v2.4.0.8

Related Party Transactions - Additional Information (Detail) (USD $) | 3 Months Ended | 9 Months Ended | 12 Months Ended | 1 Months Ended | 2 Months Ended | 1 Months Ended | 12 Months Ended | 3 Months Ended | 9 Months Ended | 12 Months Ended | 3 Months Ended | 9 Months Ended | 12 Months Ended | 1 Months Ended |  |  | 9 Months Ended | 12 Months Ended | 9 Months Ended | 12 Months Ended | 9 Months Ended
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Sep. 30, 2013 | Sep. 30, 2012 | Sep. 30, 2013 | Sep. 30, 2012 | Dec. 31, 2012 | Dec. 31, 2011 | Jun. 06, 2012 Affiliates of Third Security [Member] | Jun. 06, 2011 Affiliates of Third Security [Member] | Apr. 08, 2011 Affiliates of Third Security [Member] | May 26, 2011 Affiliates of Third Security [Member] | May 26, 2011 Affiliates of Third Security [Member] Series E Redeemable Convertible Preferred Stock [Member] | Aug. 31, 2011 Cyntellect Inc [Member] | Dec. 31, 2012 Cyntellect Inc [Member] | Dec. 31, 2011 Cyntellect Inc [Member] | Dec. 31, 2011 Cyntellect Inc [Member] General and Administrative Expense [Member] | Sep. 30, 2013 Chief Executive Officer [Member] | Sep. 30, 2012 Chief Executive Officer [Member] | Sep. 30, 2013 Chief Executive Officer [Member] | Sep. 30, 2012 Chief Executive Officer [Member] | Dec. 31, 2012 Chief Executive Officer [Member] | Dec. 31, 2011 Chief Executive Officer [Member] | Sep. 30, 2013 Affiliates of Preferred Shareholders [Member] Office | Sep. 30, 2012 Affiliates of Preferred Shareholders [Member] | Sep. 30, 2013 Affiliates of Preferred Shareholders [Member] Office | Sep. 30, 2012 Affiliates of Preferred Shareholders [Member] | Dec. 31, 2012 Affiliates of Preferred Shareholders [Member] Office | Dec. 31, 2011 Affiliates of Preferred Shareholders [Member] Office | Dec. 31, 2012 Shareholder | Dec. 31, 2011 Shareholder | Jan. 20, 2012 Ziopharm [Member] | Feb. 07, 2011 Ziopharm [Member] | Jan. 06, 2011 Ziopharm [Member] | Sep. 30, 2013 Ziopharm [Member] | Dec. 31, 2012 Ziopharm [Member] | Sep. 30, 2013 Synthetic Biologics [Member] | Dec. 31, 2012 Synthetic Biologics [Member] | Sep. 30, 2013 Oragenics [Member] | Dec. 31, 2012 Oragenics [Member] | Sep. 30, 2013 Oragenics [Member] Shares Purchased Under Right [Member] | Sep. 30, 2013 Soligenix Inc [Member]
Related Party Transaction [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Convertible promissory notes issued |  |  |  |  |  |  |  |  | $ 25,000,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Simple interest rate on promissory notes |  |  |  |  |  |  |  |  | 12.00% |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Borrowings on convertible promissory notes |  |  |  |  |  |  |  |  |  | 15,000,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Accrued interest on notes |  |  |  |  |  |  |  |  |  | 165,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Shares issued for conversion of convertible promissory notes |  |  |  |  |  |  |  |  |  |  | 2,888,635 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Expiration date of a promissory note |  |  |  |  |  |  |  |  | Terms of the notes included 12% simple interest annually with principal and interest due on or before June 30, 2011 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Payment of license fee |  |  |  |  |  |  |  | 9,000,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Annual exclusivity fee |  |  |  |  |  |  | 1,000,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Milestone payments |  |  |  |  |  |  | 54,000,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Termination period |  |  |  |  |  |  | 90 days |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Stock issued during the period, shares for purchase of assets |  |  |  |  |  |  |  |  |  |  |  | 2,386,803 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Stock issued during the period, value for purchase of assets |  |  |  |  |  |  |  |  |  |  |  | 17,000,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Costs associated with asset purchase |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 128,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Sublease Income | 91,000 | 0 | 274,000 | 64,000 | 151,000 | 158,000 |  |  |  |  |  |  | 64,000 | 77,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Sublease expired period |  |  |  |  |  |  |  |  |  |  |  |  | May 31, 2012 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Compensation expense |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 388,000 | 388,000 | 1,163,000 | 1,163,000 | 1,550,000 | 210,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Company leased facility |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 2 |  | 2 |  | 2 | 2 |  |  |  |  |  |  |  |  |  |  |  |  |
Other long term assets |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 66,000 |  | 66,000 |  | 66,000 | 66,000 |  |  |  |  |  |  |  |  |  |  |  |  |
Rent and other facility expenses | 1,272,000 | 1,255,000 | 4,284,000 | 3,739,000 | 5,036,000 | 4,000,000 |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 233,000 | 228,000 | 680,000 | 670,000 | 903,000 | 783,000 |  |  |  |  |  |  |  |  |  |  |  |  |
Related party expense incurred on research and clinical services |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 91,000 | 202,000 |  |  |  |  |  |  |  |  |  |  |
Related party expense amount payable on research and clinical services |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 0 | 30,000 |  |  |  |  |  |  |  |  |  |  |
Purchase commitment |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 29,000,000 | 29,000,000 |  |  |  |  |  |
Maximum percentage of shares of future securities offerings of collaborative partners to which the entity is entitled to purchase |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 19.99% | 19.99% | 30.00% | 30.00% |  |
Additional shares of collaborative partner to which the entity is entitled to purchase on the open market |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 10.00% | 10.00% |  |  |  |
Shares of common stock purchased from collaborative partners |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | 1,923,075 | 1,910,000 | 2,426,235 |  |  | 0 | 0 | 1,300,000 | 0 | 0 | 0
Price per share of common shares |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | $ 5.20 | $ 5.75 | $ 4.80 |  |  |  |  | $ 3.00 |  |  |
Purchase of additional common stock |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  | $ 50,000,000 |  |  |  |  |  |  |  |

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