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Income Taxes - Schedule of Effective Income Tax Rate Reconciliation (Details) - USD ($) $ in Thousands | 12 Months Ended
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Dec. 31, 2016 | Dec. 31, 2015 | Dec. 31, 2014
Income Tax Disclosure [Abstract] |  |  |
Computed statutory income tax benefit | $ (66,011) | $ (29,573) | $ (29,144)
State and provincial income tax benefit, net of federal income taxes | (7,905) | (3,157) | (3,544)
Nondeductible stock based compensation | 3,321 | 3,182 | 1,386
Nondeductible officer compensation | 0 | 2,433 | 0
Contribution of services by shareholder | 0 | 0 | 677
Research and development tax incentives | (6,350) | (348) | 258
Acquisition and internal restructuring transaction costs | 571 | 883 | 0
Enacted change in tax rates | 0 | (961) | 0
U.S.-foreign rate differential | 3,463 | 620 | 0
Other, net | 1,485 | (98) | 1,503
Income tax reconciliation income tax benefit before valuation allowance, total | (71,426) | (27,019) | (28,864)
Change in valuation allowance for deferred tax assets | 67,549 | 28,035 | 28,761
Total income tax expense (benefit) | $ (3,877) | $ 1,016 | $ (103)

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- Definition Amount of current income tax expense (benefit) and deferred income tax expense (benefit) pertaining to continuing operations. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 740 -SubTopic 10 -Section 50 -Paragraph 9 -Subparagraph (a),(b) -URI http://asc.fasb.org/extlink&oid=65882285&loc=d3e32639-109319 Reference 2: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 235 -SubTopic 10 -Section S99 -Paragraph 1 -Subparagraph (SX 210.4-08.(h)) -URI http://asc.fasb.org/extlink&oid=26873400&loc=d3e23780-122690 Reference 3: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Glossary Income Tax Expense (or Benefit) -URI http://asc.fasb.org/extlink&oid=6515339 + Details
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