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Income Taxes - Schedule of Effective Income Tax Rate Reconciliation (Details) - USD ($) $ in Thousands | 12 Months Ended
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Dec. 31, 2020 | Dec. 31, 2019 | Dec. 31, 2018
Income Tax Disclosure [Abstract] |  |  |
Computed statutory income tax benefit from continuing operations | $ (21,810) | $ (35,965) | $ (83,141)
State and provincial income tax benefit, net of federal income taxes | (5,167) | (5,494) | (21,717)
Nondeductible stock based compensation | 5,709 | 10,303 | 4,696
Nondeductible officer compensation | 728 | 595 | 294
Impairment of goodwill | 0 | 273 | 0
Research and development tax incentives | (524) | (1,772) | (185)
Acquisition and internal restructuring transaction costs | 0 | 260 | 52
Reacquired in-process research and development | 0 | 0 | 2,696
Change in deferred state tax rate | 0 | 0 | 8,666
United States-foreign rate differential | (21) | (76) | 215
Other, net | (306) | (72) | (3,517)
Income tax reconciliation income tax benefit before valuation allowance, total | (21,391) | (31,948) | (91,941)
Change in valuation allowance for deferred tax assets | 21,309 | 31,018 | 76,516
Total income tax benefit from continuing operations | $ (82) | $ (930) | $ (15,425)

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- Definition Amount of the difference between reported income tax expense (benefit) and expected income tax expense (benefit) computed by applying the domestic federal statutory income tax rates to pretax income (loss) from continuing operations attributable to nondeductible impairment loss. + References Reference 1: http://www.xbrl.org/2009/role/commonPracticeRef -Publisher FASB -Name Accounting Standards Codification -Topic 740 -SubTopic 10 -Section 50 -Paragraph 12 -URI http://asc.fasb.org/extlink&oid=84230637&loc=d3e32687-109319 + Details
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- Definition Amount of reported income tax expense (benefit) in excess of (less than) expected income tax expense (benefit) computed by applying domestic federal statutory income tax rate to pretax income (loss) from continuing operation, attributable to nondeductible expense for award under share-based payment arrangement. Includes, but is not limited to, expense determined to be nondeductible upon grant or after for award under share-based payment arrangement. + References Reference 1: http://www.xbrl.org/2009/role/commonPracticeRef -Publisher FASB -Name Accounting Standards Codification -Topic 740 -SubTopic 10 -Section 50 -Paragraph 12 -URI http://asc.fasb.org/extlink&oid=84230637&loc=d3e32687-109319 + Details
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