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Related Party Transactions - Additional Information (Details)	1 Months Ended				10 Months Ended	12 Months Ended
	Jan. 31, 2020 USD ($)	Dec. 31, 2019 USD ($)	Oct. 31, 2019 USD ($)	Jan. 31, 2018 shares	Jul. 31, 2018 shares	Dec. 31, 2020 USD ($)	Dec. 31, 2019 USD ($) shares	Dec. 31, 2018 USD ($) relatedParty shares	Oct. 31, 2017 USD ($)
Related Party Transaction [Line Items]
Shares issued as payment for services							$ 10,446,000	$ 10,695,000
Shares issued during the period (in shares) | shares				6,900,000
Dividend income from investments in preferred stock						$ 0	48,000	14,841,000
Proceeds from sales of equity securities			$ 21,587,000			0	23,456,000	217,000
Receivables		$ 2,030,000				232,000	2,030,000
Third Security
Related Party Transaction [Line Items]
Expense for services						159,000	$ 26,000	$ 47,000
Common stock calculation period							30 days
Shares issued as payment for services, shares | shares							1,606,062	696,033
Shares issued as payment for services							$ 8,233,000	$ 8,324,000
Sublease rental income						$ 83,000	89,000
Sublease rental income								89,000
Affiliates of Third Security
Related Party Transaction [Line Items]
Shares issued during the period (in shares) | shares				1,000,000
Castle Creek Biosciences, Inc.
Related Party Transaction [Line Items]
Proceeds from sales of equity securities		1,280,000
Proceeds from Convertible Preferred Shares and convertible note	$ 3,311,000
Receivables		$ 3,311,000					3,311,000
Changes in fair value, gain							3,222,000
Common Stock | Third Security
Related Party Transaction [Line Items]
Expense for services							$ 800,000
Series A Preferred Shares
Related Party Transaction [Line Items]
Shares issued during the period (in shares) | shares					0
Series A Preferred Shares | Affiliates of Third Security
Related Party Transaction [Line Items]
Convertible preferred stock, amount authorized									$ 100,000,000
Third Security | Executive Chairman
Related Party Transaction [Line Items]
Ownership interest						100.00%
ZIOPHARM Oncology, Inc.
Related Party Transaction [Line Items]
Dividend income from investments in preferred stock								$ 14,793,000
Collaboration and licensing agreements | Various ECC Agreements
Related Party Transaction [Line Items]
Number of related parties with terminated agreements | relatedParty								3
Revenue recognized from previously deferred balances								$ 11,877,000

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