njc3MDQ4NzE4NDhjMjZmOWNhMzcyMDc3L3NlYzplNDMyYWFkODY3NzA0ODcxODQ4YzI2ZjljYTM3MjA3N18xL2ZyYWc6NmI4ZmNmNzQ4YTMxNGVlZDg1NzRjNGNkNjU2ZWQ3MzkvdGV4dHJlZ2lvbjo2YjhmY2Y3NDhhMzE0ZWVkODU3NGM0Y2Q2NTZlZDczOV8xMjYz_7daff03c-978d-467b-a7c3-94a39545c086">WALTHAM</dei:EntityAddressCityOrTown>
    <dei:EntityAddressStateOrProvince
      contextRef="i99eb85ff74604dd8813b17eed2cb021d_D20220411-20220411"
      id="id3VybDovL2RvY3MudjEvZG9jOmU0MzJhYWQ4Njc3MDQ4NzE4NDhjMjZmOWNhMzcyMDc3L3NlYzplNDMyYWFkODY3NzA0ODcxODQ4YzI2ZjljYTM3MjA3N18xL2ZyYWc6NmI4ZmNmNzQ4YTMxNGVlZDg1NzRjNGNkNjU2ZWQ3MzkvdGV4dHJlZ2lvbjo2YjhmY2Y3NDhhMzE0ZWVkODU3NGM0Y2Q2NTZlZDczOV8xMjU2_3fbc340d-8192-4a40-94f5-23b18817c9dc">MA</dei:EntityAddressStateOrProvince>
    <dei:EntityAddressPostalZipCode
      contextRef="i99eb85ff74604dd8813b17eed2cb021d_D20220411-20220411"
      id="id3VybDovL2RvY3MudjEvZG9jOmU0MzJhYWQ4Njc3MDQ4NzE4NDhjMjZmOWNhMzcyMDc3L3NlYzplNDMyYWFkODY3NzA0ODcxODQ4YzI2ZjljYTM3MjA3N18xL2ZyYWc6NmI4ZmNmNzQ4YTMxNGVlZDg1NzRjNGNkNjU2ZWQ3MzkvdGV4dHJlZ2lvbjo2YjhmY2Y3NDhhMzE0ZWVkODU3NGM0Y2Q2NTZlZDczOV8xMjY0_9e2621a6-7a5f-4ccc-a3c4-a86497c7aee2">02451</dei:EntityAddressPostalZipCode>
    <dei:CityAreaCode
      contextRef="i99eb85ff74604dd8813b17eed2cb021d_D20220411-20220411"
      id="id3VybDovL2RvY3MudjEvZG9jOmU0MzJhYWQ4Njc3MDQ4NzE4NDhjMjZmOWNhMzcyMDc3L3NlYzplNDMyYWFkODY3NzA0ODcxODQ4YzI2ZjljYTM3MjA3N18xL2ZyYWc6NmI4ZmNmNzQ4YTMxNGVlZDg1NzRjNGNkNjU2ZWQ3MzkvdGV4dHJlZ2lvbjo2YjhmY2Y3NDhhMzE0ZWVkODU3NGM0Y2Q2NTZlZDczOV8xMjY1_3770e60a-a9bf-4d94-9b32-0add723d80d9">510</dei:CityAreaCode>
    <dei:LocalPhoneNumber
      contextRef="i99eb85ff74604dd8813b17eed2cb021d_D20220411-20220411"
      id="id3VybDovL2RvY3MudjEvZG9jOmU0MzJhYWQ4Njc3MDQ4NzE4NDhjMjZmOWNhMzcyMDc3L3NlYzplNDMyYWFkODY3NzA0ODcxODQ4YzI2ZjljYTM3MjA3N18xL2ZyYWc6NmI4ZmNmNzQ4YTMxNGVlZDg1NzRjNGNkNjU2ZWQ3MzkvdGV4dHJlZ2lvbjo2YjhmY2Y3NDhhMzE0ZWVkODU3NGM0Y2Q2NTZlZDczOV8xMjU3_a04b6774-b964-4dda-b018-163ec9310a20">745-1700</dei:LocalPhoneNumber>
    <dei:WrittenCommunications
      contextRef="i99eb85ff74604dd8813b17eed2cb021d_D20220411-20220411"
      id="id3VybDovL2RvY3MudjEvZG9jOmU0MzJhYWQ4Njc3MDQ4NzE4NDhjMjZmOWNhMzcyMDc3L3NlYzplNDMyYWFkODY3NzA0ODcxODQ4YzI2ZjljYTM3MjA3N18xL2ZyYWc6NmI4ZmNmNzQ4YTMxNGVlZDg1NzRjNGNkNjU2ZWQ3MzkvdGFibGU6ODlhMDNmMzNmNzRjNGNmZDhmOGY5MmVkMDQ3ZDRkOTcvdGFibGVyYW5nZTo4OWEwM2YzM2Y3NGM0Y2ZkOGY4ZjkyZWQwNDdkNGQ5N18wLTAtMS0xLTI3NzM5_84f3ad4e-4af3-4098-9ec8-74e6a3651c84">false</dei:WrittenCommunications>
    <dei:SolicitingMaterial
      contextRef="i99eb85ff74604dd8813b17eed2cb021d_D20220411-20220411"
      id="id3VybDovL2RvY3MudjEvZG9jOmU0MzJhYWQ4Njc3MDQ4NzE4NDhjMjZmOWNhMzcyMDc3L3NlYzplNDMyYWFkODY3NzA0ODcxODQ4YzI2ZjljYTM3MjA3N18xL2ZyYWc6NmI4ZmNmNzQ4YTMxNGVlZDg1NzRjNGNkNjU2ZWQ3MzkvdGFibGU6ODlhMDNmMzNmNzRjNGNmZDhmOGY5MmVkMDQ3ZDRkOTcvdGFibGVyYW5nZTo4OWEwM2YzM2Y3NGM0Y2ZkOGY4ZjkyZWQwNDdkNGQ5N18xLTAtMS0xLTI3NzM5_d56fc725-d009-442d-9364-26c6ae58d1fa">false</dei:SolicitingMaterial>
    <dei:PreCommencementTenderOffer
      contextRef="i99eb85ff74604dd8813b17eed2cb021d_D20220411-20220411"
      id="id3VybDovL2RvY3MudjEvZG9jOmU0MzJhYWQ4Njc3MDQ4NzE4NDhjMjZmOWNhMzcyMDc3L3NlYzplNDMyYWFkODY3NzA0ODcxODQ4YzI2ZjljYTM3MjA3N18xL2ZyYWc6NmI4ZmNmNzQ4YTMxNGVlZDg1NzRjNGNkNjU2ZWQ3MzkvdGFibGU6ODlhMDNmMzNmNzRjNGNmZDhmOGY5MmVkMDQ3ZDRkOTcvdGFibGVyYW5nZTo4OWEwM2YzM2Y3NGM0Y2ZkOGY4ZjkyZWQwNDdkNGQ5N18yLTAtMS0xLTI3NzM5_05e17cc0-0920-4d8d-b396-e7f87b40e9c2">false</dei:PreCommencementTenderOffer>
    <dei:PreCommencementIssuerTenderOffer
      contextRef="i99eb85ff74604dd8813b17eed2cb021d_D20220411-20220411"
