<SEC-DOCUMENT>0001869194-25-000004.txt : 20251120
<SEC-HEADER>0001869194-25-000004.hdr.sgml : 20251120
<ACCEPTANCE-DATETIME>20251120174627
ACCESSION NUMBER:		0001869194-25-000004
CONFORMED SUBMISSION TYPE:	144
PUBLIC DOCUMENT COUNT:		1
FILED AS OF DATE:		20251120
DATE AS OF CHANGE:		20251120

SUBJECT COMPANY:	

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			ARDELYX, INC.
		CENTRAL INDEX KEY:			0001437402
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		ORGANIZATION NAME:           	03 Life Sciences
		EIN:				000000000
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		144
		SEC ACT:		1933 Act
		SEC FILE NUMBER:	001-36485
		FILM NUMBER:		251504103

	BUSINESS ADDRESS:	
		STREET 1:		34175 ARDENWOOD BLVD.
		CITY:			FREMONT
		STATE:			CA
		ZIP:			94555
		BUSINESS PHONE:		510-745-7047

	MAIL ADDRESS:	
		STREET 1:		34175 ARDENWOOD BLVD.
		CITY:			FREMONT
		STATE:			CA
		ZIP:			94555

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	NTERYX INC
		DATE OF NAME CHANGE:	20080611

REPORTING-OWNER:	

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			Williams Laura A
		CENTRAL INDEX KEY:			0001869194
		ORGANIZATION NAME:           	

	FILING VALUES:
		FORM TYPE:		144

	MAIL ADDRESS:	
		STREET 1:		116 HUNTINGTON AVENUE, 6TH FLOOR
		CITY:			BOSTON
		STATE:			MA
		ZIP:			02116
</SEC-HEADER>
<DOCUMENT>
<TYPE>144
<SEQUENCE>1
<FILENAME>primary_doc.xml
<TEXT>
<XML>
<?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:com="http://www.sec.gov/edgar/common">
  <headerData>
    <submissionType>144</submissionType>
    <filerInfo>
      <filer>
        <filerCredentials>
          <cik>0001869194</cik>
          <ccc>XXXXXXXX</ccc>
        </filerCredentials>
      </filer>
      <liveTestFlag>LIVE</liveTestFlag>



    </filerInfo>
  </headerData>
  <formData>
    <issuerInfo>
      <issuerCik>0001437402</issuerCik>
      <issuerName>ARDELYX, INC.</issuerName>
      <secFileNumber>001-36485</secFileNumber>
      <issuerAddress>
        <com:street1>400 Fifth Avenue, Suite 210</com:street1>
        <com:city>Waltham</com:city>
        <com:stateOrCountry>MA</com:stateOrCountry>
        <com:zipCode>02451</com:zipCode>
      </issuerAddress>
      <issuerContactPhone>510-745-1700</issuerContactPhone>
      <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>Williams Laura A</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
      <relationshipsToIssuer>
        <relationshipToIssuer>Officer</relationshipToIssuer>
      </relationshipsToIssuer>
    </issuerInfo>
    <securitiesInformation>
      <securitiesClassTitle>Common Stock</securitiesClassTitle>
      <brokerOrMarketmakerDetails>
        <name>Morgan Stanley Smith Barney LLC </name>
        <address>
          <com:street1>Executive Financial Services</com:street1>
          <com:street2>1 New York Plaza, 8th Floor</com:street2>
          <com:city>New York</com:city>
          <com:stateOrCountry>NY</com:stateOrCountry>
          <com:zipCode>10004</com:zipCode>
        </address>
      </brokerOrMarketmakerDetails>
      <noOfUnitsSold>6354</noOfUnitsSold>
      <aggregateMarketValue>37552.14</aggregateMarketValue>
      <noOfUnitsOutstanding>242974306</noOfUnitsOutstanding>
      <approxSaleDate>11/20/2025</approxSaleDate>
      <securitiesExchangeName>NASDAQ</securitiesExchangeName>
    </securitiesInformation>
    <securitiesToBeSold>
      <securitiesClassTitle>Common Stock</securitiesClassTitle>
      <acquiredDate>11/19/2025</acquiredDate>
      <natureOfAcquisitionTransaction>Vesting of restricted stock units</natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>21372</amountOfSecuritiesAcquired>
      <paymentDate>11/19/2025</paymentDate>
      <natureOfPayment>Services Rendered</natureOfPayment>
    </securitiesToBeSold>
    <nothingToReportFlagOnSecuritiesSoldInPast3Months>N</nothingToReportFlagOnSecuritiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>Laura A. Williams</name>
        <address>
          <com:street1>400 Fifth Avenue, Suite 210</com:street1>
          <com:city>Waltham</com:city>
          <com:stateOrCountry>MA</com:stateOrCountry>
          <com:zipCode>02451</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>Common Stock</securitiesClassTitle>
      <saleDate>08/26/2025</saleDate>
      <amountOfSecuritiesSold>50000</amountOfSecuritiesSold>
      <grossProceeds>306050.00</grossProceeds>
    </securitiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>Laura A. Williams</name>
        <address>
          <com:street1>400 Fifth Avenue, Suite 210</com:street1>
          <com:city>Waltham</com:city>
          <com:stateOrCountry>MA</com:stateOrCountry>
          <com:zipCode>02451</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>Common Stock</securitiesClassTitle>
      <saleDate>08/26/2025</saleDate>
      <amountOfSecuritiesSold>30000</amountOfSecuritiesSold>
      <grossProceeds>183630.00</grossProceeds>
    </securitiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>Laura A. Williams</name>
        <address>
          <com:street1>400 Fifth Avenue, Suite 210</com:street1>
          <com:city>Waltham</com:city>
          <com:stateOrCountry>MA</com:stateOrCountry>
          <com:zipCode>02451</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>Common Stock</securitiesClassTitle>
      <saleDate>08/21/2025</saleDate>
      <amountOfSecuritiesSold>6261</amountOfSecuritiesSold>
      <grossProceeds>37138.37</grossProceeds>
    </securitiesSoldInPast3Months>
    <remarks>The transactions dated August 26, 2025, reflect the weighted average sale price, with sales prices ranging from $6.04 to $6.20, inclusive. The gross proceeds were calculated using a weighted average sales price of $6.121. Pursuant to an automatic sell-to-cover imposed by the terms of the initial grant of the restricted stock units (RSUs) awards, the shares are to be sold upon the vesting of the RSUs solely to cover applicable withholding taxes.</remarks>
    <noticeSignature>
      <noticeDate>11/20/2025</noticeDate>
      <signature>Elizabeth Grammer, as Attorney-in-Fact for Laura A. Williams</signature>
    </noticeSignature>
  </formData>
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</TEXT>
</DOCUMENT>
</SEC-DOCUMENT>
