<SEC-DOCUMENT>0001610717-24-000187.txt : 20240327
<SEC-HEADER>0001610717-24-000187.hdr.sgml : 20240327
<ACCEPTANCE-DATETIME>20240327181136
ACCESSION NUMBER:		0001610717-24-000187
CONFORMED SUBMISSION TYPE:	3
PUBLIC DOCUMENT COUNT:		2
CONFORMED PERIOD OF REPORT:	20240325
FILED AS OF DATE:		20240327
DATE AS OF CHANGE:		20240327

REPORTING-OWNER:	

	OWNER DATA:	
		COMPANY CONFORMED NAME:			Kelliher Mike
		CENTRAL INDEX KEY:			0001987188
		ORGANIZATION NAME:           	

	FILING VALUES:
		FORM TYPE:		3
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	001-36485
		FILM NUMBER:		24792458

	MAIL ADDRESS:	
		STREET 1:		C/O CAPRICOR THERAPEUTICS, INC.
		STREET 2:		10865 ROAD TO THE CURE, SUITE 150
		CITY:			SAN DIEGO
		STATE:			CA
		ZIP:			92121

ISSUER:		

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			ARDELYX, INC.
		CENTRAL INDEX KEY:			0001437402
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		ORGANIZATION NAME:           	03 Life Sciences
		IRS NUMBER:				000000000
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	BUSINESS ADDRESS:	
		STREET 1:		34175 ARDENWOOD BLVD.
		CITY:			FREMONT
		STATE:			CA
		ZIP:			94555
		BUSINESS PHONE:		510-745-7047

	MAIL ADDRESS:	
		STREET 1:		34175 ARDENWOOD BLVD.
		CITY:			FREMONT
		STATE:			CA
		ZIP:			94555

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	NTERYX INC
		DATE OF NAME CHANGE:	20080611
</SEC-HEADER>
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<ownershipDocument>

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    <documentType>3</documentType>

    <periodOfReport>2024-03-25</periodOfReport>

    <noSecuritiesOwned>1</noSecuritiesOwned>

    <issuer>
        <issuerCik>0001437402</issuerCik>
        <issuerName>ARDELYX, INC.</issuerName>
        <issuerTradingSymbol>ARDX</issuerTradingSymbol>
    </issuer>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001987188</rptOwnerCik>
            <rptOwnerName>Kelliher Mike</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>C/O ARDELYX, INC.</rptOwnerStreet1>
            <rptOwnerStreet2>400 FIFTH AVENUE, SUITE 210</rptOwnerStreet2>
            <rptOwnerCity>WALTHAM</rptOwnerCity>
            <rptOwnerState>MA</rptOwnerState>
            <rptOwnerZipCode>02451</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isOfficer>true</isOfficer>
            <officerTitle>See Remarks</officerTitle>
        </reportingOwnerRelationship>
    </reportingOwner>