      id="id3VybDovL2RvY3MudjEvZG9jOmU0MzJhYWQ4Njc3MDQ4NzE4NDhjMjZmOWNhMzcyMDc3L3NlYzplNDMyYWFkODY3NzA0ODcxODQ4YzI2ZjljYTM3MjA3N18xL2ZyYWc6NmI4ZmNmNzQ4YTMxNGVlZDg1NzRjNGNkNjU2ZWQ3MzkvdGFibGU6ODlhMDNmMzNmNzRjNGNmZDhmOGY5MmVkMDQ3ZDRkOTcvdGFibGVyYW5nZTo4OWEwM2YzM2Y3NGM0Y2ZkOGY4ZjkyZWQwNDdkNGQ5N18zLTAtMS0xLTI3NzM5_69a40725-1fef-4d68-9fca-34fdb394da89">false</dei:PreCommencementIssuerTenderOffer>
    <dei:Security12bTitle
      contextRef="i99eb85ff74604dd8813b17eed2cb021d_D20220411-20220411"
      id="id3VybDovL2RvY3MudjEvZG9jOmU0MzJhYWQ4Njc3MDQ4NzE4NDhjMjZmOWNhMzcyMDc3L3NlYzplNDMyYWFkODY3NzA0ODcxODQ4YzI2ZjljYTM3MjA3N18xL2ZyYWc6NmI4ZmNmNzQ4YTMxNGVlZDg1NzRjNGNkNjU2ZWQ3MzkvdGFibGU6ODBkMjFhODY4ODkyNDRmY2E3ZDliNjNmYzI0YzRjMTEvdGFibGVyYW5nZTo4MGQyMWE4Njg4OTI0NGZjYTdkOWI2M2ZjMjRjNGMxMV8xLTAtMS0xLTI3NzM5_ab895881-1517-47ab-9fd8-846a48eb42ac">Common Stock, par value $0.0001</dei:Security12bTitle>
    <dei:TradingSymbol
      contextRef="i99eb85ff74604dd8813b17eed2cb021d_D20220411-20220411"
      id="id3VybDovL2RvY3MudjEvZG9jOmU0MzJhYWQ4Njc3MDQ4NzE4NDhjMjZmOWNhMzcyMDc3L3NlYzplNDMyYWFkODY3NzA0ODcxODQ4YzI2ZjljYTM3MjA3N18xL2ZyYWc6NmI4ZmNmNzQ4YTMxNGVlZDg1NzRjNGNkNjU2ZWQ3MzkvdGFibGU6ODBkMjFhODY4ODkyNDRmY2E3ZDliNjNmYzI0YzRjMTEvdGFibGVyYW5nZTo4MGQyMWE4Njg4OTI0NGZjYTdkOWI2M2ZjMjRjNGMxMV8xLTItMS0xLTI3NzM5_5bdc741c-aee9-4320-b45b-c0b8764992fc">ARDX</dei:TradingSymbol>
    <dei:SecurityExchangeName
      contextRef="i99eb85ff74604dd8813b17eed2cb021d_D20220411-20220411"
      id="id3VybDovL2RvY3MudjEvZG9jOmU0MzJhYWQ4Njc3MDQ4NzE4NDhjMjZmOWNhMzcyMDc3L3NlYzplNDMyYWFkODY3NzA0ODcxODQ4YzI2ZjljYTM3MjA3N18xL2ZyYWc6NmI4ZmNmNzQ4YTMxNGVlZDg1NzRjNGNkNjU2ZWQ3MzkvdGFibGU6ODBkMjFhODY4ODkyNDRmY2E3ZDliNjNmYzI0YzRjMTEvdGFibGVyYW5nZTo4MGQyMWE4Njg4OTI0NGZjYTdkOWI2M2ZjMjRjNGMxMV8xLTQtMS0xLTI3NzM5_4067516a-2c3c-46f8-b080-f764ec23501c">NASDAQ</dei:SecurityExchangeName>
    <dei:EntityEmergingGrowthCompany
      contextRef="i99eb85ff74604dd8813b17eed2cb021d_D20220411-20220411"
      id="id3VybDovL2RvY3MudjEvZG9jOmU0MzJhYWQ4Njc3MDQ4NzE4NDhjMjZmOWNhMzcyMDc3L3NlYzplNDMyYWFkODY3NzA0ODcxODQ4YzI2ZjljYTM3MjA3N18xL2ZyYWc6NmI4ZmNmNzQ4YTMxNGVlZDg1NzRjNGNkNjU2ZWQ3MzkvdGV4dHJlZ2lvbjo2YjhmY2Y3NDhhMzE0ZWVkODU3NGM0Y2Q2NTZlZDczOV8xMjU4_5237859f-621c-4622-b3ee-2a30dd17d76d">false</dei:EntityEmergingGrowthCompany>
</xbrl>
</XML>
</TEXT>
</DOCUMENT>
<DOCUMENT>
<TYPE>EXCEL
<SEQUENCE>9
<FILENAME>Financial_Report.xlsx
<DESCRIPTION>IDEA: XBRL DOCUMENT
<TEXT>
begin 644 Financial_Report.xlsx
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M<6A4"H[<8R6,<6*T_C6"R0_L?@!02P,$%     @ Q("+5*K$(A8S 0  (@(
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M%S?W1:[-XPFNWPQP>'3^ 5!+ P04    " #$@(M499!YDAD!  #/ P  $P
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M@6)8YL_X>\87_QO.\1'"[K\_L;S63AI_YHOA/UY_ 5!+ 0(4 Q0    ( ,2
MBU0'04UB@0   +$    0              "  0    !D;V-0<F]P<R]A<' N
M>&UL4$L! A0#%     @ Q("+5)FWG";N    *P(  !$              ( !
MKP   &1O8U!R;W!S+V-O<F4N>&UL4$L! A0#%     @ Q("+5)E<G",0!@
MG"<  !,              ( !S $  'AL+W1H96UE+W1H96UE,2YX;6Q02P$"
M% ,4    " #$@(M4^D#A\3@$  "[$   &               @($-"   >&PO
M=V]R:W-H965T<R]S:&5E=#$N>&UL4$L! A0#%     @ Q("+5)^@&_"Q @
MX@P   T              ( !>PP  'AL+W-T>6QE<RYX;6Q02P$"% ,4
M" #$@(M4EXJ[',     3 @  "P              @ %7#P  7W)E;',O+G)E
M;'-02P$"% ,4    " #$@(M4JL0B%C,!   B @  #P              @ %
M$   >&PO=V]R:V)O;VLN>&UL4$L! A0#%     @ Q("+5"0>FZ*M    ^ $
M !H              ( !H!$  'AL+U]R96QS+W=O<FMB;V]K+GAM;"YR96QS
M4$L! A0#%     @ Q("+5&60>9(9 0  SP,  !,              ( !A1(
J %M#;VYT96YT7U1Y<&5S72YX;6Q02P4&      D "0 ^ @  SQ,

