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v3.19.3

Consolidated Statements of Cash Flows - USD ($) $ in Thousands | 9 Months Ended
--- | ---
Sep. 30, 2019 | Sep. 30, 2018
Cash flows from operating activities |  |
Net loss | $ (154,701) | $ (172,984)
Adjustments to reconcile net loss to net cash used in operating activities: |  |
Depreciation and amortization | 18,711 | 25,184
Loss on disposals of assets, net | 1,875 | 4,110
Impairment loss | 626 | 0
Write-off of in-process research and development acquired in asset acquisition | 0 | 8,721
Unrealized and realized (appreciation) depreciation on equity securities and preferred stock, net | (2,634) | 27,565
Noncash dividend income | (38) | (14,575)
Amortization of discounts on investments, net | (949) | (275)
Equity in net loss of affiliates | 5,034 | 9,880
Stock-based compensation expense | 14,538 | 28,340
Shares issued as payment for services | 7,987 | 8,404
Provision for bad debts | 787 | 1,597
Accretion of debt discount and amortization of deferred financing costs | 6,962 | 2,116
Deferred income taxes | (1,448) | (19,335)
Other noncash items | 3,284 | 635
Receivables: |  |
Trade | 241 | 399
Related parties | 1,190 | 6,085
Other | 462 | (909)
Inventory | 4,775 | 2,577
Prepaid expenses and other | (4,320) | (511)
Right-of-use assets | 2,593 | 0
Other assets | (41) | 584
Accounts payable | (4,432) | (731)
Accrued compensation and benefits | 535 | 17,561
Other accrued liabilities | (5,651) | 1,591
Deferred revenue | 5,056 | (22,993)
Lease liabilities | (3,680) | 0
Related party payables | 38 | (167)
Other long-term liabilities | (585) | 253
Net cash used in operating activities | (103,785) | (86,878)
Cash flows from investing activities |  |
Purchases of investments | (55,073) | (178,681)
Sales of investments | 2,996 | 0
Maturities of investments | 127,500 | 20,975
Proceeds from sales of equity securities | 589 | 217
Investments in affiliates | (3,713) | (14,139)
Decrease in cash from deconsolidation of subsidiary | (7,244) | 0
Return of investment in affiliate | 125 | 2,598
Cash received in asset acquisition | 0 | 15,500
Purchases of property, plant and equipment | (33,199) | (30,354)
Proceeds from sale of assets | 361 | 1,930
Net cash provided by (used in) investing activities | 32,342 | (181,954)
Cash flows from financing activities |  |
Proceeds from issuance of shares and warrants in public offerings, net of issuance costs | 6,611 | 87,990
Advances from lines of credit | 4,623 | 3,231
Repayments of advances from lines of credit | (4,520) | (3,264)
Proceeds from long-term debt, net of issuance costs | 376 | 194,000
Payments of long-term debt | (464) | (485)
Proceeds from stock option and warrant exercises | 313 | 1,074
Net cash provided by financing activities | 6,939 | 282,546
Effect of exchange rate changes on cash, cash equivalents, and restricted cash | (843) | 578
Net increase (decrease) in cash, cash equivalents, and restricted cash | (65,347) | 14,292
Cash, cash equivalents, and restricted cash |  |
Beginning of period | 110,182 | 75,545
End of period | 44,835 | 89,837
Supplemental disclosure of cash flow information |  |
Cash paid during the period for interest | 3,698 | 360
Cash paid during the period for income taxes | 50 | 193
Significant noncash financing and investing activities |  |
Stock received as consideration for collaboration agreements | 4,530 | 0
Long-term debt issued to a related party in an asset acquisition | 0 | 30,000
Purchases of property and equipment included in accounts payable and other accrued liabilities | 692 | 2,088
Purchases of equipment financed through debt | $ 0 | $ 193

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