EX-10.1 2 rapp-ex10_1.htm EX-10.1

Exhibit 10.1

# CERTAIN INFORMATION CONTAINED IN THIS EXHIBIT, MARKED BY [***], HAS BEEN EXCLUDED FROM THIS EXHIBIT BECAUSE THE REGISTRANT HAS DETERMINED THAT IT IS BOTH NOT MATERIAL AND IS THE TYPE THAT THE REGISTRANT TREATS AS PRIVATE OR CONFIDENTIAL.

# Rapport Therapeutics and NeuroPace Collaboration

WHEREAS, Rapport Therapeutics, Inc. (“Rapport”) and NeuroPace, Inc. (“NeuroPace”) (“the Parties”) entered into a Statement of Work #2 (“SOW #2”) on July 7, 2025, governed by the Master Services Agreement between the Parties dated November 28, 2023.

WHEREAS, the Parties now wish to amend SOW#2 as set forth in this “Amendment to Statement of Work #2,”

NOW THEREFORE, in consideration of the mutual covenants and agreements hereinafter set forth, the Parties agree as follow:

The Effective Date of this Amendment to SOW#2 -Scope of Work and Budget to support An Open-label, Long Term Study Evaluating RAP-219 in Adult Participants with Refractory Focal Onset Seizures (RAP-219-FOS-901, Phase 2) shall be the date of the last signing party’s signature. This Amendment to SOW# 2 shall fully replace and supersede SOW # 2 and shall be governed by the terms of the MSA.

I.
Project Summary and Scope

Rapport Therapeutics is planning an Open Label Extension study to continue evaluation of patients previously enrolled in the first-in-class TARP-g8 negative allosteric modulator study (RAP-219). NeuroPace’s involvement in the project will focus on continued evaluation of patient-specific biomarkers by way of analysis of RNS® System ambulatory electrocorticographic (ECoG) and device diagnostic data. It is estimated that up to [***] patients may be enrolled.

II.
Collaboration Contracting

Successful execution and operation of the study will require close collaboration and data sharing between Rapport and NeuroPace. The existing Master Services Agreement (MSA) as executed November 28, 2023, will remain as the enforcing services agreement to this SOW.

III.
Deliverables

Data collected by the NeuroPace RNS System and metrics derived from RNS System data will be provided by NeuroPace to Rapport, as described in Appendix 1. RNS System data are downloaded from the RNS Neurostimulator each time it is interrogated by the patient or clinician, then uploaded to the RNS Patient Data Management System (PDMS). Data and derived metrics will be documented and provided at specified intervals and on demand in CSV formatted text files to facilitate subsequent analysis. Raw RNS System data supporting the derived metrics will not be provided and remains proprietary to NeuroPace. The provided data and derived metrics will be shared with authorized third parties as detailed in the MSA.

The time range and frequency of the data to be provided are detailed under the Deliverables Schedule below. The nature and frequency of in-person data reviews is provided in the Data Review Schedule below.

Under the terms of this collaboration agreement, NeuroPace will not be required to develop or write regulatory submissions, contract with sites, support IRB submissions, develop or perform non-device related statistical analyses or be responsible for clinical trial management. These items will be the responsibility of Rapport.

IV.
Deliverables Schedule

Phase 1: Project Initiation

▪
Device Data Report – [***]

Phase 2: Patient Eligibility Reviews (Enrollment & Dosing)

▪
Device Data Reports – [***]
▪
Device Data Report – [***]

Phase 3: Clinical Study Support and Data Analysis

Refer to appendix A for a list of all data included in each report

▪
Device Data Report – [***]
▪
Device Data Report – [***]
▪
Device Data Report – [***]
V.
Data Review Schedule

[***]

VI.
Project Phase Obligations

Phase 1: Project Initiation

The following tasks and deliverables are included in Phase 1:

[***]

Phase 2: Patient Eligibility Reviews (Enrollment & Dosing)

The following tasks and deliverables are included in Phase 2:

[***]

Phase 3: Clinical Study Support and Data Analysis

The following tasks and deliverables are included in Phase 3:

[***]

VII.
Term of SOW and Payment Schedule

The anticipated term for study execution is from [***] through approximately [***]. In the event the study extends beyond [***], the Parties will meet and negotiate in good faith on Recurring Payments to support the ongoing obligations required to reach the Final Report milestone. In the event of the foregoing, the Parties shall amend the SOW in writing to reflect their agreement.

Requests beyond the scope of this agreement or in addition to the limits outlined within the agreement (e.g. extra reports) will be added to an amendment with additional costs associated.

The payment plan for contributions rendered by NeuroPace, including support, subject matter input, and pre-specified deliverables is provided below.

DELIVERABLE PAYMENT SCHEDULE
Deliverable Type | Description | Deliverable Frequency | Payment Frequency | Unit Cost per Payment | Total
[***] | [***] | [***] | [***] | [***] | [***]
[***] | [***] | [***] | [***] | [***] | [***]
[***] | [***] | [***] | [***] | [***] | [***]
[***] | [***] | [***] | [***] | [***] | [***]
[***] | [***] | [***] | [***] | [***] | [***]
[***] | [***] | [***] | [***] | [***] | [***]
[***] | [***] | [***] | [***] | [***] | [***]
[***] | [***] | [***] | [***] | [***] | [***]
[***] | [***] | [***] | [***] | [***] | [***]
SOW Total |  |  |  |  | $2,051,500***

* [***]

** [***]

*** [***]

IN WITNESS WHEREOF, the Parties hereto have caused this Amendment to be executed by their duly authorized representatives effective as of the date of the last Party to sign below.

Signature Page

NEUROPACE, INC. |  | RAPPORT THERAPEUTICS, INC
Printed Name | Joel Becker |  | Printed Name | Troy Ignelzi
Title | CEO and President, NeuroPace |  | Title | Chief Financial Officer
Signature | /s/ Joel Becker |  | Signature | /s/ Troy Ignelzi
Date | January 16, 2026 |  | Date | February 2, 2026

Appendix A

Data summary reports are to be provided according to the needs and timeframe specified in Section IV. The reports will include the following [***].

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