end
</TEXT>
</DOCUMENT>
<DOCUMENT>
<TYPE>XML
<SEQUENCE>10
<FILENAME>Show.js
<DESCRIPTION>IDEA: XBRL DOCUMENT
<TEXT>
// Edgar(tm) Renderer was created by staff of the U.S. Securities and Exchange Commission.  Data and content created by government employees within the scope of their employment are not subject to domestic copyright protection. 17 U.S.C. 105.
var Show={};Show.LastAR=null,Show.showAR=function(a,r,w){if(Show.LastAR)Show.hideAR();var e=a;while(e&&e.nodeName!='TABLE')e=e.nextSibling;if(!e||e.nodeName!='TABLE'){var ref=((window)?w.document:document).getElementById(r);if(ref){e=ref.cloneNode(!0);
e.removeAttribute('id');a.parentNode.appendChild(e)}}
if(e)e.style.display='block';Show.LastAR=e};Show.hideAR=function(){Show.LastAR.style.display='none'};Show.toggleNext=function(a){var e=a;while(e.nodeName!='DIV')e=e.nextSibling;if(!e.style){}else if(!e.style.display){}else{var d,p_;if(e.style.display=='none'){d='block';p='-'}else{d='none';p='+'}
e.style.display=d;if(a.textContent){a.textContent=p+a.textContent.substring(1)}else{a.innerText=p+a.innerText.substring(1)}}}
</TEXT>
</DOCUMENT>
<DOCUMENT>
<TYPE>XML
<SEQUENCE>11
<FILENAME>report.css
<DESCRIPTION>IDEA: XBRL DOCUMENT
<TEXT>
/* Updated 2009-11-04 */
/* v2.2.0.24 */

