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STATEMENTS OF CASH FLOWS - USD ($) $ in Thousands | 12 Months Ended
--- | ---
Dec. 31, 2023 | Dec. 31, 2022 | Dec. 31, 2021
Operating activities |  |  |
Net loss | $ (66,067) | $ (67,207) | $ (158,165)
Adjustments to reconcile net loss to net cash used in operating activities: |  |  |
Depreciation and amortization expense | 1,292 | 1,144 | 2,807
Non-cash lease expense | 3,624 | 3,457 | 3,085
Stock-based compensation | 13,530 | 10,750 | 12,039
Non-cash interest expense | 4,220 | 1,962 | 283
Gain on sale of equipment | 0 | (1,260) | 0
Other, net | (2,930) | 685 | (678)
Changes in operating assets and liabilities: |  |  |
Accounts receivable | (14,298) | (7,231) | (502)
Inventory | (21,141) | (28,346) | 0
Prepaid commercial manufacturing | (9,593) | (4,161) | (9,406)
Prepaid expenses and other assets | (6,035) | 2,299 | 502
Accounts payable | 279 | 6,582 | (1,349)
Accrued compensation and benefits | 5,049 | 2,126 | (250)
Operating lease liabilities | (3,928) | (3,491) | (2,853)
Accrued and other liabilities | 3,691 | 4,138 | 1,386
Deferred revenue | 2,590 | 8,509 | 550
Net cash used in operating activities | (89,717) | (70,044) | (152,551)
Investing activities |  |  |
Proceeds from maturities and redemptions of investments | 84,321 | 67,000 | 125,550
Purchases of investments | (215,225) | (50,328) | (72,735)
Proceeds from sale of property and equipment | 0 | 1,798 | 0
Purchases of property and equipment | (344) | (55) | (1,867)
Net cash (used in) provided by investing activities | (131,248) | 18,415 | 50,948
Financing activities |  |  |
Proceeds from issuance of common stock in at the market offering, net of issuance costs | 119,236 | 71,625 | 101,146
Proceeds from 2022 Loan, net of issuance costs | 22,386 | 26,971 | 0
Proceeds from the sale of future royalties, net of issuance costs | 5,000 | 9,581 | 0
Proceeds from issuance of common stock under equity incentive and stock purchase plans | 1,173 | 202 | 1,403
Payment of the 2018 Exit Fee | (1,500) | 0 | 0
Payments for the 2018 Loan, net of costs | 0 | (33,038) | (19,444)
Payments for taxes related to net share settlement of equity awards | 0 | 0 | (106)
Net cash provided by financing activities | 146,295 | 75,341 | 82,999
Net (decrease) increase in cash and cash equivalents | (74,670) | 23,712 | (18,604)
Cash and cash equivalents at beginning of period | 96,140 | 72,428 | 91,032
Cash and cash equivalents at end of period | 21,470 | 96,140 | 72,428
Supplementary disclosure of cash flow information: |  |  |
Cash paid for interest | 4,240 | 2,901 | 3,469
Cash paid for income taxes | 51 | 6 | 4
Supplementary disclosure of non-cash activities: |  |  |
Right-of-use assets obtained in exchange for lease obligations | 339 | 0 | 1,604
Issuance of common stock for services | 337 | 390 | 190
Issuance of derivative in connection with issuance of loan payable | $ 0 | $ 375 | $ 0

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