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Summary of Significant Accounting Policies - Equity Method Investments - Additional Information (Details) - USD ($) $ in Thousands | 3 Months Ended | 6 Months Ended |
--- | --- | --- | ---
Jun. 30, 2017 | Jun. 30, 2016 | Jun. 30, 2017 | Jun. 30, 2016 | Dec. 31, 2016
Schedule of Equity Method Investments [Line Items] |  |  |  |  |
Fair value of financial assets measured at fair value on a recurring basis | $ 269,759 |  | $ 269,759 |  | $ 335,307
Oragenics, Inc. |  |  |  |  |
Schedule of Equity Method Investments [Line Items] |  |  |  |  |
Company's ownership percentage | 29.40% |  | 29.40% |  | 29.50%
Equity securities |  |  |  |  |
Schedule of Equity Method Investments [Line Items] |  |  |  |  |
Fair value of financial assets measured at fair value on a recurring basis | $ 23,901 |  | $ 23,901 |  | $ 23,522
Equity securities | Oragenics, Inc. |  |  |  |  |
Schedule of Equity Method Investments [Line Items] |  |  |  |  |
Fair value of financial assets measured at fair value on a recurring basis | 4,807 |  | 4,807 |  | $ 7,244
Unrealized depreciation in fair value of equity securities | $ (1,096) | $ (4,797) | $ (2,437) | $ (11,142) |

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- Definition Fair value portion of probable future economic benefits obtained or controlled by an entity as a result of past transactions or events. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 820 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (a) -URI http://asc.fasb.org/extlink&oid=66048111&loc=d3e19207-110258 + Details
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- Definition The percentage of ownership of common stock or equity participation in the investee accounted for under the equity method of accounting. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 323 -SubTopic 10 -Section 50 -Paragraph 3 -Subparagraph (a)(1) -URI http://asc.fasb.org/extlink&oid=66011266&loc=d3e33918-111571 + Details
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- Definition The net change in the difference between the fair value and the carrying value, or in the comparative fair values, of investments, not including unrealized gains or losses on securities separately or otherwise categorized as trading, available-for-sale, or held-to-maturity, held at each balance sheet date and included in earnings for the period. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 28 -Subparagraph (b) -URI http://asc.fasb.org/extlink&oid=98514028&loc=d3e3602-108585 + Details
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