/* DefRef Styles */
..report table.authRefData{
	background-color: #def;
	border: 2px solid #2F4497;
	font-size: 1em;
	position: absolute;
}

..report table.authRefData a {
	display: block;
	font-weight: bold;
}

..report table.authRefData p {
	margin-top: 0px;
}

..report table.authRefData .hide {
	background-color: #2F4497;
	padding: 1px 3px 0px 0px;
	text-align: right;
}

..report table.authRefData .hide a:hover {
	background-color: #2F4497;
}

..report table.authRefData .body {
	height: 150px;
	overflow: auto;
	width: 400px;
}

..report table.authRefData table{
	font-size: 1em;
}

/* Report Styles */
..pl a, .pl a:visited {
	color: black;
	text-decoration: none;
}

/* table */
..report {
	background-color: white;
	border: 2px solid #acf;
	clear: both;
	color: black;
	font: normal 8pt Helvetica, Arial, san-serif;
	margin-bottom: 2em;
}

..report hr {
	border: 1px solid #acf;
}

/* Top labels */
..report th {
	background-color: #acf;
	color: black;
	font-weight: bold;
	text-align: center;
}

..report th.void	{
	background-color: transparent;
	color: #000000;
	font: bold 10pt Helvetica, Arial, san-serif;
	text-align: left;
}

..report .pl {
	text-align: left;
	vertical-align: top;
	white-space: normal;
	width: 200px;
	white-space: normal; /* word-wrap: break-word; */
}

..report td.pl a.a {
	cursor: pointer;
	display: block;
	width: 200px;
	overflow: hidden;
}

..report td.pl div.a {
	width: 200px;
}

..report td.pl a:hover {
	background-color: #ffc;
}

/* Header rows... */
..report tr.rh {
	background-color: #acf;
	color: black;
	font-weight: bold;
}

/* Calendars... */
..report .rc {
	background-color: #f0f0f0;
}

/* Even rows... */
..report .re, .report .reu {
	background-color: #def;
}

..report .reu td {
	border-bottom: 1px solid black;
}

/* Odd rows... */
..report .ro, .report .rou {
	background-color: white;
}

..report .rou td {
	border-bottom: 1px solid black;
}

..report .rou table td, .report .reu table td {
	border-bottom: 0px solid black;
}

/* styles for footnote marker */
..report .fn {
	white-space: nowrap;
}

/* styles for numeric types */
..report .num, .report .nump {
	text-align: right;
	white-space: nowrap;
}

..report .nump {
	padding-left: 2em;
}

..report .nump {
	padding: 0px 0.4em 0px 2em;
}

/* styles for text types */
..report .text {
	text-align: left;
	white-space: normal;
}

