v2.4.0.8
Consolidated Statements of Cash Flows (USD $)
In Thousands, unless otherwise specified
 9 Months Ended 12 Months Ended
Sep. 30, 2013
Sep. 30, 2012
Dec. 31, 2012
Dec. 31, 2011
Cash flows from operating activities        
Net loss $ (27,890) $ (50,937) $ (81,874) $ (85,280)
Adjustments to reconcile net loss to net cash used in operating activities:        
Depreciation and amortization 5,461 5,976 7,984 4,338
Loss on disposal of property and equipment 349 75 101 1
Unrealized (appreciation) depreciation on equity securities (5,704) (12,031) 6,290 2,675
Amortization of discount/premium of investments 251      
Collaboration revenue recognized upon achievement of milestone     (3,591)  
Equity in net loss of affiliate 390   274  
Gain on previously held equity investment (7,415)      
Stock-based compensation expense 1,841 959 1,458 983
Contribution of services by shareholder 1,163 1,163 1,550 210
Shares issued to nonemployee members of the Board of Directors 100 85 93 9
Receivables:        
Trade (49) (36) (121) 33
Related parties (4,207) 40 (93) (239)
Other (572) 932 1,015 (400)
Prepaid expenses and other (628) (535) (413) (772)
Other assets (58) 514 658 (614)
Accounts payable 182 (984) (1,229) (388)
Accrued compensation and benefits (167) 1,915 2,441 (2,249)
Other accrued liabilities (300) (936) (806) 1,204
Deferred revenue (6,091) 4,867 4,997 (2,245)
Related party payables 35 (249) (180) (215)
Other long term liabilities (150) (13) (83) 1,191
Net cash used in operating activities (43,459) (49,195) (61,529) (81,758)
Cash flows from investing activities        
Purchases of investments (233,232) (2) (2) (188)
Maturities of investments 15,498      
Purchases of equity securities (3,900) (10,000) (10,000) (22,628)
Acquisition of business, net of cash received 512     (28,662)
Investment in affiliate     (6,000)  
Purchases of property and equipment (1,262) (7,145) (7,491) (13,003)
Proceeds from sale of property and equipment 480 16 23 84
Issuance of related party note receivable (300)   (200)  
Proceeds from related party notes receivable 500 34 34 300
Net cash used in investing activities (221,704) (17,097) (23,636) (64,097)
Cash flows from financing activities        
Proceeds from IPO, net of issuance costs 168,801      
Settlement of fractional shares (5)      
Proceeds from issuance of subscriptions payable       7,440
Proceeds from short-term borrowings       15,000
Payments of capital lease obligations (42) (56) (77) (115)
Proceeds from long term debt 354      
Payments of long term debt (36)      
Proceeds from stock option exercises 55 252 473 184
Payment of preferred stock issuance costs (3,148) (11) (16) (2,675)
Net cash provided by financing activities 315,979 50,745 75,940 148,111
Effect of exchange rate changes on cash and cash equivalents 3        
Net increase (decrease) in cash and cash equivalents 50,819 (15,547) (9,225) 2,256
Cash and cash equivalents        
Beginning of period 10,403 19,628 19,628 17,372
End of period 61,222 4,081 10,403 19,628
Supplemental disclosure of cash flow information        
Cash paid during the period for interest 50 8 12 18
Significant noncash financing and investing activities        
Accretion of dividends on redeemable convertible preferred shares 18,391 16,291 21,994 13,868
Stock received as consideration for collaboration agreements 14,847 6,588 21,979 19,144
Stock received as consideration upon achievement of milestone     18,330  
Accrued contribution to S & I Ophthalmic, LLC 5,000      
Equity instruments issued in acquisitions       4,237
Purchases of equipment included in accounts payable and other accrued liabilities     24 2,231
Series D Redeemable Convertible Preferred Stock [Member]
        
Cash flows from financing activities        
Proceeds from issuance of redeemable convertible preferred shares       26,442
Significant noncash financing and investing activities        
Conversion of liabilities into redeemable convertible preferred shares and conversion of redeemable convertible preferred shares, including accrued dividends, to common stock 79,078      
Accretion of dividends on redeemable convertible preferred shares 2,827   4,328 3,971
Series E Redeemable Convertible Preferred Stock [Member]
        
Cash flows from financing activities        
Proceeds from issuance of redeemable convertible preferred shares   50,560 75,560 101,835
Significant noncash financing and investing activities        
Conversion of liabilities into redeemable convertible preferred shares and conversion of redeemable convertible preferred shares, including accrued dividends, to common stock 219,332      
Accretion of dividends on redeemable convertible preferred shares 7,931   10,465 3,621
Series F Redeemable Convertible Preferred Stock [Member]
        
Cash flows from financing activities        
Proceeds from issuance of redeemable convertible preferred shares 150,000      
Significant noncash financing and investing activities        
Conversion of liabilities into redeemable convertible preferred shares and conversion of redeemable convertible preferred shares, including accrued dividends, to common stock 150,075      
Accretion of dividends on redeemable convertible preferred shares 3,224      
Subscriptions Payable [Member] | Series D Redeemable Convertible Preferred Stock [Member]
        
Significant noncash financing and investing activities        
Conversion of liabilities into redeemable convertible preferred shares and conversion of redeemable convertible preferred shares, including accrued dividends, to common stock       2,500
Subscriptions Payable [Member] | Series E Redeemable Convertible Preferred Stock [Member]
        
Significant noncash financing and investing activities        
Conversion of liabilities into redeemable convertible preferred shares and conversion of redeemable convertible preferred shares, including accrued dividends, to common stock   7,440 7,440  
Short Term Borrowing [Member] | Series E Redeemable Convertible Preferred Stock [Member]
        
Significant noncash financing and investing activities        
Conversion of liabilities into redeemable convertible preferred shares and conversion of redeemable convertible preferred shares, including accrued dividends, to common stock       15,165
Common Shares Issuable Upon Conversion of All Series Preferred [Member] | Common Stock [Member]
        
Significant noncash financing and investing activities        
Conversion of liabilities into redeemable convertible preferred shares and conversion of redeemable convertible preferred shares, including accrued dividends, to common stock $ 571,898