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Consolidated Statements of Cash Flows - USD ($)
$ in Thousands
 3 Months Ended
Mar. 31, 2019
Mar. 31, 2018
Cash flows from operating activities    
Net loss $ (62,136) $ (47,409)
Adjustments to reconcile net loss to net cash used in operating activities:    
Depreciation and amortization 6,577 8,382
Loss on disposal of assets, net 493 316
Unrealized and realized (appreciation) depreciation on equity securities and preferred stock, net (70) 1,096
Noncash dividend income (12) (4,883)
Amortization of premiums (discounts) on investments, net (352) 0
Equity in net loss of affiliates 1,640 2,460
Stock-based compensation expense 9,054 11,362
Shares issued as payment for services 831 2,941
Provision for bad debts 64 218
Accretion of debt discount and amortization of deferred financing costs 2,213 0
Deferred income taxes (508) (4,074)
Other noncash items 247 127
Receivables:    
Trade 1,306 1,856
Related parties 1,584 4,729
Other 642 (215)
Inventory 1,381 231
Prepaid expenses and other (322) 1,062
Right-of-use assets 1,462 0
Other assets 13 (47)
Accounts payable (1,237) (764)
Accrued compensation and benefits (1,788) 4,851
Other accrued liabilities (6,129) (2,473)
Deferred revenue 1,330 (9,623)
Lease liabilities (1,433) 0
Related party payables 1,916 (165)
Other long-term liabilities 0 134
Net cash used in operating activities (43,234) (29,888)
Cash flows from investing activities    
Maturities of investments 45,000 6,000
Proceeds from sales of equity securities 418 0
Investments in affiliates (370) (5,510)
Return of investment in affiliate 0 2,598
Purchases of property, plant and equipment (11,523) (10,774)
Proceeds from sale of assets 67 230
Net cash provided by (used in) investing activities 33,592 (7,456)
Cash flows from financing activities    
Proceeds from issuance of shares and warrants in public offerings, net of issuance costs 6,611 87,990
Advances from lines of credit 1,408 1,239
Repayments of advances from lines of credit (1,597) (1,151)
Proceeds from long-term debt, net of issuance costs 376 0
Payments of long-term debt (178) (140)
Proceeds from stock option and warrant exercises 307 324
Net cash provided by financing activities 6,927 88,262
Effect of exchange rate changes on cash, cash equivalents, and restricted cash (504) 914
Net increase (decrease) in cash, cash equivalents, and restricted cash (3,219) 51,832
Cash, cash equivalents, and restricted cash    
Beginning of period 110,182 75,545
End of period 106,963 127,377
Supplemental disclosure of cash flow information    
Cash paid during the period for interest 77 82
Cash paid during the period for income taxes 30 20
Significant noncash financing and investing activities    
Purchases of property and equipment included in accounts payable and other accrued liabilities 2,531 2,016
Purchases of equipment financed through debt $ 0 $ 76