..report .text .big {
	margin-bottom: 1em;
	width: 17em;
}

..report .text .more {
	display: none;
}

..report .text .note {
	font-style: italic;
	font-weight: bold;
}

..report .text .small {
	width: 10em;
}

..report sup {
	font-style: italic;
}

..report .outerFootnotes {
	font-size: 1em;
}
</TEXT>
</DOCUMENT>
<DOCUMENT>
<TYPE>XML
<SEQUENCE>12
<FILENAME>FilingSummary.xml
<DESCRIPTION>IDEA: XBRL DOCUMENT
<TEXT>
<XML>
<?xml version='1.0' encoding='utf-8'?>
<FilingSummary>
  <Version>3.22.1</Version>
  <ProcessingTime/>
  <ReportFormat>html</ReportFormat>
  <ContextCount>1</ContextCount>
  <ElementCount>23</ElementCount>
  <EntityCount>1</EntityCount>
  <FootnotesReported>false</FootnotesReported>
  <SegmentCount>0</SegmentCount>
  <ScenarioCount>0</ScenarioCount>
  <TuplesReported>false</TuplesReported>
  <UnitCount>0</UnitCount>
  <MyReports>
    <Report instance="ardx-20220411.htm">
      <IsDefault>false</IsDefault>
      <HasEmbeddedReports>false</HasEmbeddedReports>
      <HtmlFileName>R1.htm</HtmlFileName>
      <LongName>0001001 - Document - Cover</LongName>
      <ReportType>Sheet</ReportType>
      <Role>http://www.ardelyx.com/role/Cover</Role>
      <ShortName>Cover</ShortName>
      <MenuCategory>Cover</MenuCategory>
      <Position>1</Position>
    </Report>
    <Report>
      <IsDefault>false</IsDefault>
      <HasEmbeddedReports>false</HasEmbeddedReports>
      <LongName>All Reports</LongName>
      <ReportType>Book</ReportType>
      <ShortName>All Reports</ShortName>
    </Report>
  </MyReports>
  <InputFiles>
    <File doctype="8-K" original="ardx-20220411.htm">ardx-20220411.htm</File>
    <File>a2ndamendmenttokkc-ardxlic.htm</File>
    <File>ardx-20220411.xsd</File>
    <File>ardx-20220411_lab.xml</File>
    <File>ardx-20220411_pre.xml</File>
  </InputFiles>
  <SupplementalFiles>
    <File>ardx-20220411_g1.jpg</File>
  </SupplementalFiles>
  <BaseTaxonomies>
    <BaseTaxonomy items="23">http://xbrl.sec.gov/dei/2021</BaseTaxonomy>
  </BaseTaxonomies>
  <HasPresentationLinkbase>true</HasPresentationLinkbase>
  <HasCalculationLinkbase>false</HasCalculationLinkbase>
</FilingSummary>
</XML>
</TEXT>
</DOCUMENT>
<DOCUMENT>
<TYPE>JSON
<SEQUENCE>14
<FILENAME>MetaLinks.json
<DESCRIPTION>IDEA: XBRL DOCUMENT
<TEXT>
{
 "instance": {
  "ardx-20220411.htm": {
   "axisCustom": 0,
   "axisStandard": 0,
   "contextCount": 1,
   "dts": {
    "inline": {
     "local": [
      "ardx-20220411.htm"
     ]
    },
    "labelLink": {
     "local": [
      "ardx-20220411_lab.xml"
     ]
    },
    "presentationLink": {
     "local": [
      "ardx-20220411_pre.xml"
     ]
    },
    "schema": {
     "local": [
      "ardx-20220411.xsd"
     ],
     "remote": [
      "http://www.xbrl.org/2003/xbrl-instance-2003-12-31.xsd",
      "http://www.xbrl.org/2003/xbrl-linkbase-2003-12-31.xsd",
      "http://www.xbrl.org/2003/xl-2003-12-31.xsd",
      "http://www.xbrl.org/2003/xlink-2003-12-31.xsd",
      "http://www.xbrl.org/2005/xbrldt-2005.xsd",
      "http://www.xbrl.org/lrr/role/negated-2009-12-16.xsd",
      "http://www.xbrl.org/lrr/role/net-2009-12-16.xsd",
      "https://www.xbrl.org/dtr/type/2020-01-21/types.xsd",
      "https://xbrl.sec.gov/dei/2021/dei-2021.xsd"
     ]
    }
   },
   "elementCount": 24,
   "entityCount": 1,
   "hidden": {
    "http://xbrl.sec.gov/dei/2021": 2,
    "total": 2
   },
   "keyCustom": 0,
   "keyStandard": 23,
   "memberCustom": 0,
   "memberStandard": 0,
   "nsprefix": "ardx",
   "nsuri": "http://www.ardelyx.com/20220411",
   "report": {
    "R1": {
     "firstAnchor": {
      "ancestors": [
       "span",
       "div",
       "body",
       "html"
      ],
      "baseRef": "ardx-20220411.htm",
      "contextRef": "i99eb85ff74604dd8813b17eed2cb021d_D20220411-20220411",
      "decimals": null,
      "first": true,
      "lang": "en-US",
      "name": "dei:DocumentType",
      "reportCount": 1,
      "unique": true,
      "unitRef": null,
      "xsiNil": "false"
     },
     "groupType": "document",
     "isDefault": "true",
     "longName": "0001001 - Document - Cover",
     "role": "http://www.ardelyx.com/role/Cover",
     "shortName": "Cover",
     "subGroupType": "",
     "uniqueAnchor": {
      "ancestors": [
       "span",
       "div",
       "body",
       "html"
      ],
      "baseRef": "ardx-20220411.htm",
      "contextRef": "i99eb85ff74604dd8813b17eed2cb021d_D20220411-20220411",
      "decimals": null,
      "first": true,
      "lang": "en-US",
      "name": "dei:DocumentType",
      "reportCount": 1,
      "unique": true,
      "unitRef": null,
      "xsiNil": "false"
     }
    }
   },
   "segmentCount": 0,
   "tag": {
    "dei_AmendmentFlag": {
     "auth_ref": [],
     "lang": {
      "en-us": {
       "role": {
        "documentation": "Boolean flag that is true when the XBRL content amends previously-filed or accepted submission.",
        "label": "Amendment Flag",
        "terseLabel": "Amendment Flag"
       }
      }
     },
     "localname": "AmendmentFlag",
     "nsuri": "http://xbrl.sec.gov/dei/2021",
     "presentation": [
      "http://www.ardelyx.com/role/Cover"
     ],
     "xbrltype": "booleanItemType"
    },
    "dei_CityAreaCode": {
     "auth_ref": [],
     "lang": {
      "en-us": {
       "role": {
        "documentation": "Area code of city",
        "label": "City Area Code",
        "terseLabel": "City Area Code"
       }
      }
     },
     "localname": "CityAreaCode",
