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Share-Based Payments (Tables)
 3 Months Ended
Mar. 31, 2019
Disclosure of Compensation Related Costs, Share-based Payments [Abstract]  
Schedule of Stock-Based Compensation Costs Stock-based compensation costs included in the consolidated statements of operations are presented below:
 
Three Months Ended 
 March 31,
 
2019
 
2018
Cost of products
$
8

 
$
25

Cost of services
65

 
77

Research and development
1,845

 
3,258

Selling, general and administrative
7,136

 
8,002

Total
$
9,054

 
$
11,362
Schedule of Stock Option Activity Stock option activity was as follows:
 
Number of Shares
 
Weighted Average Exercise Price
 
Weighted Average Remaining Contractual Term (Years)
Balances at December 31, 2018
11,093,063

 
$
27.95

 
6.81
Granted
864,575

 
6.39

 
 
Exercised
(17,811
)
 
(3.17
)
 
 
Forfeited
(167,234
)
 
(19.83
)
 
 
Expired
(66,752
)
 
(25.26
)
 
 
Balances at March 31, 2019
11,705,841

 
26.53

 
6.07
Exercisable at March 31, 2019
8,061,580

 
28.86

 
5.18
Schedule of Restricted Stock Unit Activity RSU activity was as follows:
 
Number of Restricted Stock Units
 
Weighted Average Grant Date Fair Value
 
Weighted Average Remaining Contractual Term (Years)
Balances at December 31, 2018
970,341

 
$
13.82

 
1.43
Granted
1,737,410

 
7.03

 
 
Vested
(419,734
)
 
(11.60
)
 
 
Balances at March 31, 2019
2,288,017

 
9.07

 
1.98