    <SEC-DOCUMENT>0001867096-26-000023-index.html : 20260423
    <SEC-HEADER>0001867096-26-000023.hdr.sgml : 20260423
    <ACCEPTANCE-DATETIME>20260423170912
    ACCESSION NUMBER:		0001867096-26-000023
    CONFORMED SUBMISSION TYPE:	ARS
    PUBLIC DOCUMENT COUNT:		1
    CONFORMED PERIOD OF REPORT:	20251231
    FILED AS OF DATE:		20260423
    DATE AS OF CHANGE:		20260423
    EFFECTIVENESS DATE:		20260423

    FILER:

    	COMPANY DATA:
    		COMPANY CONFORMED NAME:			Xeris Biopharma Holdings, Inc.
    		CENTRAL INDEX KEY:			0001867096
    		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
    		ORGANIZATION NAME:           	03 Life Sciences
    		EIN:				871082097
    		FISCAL YEAR END:			1231

    	FILING VALUES:
    		FORM TYPE:		ARS
    		SEC ACT:		1934 Act
    		SEC FILE NUMBER:	001-40880
    		FILM NUMBER:		26889631

    	BUSINESS ADDRESS:
    		STREET 1:		1375 WEST FULTON STREET, SUITE 1300
    		CITY:			CHICAGO
    		STATE:			IL
    		ZIP:			60607
    		BUSINESS PHONE:		844-445-5704

    	MAIL ADDRESS:
    		STREET 1:		1375 WEST FULTON STREET, SUITE 1300
    		CITY:			CHICAGO
    		STATE:			IL
    		ZIP:			60607
    </SEC-HEADER>
    <DOCUMENT>
    <TYPE>ARS
    <SEQUENCE>1
    <FILENAME>xers2025annualreport.pdf
    <DESCRIPTION>ARS
    <TEXT>
    Document 1 - file: xers2025annualreport.pdf

    </DOCUMENT>
    </SEC-DOCUMENT>