     "nsuri": "http://xbrl.sec.gov/dei/2021",
     "presentation": [
      "http://www.ardelyx.com/role/Cover"
     ],
     "xbrltype": "normalizedStringItemType"
    },
    "dei_CoverAbstract": {
     "auth_ref": [],
     "lang": {
      "en-us": {
       "role": {
        "documentation": "Cover page.",
        "label": "Cover [Abstract]"
       }
      }
     },
     "localname": "CoverAbstract",
     "nsuri": "http://xbrl.sec.gov/dei/2021",
     "xbrltype": "stringItemType"
    },
    "dei_DocumentPeriodEndDate": {
     "auth_ref": [],
     "lang": {
      "en-us": {
       "role": {
        "documentation": "For the EDGAR submission types of Form 8-K: the date of the report, the date of the earliest event reported; for the EDGAR submission types of Form N-1A: the filing date; for all other submission types: the end of the reporting or transition period.  The format of the date is YYYY-MM-DD.",
        "label": "Document Period End Date",
        "terseLabel": "Document Period End Date"
       }
      }
     },
     "localname": "DocumentPeriodEndDate",
     "nsuri": "http://xbrl.sec.gov/dei/2021",
     "presentation": [
      "http://www.ardelyx.com/role/Cover"
     ],
     "xbrltype": "dateItemType"
    },
    "dei_DocumentType": {
     "auth_ref": [],
     "lang": {
      "en-us": {
       "role": {
        "documentation": "The type of document being provided (such as 10-K, 10-Q, 485BPOS, etc). The document type is limited to the same value as the supporting SEC submission type, or the word 'Other'.",
        "label": "Document Type",
        "terseLabel": "Document Type"
       }
      }
     },
     "localname": "DocumentType",
     "nsuri": "http://xbrl.sec.gov/dei/2021",
     "presentation": [
      "http://www.ardelyx.com/role/Cover"
     ],
     "xbrltype": "submissionTypeItemType"
    },
    "dei_EntityAddressAddressLine1": {
     "auth_ref": [],
     "lang": {
      "en-us": {
       "role": {
        "documentation": "Address Line 1 such as Attn, Building Name, Street Name",
        "label": "Entity Address, Address Line One",
        "terseLabel": "Entity Address, Address Line One"
       }
      }
     },
     "localname": "EntityAddressAddressLine1",
     "nsuri": "http://xbrl.sec.gov/dei/2021",
     "presentation": [
      "http://www.ardelyx.com/role/Cover"
     ],
     "xbrltype": "normalizedStringItemType"
    },
    "dei_EntityAddressAddressLine2": {
     "auth_ref": [],
     "lang": {
      "en-us": {
       "role": {
        "documentation": "Address Line 2 such as Street or Suite number",
        "label": "Entity Address, Address Line Two",
        "terseLabel": "Entity Address, Address Line Two"
       }
      }
     },
     "localname": "EntityAddressAddressLine2",
     "nsuri": "http://xbrl.sec.gov/dei/2021",
     "presentation": [
      "http://www.ardelyx.com/role/Cover"
     ],
     "xbrltype": "normalizedStringItemType"
    },
    "dei_EntityAddressCityOrTown": {
     "auth_ref": [],
     "lang": {
      "en-us": {
       "role": {
        "documentation": "Name of the City or Town",
        "label": "Entity Address, City or Town",
        "terseLabel": "Entity Address, City or Town"
       }
      }
     },
     "localname": "EntityAddressCityOrTown",
     "nsuri": "http://xbrl.sec.gov/dei/2021",
     "presentation": [
      "http://www.ardelyx.com/role/Cover"
     ],
     "xbrltype": "normalizedStringItemType"
    },
    "dei_EntityAddressPostalZipCode": {
     "auth_ref": [],
     "lang": {
      "en-us": {
       "role": {
        "documentation": "Code for the postal or zip code",
        "label": "Entity Address, Postal Zip Code",
        "terseLabel": "Entity Address, Postal Zip Code"
       }
      }
     },
     "localname": "EntityAddressPostalZipCode",
     "nsuri": "http://xbrl.sec.gov/dei/2021",
     "presentation": [
      "http://www.ardelyx.com/role/Cover"
     ],
     "xbrltype": "normalizedStringItemType"
    },
    "dei_EntityAddressStateOrProvince": {
     "auth_ref": [],
     "lang": {
      "en-us": {
       "role": {
        "documentation": "Name of the state or province.",
        "label": "Entity Address, State or Province",
        "terseLabel": "Entity Address, State or Province"
       }
      }
     },
     "localname": "EntityAddressStateOrProvince",
     "nsuri": "http://xbrl.sec.gov/dei/2021",
     "presentation": [
      "http://www.ardelyx.com/role/Cover"
     ],
     "xbrltype": "stateOrProvinceItemType"
    },
    "dei_EntityCentralIndexKey": {
     "auth_ref": [
      "r5"
     ],
     "lang": {
      "en-us": {
       "role": {
        "documentation": "A unique 10-digit SEC-issued value to identify entities that have filed disclosures with the SEC. It is commonly abbreviated as CIK.",
        "label": "Entity Central Index Key",
        "terseLabel": "Entity Central Index Key"
       }
      }
     },
     "localname": "EntityCentralIndexKey",
     "nsuri": "http://xbrl.sec.gov/dei/2021",
     "presentation": [
      "http://www.ardelyx.com/role/Cover"
     ],
     "xbrltype": "centralIndexKeyItemType"
    },
    "dei_EntityEmergingGrowthCompany": {
     "auth_ref": [
      "r5"
     ],
     "lang": {
      "en-us": {
       "role": {
        "documentation": "Indicate if registrant meets the emerging growth company criteria.",
        "label": "Entity Emerging Growth Company",
        "terseLabel": "Entity Emerging Growth Company"
       }
      }
     },
