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Collaboration and Licensing Agreements - Narrative (Details) $ in Millions, ¥ in Billions | 1 Months Ended | 12 Months Ended | 74 Months Ended |  |  |  |  |  |  |
--- | --- | --- | --- | --- | --- | --- | --- | --- | --- | ---
Mar. 31, 2018 USD ($) | Dec. 31, 2017 USD ($) | Nov. 30, 2017 USD ($) | Jun. 30, 2015 USD ($) | Dec. 31, 2023 USD ($) | Dec. 31, 2023 CAD ($) | Dec. 31, 2022 USD ($) | Dec. 31, 2021 USD ($) | Dec. 31, 2023 USD ($) | Mar. 31, 2024 USD ($) | Dec. 31, 2023 JPY (¥) | Sep. 30, 2023 USD ($) | Jul. 31, 2023 USD ($) | Apr. 30, 2023 USD ($) | Oct. 31, 2022 USD ($) | Apr. 30, 2022 USD ($) payment_tranche
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Total revenues |  |  |  |  | $ 124,456,000 |  | $ 52,158,000 | $ 10,097,000 |  |  |  |  |  |  |  |
Licensing revenue |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Total revenues |  |  |  |  | 35,809,000 |  | 35,031,000 | 5,013,000 |  |  |  |  |  |  |  |
Product supply revenue |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Total revenues |  |  |  |  | 6,121,000 |  | 1,527,000 | 907,000 |  |  |  |  |  |  |  |
2017 KKC Agreement | Licensing revenue |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Total revenues |  |  |  |  | 30,000,000 |  | 35,000,000 | 5,000,000 |  |  |  |  |  |  |  |
2017 KKC Agreement | Product supply revenue |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Total revenues |  |  |  |  | 6,100,000 |  | 1,500,000 | 900,000 |  |  |  |  |  |  |  |
Fosun Agreement | Licensing revenue |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Total revenues |  |  |  |  | 5,000,000 |  | 0 | 0 |  |  |  |  |  |  |  |
Knight Agreement | Licensing revenue |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Total revenues |  |  |  |  | 0 |  | 0 | 0 |  |  |  |  |  |  |  |
Kyowa Kirin Co. Ltd | 2017 KKC Agreement |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Upfront license fees |  |  | $ 30,000,000 |  |  |  |  |  |  |  |  |  |  |  |  |
Potential development milestones |  |  | $ 55,000,000 |  |  |  |  |  |  |  |  |  |  |  |  |
Total revenues |  |  |  |  |  |  |  |  | $ 35,000,000 |  |  |  |  |  |  |
Potential commercialization milestones |  |  |  |  | 60,300,000 |  |  |  | 60,300,000 |  | ¥ 8.5 |  |  |  |  |
Fee receivable for reduction in royalty rate |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | $ 40,000,000
Number of payment tranches for fee receivable for reduction in royalty rate | payment_tranche |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 2
Kyowa Kirin Co. Ltd | 2017 KKC Agreement | Licensing revenue |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Proceeds from milestone payments |  |  |  |  |  |  |  |  |  |  |  | $ 30,000,000 |  |  | $ 35,000,000 |
Fosun Pharma | Fosun Agreement |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Proceeds from milestone payments |  |  |  |  | 8,000,000 |  |  |  | 8,000,000 |  |  |  | $ 2,000,000 |  |  |
Upfront payment received |  | $ 12,000,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |
Potential development and commercialization milestones |  |  |  |  | $ 113,000,000 |  |  |  |  |  |  |  |  |  |  |
Threshold percentage of net sales for tiered royalties |  |  |  |  | 20.00% | 20.00% |  |  |  |  |  |  |  |  |  |
Fosun Pharma | Fosun Agreement | Subsequent event |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Proceeds from milestone payments |  |  |  |  |  |  |  |  |  | $ 3,000,000 |  |  |  |  |  |
Fosun Pharma | Knight Agreement |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Potential development milestones |  |  |  |  | $ 5,000,000 |  |  |  | 5,000,000 |  |  |  |  |  |  |
Knight | Knight Agreement |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Potential development milestones |  |  |  |  | 700,000 |  |  |  | 700,000 |  |  |  |  |  |  |
Upfront payment received | $ 2,300,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Potential development and commercialization milestones |  |  |  |  | 16,700,000 | $ 22.2 |  |  |  |  |  |  |  |  |  |
METiS Therapeutics Inc | Licensing revenue |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Total revenues |  |  |  |  | 800,000 |  |  |  |  |  |  |  |  |  |  |
Proceeds from milestone payments |  |  |  |  |  |  |  |  |  |  |  |  |  | $ 243,000,000 |  |
Upfront payment |  |  |  |  |  |  |  |  |  |  |  |  |  | $ 800,000 |  |
AstraZeneca | AZ Termination Agreement |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Percentage of royalty revenue |  |  |  | 10.00% |  |  |  |  |  |  |  |  |  |  |  |
Percentage of non royalty revenue |  |  |  | 20.00% |  |  |  |  |  |  |  |  |  |  |  |
Maximum potential payment per agreement |  |  |  | $ 75,000,000 |  |  |  |  |  |  |  |  |  |  |  |
Aggregate cost of revenue recognized |  |  |  |  | 27,600,000 |  |  |  | $ 27,600,000 |  |  |  |  |  |  |
Total cost of goods sold |  |  |  |  | $ 12,400,000 |  | $ 3,600,000 | $ 1,000,000 |  |  |  |  |  |  |  |

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