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Related Party Transactions - Additional Information (Details) - USD ($) | 1 Months Ended | 3 Months Ended | 12 Months Ended
--- | --- | --- | ---
Nov. 30, 2017 | Mar. 31, 2017 | Jun. 30, 2016 | Nov. 30, 2015 | Mar. 31, 2019 | Mar. 31, 2018 | Dec. 31, 2018
Related Party Transaction [Line Items] |  |  |  |  |  |  |
Related party payables |  |  |  |  | $ 2,173,000 |  | $ 256,000
Shares issued as payment for services |  |  |  |  | 831,000 | $ 2,941,000 |
Noncash dividend income |  |  |  |  | 12,000 | 4,883,000 |
Fair value of financial assets measured at fair value on a recurring basis |  |  |  |  | 77,283,000 |  | 122,181,000
Revenues |  |  |  |  | 23,335,000 | 39,666,000 |
Third Security, LLC |  |  |  |  |  |  |
Related Party Transaction [Line Items] |  |  |  |  |  |  |
Initial term of services agreement |  |  |  | 1 year |  |  |
Expense for services |  |  |  |  | 17,000 | 14,000 |
Shares issued as payment for services |  |  |  |  |  | $ 2,041,000 |
Shares issued as payment for services (in shares) |  |  |  |  |  | 160,626 |
Sublease rental income |  |  |  |  | 22,000 | $ 21,000 |
Third Security, LLC | Common Stock |  |  |  |  |  |  |
Related Party Transaction [Line Items] |  |  |  |  |  |  |
Expense for services |  |  |  | $ 800,000 |  |  |
Related party payables |  |  |  |  | 2,078,000 |  |
Convertible Note and Warrants | Other Noncurrent Assets | Fibrocell Science, Inc. |  |  |  |  |  |  |
Related Party Transaction [Line Items] |  |  |  |  |  |  |
Fair value of financial assets measured at fair value on a recurring basis |  |  |  |  | $ 156,000 |  | 120,000
Fibrocell Science, Inc. |  |  |  |  |  |  |
Related Party Transaction [Line Items] |  |  |  |  |  |  |
Convertible preferred shares issued (in shares) |  | 1,161 |  |  |  |  |
Warrants, number of common shares into which warrants can be converted (in shares) |  | 99,769 |  |  |  |  |
Convertible preferred shares, dividend rate |  | 4.00% |  |  |  |  |
ZIOPHARM Oncology, Inc. |  |  |  |  |  |  |
Related Party Transaction [Line Items] |  |  |  |  |  |  |
Preferred shares, stated value (in usd per share) |  |  | $ 1,200 |  |  |  |
Preferred shares, dividend rate (in usd per share) |  |  | $ 12.00 |  |  |  |
Third Security, LLC | Chief Executive Officer |  |  |  |  |  |  |
Related Party Transaction [Line Items] |  |  |  |  |  |  |
Ownership interest |  |  |  |  | 100.00% |  |
Collaboration and licensing agreements |  |  |  |  |  |  |
Related Party Transaction [Line Items] |  |  |  |  |  |  |
Revenues |  |  |  |  | $ 5,970,000 | 19,848,000 |
Collaboration and licensing agreements | Histogenics Corporation, OvaScience Inc., and Synthetic Biologics Inc. |  |  |  |  |  |  |
Related Party Transaction [Line Items] |  |  |  |  |  |  |
Revenues |  |  |  |  |  | $ 3,183,000 | 11,877,000
ZIOPHARM Oncology, Inc. |  |  |  |  |  |  |
Related Party Transaction [Line Items] |  |  |  |  |  |  |
Dividend income, number of preferred shares received (in shares) |  |  |  |  |  | 3,624 |
Noncash dividend income |  |  |  |  |  | $ 4,871,000 |
Fibrocell Science, Inc. |  |  |  |  |  |  |
Related Party Transaction [Line Items] |  |  |  |  |  |  |
Purchases of preferred stock and warrants |  | $ 1,161,000 |  |  |  |  |
Preferred stock | Fibrocell Science, Inc. | Other Noncurrent Assets |  |  |  |  |  |  |
Related Party Transaction [Line Items] |  |  |  |  |  |  |
Fair value of financial assets measured at fair value on a recurring basis |  |  |  |  | 248,000 |  | 191,000
Preferred stock | Oragenics, Inc. |  |  |  |  |  |  |
Related Party Transaction [Line Items] |  |  |  |  |  |  |
Fair value of financial assets measured at fair value on a recurring basis |  |  |  |  | $ 0 |  | $ 0
Receivables converted to preferred stock | $ 3,385,000 |  |  |  |  |  |
Preferred shares, initial dividend rate |  |  |  |  | 12.00% |  |
Preferred shares, subsequent dividend rate |  |  |  |  | 20.00% |  |
ZIOPHARM Oncology, Inc. | Collaboration and licensing agreements |  |  |  |  |  |  |
Related Party Transaction [Line Items] |  |  |  |  |  |  |
Collaborative arrangement consideration received, number of preferred shares (in shares) |  |  | 100,000 |  |  |  |
Revenues |  |  |  |  | $ 1,166,000 | $ 5,377,000 |

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