     "localname": "EntityEmergingGrowthCompany",
     "nsuri": "http://xbrl.sec.gov/dei/2021",
     "presentation": [
      "http://www.ardelyx.com/role/Cover"
     ],
     "xbrltype": "booleanItemType"
    },
    "dei_EntityFileNumber": {
     "auth_ref": [],
     "lang": {
      "en-us": {
       "role": {
        "documentation": "Commission file number. The field allows up to 17 characters. The prefix may contain 1-3 digits, the sequence number may contain 1-8 digits, the optional suffix may contain 1-4 characters, and the fields are separated with a hyphen.",
        "label": "Entity File Number",
        "terseLabel": "Entity File Number"
       }
      }
     },
     "localname": "EntityFileNumber",
     "nsuri": "http://xbrl.sec.gov/dei/2021",
     "presentation": [
      "http://www.ardelyx.com/role/Cover"
     ],
     "xbrltype": "fileNumberItemType"
    },
    "dei_EntityIncorporationStateCountryCode": {
     "auth_ref": [],
     "lang": {
      "en-us": {
       "role": {
        "documentation": "Two-character EDGAR code representing the state or country of incorporation.",
        "label": "Entity Incorporation, State or Country Code",
        "terseLabel": "Entity Incorporation, State or Country Code"
       }
      }
     },
     "localname": "EntityIncorporationStateCountryCode",
     "nsuri": "http://xbrl.sec.gov/dei/2021",
     "presentation": [
      "http://www.ardelyx.com/role/Cover"
     ],
     "xbrltype": "edgarStateCountryItemType"
    },
    "dei_EntityRegistrantName": {
     "auth_ref": [
      "r5"
     ],
     "lang": {
      "en-us": {
       "role": {
        "documentation": "The exact name of the entity filing the report as specified in its charter, which is required by forms filed with the SEC.",
        "label": "Entity Registrant Name",
        "terseLabel": "Entity Registrant Name"
       }
      }
     },
     "localname": "EntityRegistrantName",
     "nsuri": "http://xbrl.sec.gov/dei/2021",
     "presentation": [
      "http://www.ardelyx.com/role/Cover"
     ],
     "xbrltype": "normalizedStringItemType"
    },
    "dei_EntityTaxIdentificationNumber": {
     "auth_ref": [
      "r5"
     ],
     "lang": {
      "en-us": {
       "role": {
        "documentation": "The Tax Identification Number (TIN), also known as an Employer Identification Number (EIN), is a unique 9-digit value assigned by the IRS.",
        "label": "Entity Tax Identification Number",
        "terseLabel": "Entity Tax Identification Number"
       }
      }
     },
     "localname": "EntityTaxIdentificationNumber",
     "nsuri": "http://xbrl.sec.gov/dei/2021",
     "presentation": [
      "http://www.ardelyx.com/role/Cover"
     ],
     "xbrltype": "employerIdItemType"
    },
    "dei_LocalPhoneNumber": {
     "auth_ref": [],
     "lang": {
      "en-us": {
       "role": {
        "documentation": "Local phone number for entity.",
        "label": "Local Phone Number",
        "terseLabel": "Local Phone Number"
       }
      }
     },
     "localname": "LocalPhoneNumber",
     "nsuri": "http://xbrl.sec.gov/dei/2021",
     "presentation": [
      "http://www.ardelyx.com/role/Cover"
     ],
     "xbrltype": "normalizedStringItemType"
    },
    "dei_PreCommencementIssuerTenderOffer": {
     "auth_ref": [
      "r2"
     ],
     "lang": {
      "en-us": {
       "role": {
        "documentation": "Boolean flag that is true when the Form 8-K filing is intended to satisfy the filing obligation of the registrant as pre-commencement communications pursuant to Rule 13e-4(c) under the Exchange Act.",
        "label": "Pre-commencement Issuer Tender Offer",
        "terseLabel": "Pre-commencement Issuer Tender Offer"
       }
      }
     },
     "localname": "PreCommencementIssuerTenderOffer",
     "nsuri": "http://xbrl.sec.gov/dei/2021",
     "presentation": [
      "http://www.ardelyx.com/role/Cover"
     ],
     "xbrltype": "booleanItemType"
    },
    "dei_PreCommencementTenderOffer": {
     "auth_ref": [
      "r3"
     ],
     "lang": {
      "en-us": {
       "role": {
        "documentation": "Boolean flag that is true when the Form 8-K filing is intended to satisfy the filing obligation of the registrant as pre-commencement communications pursuant to Rule 14d-2(b) under the Exchange Act.",
        "label": "Pre-commencement Tender Offer",
        "terseLabel": "Pre-commencement Tender Offer"
       }
      }
     },
     "localname": "PreCommencementTenderOffer",
     "nsuri": "http://xbrl.sec.gov/dei/2021",
     "presentation": [
      "http://www.ardelyx.com/role/Cover"
     ],
     "xbrltype": "booleanItemType"
    },
    "dei_Security12bTitle": {
     "auth_ref": [
      "r0"
     ],
     "lang": {
      "en-us": {
       "role": {
        "documentation": "Title of a 12(b) registered security.",
        "label": "Title of 12(b) Security",
        "terseLabel": "Title of 12(b) Security"
       }
      }
     },
     "localname": "Security12bTitle",
     "nsuri": "http://xbrl.sec.gov/dei/2021",
     "presentation": [
      "http://www.ardelyx.com/role/Cover"
     ],
     "xbrltype": "securityTitleItemType"
    },
    "dei_SecurityExchangeName": {
     "auth_ref": [
      "r1"
     ],
     "lang": {
      "en-us": {
       "role": {
        "documentation": "Name of the Exchange on which a security is registered.",
        "label": "Security Exchange Name",
        "terseLabel": "Security Exchange Name"
       }
      }
     },
