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Consolidated Statements of Cash Flows - USD ($)
$ in Thousands
 9 Months Ended
Sep. 30, 2019
Sep. 30, 2018
Cash flows from operating activities    
Net loss $ (154,701) $ (172,984)
Adjustments to reconcile net loss to net cash used in operating activities:    
Depreciation and amortization 18,711 25,184
Loss on disposals of assets, net 1,875 4,110
Impairment loss 626 0
Write-off of in-process research and development acquired in asset acquisition 0 8,721
Unrealized and realized (appreciation) depreciation on equity securities and preferred stock, net (2,634) 27,565
Noncash dividend income (38) (14,575)
Amortization of discounts on investments, net (949) (275)
Equity in net loss of affiliates 5,034 9,880
Stock-based compensation expense 14,538 28,340
Shares issued as payment for services 7,987 8,404
Provision for bad debts 787 1,597
Accretion of debt discount and amortization of deferred financing costs 6,962 2,116
Deferred income taxes (1,448) (19,335)
Other noncash items 3,284 635
Receivables:    
Trade 241 399
Related parties 1,190 6,085
Other 462 (909)
Inventory 4,775 2,577
Prepaid expenses and other (4,320) (511)
Right-of-use assets 2,593 0
Other assets (41) 584
Accounts payable (4,432) (731)
Accrued compensation and benefits 535 17,561
Other accrued liabilities (5,651) 1,591
Deferred revenue 5,056 (22,993)
Lease liabilities (3,680) 0
Related party payables 38 (167)
Other long-term liabilities (585) 253
Net cash used in operating activities (103,785) (86,878)
Cash flows from investing activities    
Purchases of investments (55,073) (178,681)
Sales of investments 2,996 0
Maturities of investments 127,500 20,975
Proceeds from sales of equity securities 589 217
Investments in affiliates (3,713) (14,139)
Decrease in cash from deconsolidation of subsidiary (7,244) 0
Return of investment in affiliate 125 2,598
Cash received in asset acquisition 0 15,500
Purchases of property, plant and equipment (33,199) (30,354)
Proceeds from sale of assets 361 1,930
Net cash provided by (used in) investing activities 32,342 (181,954)
Cash flows from financing activities    
Proceeds from issuance of shares and warrants in public offerings, net of issuance costs 6,611 87,990
Advances from lines of credit 4,623 3,231
Repayments of advances from lines of credit (4,520) (3,264)
Proceeds from long-term debt, net of issuance costs 376 194,000
Payments of long-term debt (464) (485)
Proceeds from stock option and warrant exercises 313 1,074
Net cash provided by financing activities 6,939 282,546
Effect of exchange rate changes on cash, cash equivalents, and restricted cash (843) 578
Net increase (decrease) in cash, cash equivalents, and restricted cash (65,347) 14,292
Cash, cash equivalents, and restricted cash    
Beginning of period 110,182 75,545
End of period 44,835 89,837
Supplemental disclosure of cash flow information    
Cash paid during the period for interest 3,698 360
Cash paid during the period for income taxes 50 193
Significant noncash financing and investing activities    
Stock received as consideration for collaboration agreements 4,530 0
Long-term debt issued to a related party in an asset acquisition 0 30,000
Purchases of property and equipment included in accounts payable and other accrued liabilities 692 2,088
Purchases of equipment financed through debt $ 0 $ 193