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STATEMENTS OF CASH FLOWS - USD ($) $ in Thousands | 12 Months Ended
--- | ---
Dec. 31, 2024 | Dec. 31, 2023 | Dec. 31, 2022
Operating activities |  |  |
Net loss | $ (39,136) | $ (66,067) | $ (67,207)
Adjustments to reconcile net loss to net cash used in operating activities |  |  |
Depreciation and amortization expense | 2,063 | 1,292 | 1,144
Non-cash lease expense | 4,008 | 3,624 | 3,457
Stock-based compensation | 37,381 | 13,530 | 10,750
Non-cash interest expense | 7,400 | 4,220 | 1,962
Non-cash royalty revenue related to the sale of future royalties | (2,692) | 0 | 0
Gain on sale of equipment | 0 | 0 | (1,260)
Other, net | (4,664) | (2,930) | 685
Changes in operating assets and liabilities |  |  |
Accounts receivable | (35,674) | (14,298) | (7,231)
Inventory | (41,697) | (21,141) | (28,346)
Prepaid commercial manufacturing | 6,782 | (9,593) | (4,161)
Prepaid expenses and other assets | (4,543) | (6,035) | 2,299
Accounts payable | 4,862 | 279 | 6,582
Accrued compensation and benefits | 2,343 | 5,049 | 2,126
Operating lease liabilities | (4,588) | (3,928) | (3,491)
Accrued and other liabilities | 21,254 | 3,691 | 4,138
Deferred revenue | 2,092 | 2,590 | 8,509
Net cash used in operating activities | (44,809) | (89,717) | (70,044)
Investing activities |  |  |
Proceeds from maturities and redemptions of investments | 177,854 | 84,321 | 67,000
Purchases of investments | (195,161) | (215,225) | (50,328)
Proceeds from sale of property and equipment | 0 | 0 | 1,798
Purchases of property and equipment | (1,011) | (344) | (55)
Net cash (used in) provided by investing activities | (18,318) | (131,248) | 18,415
Financing activities |  |  |
Proceeds from issuance of common stock in at the market offering, net of issuance costs | 0 | 119,236 | 71,625
Proceeds from 2022 Loan Agreement, net of issuance costs | 99,451 | 22,386 | 26,971
Proceeds from the sale of future royalties, net of issuance costs | 0 | 5,000 | 9,581
Proceeds from issuance of common stock under equity incentive and stock purchase plans | 8,138 | 1,173 | 202
Payment of the exit fees | (1,000) | (1,500) | 0
Payments for the 2018 Loan, net of costs | 0 | 0 | (33,038)
Net cash provided by financing activities | 106,589 | 146,295 | 75,341
Net increase (decrease) in cash and cash equivalents | 43,462 | (74,670) | 23,712
Cash and cash equivalents at beginning of period | 21,470 | 96,140 | 72,428
Cash and cash equivalents at end of period | 64,932 | 21,470 | 96,140
Supplementary disclosure of cash flow information |  |  |
Cash paid for interest | 11,408 | 4,240 | 2,901
Cash paid for income taxes | 266 | 51 | 6
Supplementary disclosure of non-cash activities |  |  |
Right-of-use assets obtained in exchange for lease obligations | 1,010 | 339 | 0
Issuance of common stock for services | 257 | 337 | 390
Issuance of derivative in connection with issuance of loan payable | $ 0 | $ 0 | $ 375

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