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Collaboration and Licensing Agreements - Narrative (Details) $ in Thousands, $ in Millions, ¥ in Billions | 1 Months Ended | 12 Months Ended | 86 Months Ended |  |  |
--- | --- | --- | --- | --- | --- | ---
Dec. 31, 2017 USD ($) | Nov. 30, 2017 USD ($) | Jun. 30, 2015 USD ($) | Dec. 31, 2024 USD ($) payment_tranche | Dec. 31, 2024 CAD ($) | Dec. 31, 2023 USD ($) | Dec. 31, 2022 USD ($) | Dec. 31, 2024 USD ($) payment_tranche | Dec. 31, 2024 JPY (¥) payment_tranche | Apr. 30, 2023 USD ($) | Mar. 31, 2018 USD ($)
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |  |  |  |  |  |  |  |
Total revenues |  |  |  | $ 333,615 |  | $ 124,456 | $ 52,158 |  |  |  |
Licensing revenue |  |  |  |  |  |  |  |  |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |  |  |  |  |  |  |  |
Total revenues |  |  |  | 78 |  | 35,809 | 35,031 |  |  |  |
Kyowa Kirin | 2017 KKC Agreement |  |  |  |  |  |  |  |  |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |  |  |  |  |  |  |  |
Upfront license fees |  | $ 30,000 |  |  |  |  |  |  |  |  |
Potential development milestones |  | $ 55,000 |  |  |  |  |  |  |  |  |
Total revenues |  |  |  |  |  |  |  | $ 35,000 |  |  |
Potential commercialization milestones |  |  |  | $ 54,000 |  |  |  | 54,000 | ¥ 8.5 |  |
Period to reduce royalty rate |  |  |  | 2 years | 2 years |  |  |  |  |  |
Fee receivable for reduction in royalty rate |  |  |  | $ 40,000 |  |  |  | $ 40,000 |  |  |
Number of payment tranches for fee receivable for reduction in royalty rate | payment_tranche |  |  |  | 2 |  |  |  | 2 | 2 |  |
Kyowa Kirin | 2017 KKC Agreement | Licensing revenue |  |  |  |  |  |  |  |  |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |  |  |  |  |  |  |  |
Total revenues |  |  |  | $ 0 |  | 30,000 | 35,000 |  |  |  |
Fosun Pharma | Fosun Agreement |  |  |  |  |  |  |  |  |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |  |  |  |  |  |  |  |
Upfront payment received | $ 12,000 |  |  |  |  |  |  |  |  |  |
Potential development and commercialization milestones |  |  |  | 113,000 |  |  |  |  |  |  |
Proceeds from milestone payments |  |  |  | $ 8,000 |  |  |  | $ 8,000 |  |  |
Threshold percentage of net sales for tiered royalties |  |  |  | 20.00% | 20.00% |  |  |  |  |  |
Fosun Pharma | Fosun Agreement | Licensing revenue |  |  |  |  |  |  |  |  |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |  |  |  |  |  |  |  |
Total revenues |  |  |  | $ 0 |  | 5,000 | 0 |  |  |  |
Knight | Knight Agreement |  |  |  |  |  |  |  |  |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |  |  |  |  |  |  |  |
Potential development milestones |  |  |  | 700 |  |  |  | 700 |  |  |
Potential development and commercialization milestones |  |  |  | 15,400 | $ 22.2 |  |  |  |  |  |
Upfront payment |  |  |  |  |  |  |  |  |  |  | $ 2,300
Knight | Knight Agreement | Licensing revenue |  |  |  |  |  |  |  |  |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |  |  |  |  |  |  |  |
Total revenues |  |  |  | 78 |  | 59 | 31 |  |  |  |
AstraZeneca | AZ Termination Agreement |  |  |  |  |  |  |  |  |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |  |  |  |  |  |  |  |
Percentage of royalty revenue |  |  | 10.00% |  |  |  |  |  |  |  |
Percentage of non royalty revenue |  |  | 20.00% |  |  |  |  |  |  |  |
Maximum potential payment per agreement |  |  | $ 75,000 |  |  |  |  |  |  |  |
Aggregate cost of revenue recognized |  |  |  | 62,300 |  |  |  | $ 62,300 |  |  |
Cost of revenue |  |  |  | 34,700 |  | 12,400 | 3,600 |  |  |  |
METiS Therapeutics Inc | Licensing revenue |  |  |  |  |  |  |  |  |  |  |
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items] |  |  |  |  |  |  |  |  |  |  |
Total revenues |  |  |  | $ 0 |  | $ 750 | $ 0 |  |  |  |
Proceeds from milestone payments |  |  |  |  |  |  |  |  |  | $ 243,000 |
Upfront payment |  |  |  |  |  |  |  |  |  | $ 800 |

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