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Property, Plant and Equipment, Net - Schedule of Property Plant and Equipment (Detail) (USD $)
In Thousands, unless otherwise specified
Sep. 30, 2013
Dec. 31, 2012
Dec. 31, 2011
Property Plant And Equipment [Abstract]      
Land $ 55    
Building 945    
Furniture and fixtures 869 857 844
Lab equipment 22,044 22,195 18,010
Leasehold improvements 5,149 4,972 3,016
Computer hardware 3,220 3,136 2,897
Construction in progress 10 14 2,024
Software 1,003 888 665
Property, plant and equipment, gross 33,295 32,062 27,456
Less: Accumulated depreciation and amortization (16,275) (13,375) (8,972)
Property, plant and equipment, net $ 17,020 $ 18,687 $ 18,484