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Share-based payment (Details) - Schedule of stock option activity plan - $ / shares
 12 Months Ended
Dec. 31, 2020
Dec. 31, 2019
Dec. 31, 2018
Schedule of stock option activity plan [Abstract]      
Number of shares, Outstanding at beginning (in Shares) 47,277 54,962 56,362
Weighted average exercise price, Outstanding at beginning $ 881.97 $ 889.35 $ 892.24
Weighted average grant date fair value, Outstanding at beginning $ 343.83 $ 346.63 $ 350.52
Weighted average remaining contractual life, Outstanding at beginning     9 years 1 month 6 days
Number of shares, Granted (in Shares) 176,890   1,000
Weighted average exercise price, Granted $ 1,005.85   $ 1,005.85
Weighted average grant date fair value, Granted $ 495.95   $ 225.30
Weighted average remaining contractual life, Granted  
Number of shares, Forfeited (in Shares) (7,461) (7,685) (2,400)
Weighted average exercise price, Forfeited $ 623.31 $ 934.82 $ 1,005.85
Weighted average grant date fair value, Forfeited $ 326.36 $ 363.82 $ 387.63
Weighted average remaining contractual life, Forfeited
Number of shares, Outstanding at ending (in Shares) 216,706 47,277 54,962
Weighted average exercise price, Outstanding at ending $ 991.99 $ 881.97 $ 889.35
Weighted average grant date fair value, Outstanding at ending $ 468.60 $ 343.83 $ 346.63
Weighted average remaining contractual life, Outstanding at ending 9 years 7 years 1 month 6 days 8 years 1 month 6 days
Number of shares, Expected to vest and exercisable (in Shares) 216,706    
Weighted average exercise price, Expected to vest and exercisable $ 991.99    
Weighted average grant date fair value, Expected to vest and exercisable $ 468.60    
Weighted average remaining contractual life, Expected to vest and exercisable 9 years