     "localname": "SecurityExchangeName",
     "nsuri": "http://xbrl.sec.gov/dei/2021",
     "presentation": [
      "http://www.ardelyx.com/role/Cover"
     ],
     "xbrltype": "edgarExchangeCodeItemType"
    },
    "dei_SolicitingMaterial": {
     "auth_ref": [
      "r4"
     ],
     "lang": {
      "en-us": {
       "role": {
        "documentation": "Boolean flag that is true when the Form 8-K filing is intended to satisfy the filing obligation of the registrant as soliciting material pursuant to Rule 14a-12 under the Exchange Act.",
        "label": "Soliciting Material",
        "terseLabel": "Soliciting Material"
       }
      }
     },
     "localname": "SolicitingMaterial",
     "nsuri": "http://xbrl.sec.gov/dei/2021",
     "presentation": [
      "http://www.ardelyx.com/role/Cover"
     ],
     "xbrltype": "booleanItemType"
    },
    "dei_TradingSymbol": {
     "auth_ref": [],
     "lang": {
      "en-us": {
       "role": {
        "documentation": "Trading symbol of an instrument as listed on an exchange.",
        "label": "Trading Symbol",
        "terseLabel": "Trading Symbol"
       }
      }
     },
     "localname": "TradingSymbol",
     "nsuri": "http://xbrl.sec.gov/dei/2021",
     "presentation": [
      "http://www.ardelyx.com/role/Cover"
     ],
     "xbrltype": "tradingSymbolItemType"
    },
    "dei_WrittenCommunications": {
     "auth_ref": [
      "r6"
     ],
     "lang": {
      "en-us": {
       "role": {
        "documentation": "Boolean flag that is true when the Form 8-K filing is intended to satisfy the filing obligation of the registrant as written communications pursuant to Rule 425 under the Securities Act.",
        "label": "Written Communications",
        "terseLabel": "Written Communications"
       }
      }
     },
     "localname": "WrittenCommunications",
     "nsuri": "http://xbrl.sec.gov/dei/2021",
     "presentation": [
      "http://www.ardelyx.com/role/Cover"
     ],
     "xbrltype": "booleanItemType"
    }
   },
   "unitCount": 0
  }
 },
 "std_ref": {
  "r0": {
   "Name": "Exchange Act",
   "Number": "240",
   "Publisher": "SEC",
   "Section": "12",
   "Subsection": "b"
  },
  "r1": {
   "Name": "Exchange Act",
   "Number": "240",
   "Publisher": "SEC",
   "Section": "12",
   "Subsection": "d1-1"
  },
  "r2": {
   "Name": "Exchange Act",
   "Number": "240",
   "Publisher": "SEC",
   "Section": "13e",
   "Subsection": "4c"
  },
  "r3": {
   "Name": "Exchange Act",
   "Number": "240",
   "Publisher": "SEC",
   "Section": "14d",
   "Subsection": "2b"
  },
  "r4": {
   "Name": "Exchange Act",
   "Number": "240",
   "Publisher": "SEC",
   "Section": "14a",
   "Subsection": "12"
  },
  "r5": {
   "Name": "Regulation 12B",
   "Number": "240",
   "Publisher": "SEC",
   "Section": "12",
   "Subsection": "b-2"
  },
  "r6": {
   "Name": "Securities Act",
   "Number": "230",
   "Publisher": "SEC",
   "Section": "425"
  }
 },
 "version": "2.1"
}
</TEXT>
</DOCUMENT>
<DOCUMENT>
<TYPE>ZIP
<SEQUENCE>15
<FILENAME>0001628280-22-008924-xbrl.zip
<DESCRIPTION>IDEA: XBRL DOCUMENT
<TEXT>
begin 644 0001628280-22-008924-xbrl.zip
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M71%/(W+YYAUB )2B\[]!9<6,O"S>X<8L'Y4H))WJP(2#Z1UIK;MD86 B=:I
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MJP&J2_"C* F$"*R)#WG^?-&48E0$)GU91S3OECQMLPEQE"7.7A/B:$(<^N=
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MAY. _0JJ?B5L:%!(VTT])Y1AHB^H^M)Y@KFB4_#GJN6KKJ^KZY\3(;VZO&%
MG4.386RR'P1R5?FJ\S^D\],;.J^9@MB^KV'-U358M#H<>X9K86$'CNU13;B^
M_BOH/ @=]A>D[IM^GE".]0WOS7H6(&_[:@/N:0,::3H6R:LE^'F6X/*&);!<
M)F\O,S$)A,PN6A#H!S[#!@TXF 3*F>.^6H)5EL" Q=&&OYXE*-K>LR2$/E4>
M:F$=DR>&1"+X$BF*DZ&(**-8)(H _;7R0M8+*^DWRI9KWBLS=/<S1__Y%?VZ
M729DO7S3TP,+E'7H>L.^@&K!]=QH6U[IEY_:]7O(CUB:?H<Y74IHOWA2)$QM
M*!Y.!UX<;:3?4R[XCR)$JSBOID1"S+P)F->+7@B_7-G@[XDH"Y,J#>XMNR//
MB3"KO?-#YIAR'S<ENJ=4\D4'D7^<-?L?>C /W:^=35NU@T%'KT/@&(6M?FL
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M'PRLHH5XRJ)LBA(93XS85'DAQ0N!"F9)S!:Q&8^@^U!D*&61R"$00P8M(3J
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M \?@VF, =#Z+Y+.:>V$N.7-O"G(TZL7I"(R"&(1L47A?@N&5^@5<  U/QP-
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M0"%9C4BHL'%:7M4KF)RFXXJ(>]  O^@)K2GYU9^TOV3_'2SJ_Y+]"_9OUP1
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MXA7GC".N(L $Y0#+$ ,:*@:42@3U(0]C'_UR\0K&,,94)@"&S <8*@$HC2&
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M^3N)U9IK+WG6(XTF2&L"VQ*T-W 7W>;IZ8='!G^CI9QS10*BE !0101@'X6
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M:Q/O-N-G^NCMB\TGZ>H=^F]?_!]02P,$%     @ Q("+5'M14Q',!@  ]#(
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MO/>9*,ZM],$$8,.(^!OC_< 8?;UQN+"CX.,$):O]\A2W.)N?X79NC4HJ"9R
MY@E%,18GX(!8[V@*UG,NAY4?GC3;CXD1ER"'B_G*-!SC?C>U>]YW2[^8@U3"
M!9-(H %7O+9DXA4FSY@P(\B>*F'\( JVS/7S_HBKD"\7;V=>?S-[)-X9'CC:
MNS_1/K7_)G&T]S]02P$"% ,4    " #$@(M44*8@Q7L6   XP0  '@
M        @ $     83)N9&%M96YD;65N='1O:VMC+6%R9'AL:6,N:'1M4$L!
M A0#%     @ Q("+5)(T "\@%@  NHL  !$              ( !MQ8  &%R
M9'@M,C R,C T,3$N:'1M4$L! A0#%     @ Q("+5']+%>1I @  :P<  !$
M             ( !!BT  &%R9'@M,C R,C T,3$N>'-D4$L! A0#%     @
MQ("+5)2F*=^'"0  "@H  !0              ( !GB\  &%R9'@M,C R,C T
M,3%?9S$N:G!G4$L! A0#%     @ Q("+5(A3*@B1"@  $6$  !4
M     ( !5SD  &%R9'@M,C R,C T,3%?;&%B+GAM;%!+ 0(4 Q0    ( ,2
MBU1[45,1S 8  /0R   5              "  1M$  !A<F1X+3(P,C(P-#$Q
>7W!R92YX;6Q02P4&      8 !@"2 0  &DL

end
</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
