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Segments - Reconciliation of Net Loss Before Income Taxes (Details) - USD ($)
$ in Thousands
 12 Months Ended
Dec. 31, 2020
Dec. 31, 2019
Dec. 31, 2018
Segment Reporting Information [Line Items]      
Segment Adjusted EBITDA $ (28,713) $ (56,115) $ (62,067)
Other expenses:      
Depreciation and amortization (17,516) (24,896) (33,112)
Loss on settlement agreement (11,436) 0 0
Stock-based compensation expense (18,366) (18,950) (36,296)
Equity in net loss of affiliates (1,176) (6,730) (11,608)
Other (226) (837) (1,093)
Loss from continuing operations before income taxes (103,855) (171,264) (395,912)
Operating segments      
Segment Reporting Information [Line Items]      
Remove cash paid for capital expenditures and investments in affiliates 6,970 12,512 15,276
Other expenses:      
Other expenses:      
Interest expense (18,400) (17,666) (8,473)
Depreciation and amortization (15,042) (16,142) (20,612)
Impairment losses (920) (30,810) 0
Reacquisition of in-process research and development 0 0 (236,748)
Loss on settlement agreement (11,436) 0 0
Stock-based compensation expense (19,746) (15,098) (30,554)
Adjustment related to accrued bonuses paid in equity awards 2,833 0 0
Equity in net loss of affiliates (1,138) (2,416) (8,986)
Other 11 67 0
Unallocated corporate costs      
Other expenses:      
Loss from continuing operations before income taxes (37,566) (46,011) (74,609)
Eliminations      
Other expenses:      
Loss from continuing operations before income taxes (5,713) (14,306) (2,343)
Reportable segments      
Segment Reporting Information [Line Items]      
Segment Adjusted EBITDA (32,987) (51,214) (51,359)
All Other      
Segment Reporting Information [Line Items]      
Segment Adjusted EBITDA 4,274 (4,901) (10,708)
Upfront and Milestone Payments | Operating segments      
Segment Reporting Information [Line Items]      
Add recognition of previously deferred revenue associated with upfront and milestone payments $ 25,005 $ 14,721 $ 33,204