CERTAIN INFORMATION CONTAINED IN THIS EXHIBIT, MARKED BY [***], HAS BEEN EXCLUDED FROM THIS EXHIBIT BECAUSE THE REGISTRANT HAS DETERMINED THAT IT IS BOTH NOT MATERIAL AND IS THE TYPE THAT THE REGISTRANT TREATS AS PRIVATE OR CONFIDENTIAL.
Rapport Therapeutics and NeuroPace Collaboration
WHEREAS, Rapport Therapeutics, Inc. (“Rapport”) and NeuroPace, Inc. (“NeuroPace”) (“the Parties”) entered into a Statement of Work #2 (“SOW #2”) on July 7, 2025, governed by the Master Services Agreement between the Parties dated November 28, 2023.
WHEREAS, the Parties now wish to amend SOW#2 as set forth in this “Amendment to Statement of Work #2,”
NOW THEREFORE, in consideration of the mutual covenants and agreements hereinafter set forth, the Parties agree as follow:
The Effective Date of this Amendment to SOW#2 -Scope of Work and Budget to support An Open-label, Long Term Study Evaluating RAP-219 in Adult Participants with Refractory Focal Onset Seizures (RAP-219-FOS-901, Phase 2) shall be the date of the last signing party’s signature. This Amendment to SOW# 2 shall fully replace and supersede SOW # 2 and shall be governed by the terms of the MSA.
Rapport Therapeutics is planning an Open Label Extension study to continue evaluation of patients previously enrolled in the first-in-class TARP-g8 negative allosteric modulator study (RAP-219). NeuroPace’s involvement in the project will focus on continued evaluation of patient-specific biomarkers by way of analysis of RNS® System ambulatory electrocorticographic (ECoG) and device diagnostic data. It is estimated that up to [***] patients may be enrolled.
Successful execution and operation of the study will require close collaboration and data sharing between Rapport and NeuroPace. The existing Master Services Agreement (MSA) as executed November 28, 2023, will remain as the enforcing services agreement to this SOW.
Data collected by the NeuroPace RNS System and metrics derived from RNS System data will be provided by NeuroPace to Rapport, as described in Appendix 1. RNS System data are downloaded from the RNS Neurostimulator each time it is interrogated by the patient or clinician, then uploaded to the RNS Patient Data Management System (PDMS). Data and derived metrics will be documented and provided at specified intervals and on demand in CSV formatted text files to facilitate subsequent analysis. Raw RNS System data supporting the derived metrics will not be provided and remains proprietary to NeuroPace. The provided data and derived metrics will be shared with authorized third parties as detailed in the MSA.
The time range and frequency of the data to be provided are detailed under the Deliverables Schedule below. The nature and frequency of in-person data reviews is provided in the Data Review Schedule below.
Under the terms of this collaboration agreement, NeuroPace will not be required to develop or write regulatory submissions, contract with sites, support IRB submissions, develop or perform non-device related statistical analyses or be responsible for clinical trial management. These items will be the responsibility of Rapport.
Phase 1: Project Initiation