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Collaboration and Licensing Agreements - Recognized Revenue (Details) - USD ($)
$ in Thousands
 12 Months Ended 86 Months Ended
Dec. 31, 2024
Dec. 31, 2023
Dec. 31, 2022
Dec. 31, 2024
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]        
Total revenues $ 333,615 $ 124,456 $ 52,158  
2017 KKC Agreement | Kyowa Kirin        
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]        
Total revenues       $ 35,000
Licensing revenue        
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]        
Total revenues 78 35,809 35,031  
Licensing revenue | METiS Therapeutics Inc        
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]        
Total revenues 0 750 0  
Licensing revenue | 2017 KKC Agreement | Kyowa Kirin        
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]        
Total revenues 0 30,000 35,000  
Licensing revenue | Fosun Agreement | Fosun Pharma        
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]        
Total revenues 0 5,000 0  
Licensing revenue | Knight Agreement | Knight        
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]        
Total revenues 78 59 31  
Product supply revenue        
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]        
Total revenues 11,649 6,121 1,527  
Product supply revenue | 2017 KKC Agreement | Kyowa Kirin        
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]        
Total revenues 11,649 6,092 1,518  
Product supply revenue | Fosun Agreement | Fosun Pharma        
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]        
Total revenues 0 29 9  
Non-cash royalty revenue related to the sale of future royalties        
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]        
Total revenues 2,692 0 0  
Non-cash royalty revenue related to the sale of future royalties | 2017 KKC Agreement | Kyowa Kirin        
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]        
Total revenues $ 2,692 $ 0 $ 0