    <remarks>Executive Vice President, Corporate Development and Strategy</remarks>

    <ownerSignature>
        <signatureName>/s/ Elizabeth Grammer, Attorney-in-Fact for Mike Kelliher</signatureName>
        <signatureDate>2024-03-27</signatureDate>
    </ownerSignature>
</ownershipDocument>
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    <div style="text-align: center; margin-bottom: 12pt; font-size: 12pt; font-weight: bold;">POWER OF ATTORNEY</div>
    <div style="text-indent: 36pt;">Know all by these presents, that the undersigned hereby constitutes and appoints each of (i) the Chief Executive Officer of Ardelyx, Inc.,
      a Delaware corporation (the &#8220;<font style="font-weight: bold;">Company</font>&#8221;), who is currently Michael Raab, (ii) the Company's Chief Financial and Operations Officer, who is currently
      Justin Renz and (iii) the Chief Legal and Administrative Officer, who is currently Elizabeth Grammer, and their respective successors, signing singly, with full power of substitution and resubstitution, as the undersigned's true and lawful
      attorney-in-fact to:</div>
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          <td style="width: 36pt; vertical-align: top;">&#160;(1)</td>
          <td style="width: auto; vertical-align: top; text-align: justify;">
            <div>execute for and on behalf of the undersigned, in the undersigned&#8217;s capacity as an officer
                and/or director of the Company, (a) Schedules 13D and 13G in accordance with Section 13 of the Securities Exchange Act of 1934, as amended (the &#8220;<font style="font-style: italic;">Exchange Act</font>&#8221;), and the rules thereunder, (b) Forms&#160;3, 4 and 5 (including amendments thereto) in accordance with Section&#160;16(a) of Exchange Act and
                the rules and regulations thereunder, (c) Notices of Proposed Sale of Securities Pursuant to Rule 144 (&#8220;<font style="font-style: italic;">Form 144</font>&#8221;), in
              accordance with the requirements of Rule 144 under the Securities Act of 1933, as amended (the &#8220;<font style="font-style: italic;">Securities Act</font>&#8221;) and (d) Form ID, Uniform Application for Access Codes to File on EDGAR;</div>
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          <td style="width: 36pt; vertical-align: top;">(2)</td>
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            <div>do and perform any and all acts for and on behalf of the undersigned which may be necessary
                or desirable to complete and execute any such Schedule 13D, Schedule 13G, Forms 3, 4, 5 or 144 or Form ID, or any amendment thereto, and timely file such
                forms (including amendments thereto) and application with the United States Securities and Exchange Commission and any stock exchange or similar authority; and</div>
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          <td style="width: 36pt; vertical-align: top;">(3)</td>
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            <div>take any other action of any type whatsoever in connection with the foregoing which, in the opinion of such attorney-in-fact, may be of benefit to, in the best interest
              of, or legally required by, the undersigned, it being understood that the documents executed by such attorney-in-fact on behalf of the undersigned pursuant to this Power of Attorney shall be in such form and shall contain such terms and
              conditions as such attorney-in-fact may approve in such attorney-in-fact's discretion.</div>
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    </table>
    <div style="text-align: justify; text-indent: 72pt; margin-bottom: 12pt;">The undersigned hereby grants to each such attorney-in-fact full power and authority to do and perform any and
      every act and thing whatsoever requisite, necessary or proper to be done in the exercise of any of the rights and powers herein granted, as fully to all intents and purposes as the undersigned might or could do if personally present, with full power
      of substitution and resubstitution or revocation, hereby ratifying and confirming all that such attorney-in-fact, or such attorney-in-fact's substitute or substitutes, shall lawfully do or cause to be done by virtue of this power of attorney and the
      rights and powers herein granted.&#160; The undersigned acknowledges that the foregoing attorneys-in-fact, in serving in such capacity at the request of the undersigned, are not assuming, nor is the Company assuming, any of the undersigned's
      responsibilities to comply with Section&#160;13 and 16 of the Exchange Act or Rule 144 under the Securities Act.</div>
    <div style="text-align: justify; text-indent: 36pt; margin-bottom: 12pt;">The undersigned agrees that each such attorney-in-fact herein may rely entirely on information furnished orally or
      in writing by the undersigned to such attorney-in-fact.&#160; The undersigned also agrees to indemnify and hold harmless the Company and each such attorney-in-fact against any losses, claims, damages or liabilities (or actions in these respects) that
      arise out of or are based upon any untrue statements or omission of necessary facts in the information provided by the undersigned to such attorney-in fact for purposes of executing, acknowledging, delivering or filing Forms 3, 4, 5 or 144 (including
      amendments thereto) or Form ID and agrees to reimburse the Company and such attorney-in-fact for any legal or other expenses reasonably incurred in connection with investigating or defending against any such loss, claim, damage, liability or action.</div>
    <div style="text-align: justify; text-indent: 36pt; margin-bottom: 12pt;">This Power of Attorney supersedes any power of attorney previously executed by the undersigned regarding the
      purposes outlined in the first paragraph hereof (&#8220;<font style="font-weight: bold; font-style: italic;">Prior Powers of Attorney</font>&#8221;), and the authority of the attorneys-in-fact named
      in any Prior Powers of Attorney is hereby revoked.</div>
    <div style="text-align: justify; text-indent: 36pt; margin-bottom: 12pt;">This Power of Attorney shall remain in full force and effect until the undersigned is no longer required to file
      Schedule 13D or 13G and Forms&#160;3, 4, 5 or 144 with respect to the undersigned's holdings of and transactions in securities issued by the Company, unless earlier (a)&#160;revoked by the undersigned in a signed writing delivered to the foregoing
      attorneys-in-fact or (b)&#160;superseded by a new power of attorney regarding the purposes outlined in the first paragraph hereof dated as of a later date.</div>
    <div style="text-indent: 36pt;">IN WITNESS WHEREOF, the undersigned has caused this Power of Attorney to be executed as of this 26th day of March, 2024.</div>
    <div style="text-indent: 36pt;"> <br>
    </div>
    <div style="text-indent: 36pt;"> <u>/s/ Michael Kelliher</u></div>
    <div style="text-indent: 36pt;"> Michael Kelliher</div>
    <div><br>
    </div>
    <div style="text-indent: 9pt; margin-left: 279pt; font-weight: bold;"><br>
    </div>
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