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v3.20.4

Consolidated Statements of Cash Flows - USD ($) $ in Thousands | 12 Months Ended
--- | ---
Dec. 31, 2020 | Dec. 31, 2019 | Dec. 31, 2018
Cash flows from operating activities |  |  |
Net loss | $ (170,521) | $ (323,916) | $ (514,706)
Adjustments to reconcile net loss to net cash used in operating activities: |  |  |
Depreciation and amortization | 17,516 | 24,896 | 33,112
Loss on abandonment and disposals of assets, net | 4,442 | 3,071 | 20,928
Impairment of goodwill | 9,635 | 87,862 | 0
Impairment of other noncurrent assets | 13,326 | 32,627 | 60,504
Gain on sale of discontinued operations | (672) | 0 | 0
Loss on release of cumulative foreign currency translation adjustment | 26,957 | 0 | 0
Reacquisition of in-process research and development | 0 | 0 | 236,748
Loss on settlement agreement | 11,436 | 0 | 0
Unrealized and realized (appreciation) depreciation on equity securities and preferred stock, net | 106 | (7,833) | 30,200
Noncash dividend income | 0 | (48) | (14,841)
Amortization of discounts on investments, net | (699) | (1,005) | (771)
Equity in net loss of affiliates | 1,176 | 6,730 | 11,608
Stock-based compensation expense | 18,366 | 18,950 | 36,296
Shares issued as payment for services | 1,006 | 10,446 | 10,695
Provision for credit losses | 899 | 3,242 | 1,779
Accretion of debt discount and amortization of deferred financing costs | 10,587 | 9,459 | 4,378
Deferred income taxes | (156) | (3,674) | (21,278)
Other noncash items | 226 | 837 | 1,093
Receivables: |  |  |
Trade | 2,214 | (262) | (2,698)
Related parties | 258 | 967 | 11,003
Other | 1,853 | (656) | (542)
Inventory | 2,511 | 4,100 | (478)
Prepaid expenses and other | (812) | (2,262) | 1,006
Other assets | (142) | 333 | 652
Accounts payable | (1,097) | (5,349) | 4,680
Accrued compensation and benefits | (789) | 5,186 | 4,385
Other accrued liabilities | (2,682) | (5,516) | 356
Deferred revenue | (21,045) | 7,423 | (38,578)
Lease liabilities | (887) | (995) | 0
Related party payables | (33) | 45 | (52)
Other long-term liabilities | 0 | (585) | 281
Net cash used in operating activities | (77,021) | (135,927) | (124,240)
Cash flows from investing activities |  |  |
Purchases of investments | (171,360) | (55,073) | (178,681)
Sales and maturities of investments | 133,000 | 166,495 | 65,975
Proceeds from sales of equity securities | 0 | 23,456 | 217
Acquisitions of businesses, net of cash received | 0 | 0 | (920)
Investments in affiliates | 0 | (3,713) | (16,582)
Decrease in cash from deconsolidation of subsidiary | 0 | (7,244) | 0
Return of investment in affiliate | 0 | 125 | 2,598
Cash received in asset acquisitions | 0 | 0 | 15,500
Purchases of property, plant and equipment | (7,527) | (37,883) | (41,587)
Proceeds from sale of assets | 6,484 | 688 | 2,267
Proceeds from sale of discontinued operations, net of cash sold | 64,240 | 0 | 0
Proceeds from repayment of notes receivable | 2,942 | 0 | 0
Net cash provided by (used in) investing activities | 27,779 | 86,851 | (151,213)
Cash flows from financing activities |  |  |
Proceeds from issuance of shares in a private placement | 35,000 | 0 | 0
Proceeds from issuance of shares and warrants in public offerings, net of issuance costs | 0 | 6,611 | 87,990
Advances from lines of credit | 10,005 | 11,757 | 4,561
Repayments of advances from lines of credit | (11,927) | (10,301) | (4,328)
Proceeds from long-term debt, net of issuance costs | 0 | 376 | 219,859
Payments of long-term debt | (490) | (618) | (623)
Proceeds from stock option and warrant exercises | 117 | 313 | 2,336
Net cash provided by financing activities | 32,705 | 8,138 | 309,795
Effect of exchange rate changes on cash, cash equivalents, and restricted cash | 353 | (810) | 295
Net increase (decrease) in cash, cash equivalents, and restricted cash | (16,184) | (41,748) | 34,637
Cash, cash equivalents, and restricted cash |  |  |
Beginning of year | 68,434 | 110,182 | 75,545
End of year | 52,250 | 68,434 | 110,182
Supplemental disclosure of cash flow information |  |  |
Cash paid during the period for interest | 7,202 | 3,751 | 3,868
Cash paid during the period for income taxes | 48 | 50 | 216
Significant noncash activities |  |  |
Fair value of stock received as consideration for collaboration agreements | 0 | 4,530 | 0
Fair value of stock issued for reacquired in-process research and development | 0 | 0 | 159,323
Fair value of stock issued upon conversion of long-term debt | 56,827 | 0 | 0
Fair value of stock issued in conjunction with settlement agreement | 18,103 | 0 | 0
Long-term debt issued to a related party in an asset acquisition | 0 | 0 | 30,000
Accrued compensation paid in equity awards | 5,100 | 1,102 | 0
Purchases of property and equipment included in accounts payable and other accrued liabilities | 277 | 694 | 2,267
Purchases of equipment financed through debt | 0 | 0 | 234
Sales of assets included in receivables | $ 4,227 | $ 0 | $ 0

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